Deissy Herrera-Covarrubias

Universidad Veracruzana | UV · Instituto de Investigaciones Cerebrales

Preface It is a privilege and a pleasure to introduce this scientific publication that compiles original and review manuscripts in Animal Perinatology. Veterinary medicine is advancing rapidly with the expansion of knowledge and emerging technologies. New medical specialization areas provide more precise understandings of numerous aspects of animal...

La enfermedad de Parkinson es una afección neurológica crónica que se caracteriza por la presencia de anormalidades en el movimiento, tales como bradicinesia, rigidez, temblor, inestabilidad postural y trastornos de la marcha y del habla. En lo que respecta al tratamiento, por años ha sido aceptado que la terapia de reemplazo de dopamina es la opci...

Understanding the autonomic supply at the gastrointestinal tract is one of the significant challenges for science. Its complex network of neurons exists on a broad evolutionary scale, from Hydra to mammals, and in a higher number than those found in the vertebrate spinal cord. Inside the gastrointestinal tract, enteric neurons regulate several func...

The role of diet in health is crucial, with calorie intake playing a significant role. Hypercaloric diets (HD) often lead to adipose tissue accumulation and increased risk of chronic diseases, including reproductive impairments. By contrast, restriction diets (RD) help with weight loss, improve cardiovascular function, and ameliorate reproduction....

Autism in humans is a lifelong behavioral disorder that typically manifests in early infancy, primarily affecting boys. It arises from neurodevelopmental changes that significantly impact social behavior, with the cerebellum being one of the principal affected regions. In this study, we investigated the cerebellum in an autism animal model, recordi...

It is well known that amyloid precursor protein (APP), the enzyme β-secretase 1 (BACE1), cyclooxygenase 2 (COX-2), nicastrin (NCT), and hyperphosphorylated tau protein (p-tau) are closely related to the development of Alzheimer's disease (AD). In addition, recent evidence shows that neuroinflammation also contributes to the pathogenesis of AD. Alth...

Autism is a complex alteration in children’s developing nervous system that manifests in behavioral patterns that do not match those of typical subjects. Moreover, starting at puberty, these children may encounter problems regarding social interaction related to sexual encounters. As studies are scarce, we used the valproate model of autism in the...

Among the different species of mammals, the expression of maternal behavior varies considerably, although the end points of nurturance and protection are the same. Females may display passive or active responses of acceptance, recognition, rejection/fear, or motivation to care for the offspring. Each type of response may indicate different levels o...

El trastorno del espectro autista (TEA) es un desorden del neurodesarrollo de alta prevalencia, con manifestaciones significativas en las áreas socioafectiva y comportamental, cuyas causas aún permanecen indeterminadas. La investigación de sus posibles causas y tratamientos se apoya en modelos animales manipulados genéticamente y los no genéticos c...

Objective: To evaluate the effect of prolactin (PRL) on the migration of MCF-7 breast cancer cells and the expression of E-cadherin. Methods: We used the wound healing assays to evaluate the migration of MCF-7 cells and the Western blot technique to evaluate the expression of E-cadherin. Results: The results show that PRL produced an increase in...

El autismo es un trastorno del neurodesarrollo que se presenta en niños y tiene al cerebelo como una de las principales áreas afectadas, incluyendo alteraciones en la neurotransmisión del ácido gamma-aminobutírico (GABA). Esto ha estimulado el desarrollo de tratamientos dirigidos al sistema GABAérgico, aunque también se sabe que el ambiente enrique...

The prostate is an accessory sex gland responsible for producing and excreting prostate fluid. In the male rat, hormones such as testosterone (T) and prolactin (PRL) and the pelvic and hypogastric nerves regulate the gland, providing afferent information and adrenergic and cholinergic innervation to the prostate. Damages in the innervation or alter...

Background: Hypercaloric intake can lead to obesity, which is a major risk factor associated with chronic subclinical inflammation and many types of cancer. It can increase the serum levels of leptin, prolactin, nuclear factor kappa B (NF-кB) and interleukin (IL)-6, implicated in cell proliferation, differentiation and survival. Aim: To explore...

Brain mechanisms of sexual attraction toward reproductive partners develop from a systematic interrelationship between biology (nature) and learning (nurture). However, the causes of attraction toward non-reproductive partners are poorly understood. Here, we explored the role of Pavlovian learning under dopaminergic agonism on the development of se...

