Deetje Iggena

Deetje Iggena
Charité Universitätsmedizin Berlin | Charité · Department of Neurology with Chair in Experimental Neurology/BNIC

MD

About

12
Publications
1,323
Reads
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332
Citations
Introduction
I'm a postdoctoral researcher and medical doctor at the Charité-Universitätsmedizin. I investigate spatial memory consolidation in humans with hippocampal dysfunction using VR and real-life experimental settings. Previously, I examined the influence of lifestyle-interventions on hippocampal neurogenesis and spatial memory in young adult mice.
Additional affiliations
October 2018 - present
Charité Universitätsmedizin Berlin
Position
  • Medical Doctor
February 2018 - October 2018
Charité Universitätsmedizin Berlin
Position
  • Medical Doctor
November 2016 - February 2018
University of Cologne
Position
  • Medical Doctor

Publications

Publications (12)
Research
Full-text available
Spatial navigation is a complex multisensory process that requires the integration of visual, somatosensory and vestibular input and re-afferents from the motor system with mnemonic representations of the environment. Despite this complexity, most human adaptations of the Morris water maze (MWM, Morris et al., 1982) in spatial navigation studies ar...
Preprint
Full-text available
We investigated the role of the post-encoding period for consolidation of self-centered (egocentric) and world-centered (allocentric) spatial memory in neurologically normal human subjects. We used the GABA A -ergic anesthetic propofol to transiently modulate neural activity during the early stage of spatial memory consolidation. A total of 52 pati...
Article
The neurodegenerative disorder Parkinson's disease affects motor abilities as well as cognition. The gold standard therapy is L-Dopa, which mainly restores motor skills. Therefore, we require additional interventions to sustain cognitive functions in Parkinson's disease. The lifestyle intervention “physical activity” improves adult hippocampal neur...
Article
Frequent flyers and shift workers undergo circadian dysrhythmia with adverse impact on body and mind. The circadian rhythm disorder "jet lag" disturbs hippocampal neurogenesis and spatial cognition, which represent morphological and functional adult brain plasticity. This raises the question if pro-neurogenic stimuli might prevent those consequence...
Article
Full-text available
Cancer is a disease of the genome caused by oncogene activation and tumor suppressor gene inhibition. Deep sequencing studies including large consortia such as TCGA and ICGC identified numerous tumor-specific mutations not only in protein-coding sequences but also in non-coding sequences. Although 98% of the genome is not translated into proteins,...
Article
Full-text available
In the context of television consumption and its opportunity costs the question arises how far experiencing mere representations of the outer world would have the same neural and cognitive consequences than actively interacting with that environment. Here we demonstrate that physical interaction and direct exposition are essential for the beneficia...
Article
Full-text available
Immune mechanisms are included in stroke pathophysiologic factors, but the frequency and role of intrathecal antibodies is unclear and diagnostic tests are not routinely performed on cerebrospinal fluid (CSF). To determine the frequency of intrathecal immunoglobulin synthesis in a well-characterized cohort of patients who experienced “noninflammato...

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Projects

Project (1)
Project
The goal of this project is to develop and test digital methods to assess and rehabilitate cognitive dysfunction in pursuit of tools that are more ecologically valid, observer-independent, and multidimensional than current approaches. The focus is on leveraging the potential of Virtual Reality paradigms to make progress in this direction.