Denis Roda Dos Santos

Denis Roda Dos Santos
International Iberian Nanotechnology Laboratory · Nanoelectronics

PhD

About

111
Publications
172,047
Reads
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8,023
Citations
Additional affiliations
November 2018 - present
International Iberian Nanotechnology Laboratory
Position
  • Research Associate
November 2007 - December 2013
CERN
Position
  • Electronics Engineer at the ATLAS particle physics detector
September 2005 - September 2007
Institute of Electronics and Telematics Engineering
Position
  • Master's Student
Education
January 2014 - October 2018
Technical University of Lisbon
Field of study
  • Bioengineering
September 2005 - July 2008
University of Aveiro
Field of study
  • Biomedical Engineering
September 1999 - July 2005
University of Aveiro
Field of study
  • Electronics and Telecommunications Engineering

Publications

Publications (111)
Article
Recently, systems for rapid diagnosis of diseases and infections have motivated the development of new DNA detection platforms. However, these platforms have failed to reach the market mainly because of the potential risk of misdiagnosis. Thus, developing a system with an effective internal control, guaranteeing the veracity of the result, could he...
Article
Full-text available
Colorectal cancer is the second leading cause of cancer death worldwide. Significant advances in the molecular mechanisms underlying colorectal cancer have been made; however, the clinical approval of new drugs faces many challenges. Drug discovery is a lengthy process causing a rapid increase in global health care costs. Patient-derived tumour org...
Article
Label-free approaches to biomolecular detection in microfluidics avoid potential labeling interference, are suitable for the screening of analytes which are not easily tagged and simplify assay development towards point-of-use applications. In this work, multimodal label-free detection of biomolecules was performed in a microfluidic system (i) opti...
Conference Paper
Nanoporous microbead-based microfluidic systems for biosensing applications allow enhanced sensitivities, while being low cost and amenable for miniaturization. The regeneration of the microfluidic biosensing system results in a further decrease in costs while the integration of on-chip signal transduction enhances portability. Here, we present a r...
Article
The rapid and sensitive detection of specific nucleic acid sequences at the point-of-care (PoC) is becoming increasingly in demand for a variety of emergent biomedical applications ranging from infectious disease diagnostics to the screening of antimicrobial resistance. To meet such demand, considerable efforts have been invested towards the develo...
Article
Microfluidic devices with integrated optical-to-electrical signal transduction using miniaturized photodetectors can address the need for compact and portable biosensing platforms for medical, veterinary, environmental and food safety applications. However, for different applications the features of the microfluidic point-of-need device will differ...
Article
Portable, rapid, cost effective and simple analytical tools are in increasing demand to facilitate the routine monitoring of target chemical/ biological compounds at the point-of-need. Such devices are highly relevant within the context of food safety, particularly concerning the screening of highly toxic and strictly regulated mycotoxins. To achie...
Conference Paper
This paper presents an innovative integrated microfluidic platform which allows an ultrarapid detection of mycotoxins, a prevalent and increasingly monitored class of food contaminants. The simultaneous detection of aflatoxin B1 (AFB1), deoxynivalenol (DON) and ochratoxin A (OTA), within their respective regulatory limits is achieved in a single st...
Conference Paper
This work presents a simple and innovative approach for the quantitative analysis of optical transduction signals from fluorescence, chemiluminescence and colorimetry coupled to a model affinity interaction inside a microfluidic device. By coupling nanoporous microbeads packed inside a microfluidic channel with an integrated photodetector, it was p...
Article
The optimization of chromatography operating conditions is a lengthy and demanding task that typically requires large volumes of reagents and costly dedicated equipment. In particular, the use of multimodal chromatography, in which multiple interaction groups co-exist in the same ligand, can make the optimization process even more challenging. Neve...
Article
Thin-film optical transducers integrated in lab-on-a-chip (LoC) devices have the potential to facilitate miniaturization, multiplexing capabilities, portability, and sensitivity. However, there are few systematic studies that provide detailed characterization of these photosensors to particular miniaturized bioassays at reduced light intensities. A...
Article
For a point-of-use analytical device to be successful in real-world applications, it needs to be rapid, simple to operate and, ideally, able to multiplex the detection of several analytes and samples. Mycotoxin detection in food and feedstock in particular has become increasingly relevant as these toxins, such as ochratoxin A (OTA), aflatoxin B1 (A...
Conference Paper
Full-text available
Chromatography is a robust purification technique, but requires time-consuming optimization on a case-by-case basis, particularly for monoclonal antibodies (mAbs). This work presents a novel microfluidic platform that significantly speeds up the optimization process and reduces the amount of reagent needed. Binding kinetics for a fluorescent conjug...
