Delphine Courvoisier

Delphine Courvoisier
Hôpitaux Universitaires de Genève | HUG · Service de rhumatologie

PhD

About

437
Publications
144,691
Reads
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10,505
Citations
Introduction
I am an epidemiologist and statistician working in a University hospital. My research focuses on the emotional burden associated with providing healthcare, the regrets following difficult decision-making, and their consequences on healthcare professionals' health. Methodologically, I work on improving longitudinal research to better assess causality.
Additional affiliations
November 2019 - October 2022
Hôpitaux Universitaires de Genève
Position
  • Professor (Assistant)
July 2015 - present
Hôpitaux Universitaires de Genève
Position
  • Statistician

Publications

Publications (437)
Preprint
Full-text available
Objectives This study aims to examine the evolution and influencing factors of women’s authorship in randomized controlled trials (RCTs) published in rheumatology. Methods This study included all rheumatology RCTs published from 2009 to 2023. The gender of authors was determined using forenames and countries of affiliation via the gender API servi...
Preprint
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Objectives: Previous literature has primarily viewed physical effort as an aversive experience. However, recent research suggests that effort can also be valued positively. These differences in approach and avoidance tendencies toward physical effort may play a key role in the self- regulation of physical activity behaviors. The aim was to develop...
Article
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Objectives: The current study investigates the prevalence of illegitimate tasks in a hospital setting and their association with patient safety culture outcomes, which has not been previously investigated. Methods: We conducted a cross-sectional survey in a tertiary referral hospital. Patient safety culture outcomes were measured using the Hospital...
Article
Full-text available
The immunity conferred by SARS-CoV-2 vaccines and infections reduces the transmission of the virus. To answer how the effect of immunity is shared between a reduction of infectiousness and an increased protection against infection, we examined >50,000 positive cases and >110,000 contacts from Geneva, Switzerland (June 2020 to March 2022). We assess...
Article
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Introduction assessing the ability to cope with regret can contribute to support strategies for health professionals. However, in Brazil only few instruments evaluate this ability in general. Objective this study aimed was to adapt and validate the Regret Coping Scale for Healthcare Professionals (RCS-HCP) to Brazilian Portuguese. Methods the ins...
Article
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Objective: To assess the time from completion to publication of randomized controlled trials (RCTs) on connective tissue diseases (CTDs), investigate the factors associated with, and explore the influence of significance of study results on time to publication (time-lag publication bias). Methods: We included interventional, phase 2/3, 3, or 4 R...
Article
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1) Background: France implemented a COVID-19 certificate in July 2021 to incentivize the population to uptake COVID-19 vaccines. However, little is known about the variation in its impact across age groups and its dependence on socio-demographic, economic, logistic, or political factors. (2) Methods: Using France's weekly first dose vaccination rat...
Article
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Background Interstitial lung diseases (ILD), such as idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP), and chronic obstructive pulmonary disease (COPD) are severe, progressive pulmonary disorders with a poor prognosis. Prompt and accurate diagnosis is important to enable patients to receive appropriate care at the...
Article
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Background Gout is the most common inflammatory rheumatism worldwide. Despite guidelines on acute and chronic management, it remains largely undertreated [1] . To evaluate the current standard of gout care, there is an unmet need for gout registers, especially in the non-rheumatology setting. The vast clinical information available in electronic he...
Conference Paper
Background Results of the “ORAL Surveillance” trial showed higher risk of major adverse cardiovascular (CV) events (MACE) for Janus kinase inhibitors (JAKi) than for TNF-inhibitors (TNFi). Currently, there is limited evidence of the real-world cardiovascular safety of JAKi. Objectives To assess the incidence of MACE in rheumatoid arthritis (RA) pa...
Article
Background The development of biologic and targeted synthetic (b/ts)DMARDs contributed to improved treatment outcomes in rheumatoid arthritis (RA). However, high medications costs may limit their use. Previously we showed that in countries with a lower socioeconomic status (SES), b/tsDMARDs were prescribed to fewer patients than in countries with h...
Article
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Background Connective tissue diseases (CTDs) are systemic autoimmune diseases, some of which rare, characterized by a dysregulated immune response and a heterogeneous clinical picture. Similarly to nonpublication, a long time from completion to publication of randomized controlled trials (RCTs) results can indirectly harm patients by allowing ineff...
