Delphine Raucher-Chéné

Delphine Raucher-Chéné
Douglas Mental Health University Institute

M.D., PhD

About

64
Publications
10,544
Reads
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364
Citations
Additional affiliations
July 2019 - present
McGill University
Position
  • PostDoc Position
December 2013 - July 2018
Université de Reims Champagne-Ardenne
Position
  • PhD Student

Publications

Publications (64)
Article
Full-text available
Many individuals living with severe mental illness, such as schizophrenia, present cognitive deficits and reasoning biases negatively impacting clinical and functional trajectories. Remote cognitive assessment presents many opportunities for advancing research and treatment but has yet to be widely used in psychiatric populations. We conducted a sc...
Article
Full-text available
Persistent negative symptoms (PNS) are linked to poor functional outcomes and may be primary or caused by secondary factors. Although several studies have examined PNS in first-episode psychosis (FEP), a comparison with a data-driven approach is lacking. Here, we compared clinically defined PNS subgroups with class trajectories identified through l...
Article
Full-text available
Schizophrenia, a severe psychiatric disorder, is associated with abnormal brain activation during theory of mind (ToM) processing. Researchers recently suggested that there is a continuum running from subclinical schizotypal personality traits to fully expressed schizophrenia symptoms. Nevertheless, it remains unclear whether schizotypal personalit...
Chapter
Episodic memory research in schizophrenia has a long history already which has clearly established significant impairments and strong associations with brain measures and functional outcome. The purpose of this chapter is not to make an exhaustive review of the recent literature but to highlight some relatively recent developments in the cognitive...
Article
Prior research suggests that certain psychiatric symptoms could be associated with increased risk of death. However, it remains unclear whether this association could rely on all or specific symptoms. In this report, we used data from a multicenter 5-year prospective study (N = 641) of older adults with an ICD-10 diagnosis of schizophrenia, bipolar...
Article
Verbal memory (VM) dysfunction is prevalent in first-episode psychosis (FEP) and has major impacts on long-term functional and clinical outcomes. Nevertheless, a substantial proportion of FEP patients have VM performance in the norm, called normal-range (NR) VM, and only a few studies have explored its relation to outcomes. Moreover, probable decre...
Article
Background Persistent negative symptoms (PNS, e.g., avolition, anhedonia, alogia) are present in up to 30% of individuals diagnosed with a first episode of psychosis and greatly impact functional outcomes. PNS and secondary PNS (sPNS: concomitant with positive, depressive, or extrapyramidal symptoms) may index distinct pathophysiologies reflected b...
Article
Full-text available
Severe cognitive impairments and cognitive distortions are core to schizophrenia-spectrum disorders (SSDs) and are associated with deteriorated social functioning. Despite well-established efficacy of group psychosocial therapies targeting cognitive health in SSDs, dissemination of these programs remains limited. Remote delivery offers a promising...
Article
Introduction Among the cognitive domains impaired in Parkinson's disease (PD), social cognition has received particular attention in recent years. Nevertheless, attributional bias, a social-cognitive subdomain, has not yet been studied in this population, despite its potential relationship with neuropsychiatric symptoms, and despite the possibility...
Article
Full-text available
Background Even if bariatric surgery is considered the most effective therapeutic approach, it is not equally successful among individuals suffering from severe obesity and candidates for this weight loss surgery. Among the factors that influence postsurgical outcomes, eating behaviors styles are known to play a key role in relapses. The aim of our...
Article
Understanding others’ intentions requires both the identification of social cues (e.g., emotional facial expressions, gaze direction) and the attribution of a mental state to another. The neural substrates of these processes have often been studied separately, and results are heterogeneous, in part attributable to the variety of paradigms used. The...
Article
Schizophrenia is characterized by cognitive impairments and widespread structural brain abnormalities. Brain structure-cognition associations have been extensively studied in schizophrenia, typically involving individual cognitive domains or brain regions of interest. Findings in overlapping and diffuse brain regions may point to structural alterat...
Article
From the onset of schizophrenia, verbal memory (VM) deficits and negative symptoms are strongly associated, and both additively predict functional outcomes. Emotion recognition (ER) and theory of mind (ToM; the ability to infer others' mental states), two components of social cognition, are also particularly affected in schizophrenia. Explanatory m...
Article
Objective Treatment guidelines for the treatment of psychotic disorders suggest evidence-based interventions. These interventions target several domains such as self-management of clinical symptoms, social, familial and love relationships as well as cognitive functioning. However, these general guidelines do not provide specific evidence for people...
Article
Objective Impairment of executive functions (EF) has been documented for decades in patients with alcohol use disorders (AUD), while more recent studies have also reported impaired theory of mind. Both have been associated with negative outcomes, particularly a high risk of relapse. However, the interrelatedness of EF and theory of mind impairments...
Article
