Delan Jinapriya

Queen's University | QueensU · Department of Ophthalmology

Objective To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10 and 15 µg bimatoprost implant in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT).Methods This randomized, 20-month, multicenter, masked, parallel-group, phase 3 trial enrolled 528 patients with OAG or OHT and an open iridocorneal angle infer...

Purpose Compare efficacy and safety of early compared to later surgical cases in patients receiving an ab-interno gelatin microstent with mitomycin C (MMC). Design Canada-wide, multicenter, retrospective propensity score matched cohort study. Participants Two hundred and seventy eyes (135 early cases and 135 later cases group) with no prior incis...

Glaucoma is a medical term describing a group of progressive optic neuropathies characterized by degeneration of retinal ganglion cells and retinal nerve fibre layer and resulting in changes in the optic nerve head. Glaucoma is a leading cause of irreversible vision loss worldwide. With the aging population it is expected that the prevalence of gla...

Aims To compare the outcomes of Ex-PRESS versus trabeculectomy at 3 years. Methods Consenting patients aged 18–85 years with medically uncontrolled open-angle glaucoma scheduled for trabeculectomy were included in this study. 63 subjects were randomised to undergo Ex-PRESS (32) or trabeculectomy (31). Follow-up data included intraocular pressure (I...

Purpose: To investigate the effect of anti-inflammatory therapy on selective laser trabeculoplasty (SLT) outcomes. Design: Randomized, double-masked, placebo-controlled trial. Participants: Patients with primary open-angle or pseudo-exfoliation glaucoma. Methods: Patients undergoing SLT were randomized to receive placebo (artificial tears),...

To compare the efficacy and safety of the Ex-PRESS glaucoma shunt with standard trabeculectomy. Consenting patients with medically uncontrolled open-angle glaucoma were prospectively randomized to trabeculectomy or Ex-PRESS shunt both with mitomycin-C. Exclusion criteria included previous ocular surgery with the exception of clear cornea phaco or 1...

In Reply The criterion standard for measurement of intraocular pressure is GAT. Dr Huang and colleagues state that general physicians should be cautious when using a commonly accepted threshold intraocular pressure of 22 mm Hg if measurements were not performed using GAT. All studies in our meta-analysis used GAT under rigorous conditions. The resu...

To compare the rate of visual recovery after Ex-PRESS implantation versus standard trabeculectomy. Subjects enrolled in a prospective randomized controlled trial comparing Ex-PRESS to trabeculectomy were analyzed for postoperative changes in visual acuity (VA). Risk factors for visual loss (split fixation, cup-disc ratio, intraocular pressure, visu...

Glaucoma is the second leading cause of blindness worldwide, and its insidious onset is often associated with diagnostic delay. Since glaucoma progression can often be effectively diminished when treated, identifying individuals at risk for glaucoma could potentially lead to earlier detection and prevent associated vision loss. To quantify the diag...

To evaluate the efficacy of a combination anaesthetic plus dilating gel (ADG) on pupil dilation (PD) and corneal anaesthesia (KA) compared to traditional preoperative pharmacotherapy for cataract surgery. Prospective, noninferiority study. We studied 20 consenting adults who experienced unilateral cataracts and underwent routine cataract surgery, r...

To determine whether sponsorship of prostaglandin analogue (PGA) clinical trials results in investigator bias in outcomes when studying intraocular pressure (IOP). Retrospective, observational cohort study. A PubMed search was performed for latanoprost or Xalatan, bimatoprost or Lumigan, and travoprost or Travatan, with limits to humans, clinical t...

To evaluate the prevalence of undetected glaucoma in a Toronto population. A cross-sectional survey. Toronto residents aged 50 years or older. Telephone calls were randomly made to Toronto residents. Those who indicated they did not have glaucoma were invited to the Toronto Western Hospital for a comprehensive ophthalmic assessment, including best...

Purpose: To report a case of unilateral brachial plexus neuropathy after prone positioning for macular hole repair. Methods: Case report. Results: After 7 days of strict prone positioning post-macular hole surgery, a 60-year-old patient developed severe pain and weakness in the left arm. Neurologic examination, imaging, and electromyography sh...

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To identify gender differences in career satisfaction and practice patterns among Ontario ophthalmologists. Survey mailed to all Ontario female ophthalmologists (n = 65) and a random sample of male ophthalmologists (n = 72). Men reported performing more operations per month (p = 0.039) and more operations in the last typical year (p = 0.003). More...