Article
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Binding antibody levels against SARS-CoV-2 have shown to be correlates of protection against infection with pre-Omicron lineages. This has been challenged by the emergence of immune-evasive variants, notably the Omicron sublineages, in an evolving immune landscape with high levels of cumulative incidence and vaccination coverage. This in turn limit...
Preprint
Full-text available
Background Contact tracing has been one of the central non-pharmaceutical interventions implemented worldwide to try to control the spread of Sars-CoV-2, but its effectiveness strongly depends on its ability to detect contacts. Methods We analysed 166’892 concomitant infections occurring at the same address from June 2020 until February 2022 using...
Preprint
Full-text available
The immunity conferred by SARS-CoV-2 vaccines and infections reduces the transmission of the virus. But it is not clear how the effect of immunity is shared between a reduction of the contagiousness and an increased protection against infection. To answer this question, we used a register of >50'000 SARS-CoV-2 positive index cases and their >110'00...
Article
Full-text available
Introduction Postoperative health-related quality of life (HRQoL) is an essential outcome in oncological surgery, particularly for elderly patients undergoing high-risk surgery. Previous studies have suggested that, on average, HRQoL returns to premorbid normal levels in the months following major surgery. However, the averaging of effect over a st...
Article
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Background Post-COVID symptoms can persist several months after SARS-CoV-2 infection. Little is known, however, about the prevalence of post-COVID condition following infections from Omicron variants and how this varies according to vaccination status Objective This study evaluates the prevalence of symptoms and functional impairment 12 weeks afte...
Preprint
Full-text available
Binding antibody levels against SARS-CoV-2 have shown to be correlates of protection against infection with pre-Omicron lineages. This has been challenged by the emergence of immune-evasive variants, notably the Omicron sublineages, in an evolving immune landscape with high levels of cumulative incidence and vaccination coverage. This in turn limit...
Article
Full-text available
There are concerns about acute and long-term mental health effects of the COVID-19 pandemic. This study examined the prevalence and predictors of psychological distress before, during, and after a pandemic wave in Switzerland, 2021. Prevalence of psychological distress was estimated in adults aged 35–96 years using the General Health Questionnaire-...
Article
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Objective To assess the proportion, the reasons, and the factors associated with the discontinuation or nonpublication of randomized controlled trials (RCTs) on connective tissue diseases (CTDs). Methods We searched all interventional RCTs on CTDs registered in ClinicalTrials.gov since 2000. Two reviewers selected studies according to prespecified...
Article
Objectives To develop EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in patients with autoimmune inflammatory rheumatic diseases (AIIRD). Methods An international Task Force (TF) (22 members/15 countries) formulated recommendations, supported by systematic literature review findings. Level of evidence a...
Article
Full-text available
Objective: To conduct a systematic literature review (SLR) on the screening and prophylaxis of opportunistic and chronic infections in autoimmune inflammatory rheumatic diseases (AIIRD). Methods: SLR (inception-12/2021) based on the following search domains: (1) infectious agents, (2) AIIRD, (3) immunosuppressives/immunomodulators used in rheuma...
Article
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Background Resources are essential for mental health. In temporary stressful situations throughout life, people need to use a particular type of resources, their “reserves”, to handle the stress. We do not know whether “reserves” (economic, cognitive, and relational) are more protective of mental health than “conventional” resources. Using a cohort...
Preprint
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BACKGROUND Delays in reviewing issued laboratory results in emergency departments (ED) can adversely affect efficiency and quality of care. One opportunity to improve therapeutic turnaround time could be to provide real-time access to laboratory results on mobile devices available to every caregiver. We developed a mobile app named “Patients In My...
Article
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Background: Delays in reviewing issued laboratory results in emergency departments (EDs) can adversely affect efficiency and quality of care. One opportunity to improve therapeutic turnaround time could be to provide real-time access to laboratory results on mobile devices available to every caregiver. We developed a mobile app named "Patients In...