Conference Paper
Full-text available
The assurance of strict food safety standards is a major challenge in modern society. Mycotoxins, in particular, are produced by fungi during production, storage or transport, posing serious health concerns to humans and animals. Aiming at developing a point-of-use tool for the rapid detection of mycotoxins at the required regulatory levels, we rep...
Conference Paper
Full-text available
Food safety can be seriously compromised by the presence of mycotoxins. Their detection becomes increasingly relevant as they are subject to strict regulations in the European Union. To cope with this demand, a novel device with manually operated magnetic valves was developed and applied in a direct competitive immunoassay with multiplexed chemilum...
Article
Full-text available
A search is made for massive long-lived highly ionising particles with the ATLAS experiment at the Large Hadron Collider, using 3.1 pb-1 of pp collision data taken at sqrt(s)=7 TeV. The signature of energy loss in the ATLAS inner detector and electromagnetic calorimeter is used. No such particles are found and limits on the production cross section...
Article
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A search is presented for production of a heavy up-type quark ( t ′ ) together with its antiparticle, assuming a significant branching ratio for subsequent decay into a W boson and a b quark. The search is based on 4.7 fb−1 of pp collisions at s = 7 TeV recorded in 2011 with the ATLAS detector at the CERN Large Hadron Collider. Data are analyzed in...
Article
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The ATLAS experiment has observed 1995 Z boson candidates in data corresponding to 0.15 nb^{-1} of integrated luminosity obtained in the 2011 LHC Pb+Pb run at sqrt[s_{NN}]=2.76 TeV. The Z bosons are reconstructed via dielectron and dimuon decay channels, with a background contamination of less than 3%. Results from the two channels are consistent a...
Article
Full-text available
Results of a search for new phenomena in events with an energetic photon and large missing transverse momentum in proton-proton collisions at sqrt[s]=7 TeV are reported. Data collected by the ATLAS experiment at the LHC corresponding to an integrated luminosity of 4.6 fb^{-1} are used. Good agreement is observed between the data and the standard mo...
Article
Full-text available
Measurements of luminosity obtained using the ATLAS detector during early running of the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV are presented. The luminosity is independently determined using several detectors and multiple algorithms, each having different acceptances, systematic uncertainties and sensitivity to background. The ratios of th...
Article
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This Letter presents a search for magnetic monopoles with the ATLAS detector at the CERN Large Hadron Collider using an integrated luminosity of 2.0 fb^{-1} of pp collisions recorded at a center-of-mass energy of sqrt[s]=7 TeV. No event is found in the signal region, leading to an upper limit on the production cross section at 95% confidence level...
Article
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A search for direct pair production of supersymmetric top squarks (t[over ˜]_{1}) is presented, assuming the t[over ˜]_{1} decays into a top quark and the lightest supersymmetric particle, χ[over ˜]_{1}^{0}, and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted standard model b...
Article
Full-text available
A search is presented for direct top squark pair production in final states with one isolated electron or muon, jets, and missing transverse momentum in proton-proton collisions at sqrt[s]=7  TeV. The measurement is based on 4.7  fb^{-1} of data collected with the ATLAS detector at the LHC. Each top squark is assumed to decay to a top quark and the...
Article
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This Letter presents a search for pair production of heavy down-type quarks decaying via b' → Wt in the lepton + jets channel, as b'b' → W- tW+ t → bbW+ W- W+ W- → l± νbbqqqqqq. In addition to requiring exactly one lepton, large missing transverse momentum, and at least six jets, the invariant mass of nearby jet pairs is used to identify high trans...
Article
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A QCD analysis is reported of ATLAS data on inclusive W^{±} and Z boson production in pp collisions at the LHC, jointly with ep deep-inelastic scattering data from HERA. The ATLAS data exhibit sensitivity to the light quark sea composition and magnitude at Bjorken x∼0.01. Specifically, the data support the hypothesis of a symmetric composition of t...
Article
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The results of a search for pair production of the scalar partners of bottom quarks in 2.05  fb(-1) of pp collisions at sqrt[s]=7  TeV using the ATLAS experiment are reported. Scalar bottom quarks are searched for in events with large missing transverse momentum and two jets in the final state, where both jets are identified as originating from a b...
Article
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A measurement of the production cross-section for top quark pairs (tt¯) in pp collisions at s=7 TeV is presented using data recorded with the ATLAS detector at the Large Hadron Collider. Events are selected in the single lepton topology by requiring an electron or muon, large missing transverse momentum and at least three jets. With a data sample o...
Article
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The χ(b)(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider at sqrt[s] = 7  TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4  fb(-1), these states are reconstructed through their radiative decays to Υ(1S,2S) with Υ → μ+ μ-. In addition to the mass p...
Article
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This Letter presents a search for the Standard Model Higgs boson in the decay channel H→ZZ→ℓ+ℓ-ℓℓ, where ℓ,ℓ′=e or μ, using proton-proton collisions at s=7 TeV recorded with the ATLAS detector and corresponding to an integrated luminosity of 4.8 fb-1. The four-lepton invariant mass distribution is compared with Standard Model background expectation...