Introduction The study of behaviour is a fundamental part of comprehensive patient care, since the patient should be considered as a biopsychosocial entity. In the case of Alzheimer's disease (AD), the major limitation in the diagnosis of the patient is that it can only be made after death. Therefore, identification of behaviours consistent with be...

Considered a neurodegenerative disease, Alzheimer’s disease (AD) involves a physiopathological process characterized by the presence of the beta-amyloid peptide, hyperphosphorylated Tau protein, and neuroinflammation. Diabetes mellitus (DM) is an endocrine disease characterized by insulin resistance, where decreased production of this hormone cause...

La próstata es una glándula sexual accesoria encargada de producir y secretar el líquido prostático. En la rata macho este órgano está regulado por hormonas tales como testosterona (T) y prolactina (PRL), así como por el sistema nervioso autónomo (SNA), quien, a través de los nervios pélvico e hipogástrico que convergen en el ganglio pélvico mayor...

El estrés aumenta los niveles séricos de leptina y prolactina, lo cual puede facilitar la proliferación, diferenciación y supervivencia celular implicadas en el desarrollo del cáncer. Se exploró el efecto del estrés prepuberal agudo inducido por una inyección de lipopolisacárido de E. coli (LPS) sobre los cambios histológicos en la próstata dorsola...

El ganglio pélvico mayor es un complejo autonómico compuesto por una mezcla de fibras noradrenérgicas y colinérgicas cuyo objetivo es inervar órganos de la visera pélvica. Para llevar a cabo esto, las neuronas expresan receptores a andrógenos, noradrenalina y acetilcolina. Se conoce que la conducta sexual produce una importante actividad neuronal d...

Entre la Enfermedad de Alzheimer (EA) y la Diabetes Mellitus (DM) ha sido evidenciado que existen múltiples mecanismos en común en ambas patologías, que van desde el deterioro cognitivo en el aspecto clínico hasta alteraciones bioquímicas de las cuales destacan; el aumento de los agentes proinflamatorios y la excitotoxicidad, aumento del estrés oxi...

Entre la Enfermedad de Alzheimer (EA) y la Diabetes Mellitus (DM) ha sido evidenciado que existen múltiples mecanismos en común en ambas patologías, que van desde el deterioro cognitivo en el aspecto clínico hasta alteraciones bioquímicas de las cuales destacan; el aumento de los agentes proinflamatorios y la excitotoxicidad, aumento del estrés oxi...

An extensive database of sterols and triterpenoids isolated from Ganoderma mushrooms was evaluated by in silico structure-based virtual screening to determine their respective ligand affinities for the glucocorticoid or mineralocorticoid receptor (GCR or MNR). The main ligands for GCR in our database were ergosta-7,22-dien-3-one (compound 1) and ga...

Background We conducted an observational study of 15 patients from a Southeastern area of Mexico with symptoms compatible with SARS-Cov-2, which were treated with the antiviral amantadine.MethodologyIn this study, data were collected from 15 individuals with clinical symptoms of COVID-19 infection, which were treated on an ambulatory basis with 100...

Objectives Alzheimer’s disease is complex and involves several proteins. Most affected are Tau protein and amyloid precursor protein (APP) which, when cleaved by the enzymes β-secretase (BACE1) and γ -secretase (Nicastrin), yield the amyloid peptide. Although these processes take place mainly in neurons, it is not exclusive of them, as glia cells a...

Explicarle a alguien qué es el amor es tan difícil como explicar qué es el viento. No importa cuántos libros se lean al respecto: uno mismo debe sentirlo para saber de qué se trata. Quizá por eso es tan complicado para algunos humanos aceptar la idea de que otras especies de animales (no humanos) también pueden amar. Sin embargo, de manera general...

The organizational-activational hypothesis indicates that activation of adult sexual behavior in males depends on organization of the masculine brain during the perinatal sensitive period. In the medial preoptic area such masculinization depends on a neuroendocrine cascade that includes exposure to testosterone, aromatization to estradiol, activati...

Prostate function is regulated by androgens and a neural control via the pelvic and hypogastric nerves. As such, this sexual gland contains receptors for acetylcholine and noradrenaline, although it is unknown whether the expression of these receptors is affected by sexual behavior and even less by denervation of the gland. Thus, the purpose of thi...

