
Deepika DeepikaUniversidad Rovira i Virgili | URV · Department of Chemical Engineering
Deepika Deepika
Developing Physiologically Based Pharmacokinetic Models (PBPK) and Systems Biology models for evaluating toxicity.
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46
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Introduction
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Education
July 2014 - July 2016
Publications
Publications (46)
Human biomonitoring (HBM) data indicate that exposure to pyrethroids is widespread in Europe, with significantly higher exposure observed in children compared to adults. Epidemiological, toxicological, and mechanistic studies raise concerns for potential human health effects, particularly, behavioral effects such as attention deficit hyperactivity...
The prevalence of hormone-related health issues caused by exposure to endocrine disrupting chemicals (EDCs) is a significant, and increasing, societal challenge. Declining fertility rates together with rising incidence rates of reproductive disorders and other endocrine-related diseases underscores the urgency in taking more action. Addressing the...
Background: Adverse Outcome Pathways (AOPs) provide a basis for non-animal testing, by outlining and encoding the cascade of molecular and cellular events initiated upon stressor exposure, leading to adverse effects. AOPs are therefore considered an integral part of the New Approach Methodology (NAMs) to human health risk assessment. Over the last...
In the current work, screening of polymers viz. polyacrylic acid (PAA), polyvinyl pyrrolidone vinyl acetate (PVP VA), and hydroxypropyl methyl cellulose acetate succinate (HPMC AS) based on drug-polymer interaction and wetting property was done for the production of a stable amorphous solid dispersion (ASD) of a poorly water-soluble drug Riluzole (...
A simple, efficient, and practical metal-free protocol has been devised to synthesize imidazopyrido[3,4-b]indole-based fluorophores decorated with carbazole/β-carboline/pyridine scaffolds via three consecutive C–N bond formations in a single operation. A wide range of aromatic amines (2-aminopyridines, 3-aminocarbazole, and anilines) were successfu...
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP), Tris (1-chloro-2-propyl) phosphate (TCIPP) and tris (2-chloroethyl) phosphate (TCEP) are three widely used organophosphate flame retardants (OPFRs) being frequently detected in human body fluids. Although OPFRs are being detected in human beings, the toxicological effects of their exposure are not cle...
Physiologically Based Pharmacokinetic (PBPK) models are mechanistic tools generally employed in the pharmaceutical industry and environmental health risk assessment. These models are recognized by regulatory authorities for predicting organ concentration-time profiles, pharma-cokinetics and daily intake dose of xenobiotics. The extension of PBPK mo...
Physiologically Based Pharmacokinetic Models (PBPK) are mechanistical tools generally employed in the pharmaceutical industry and environmental health risk assessment. These models are recognised by regulatory authorities for predicting organ concentration-time profile, pharmacokinetic and daily intake dose of xenobiotics. Extension of PBPK models...
Daily exposure to xenobiotics affects human health, especially the nervous system, causing neurodegenerative diseases. The nervous system is protected by tight junctions present at the blood–brain barrier (BBB), but only molecules with desirable physicochemical properties can permeate it. This is why permeation is a decisive step in avoiding unwant...
The blood-brain barrier (BBB) is a structural and functional interface between the plasma and the human brain. Predictive BBB in-vitro models like immortalized human capillary microvascular endothelial cells (HCMEC/D3) can be used to explore the BBB disruption potential of daily exposed chemicals. The present study was focused on investigating the...
The novel coronavirus disease (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), affected millions of people worldwide at an alarming rate. Moreover, the development of vaccines is still hope, but its camouflage mutations during transmission are still a challenge. In the dire condition of this pandemic, dru...
Organophosphate Flame Retardants (OPFRs) are the second most
widely used flame retardants in Europe with approximate consumption
of 89640 metric tons almost double of Brominated Flame retardants.
Several epidemiological and animal studies have published the health
impact of OPFRs exposure causing endocrine disruption, carcinogenicity, neurodegenera...
Bisphenol A (BPA) is a widely known endocrine disruptor (ED) found in many children's products such as toys, feeding utensils, and teething rings. Recent epidemiology association studies have shown postnatal BPA exposure resulted in developing various diseases such as diabetes, obesity, and neurodegeneration, etc., later in their lives. However, li...
Human biomonitoring (HBM) is a rapidly developing field that is emphasized as an important approach for the assessment of health risks. However, its value for health risk assessment (HRA) remains to be clarified. We performed a review of publications concerned with applications of HBM in the assessment of health risks. The selection of publications...
Over the last years, research has focused on microbiota to establish a missing link between neuronal health and intestine imbalance. Many studies have considered microbiota as critical regulators of the gut–brain axis. The crosstalk between microbiota and the central nervous system is mainly explained through three different pathways: the neural, e...
Endocrine-disrupting chemicals (EDCs) refer to a group of chemicals that cause adverse effects in human health, impairing hormone production and regulation, resulting in alteration of homeostasis, reproductive, and developmental, and immune system impairments. The immunotoxicity of EDCs involves many mechanisms altering gene expression that depend...
Perfluoroalkyl substances (PFAS), especially PFOS and PFOA, are two widely used synthetic chemicals that can impact human health based on evidence from animal and epidemiologic studies. In this paper, we have reviewed and summarized the influence of PFAS exposure on health, pointing the quality of evidence, and applied translational techniques to i...
The widespread use of Perfluorooctane sulfonate (PFOS) in everyday life, its long half-life, and the lipophilicity that makes it easily accumulate in the body, raises the question of its safe exposure among different population groups. There are currently enough epidemiological studies showing evidence of PFOS exposure and its associated adverse ef...
In the recent past, there has been a tremendous increase in the kind of data being generated by high-throughput analysis (omics) for endocrine disruptors (EDs). In parallel, several in silico tools [physiologically based pharmacokinetic (PBPK), pharmacodynamic (PD), systems biology and adverse outcome pathways (AOPs)] offer an opportunity to unders...
Many chemicals in day-today and industrial usage have the ability to cross the blood-brain barrier and develop neurotoxicity in humans. There are numerous in vitro, in vivo, epidemiological and in silico studies developed to test the neurotoxicity of such chemicals. This systematic review summarized the endpoints and biochemical markers generated f...
It explains the multidisciplinary work being done by researchers in Neurosome through in-vitro, in-vivo, human biomonitoring and computational model for describing co-relation between neurodevelopmental disorders and multiple chemical exposure.
PFOS is one of the most abundant perfluoroalkyl substances (PFASs)
in environment with wide exposure to the human population
through contaminated food, water, consumer products and occupational exposure. Various epidemiological, in vitro and in vivo studies
have found the causal link between the exposure of PFOS and developmental neurotoxicity. Sev...
The present application relates to a topical composition comprising one or more hair growth promoting agents, at least one acidifying agent, and a suitable carrier system. The present application also relates to a method of treating alopecia or androgenic alopecia using said composition.
The study was designed to fabricate the moxifloxacin nanostructured lipid carriers (MOX-NLCs)loaded in situ gel for opthalmic application to improve the corneal permeation and retention and also subside the toxic effect associated with intracameral injection of moxifloxacin in endophthalmitis treatment. Initially, Box-Behnken design was used to opt...
The objective of present study was to develop polymeric nanoparticles (PNPs) of Frovatriptan Succinate (FS) for brain targeting by nasal route. