
Demetria M DickinsonRensselaer Polytechnic Institute | RPI · Department of Chemistry and Chemical Biology
Demetria M Dickinson
PhD
About
2
Publications
254
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Introduction
Publications
Publications (2)
Chemoenzymatic synthesis is a strategy to produce heparin oligosaccharides with clearly defined structures and properties. Chemical synthesis involving protection and deprotection is combined with enzymatic synthesis. Chemical synthesis is used to construct appropriate acceptor and donor molecules, while enzymatic synthesis is used in extension and...
The
chemoenzymatic synthesis of heparan sulfate tetrasaccharide
(1) and hexasaccharide (2) with a fluorous
tag attached at the reducing end is reported. The fluorous tert-butyl dicarbonate (FBoc) tag did not interfere
with enzymatic recognition for both elongation and specific sulfation,
and flash purification was performed by standard fluorous sol...
Projects
Project (1)