Denis Dauvergne

Denis Dauvergne
Laboratoire de Physique Subatomique et Cosmologie, Grenoble, France

About

261
Publications
19,253
Reads
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2,449
Citations
Citations since 2016
60 Research Items
1374 Citations
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
Additional affiliations
March 2012 - December 2019
University of Lyon
Position
  • Co-director of LabEx PRIMES (Physics, Radiobiology, Medical Imaging and Simulations)
September 1990 - September 2015
Institut de Physique Nucléaire de Lyon
Position
  • Senior Researcher

Publications

Publications (261)
Article
Objective: Study the performance of a spectral reconstruction method for Compton imaging of polychromatic sources and compare it to standard Compton reconstruction based on the selection of photopeak events. Approach: The proposed spectral and the standard photopeak reconstruction methods are used to reconstruct images from simulated sources emi...
Article
Objective. Proton computed tomography (CT) is similar to x-ray CT but relies on protons rather than photons to form an image. In its most common operation mode, the measured quantity is the amount of energy that a proton has lost while traversing the imaged object from which a relative stopping power map can be obtained via tomographic reconstructi...
Preprint
Full-text available
Proton computed tomography (CT) is similar to x-ray CT but relies on protons rather than photons to form an image. In its most common operation mode, the measured quantity is the amount of energy that a proton has lost while traversing the imaged object from which a relative stopping power map can be obtained via tomographic reconstruction. To this...
Article
In the context of online ion range verification in particle therapy, the CLaRyS collaboration is developing Prompt-Gamma (PG) detection systems. The originality in the CLaRyS approach is to use a beam-tagging hodoscope in coincidence with the gamma detectors to provide both temporal and spatial information of the incoming ions. The ion range sensit...
Article
This note addresses an issue faced by every proton computed tomography (CT) reconstruction software: the modelling and the parametrisation of the multiple Coulomb scattering power for the estimation of the most likely path (MLP) of each proton. The conventional approach uses a polynomial model parameterised as a function of depth for a given initia...
Article
Full-text available
Experimental fission studies for reaction physics or nuclear spectroscopy can profit from fast, efficient, and radiation-resistant fission fragment (FF) detectors. When such experiments are performed in-beam in intense thermal neutron beams, additional constraints arise in terms of target-detector interface, beam-induced background, etc. Therefore,...
Article
Online ion range monitoring in hadron therapy can be performed via detection of secondary radiation, such as prompt γ-rays, emitted during treatment. The prompt γ emission profile is correlated with the ion depth-dose profile and can be reconstructed via Compton imaging. The line-cone reconstruction, using the intersection between the primary beam...
Article
We propose a novel Prompt-Gamma (PG) imaging modality for real-time monitoring in proton therapy: PG Time Imaging (PGTI). By measuring the Time-Of-Flight (TOF) between a beam monitor and a PG detector, our goal is to reconstruct the PG vertex distribution in 3D. In this paper, a dedicated, non-iterative reconstruction strategy is proposed (PGTI rec...
Preprint
Full-text available
In the context of online ion range verification in particle therapy, the CLaRyS collaboration is developing Prompt-Gamma (PG) detection systems. The originality in the CLaRyS approach is to use a beam-tagging hodoscope in coincidence with the gamma detectors to provide both temporal and spatial information of the incoming ions. The ion range sensit...
Article
This article introduces a design of a Low Noise Amplifier (LNA), for the field of diamond particle detectors. This amplifier is described from simulation to measurements, which include pulses from α particles detection. In hadron therapy, with high-frequency pulsed particle beams, the diamond detector is a promising candidate for beam monitoring an...
Preprint
Full-text available
This article introduces a design of a Low Noise Amplifier (LNA), for the field of diamond particle detectors. This amplifier is described from simulation to measurements, which include pulses from {\alpha} particles detection. In hadron therapy, with high-frequency pulsed particle beams, the diamond detector is a promising candidate for beam monito...
Preprint
Full-text available
A beam tagging hodoscope prototype made of squared 1 mm$^2$ fibers arranged in two perpendicular planes and coupled to multi-anode photomultipliers has been studied using 65 MeV proton as well as 95 MeV/u $^{12}$C beams at various intensities. This hodoscope successfully provided 2D images of proton beams with a detection efficiency larger than 98...
Preprint
Full-text available
We are currently conceiving, through (MC) simulation, a multi-channel gamma detector array (TIARA for Time-of-flight Imaging ARrAy) for the online monitoring of protontherapy treatments. By measuring the Time-Of-Flight (TOF) between a beam monitor placed upstream and the Prompt-Gamma (PG) detector, our goal is to reconstruct the PG vertex distribut...
Article
The intrinsic electronic properties of diamond make it suitable for radiation-hard and very fast detector development with good signal to noise ratios. With the advent of new generations of ion accelerators either for physics (nuclear and high energy physics) or medical applications (hadrontherapy and synchrotron radiation radiotherapy) there is a...