The SARS-CoV-2 virus has spread around the world. At this time, there is no vaccine that can help people prevent the spread of coronavirus. We are proposing amantadine as a drug that can be used to mitigate the effects of the virus. It is demonstrated by docking models how amantadine can exert its action on Coronavirus viroporin E.

According to the organizational-activational hypothesis, testosterone or its metabolite estradiol, can organize the brain in a male direction (permanently or for long periods) if exposure occurs during a critical (sensitive) time of brain development like the prenatal period. Male rodents with insufficient levels of testosterone during such critica...

Stress during puberty and obesity can represent conditions that facilitate the long-term development of diseases, especially for stress-related disorders that depend on neuroendocrine and immune responses. The prostate is prone to diseases that result from neuroendocrine or immune challenges, such as cancer. Aim: In the present study, we assessed...

La Agencia Internacional de Investigación en Cáncer (IARC por sus siglas en inglés) clasifica al formaldehído como un carcinógeno de tipo 1. Existe evidencia que indica que, aquellas personas que están expuestas en sus centros de trabajo a grandes concentraciones de este compuesto tienen una mayor probabilidad de padecer cáncer nasofaríngeo y pulmo...

El trastorno por consumo de alcohol (TCA) es una enfermedad derivada de la ingesta excesiva y prolongada de esta sustancia, con efectos negativos a nivel cognitivo. Durante muchos años se ha estudiado la etiología de la dependencia al alcohol y se ha encontrado que la impulsividad es uno de sus rasgos más distintivos, una característica cognitiva q...

En el presente trabajo estudiamos la conducta sexual y la histología de la próstata en un modelo de autismo en ratas macho. Los machos autistas presentaron todos los parámetros conocidos de la copula pero la mayoría de ellos fuera de los niveles normales. Los patrones de conducta indicaron un decremento en el estado motivacional y una reducción en...

Purpose of Review The aim of this review is to provide current evidence on the biological and psychological mechanisms that underlie sexual partner preferences (SPP) in humans and animals. Recent Findings SPP depend mainly on prenatal (adaptive) organization of the brain, but can be drastically modified via learning under enhanced dopaminergic (DA...

Aim: In the present study, we assessed the long-term effects of an acute pubertal stressor (immune-challenge) on the development of precancerous lesions in adult rats, and compared them with testosterone-induced prostatic lesions. Materials and methods: Pubertal male rats received a single injection of lipopolysaccharide (LPS) or saline during p...

Poster #67.20 Sexual preferences can be strengthened, weakened or drastically modified via conditioning, specially during certain neurochemical states. For example, cohabitation with another individual under the effects of Quinpirole (a D2-type receptor agonist) induces a conditioned socio-sexual partner preference. Such preference is powerful enou...

Justicia spicigera Schltdl. (Acanthaceae) is a plant used in traditional Mexican medicine to treat several types of cancer. Some studies reported cytotoxic effects of J. spicigera extracts on cancer cell lines, but that the androgen-independent DU-145 prostate cancer cell line resists its cytotoxic action. The aim of the present study was to invest...

The dopamine D2-type receptor agonist quinpirole (QNP) facilitates the development of conditioned same-sex partner preference in males during cohabitation, but not in ovariectomized (OVX) females, primed with estradiol benzoate (EB) and progesterone (P). Herein we tested the effects of QNP on OVX, EB-only primed females. Females received a systemic...

Sexual partner preferences can be strengthened, weakened or even drastically modified via Pavlovian conditioning. For example, conditioned same-sex partner preference develops in sexually-naïve male rats that undergo same-sex cohabitation under the effects of quinpirole (QNP, D2 agonist). Here, we assessed the effect of prior heterosexual experienc...

Background The effect of orgasm on the development and shaping of partner preferences may involve a catalysis of the neurochemical mechanisms of bonding. Therefore, understanding such process is relevant for neuroscience and psychology. Methods A systematic review was carried out using the terms Orgasm, Sexual Reward, Partner Preference, Pair Bond...

Unlabelled: The prostate is an exocrine reproductive gland that participates in ejaculation and it is prone to diseases, including cancer. Aim: In the pre-sent study, we assessed the long-term effects of copulation on the development of precancerous lesions in rats, and compared them with testosterone-induced prostatic lesions. Materials and me...

http://ebooks.uv.mx/product/neurofisiologa-de-la-conducta El cerebro es el órgano más complejo e importante de cualquier ser vivo. Su funcionamiento adecuado nos permite sentir, desear, buscar, obtener y decidir entre lo que es biológicamente importante o no. Por lo tanto, el cerebro es el principal sensor e integrador de información externa (se p...