Article
Full-text available
The ATLAS experiment at the LHC has measured the centrality dependence of charged particle pseudorapidity distributions over |η|<2 in lead-lead collisions at a nucleon-nucleon centre-of-mass energy of sNN=2.76 TeV. In order to include particles with transverse momentum as low as 30 MeV, the data were recorded with the central solenoid magnet off. C...
Article
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A search for the Higgs boson has been performed in the H→WW(*)→ℓ(+)νℓ(-)ν[over ¯] channel (ℓ=e/μ) with an integrated luminosity of 2.05 fb(-1) of pp collisions at √s=7 TeV collected with the ATLAS detector at the Large Hadron Collider. No significant excess of events over the expected background is observed and limits on the Higgs boson production...
Article
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A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb(-1) collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV. In the diphoton mass range 110-150 GeV, the largest excess with...
Article
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A search for squarks and gluinos in final states containing high-p T jets, missing transverse momentum and no electrons or muons is presented. The data were recorded in 2012 by the ATLAS experiment in \( \sqrt{s}=8 \) TeV proton-proton collisions at the Large Hadron Collider, with a total integrated luminosity of 20.3 fb−1. Results are interpreted...
Article
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A combined search for the Standard Model Higgs boson with the ATLAS experiment at the LHC using datasets corresponding to integrated luminosities from 1.04 fb-1 to 4.9 fb-1 of pp collisions collected at s=7 TeV is presented. The Higgs boson mass ranges 112.9-115.5 GeV, 131-238 GeV and 251-466 GeV are excluded at the 95% confidence level (CL), while...
Article
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A measurement of the ZZ production cross section in proton-proton collisions at sqrt[s] = 7 TeV using data corresponding to an integrated luminosity of 1.02 fb(-1) recorded by the ATLAS experiment at the LHC is presented. Twelve events containing two Z boson candidates decaying to electrons and/or muons are observed, with an expected background of...
Article
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A search for new phenomena in tt events with large missing transverse momentum in proton-proton collisions at a center-of-mass energy of 7 TeV is presented. The measurement is based on 1.04 fb(-1) of data collected with the ATLAS detector at the LHC. Contributions to this final state may arise from a number of standard model extensions. The results...
Article
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This Letter reports on a search for narrow high-mass resonances decaying into dilepton final states. The data were recorded by the ATLAS experiment in pp collisions at √s=7  TeV at the Large Hadron Collider and correspond to a total integrated luminosity of 1.08 (1.21)  fb(-1) in the e(+)e(-) (μ(+)μ(-)) channel. No statistically significant excess...
Article
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A search for a Higgs boson has been performed in the H→WW→ℓνjj channel in 1.04 fb(-1) of pp collision data at √s=7 TeV recorded with the ATLAS detector at the Large Hadron Collider. No significant excess of events is observed over the expected background and limits on the Higgs boson production cross section are derived for a Higgs boson mass in th...
Article
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A search for pair-produced scalar particles decaying to a four-jet final state is presented. The analysis is performed using an integrated luminosity of 34pb−1 recorded by the ATLAS detector in 2010. No deviation from the Standard Model is observed. For a scalar mass of 100GeV (190GeV) the limit on the scalar gluon pair production cross section at...
Article
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The inclusive and dijet production cross-sections have been measured for jets containing b-hadrons ( b-jets) in proton-proton collisions at a centre-of-mass energy of sqrt{s} = 7 TeV, using the ATLAS detector at the LHC. The measurements use data corresponding to an integrated luminosity of 34 pb-1. The b-jets are identified using either a lifetime...
Article
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A search for a heavy standard model Higgs boson decaying via H→ZZ→→ℓ(+)ℓ(-)νν, where ℓ=e, μ, is presented. It is based on proton-proton collision data at √s=7 TeV, collected by the ATLAS experiment at the LHC in the first half of 2011 and corresponding to an integrated luminosity of 1.04 fb(-1). The data are compared to the expected standard model...
Article
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A measurement of the cross-section for ϒ(1S)→μμ production in proton-proton collisions at centre of mass energy of 7 TeV is presented. The cross-section is measured as a function of the ϒ(1S) transverse momentum in two bins of rapidity, |y|<1.2 and 1.2<|y|<2.4. The measurement requires that both muons have transverse momentum pTμ>4 GeV and pseudora...
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A search for new phenomena in events featuring a high energy jet and large missing transverse momentum in proton-proton collisions at s = 7 TeV is presented using a dataset corresponding to an integrated luminosity of 33 pb -1 recorded with the ATLAS detector at the Large Hadron Collider. The number of observed events is consistent with the Standa...