Article
Full-text available
We measured the radiation tolerance of commercially available diamonds grown by the Chemical Vapor Deposition process by measuring the charge created by a 120 GeV hadron beam in a 50 μm pitch strip detector fabricated on each diamond sample before and after irradiation. We irradiated one group of samples with 70 MeV protons, a second group of sampl...
Article
Full-text available
Biomedical applications at high-energy particle accelerators have always been an important section of the applied nuclear physics research. Several new facilities are now under constructions or undergoing major upgrades. While the main goal of these facilities is often basic research in nuclear physics, they acknowledge the importance of including...
Article
Full-text available
Within the frame of the CLaRyS collaboration, we discuss the assets of using a reduced-intensity in vivo treatment control phase during one or a few beam spots at the beginning of a particle therapy session. By doing so we can improve considerably the conditions for secondary radiation detection and particle radiography. This also makes Time-of-Fli...
Article
Imaging is critical to each step of precision radiation therapy, i.e. planning, setup, delivery and assessment of response. Hadrontherapy can be considered to deliver more precise dose distribution that may better spare normal tissues from intermediate low doses of radiation. In addition, hadrontherapy using high linear energy transfer ions may als...
Article
In order to fully exploit the ballistic potential of particle therapy, we propose an online range monitoring concept based on Time-Of-Flight (TOF)-resolved Prompt Gamma (PG) detection in a single proton counting regime. In a proof of principle experiment, different types of monolithic scintillating gamma detectors are read in time coincidence with...
Preprint
Full-text available
The accuracy of hadrontherapy treatment is currently limited by ion-range uncertainties. In order to fully exploit the potential of this technique, we propose the development of a novel system for online control of particle therapy, based on TOF-resolved (time-of-flight) Prompt Gamma (PG) imaging with 100 ps time resolution. Our aim is to detect a...
Preprint
Full-text available
In order to fully exploit the ballistic potential of particle therapy, we propose an online range monitoring concept based on high-resolution Time-Of-Flight (TOF)-resolved Prompt Gamma (PG) detection in a single proton counting regime. In a proof of principle experiment, different types of monolithic scintillating gamma detectors are read in time c...
Article
Compton cameras are gamma-ray imaging systems which have been proposed for a wide variety of applications such as medical imaging, nuclear decommissioning or homeland security. In the design and optimization of such a system Monte Carlo simulations play an essential role. In this work, we propose a generic module to perform Monte Carlo simulations...
Preprint
Diamond is a material in use at many nuclear and high energy facilities due to its inherent radiation tolerance and ease of use. We have characterized detectors based on chemical vapor deposition (CVD) diamond before and after proton irradiation. We present preliminary results of the spatial resolution of unirradiated and irradiated CVD diamond str...
Article
Chemical Vapour Deposition (CVD) diamond is being considered as a material for particle detectors in a harsh radiation environment. This article presents beam test results of 3D pixel detectors fabricated with poly-crystalline CVD diamonds. The cells of the devices had a size of 50 µm×50 µm with columns 2.6 µm in diameter. The cells were ganged in...
Article
As more and more particle therapy centers are being built world-wide, there is increasing need in treatment monitoring methods, ideally in real-time. The present work investigates the clinical applicability of a Compton camera design by means of Monte Carlo simulations. The Compton camera performance has been studied with the simulation of point-li...
Article
Full-text available
We have measured the radiation tolerance of poly-crystalline and single-crystalline diamonds grown by the chemical vapor deposition (CVD) process by measuring the charge collected before and after irradiation in a 50 m pitch strip detector fabricated on each diamond sample. We irradiated one group of sensors with 800 MeV protons, and a second group...
Article
Time resolution measurements were performed using four digital timing algorithms and a pair of truncated-cone shaped, 38-mm diameter LaBr3(Ce) fast-timing scintillator detectors. The best resolution [FWHM=143(3) ps] was found for transitions from a ⁶⁰Co source when fitting the rising part of sampled waveforms with a cubic polynomial and applying a...
Article
The CLaRyS collaboration focuses on the development of gamma detectors for medical applications, in particular for what concerns the range monitoring in ion beam therapy. Part of the research program aims to implement two gamma-camera clinical prototypes, a multi-collimated camera and a Compton camera. A common absorber detector has been designed f...
Article
In sight of the luminosity increase of the High Luminosity-LHC (HL-LHC), most experiments at the CERN Large Hadron Collider (LHC) are planning upgrades for their innermost layers in the next 5–10 years. These upgrades will require more radiation tolerant technologies than exist today. Usage of Chemical Vapor Deposition (CVD) diamond as detector mat...
Article