Article
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Objectives The expanded therapeutic arsenal in rheumatoid arthritis (RA) raises new clinical questions. The objective of this study is to compare the effectiveness of cycling Janus kinase inhibitors (JAKi) with switching to biologic disease-modifying antirheumatic drug (bDMARD) in patients with RA after failure to the first JAKi. Methods This is a...
Article
Objectives: To estimate the long-term exposure to glucocorticoids (GC), the factors associated with, and the variations in prescribing practices over time and across recruiting countries. Methods: We included patients with systemic sclerosis (SSc) having a visit in the EUSTAR database from January 2013 onward. We analyzed the prevalence and the...
Article
Full-text available
The present study proposes to measure and quantify the heart rate variability (HRV) changes during effort as a function of the heart rate and to test the capacity of the produced indices to predict cardiorespiratory fitness measures. Therefore, the beat-to-beat cardiac time interval series of 18 adolescent athletes (15.2 ± 2.0 years) measured durin...
Article
Background No study assessed risk factors of progression from discoid lupus erythematosus (DLE) to severe systemic lupus erythematosus (sSLE) (defined as requiring hospitalization and specific treatment). Objective To identify risks factors and generate a predicting score of progression to sSLE among patients with isolated DLE or associated with S...
Article
A clinical guideline is a document with the aim of guiding decisions based on evidence regarding diagnosis, management and treatment in specific areas of healthcare. Specific to rheumatic and musculoskeletal diseases (RMDs), adherence to clinical guidelines recommendations impacts the outcomes of people with these diseases. However, currently, the...
Article
Full-text available
The last decades have seen an increased interest in the use of differential equations to model longitudinal changes in behavioral science. Numerous statistical methods have been developed to estimate the coefficients of first- and second-order differential equations, with the goal of modeling the dynamics of return to equilibrium in a wide range of...
Article
Full-text available
Post-COVID condition is prevalent in 10–35% of cases in outpatient settings, however a stratification of the duration and severity of symptoms is still lacking, adding to the complexity and heterogeneity of the definition of post-COVID condition and its oucomes. In addition, the potential impacts of a longer duration of disease are not yet clear, a...
Article
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Purpose The aim of this retrospective case study was to evaluate the impact of the COVID-19 confinement on consultation number and nature of dental emergencies. Materials and Methods : The investigators implemented a retrospective case-control study and enrolled a sample of patients who presented to the University Hospital of Geneva for dental eme...
Poster
Full-text available
While physical activity provides substantial health benefits, cardiac rehabilitation patients do not reach the recommended physical activity levels after discharge from clinics (1, 2). Traditional interventions providing knowledge about theses expected health benefits do not appear to be sufficient (3). Recent research on automatically activated pr...
Article
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Healthcare workers have potentially been among the most exposed to SARS-CoV-2 infection as well as the deleterious toll of the pandemic. This study has the objective to differentiate the pandemic toll from post-acute sequelae of SARS-CoV-2 infection in healthcare workers compared to the general population. The study was conducted between April and...
Article
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Background: JAK-inhibitors (JAKi), recently approved in rheumatoid arthritis (RA), have changed the landscape of treatment choices. We aimed to compare the effectiveness of four current second-line therapies of RA with different modes of action, since JAKi approval, in an international collaboration of 19 registers. Methods: In this observational...
Article
Background Store-and-forward (SAF) tele-dermatology (TD) platforms could help promote coordination between hospital and general practitioners (GPs). However, very little data exists on the performance accuracy and opinions of GPs participating in this type of project in France. Methods We report on the diagnostic and management plan accuracy of an...
Article
Background Opportunistic and chronic infections can arise in the context of treatment used for Autoimmune Rheumatic Diseases (ARDs). Although it is recognized that screening procedures and prophylactic measures must be followed, clinical practice is largely heterogeneous, with relevant recommendations not currently developed or disparately located...
Conference Paper
Full-text available
Background The recently presented “ORAL Surveillance Study” has suggested increased risk of serious adverse events (AEs) with tofacitinib, a JAK-inhibitor (JAKi), compared to a comparator TNF-inhibitor (TNFi). Currently, there is limited real world evidence for the tolerability and safety of JAKi (1). Objectives To assess the safety of JAKi compar...