De acuerdo con la Organización Mundial de la Salud, cada año fallecen 3,4 millones de personas adultas por consecuencias del sobrepeso u obesidad. Personas con un índice de masa corporal superior a 30, presentan cierto aumento en la incidencia de algunas enfermedades entre las que se encuentran algunos tipos de cánceres. En esta revisión de tipo na...

Resumen La hipersexualidad puede ser un síntoma secundario al tratamiento de la enfermedad de Parkinson (EP) y forma parte de algunos desórdenes en el control de impulsos en una proporción que va del 20-50% de los pacientes. En esta revisión analizamos las evidencias neurobiológicas que explican el incremento de la hipersexualidad durante el tratam...

According to the World Health Organization, every year about 3.4 million adults die of consequences related to overweight or obesity. People with a Body Mass Index above 30 are more likely to express certain diseases, including some types of cancer. In this narrative review, we assess the role of adipose tissue as a modulator of the endocrine syste...

http://ebooks.uv.mx/product/neurofisiologa-de-la-conducta

Endocrine studies have shown prolactin (PRL) and testosterone (T) regulate prostate function. Both hormones are involved in the diseases of this gland as hyperplasia, dysplasia, and metastatic cancer. Since it has been reported metalloproteinases (MMPs) are underlying processes of metastasis and these are regulated by PRL and T. By histological stu...

The growth and function of the prostate gland is under hormonal and autonomic control. The pelvic (Pv) and hypogastric (Hg) nerves supply the gland and regulate receptors and other factors underlying its structure, development and pathology. In this work, we evaluated the messenger for androgen receptors (AR), muscarinic acetylcholine (M3), and alp...

Evidence indicates that prolactin plays a crucial role in the normal function and development of the prostate, but abnormal high levels of the hormone are associated with hyperplasia and cancer of the gland. The present study was designed to describe the progressive specific histological abnormalities in the prostate of rats with chronic hyperprola...

Conditioned same-sex partner preference can develop in male rats that undergo cohabitation under the effects of quinpirole (QNP, D2 agonist). Herein, we assessed the development of conditioned same-sex social/sexual preference in males that received either nothing, saline, QNP, oxytocin (OT), or QNP + OT during cohabitation with another male (+) or...

Introduction: The brain is sexually dimorphic because males express bigger nuclei in certain regions as compared to females. Brain dimorphism occurs during the perinatal period, much later than the period when genitals and accesory organs are formed. In general, it is well accepted the idea that sexual preference correlates with brain dimorphism, a...

Introduction: Three groups of hypothalamic dopaminergic neurons regulate the adenohypophysis to release systemic prolactin. The inhibition of dopamine stimulates prolactin release that in turn is selfregulated by stimulating the release of dopamine. This is possible because dopaminergic neurons have prolactin receptors which increase their concentr...

En la actualidad el cáncer ha ido en aumento en la población mexicana. Durante el 2011, el 86.3% de las defunciones por neoplasias en la población mexicana menor de 20 años fue debida a tumores malignos. En ese mismo año ocho de cada 100 hombres de 20 años o mayores diagnosticados con cáncer presentaron neoplasia de próstata. Se calcula que de cada...

Animal welfare is commonly regarded as the physical and psychological well-being of animals, fulfilled if animals are free: 1) from hunger, thirst and malnutrition, 2) from discomfort, 3) from pain, 4) to express normal behavior, and 5) from fear and distress. This paper is meant to provoke the reader to re-think the concept of welfare. Evidence in...

Female sexual behavior is sensitive to stress and diseases. Some studies have shown that status epilepticus (SE) can affect sexual proceptivity and receptivity in female rats and also increases reject responses towards males. However, epidemiologic studies indicate that SE is more frequent in young individuals. Herein, we assessed the effects of SE...

La prolactina es una hormona proteica que es sintetizada y secretada principalmente por los lactotropos en la adenohipófisis. Se ha mostrado que presenta diversas funciones, dentro de las que se encuentran aquéllas relacionadas con la reproducción. En este sentido, se ha visto que la prolactina tiene receptores en diversas glándulas sexuales acceso...