Detectors based on Chemical Vapor Deposition (CVD) diamond have been used extensively and successfully in beam conditions/beam loss monitors as the innermost detectors in the highest radiation areas of Large Hadron Collider (LHC) experiments. The startup of the LHC in 2015 brought a new milestone where the first polycrystalline CVD (pCVD) diamond p...
Article
Beam test results of the radiation tolerance study of chemical vapour deposition (CVD) diamond against different particle species and energies is presented. We also present beam test results on the independence of signal size on incident particle rate in charged particle detectors based on un-irradiated and irradiated poly-crystalline CVD diamond o...
Article
Full-text available
The MoniDiam project is part of the French national collaboration CLaRyS (Contrôle en Ligne de l’hAdronthérapie par RaYonnements Secondaires) for on-line monitoring of hadron therapy. It relies on the imaging of nuclear reaction products that is related to the ion range. The goal here is to provide large area beam detectors with a high detection ef...
Article
Full-text available
Introduction Single Photon Emission Computed Tomography (SPECT) is at present one of the major techniques for non-invasive diagnostics in nuclear medicine. Almost the whole clinical routine is based on collimated cameras, originally proposed by Anger. Due to the presence of mechanical collimation, detection efficiency and energy acceptance are limi...
Article
Single-Photon Avalanche Diodes (SPADs) are p–n junctions operated in Geiger Mode by applying a reverse bias above the breakdown voltage. SPADs have the advantage of featuring single photon sensitivity with timing resolution in the picoseconds range. Nevertheless, their relatively high Dark Count Rate (DCR) is a major issue for charged particle dete...
Article
Single Photon Emission Computed Tomography (SPECT) is at present one of the major techniques for non-invasive diagnostics in nuclear medicine. The clinical routine is mostly based on collimated cameras, originally proposed by Hal Anger. Due to the presence of mechanical collimation, detection eciency and energy acceptance are limited and xed by the...
Article
Secondary radiation emission induced by nuclear reactions is correlated to the path of ions in matter. Therefore, such penetrating radiation can be used for in vivo control of hadrontherapy treatments, for which the primary beam is absorbed inside the patient. Among secondary radiations, prompt-gamma rays were proposed for real-time verification of...
Article
For the purpose of detecting deviations from the prescribed treatment during particle therapy, the integrals of uncollimated prompt gamma-ray timing distributions are investigated. The intention is to provide information, with a simple and cost-effective setup, independent from monitoring devices of the beamline. Measurements have been performed wi...
Article
The transmission of protons in planar channeling or in the regime of crystal reflection in bent crystals is now routinely used at high energy. We used the property that channeling critical angle increases as the incident particle momentum decreases, to explore the region of moderate energies (100 MeV–1 GeV). Indeed, such energies are particularly i...
Article
Full-text available
Purpose: Online in vivo control of the ion range in a patient during proton therapy is a major challenge for quality assurance of treatments. After measurements showed that prompt-γ emission is correlated to the ion range (Min et al 2006, Testa et al 2008), prompt-γ imaging emerged as a promising method (Verburg et al 2013). Fast methods are requir...
Article
Full-text available
Monte Carlo tools have been long used to assist the research and development of solutions for proton therapy monitoring. The present work focuses on the prompt-gamma emission yields by comparing experimental data with the outcomes of the current version of Geant4 using all applicable proton inelastic models. For the case in study and using the bina...
Article
This paper addresses the problem of evaluating the system matrix and the sensitivity for iterative reconstruction in Compton camera imaging. Proposed models and numerical calculation strategies are compared through the influence they have on the three-dimensional reconstructed images. The study attempts to address four questions. First, it proposes...
Article
Full-text available
A Monte Carlo (MC) variance reduction technique is developed for prompt-γ emitters calculations in proton therapy. Prompt-γ emitted through nuclear fragmentation reactions and exiting the patient during proton therapy could play an important role to help monitoring the treatment. However, the estimation of the number and the energy of emitted promp...
Article
Proton computed tomography (CT) has been described as a solution for imaging the proton stopping power of patient tissues, therefore reducing the uncertainty of the conversion of x-ray CT images to relative stopping power (RSP) maps and its associated margins. This study aimed to investigate this assertion under the assumption of ideal detection sy...
Article
Full-text available
We present a review of the channeling and blocking experiments that have been performed at GANIL during the 30 years of stable beam operation, with the strong support of the multi-disciplinary CIRIL-CIMAP laboratory. These experiments combine atomic physics, solid state physics and nuclear physics.
Article
The quantification of the intrinsic performances of proton computed tomography (pCT) as a modality for treatment planning in proton therapy. The performance of an ideal pCT scanner is studied as a function of various parameters. Using GATE/Geant4, we simulated an ideal pCT scanner and scans of several cylindrical phantoms with various tissue equiva...