Conference Paper
Full-text available
Background Management guidelines of RA suggest to administer biological or targeted synthetic DMARD (b/tsDMARD) in combination with conventional synthetic DMARD (csDMARD). Limited data exists about the impact of such csDMARD combination therapy (co-therapy) in real life settings, in particular for baricitinib use compared to other types of b/tsDMAR...
Conference Paper
Full-text available
Background Drug maintenance is a common outcome measure of real world effectiveness studies, because it combines a measure of drug effectiveness and its tolerance / safety. Major hurdles of observational studies are potential selection biases and confounding. Cox proportional hazard ratio models address this issue by adjusting for potential confoun...
Conference Paper
Full-text available
Background The use of glucocorticoids (GC) in systemic sclerosis (SSc) is controversial (1). Despite the lack of solid evidence about their efficacy in SSc, GC are prescribed to control musculoskeletal symptoms, or in combination with immunosuppressive drugs (1). The extent of GC use over the disease course has been poorly investigated in SSc. As l...
Conference Paper
Full-text available
Background/Aims Previous research has suggested that switching between b/tsDMARDs with different mode of action may be more effective than switching agents within the same mechanism of action. Limited data exists about the impact of an inadequate response to a previous JAK-inhibitor (JAKi) on subsequent JAKi effectiveness. Methods This is a nested...
Article
Full-text available
Background: Neighbourhood socio-economic inequities have been shown to affect COVID-19 incidence and mortality, as well as access to tests. This article aimed to study how associations of inequities and COVID-19 outcomes varied between the first two pandemic waves from a gender perspective. Methods: We performed an ecological study based on the CO...
Article
Full-text available
The aim of our study is to investigate successful pre-rewarming resuscitation after hypothermic cardiac arrest (HCA). The hypothermic heart may be insensitive to defibrillation when core temperature is below 30 °C and after successful defibrillation, sinus rhythm often returns into ventricular fibrillation. Recurrent defibrillation attempts may ind...
Article
Full-text available
Background: Persistent symptoms of SARS-CoV-2 are prevalent weeks to months following the infection. To date, it is difficult to disentangle the direct from the indirect effects of SARS-CoV-2, including lockdown, social, and economic factors. Objective: The study aims to characterize the prevalence of symptoms, functional capacity, and quality o...
Article
Full-text available
Introduction: Access to the healthcare system when patients are vulnerable and living outside metropolitan areas can be challenging. Our objective was to explore healthcare system satisfaction of urban and rural inhabitants depending on financial and health vulnerabilities. Methods: Repeated cross-sectional data from 353,523 European citizens (2002...
Article
The purpose of the present study was to evaluate the association between initial TMJ examination findings and clinical and MRI severity of TMJ arthritis in a cohort of patients with JIA. The clinical variables were signs and symptoms at the initial TMJ evaluation. Outcome was the severity of TMJ arthritis as evaluated clinically by the Helkimo clin...
Article
Background Comparing treatment effectiveness over time in observational settings is hampered by several major threats, among them confounding and attrition bias. Objectives To develop European Alliance of Associations for Rheumatology (EULAR) points to consider (PtC) when analysing and reporting comparative effectiveness research using observation...
Article
Full-text available
Objectives To assess the performance of statistical methods used to compare the effectiveness between drugs in an observational setting in the presence of attrition. Methods In this simulation study, we compared the estimations of low disease activity (LDA) at 1 year produced by complete case analysis (CC), last observation carried forward (LOCF),...
Article
Purpose This systematic review aimed to evaluate complications and survival rates of dental implants placed in patients suffering from autoimmune diseases. Materials and Methods A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses systematic review guidelines (PRISMA), using Google scholar...
Article
Full-text available
The burden of COVID-19 has disproportionately impacted the elderly, who are at increased risk of severe disease, hospitalization, and death. This cross-sectional study aimed to assess the association between SARS-CoV-2 seroprevalence among nursing home staff, and cumulative incidence rates of COVID-19 cases, hospitalizations, and deaths among resid...
Article
Objectives This cohort study including essential workers, assessed the risk and incidence of SARS-CoV-2 infection during the second surge of COVID-19 according to baseline serostatus and occupational sector. Methods Essential workers were selected from a seroprevalence survey cohort in Geneva, Switzerland and were linked to a state centralised reg...