Persistent negative symptoms (PNS) are an important factor of first episode of psychosis (FEP) that present early on in the course of illness and have a major impact on long-term functional outcome. Lack of clinical insight is consistently associated with negative symptoms during the course of schizophrenia, yet only a few studies have explored its...
Article
In addition to symptoms specifically related to mood dysregulation, patients with bipolar disorder (BD) show frequent alterations in formal thought organization. A disruption in semantic processing, notably in semantic inhibition, is one of the possible mechanisms that might explain this modified organization. However, to date, little is known abou...
Preprint
Full-text available
Background: Even if bariatric surgery is considered the most effective therapeutic approach, it is not equally successful among individuals suffering from severe obesity and candidates for this weight loss surgery. Among the factors that influence postsurgical outcomes, eating behaviors styles are known to play a key role in relapses. The aim of ou...
Preprint
Background: Psychosis is often characterized by global and regional brain structure alterations as well as general and domain-specific cognitive deficits. Previous brain structure-cognition findings in psychosis generally involve brain regions of interest or individual cognitive domains that may reflect global/general rather than regional/domain-sp...
Preprint
Full-text available
Schizophrenia is characterized by cognitive impairments and widespread structural brain alterations (e.g., decreased volume, thickness, surface area). Brain structure-cognition associations have been extensively studied in schizophrenia, typically involving individual cognitive domains or brain regions of interest. Findings in overlapping and diffu...
Article
Negative symptoms are present at the onset of psychosis and their persistence is significantly associated with poor psychosocial functioning and lower quality of life. Persistent negative symptoms (PNS) may be idiopathic or secondary to other factors such as depression, positive symptoms, and medication side-effects. Several studies have examined n...
Article
Bipolar disorder (BD) is a disabling disorder with functional impact on everyday life. Recent studies suggest that autobiographical memory impairment may contribute to the maintenance of psychopathology, leading to enduring altered self-construct. Moreover, past personal experiences also support the ability to project oneself into the future to pre...
Preprint
Full-text available
Background Even if bariatric surgery appears as the most effective therapeutic approach, it is not equally successful across individuals suffering from obesity. Among the factors that influence postsurgical outcomes, eating behaviors are known to play a key role in relapses. The aim of our study was to assess eating behaviors styles and several mod...
Preprint
Many individuals living with severe mental illness present cognitive deficits and reasoning biases negatively impacting clinical and functional trajectories. Within the context of the current COVID-19 pandemic, clinicians and researchers must adapt traditional in-person assessments for remote delivery, but little guidance is available for this ende...
Article
Full-text available
Fibromyalgia is central sensitization pain disorder with various psychological symptoms. Our aim is to compare trait paranoia, self-esteem and impulsivity between fibromyalgia patients (FM), chronic neuropathic pain sufferers (CNP) and healthy control. We administrated the Mini International Neuropsycho-logic Interview to 30 FM, 27 CNP and 22 HC. A...
Article
Background: Self-Defining Memories (SDMs) are a specific type of autobiographical memory, and that plays a key role in the construction of personal identity. Objective: We investigated the characteristics of SDMs in elderly subjects. The originality of the present study is to compare our elderly group to middle-aged subjects instead of young adu...
Poster
Introduction La stimulation cérébrale profonde des noyaux sous-thalamiques (SCP NST) chez les patients présentant une maladie de parkinson (MPI) est à l’origine de troubles de la cognition sociale. Le biais attributionnel n’a pas encore été étudié dans cette population. Objectifs L’objectif principal était d’évaluer le biais attributionnel chez le...
Article
Background Theory of mind (ToM), the cognitive capacity to attribute mental states to self and others, is robustly affected in schizophrenia. The neural substrates of ToM impairment have been largely studied with functional imaging but little is known about structural abnormalities. We compared structural covariance (between-subjects correlations o...
Poster
22nd Annual Conference of the International-Society-for-Bipolar-Disorders (ISBD), ELECTR NETWORK, JUN 18-21, 2020
Poster
22nd Annual Conference of the International-Society-for-Bipolar-Disorders (ISBD), ELECTR NETWORK, JUN 18-21, 2020
Article
Full-text available
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translate...
Article
Excessive alcohol use among adolescents has become a pressing challenge among Western societies. Accordingly, one of the current research objectives is to identify the processes associated with this harmful habit. Although numerous studies have underlined the role of executive and motivational processes, few have explored emotional and interpersona...
Article
Metabolic syndrome and its associated morbidity and mortality have been well documented in adults with schizophrenia. However, data is lacking for their geriatric counterparts. We sought to investigate the frequency of screening and the prevalence of metabolic syndrome in older adults with schizophrenia, as well as its possible correlates, using th...
Article
Full-text available
Objective: Self-defining memories (SDMs) are vivid, emotionally intense and well-rehearsed autobiographical memories that provide fundamental information about one's cognitive affective motivational representation of self. Exploring SDMs in fibromyalgia (FM) is of interest for understanding the psychopathology of this disorder and improving clinic...
