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September 2011 - May 2013
- Research Assistant
- Supervised undergraduate lab classes in general chemistry and organic chemistry; taught lab safety and procedures; graded lab reports
Chemoenzymatic synthesis is a strategy to produce heparin oligosaccharides with clearly defined structures and properties. Chemical synthesis involving protection and deprotection is combined with enzymatic synthesis. Chemical synthesis is used to construct appropriate acceptor and donor molecules, while enzymatic synthesis is used in extension and...
The chemoenzymatic synthesis of heparan sulfate tetrasaccharide (1) and hexasaccharide (2) with a fluorous tag attached at the reducing end is reported. The fluorous tert-butyl dicarbonate (FBoc) tag did not interfere with enzymatic recognition for both elongation and specific sulfation, and flash purification was performed by standard fluorous sol...