Article
Full-text available
Understanding the risk of infection from household- and community-exposures and the transmissibility of asymptomatic infections is critical to SARS-CoV-2 control. Limited previous evidence is based primarily on virologic testing, which disproportionately misses mild and asymptomatic infections. Serologic measures are more likely to capture all prev...
Article
Introduction Face à la diminution du nombre de dermatologues, le développement de la télédermatologie peut faciliter la communication entre médecins généralistes (MG) et hôpital, et réduire certains délais de prise en charge grâce à un tri efficace des patients. Cependant, peu de données sont disponibles en France sur les performances diagnostiques...
Article
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Objective To determine whether patients with inflammatory autoimmune diseases treated with rituximab (RTX) have more severe forms of COVID-19 compared with patients treated with anticytokine therapies, such as Tumour Necrosis Factor (TNF) inhibitors. Methods We included all patients who were on either RTX or infliximab (IFX) in two Swiss cantons d...
Article
Full-text available
Purpose The Actionable Register of Geneva Outpatients and inpatients with SARS-CoV-2 (ARGOS) is an ongoing prospective cohort created by the Geneva Directorate of Health. It consists of an operational database compiling all SARS-CoV-2 test results recorded in the Geneva area since late February 2020. This article aims at presenting this comprehensi...
Article
Full-text available
A validated Chinese version of Exercise Dependence Scale-Revised (EDS-R) is currently lacking. Thus, this study aimed to investigate the psychometric properties of this translated scale in a Chinese sample. Following a forward–backward translation of the EDS-R, the Chinese version (EDS-C) and validated scales assessing associated constructs were ad...
Article
Objective: This study used published studies to assess the survival rate of dental implants placed in patients with bone dysplasia of the maxillofacial region.Material and methods: An electronic search without a specified date range was performed using the MEDLINE, PubMed, EMBASE, Web of Science, and Cochrane databases. No gender or age restriction...
Article
Full-text available
Objectives To evaluate the analysis and reporting of comparative effectiveness research with observational data in rheumatology, informing European Alliance of Associations for Rheumatology points to consider. Methods We performed a systematic literature review searching Ovid MEDLINE for original articles comparing drug effectiveness in longitudin...
Article
Full-text available
Objectives: The aim of the study was to adapt and validate the Regret Intensity Scale-10 (RIS-10) for Brazilian health professionals. Methods: The validation study took place in two phases, in which the first was the translation of the instruments and the second, the field validation using psychometric properties validity and reliability of the...
Article
Full-text available
The examination of all COVID19 cases and patient movements in Geneva indicates an important disease activity within the healthcare system since the beginning of the pandemic. We estimate that 4.3% of the total COVID19 cases were likely acquired within the healthcare system, contributing to 61% of the COVID19 related deaths.
Preprint
Full-text available
The present study proposes to measure and quantify the heart rate variability (HRV) changes during effort and to test the capacity of the produced indices to predict cardiorespiratory fitness measures. Therefore, the beat-to-beat cardiac time interval series of 18 adolescent athletes (15.2 +- 2.0 years) measured during maximal graded effort test we...
Article
Objective To describe the main features at diagnosis and evolution over time of patients with localised granulomatosis with polyangiitis (L-GPA) compared to those of systemic GPA (S-GPA). Methods EULAR definitions of L-GPA, i.e., upper and/or lower respiratory tract involvement, and S-GPA were applied to patients from the French Vasculitis Study G...
Article
Full-text available
Background Blended learning, defined as the combination of traditional face-to-face instructor-led learning and e-learning course, has never been validated as a teaching method for the effective use of manual defibrillators in cardiopulmonary resuscitation. Aim To evaluate whether paediatric emergency and critical care providers exposed to a blend...
Article
Full-text available
University and college students present specific health issues with vulnerabilities related to mental health and sexual health, risk-taking behaviors, and delayed access to primary care. A new student outpatient clinic was created in September 2016 at Geneva University Hospitals to respond to the health needs of this population. We present here the...
Article
Full-text available
Introduction Being physically active is associated with a wide range of health benefits in patients. However, many patients do not engage in the recommended levels of physical activity (PA). To date, interventions promoting PA in patients mainly rely on providing knowledge about the benefits associated with PA to develop their motivation to be acti...