Article
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The jet fragmentation function and transverse profile for jets with 25GeV<p T jet<500GeV and |η jet|<1.2 produced in proton–proton collisions with a center-of-mass energy of 7TeV are presented. The measurement is performed using data with an integrated luminosity of 36 pb−1. Jets are reconstructed and their momentum measured using calorimetric info...
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A search for long-lived charged particles reaching the muon spectrometer is performed using a data sample of 37 pb - 1 from pp collisions at s = 7 TeV collected by the ATLAS detector at the LHC in 2010. No excess is observed above the estimated background. Stable τ ˜ sleptons are excluded at 95% CL up to a mass of 136 GeV , in GMSB models with N =...
Article
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The inclusive J/ψ production cross-section and fraction of J/ψ mesons produced in B-hadron decays are measured in proton-proton collisions at s=7 TeV with the ATLAS detector at the LHC, as a function of the transverse momentum and rapidity of the J/ψ, using 2.3 pb-1 of integrated luminosity. The cross-section is measured from a minimum p of 1 GeV t...
Article
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This Letter presents a measurement of the W+ W- production cross section in sqrt(s) = 7  TeV pp collisions by the ATLAS experiment, using 34  pb(-1) of integrated luminosity produced by the Large Hadron Collider at CERN. Selecting events with two isolated leptons, each either an electron or a muon, 8 candidate events are observed with an expected b...
Article
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A search for the Standard Model Higgs boson at the Large Hadron Collider (LHC) running at a centre-of-mass energy of 7TeV is reported, based on a total integrated luminosity of up to 40pb−1 collected by the ATLAS detector in 2010. Several Higgs boson decay channels: H→γγ, H→ZZ (∗)→ℓℓℓℓ, H→ZZ→ℓℓνν, H→ZZ→ℓℓqq, H→WW (∗)→ℓνℓν and H→WW→ℓνqq (ℓis e, μ) a...
Article
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Results are presented of searches for the production of supersymmetric particles decaying into final states with missing transverse momentum and exactly two isolated leptons in Ös=7TeV\sqrt {s}=7~\mbox{TeV} proton–proton collisions at the Large Hadron Collider. Search strategies requiring lepton pairs with identical-sign or opposite-sign electric c...
Article
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Results are presented of a search for particles decaying into final states with significant missing transverse momentum and exactly two identical flavour leptons (e, μ) of opposite charge in Ös=7\sqrt{s}=7TeV collisions at the Large Hadron Collider. This channel is particularly sensitive to supersymmetric particle cascade decays producing flavour c...
Article
Full-text available
A search for squarks and gluinos in final states containing jets, missing transverse momentum and no electrons or muons is presented. The data were recorded by the ATLAS experiment in sqrt(s) = 7 TeV proton-proton collisions at the Large Hadron Collider. No excess above the Standard Model background expectation was observed in 35 inverse picobarns...
Article
Full-text available
This Letter presents the first search for a heavy particle decaying into an e ± μ(-/+) final state in sqrt[s] = 7 TeV pp collisions at the LHC. The data were recorded by the ATLAS detector during 2010 and correspond to a total integrated luminosity of 35 pb(-1). No excess above the standard model background expectation is observed. Exclusions at 95...
Article
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We present studies of W and Z bosons with associated high energy photons produced in pp collisions at Ös = 7 \sqrt {s} = 7 TeV. The analysis uses 35 pb−1 of data collected by the ATLAS experiment in 2010. The event selection requires W and Z bosons decaying into high p T leptons (electrons or muons) and a photon with E T > 15GeV separated from the...
Article
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This Letter presents a search for high mass e+e- or μ+μ- resonances in pp collisions at s=7 TeV at the LHC. The data were recorded by the ATLAS experiment during 2010 and correspond to a total integrated luminosity of ˜40 pb-1. No statistically significant excess above the Standard Model expectation is observed in the search region of dilepton inva...
Article
Full-text available
A search for new interactions and resonances produced in LHC proton–proton (pp) collisions at a centre-of-mass energy was performed with the ATLAS detector. Using a dataset with an integrated luminosity of 36 pb− 1, dijet mass and angular distributions were measured up to dijet masses of ~3.5 TeV and were found to be in good agreement with Standard...
Article
Full-text available
Measurements are presented from proton–proton collisions at centre-of-mass energies of , 2.36 and 7 TeV recorded with the ATLAS detector at the LHC. Events were collected using a single-arm minimum-bias trigger. The charged-particle multiplicity, its dependence on transverse momentum and pseudorapidity and the relationship between the mean transver...
Article
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Azimuthal decorrelations between the two central jets with the largest transverse momenta are sensitive to the dynamics of events with multiple jets. We present a measurement of the normalized differential cross section based on the full data set (∫Ldt=36  pb(-1)) acquired by the ATLAS detector during the 2010 sqrt(s)=7  TeV proton-proton run of th...