Article
Objective Both bipolar disorder (BD) and schizophrenia (SZ) are associated with language and thought symptoms that probably reflect a semantic memory-related impairment. We conducted a preliminary study to explore the nature of semantic processing in these disorders, using event-related potentials (ERPs). Methods Twelve patients with BD, 10 patien...
Article
Background: Few studies have examined the prevalence and correlates of subsyndromal and syndromal depressive symptoms (SSSD) among older adults with schizophrenia spectrum disorder. In this report, we examined the prevalence of SSSD and their associations with sociodemographic characteristics, clinical characteristics of schizophrenia, comorbidity,...
Article
Background: Interest in social cognition in bipolar disorder (BD) has increased considerably over the past decade, with studies highlighting major impairments, especially in mental state reasoning, even during euthymia. A causal relationship between social cognition deficits and social functioning has already been established in individuals with s...
Data
HPS score and sub-scores for each participant (n = 36).
Article
Full-text available
Objectives Language modifications are a core feature of mania, but little is known about the semantic mechanisms behind these disturbances. The aim of the present study was thus to identify deficits in semantic inhibition and their respective neural activation patterns in a sample of individuals assessed for hypomanic personality traits. Methods T...
Article
Aim: High levels of hypomanic personality traits have been associated with an increased risk of developing bipolar disorder (BD). Changes in semantic content, impaired verbal associations, abnormal prosody and abnormal speed of language are core features of BD, and are thought to be related to semantic processing abnormalities. In the present stud...
Article
Résumé Dans cette étude préliminaire, 124 cas consécutifs d’intoxication médicamenteuse volontaire ont été recueillis pour étudier les caractéristiques de la létalité perçue par les patients de leur geste et la relation entre létalité perçue et récidive d’une conduite suicidaire. La létalité perçue a été évaluée par une échelle visuelle analogique,...
Article
Background: One of the main features of bipolar disorder (BD), besides mood dysregulation, is an alteration of the structure of language. Bipolar patients present changes in semantic contents, impaired verbal associations, abnormal prosody and abnormal speed of language highlighted with various experimental tasks. Verbal fluency tasks are widely u...
Article
Patients with alcohol dependence have been shown to be impaired in recalling specific autobiographical events, yet little is known on how changes in the memory of these events may impact their self-representation. In this study, we examined Self-Defining Memories (SDMs), a specific type of autobiographical memory that plays a key role in the constr...
Article
Full-text available
Thirty-five healthy adult women offspring of alcohol-dependent probands (AWOA) were compared with 63 healthy controls to test whether personality dimensions on the Temperament and Character Inventory questionnaire were associated with the brain-derived neurotrophic factor Val66Met polymorphism in offspring. We found a significantly lower reward dep...
Article
Full-text available
The increased life expectancy in people with severe and persistent psychiatric illness, such as schizophrenia or bipolar disorder, has been predicted to substantially affect mental healthcare system (Bartels et al ., 2002) that must adapt to meet the needs of older adults (Jeste et al ., 1999). Development of specialized geriatric psychiatry servic...
Article
Full-text available
Social anxiety disorder (SAD), which is characterized by the fear of being rejected and negatively evaluated, involves altered brain activation during the processing of negative emotions in a social context. Although associated temperament traits, such as shyness or behavioral inhibition, have been studied, there is still insufficient knowledge to...
Article
Introduction Alexithymia has been studied in several addictive disorders with a special interest in alcohol dependence (Thorberg et al., 2009; Taieb et al., 2002). Nevertheless, recent studies failed to demonstrate the relationship with drinking outcomes (de Haan et al., 2012; Stasiewicz et al., 2012). Evaluation of emotional awareness in these pop...
Article
Objective: Although weight gain is one of the most widely studied adverse effects of second-generation antipsychotics, only relatively few studies have specifically evaluated the long-term effect of switching antipsychotic medication on body weight. We aimed to evaluate the impact of switching antipsychotics on body mass index (BMI) during a 6-mon...
Article
Full-text available
A total of 136 with or without first-degree relatives with alcohol dependence were compared according to lifetime prevalence of psychiatric disorders and personality dimensions. Family history positive women showed significant higher prevalence rates of depression and agoraphobia, and exhibited lower scores on Reward Dependence, Self-Directedness a...
Article
Patterns of care offered to schizophrenic patients have evolved during the last decades. The psychosocial and pharmaceutical developments, associated with the demographic progression of the general population have led to an increase in life expectancy and quality of life of these patients. Today, the prevalence of elderly schizophrenic subjects is...
Article
Manic symptoms have been reported as adverse effects of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease. In previous reports, manic symptoms were described as transient, not associated with psychotic features, and improved spontaneously or with medical adjustments. The medial part of the...

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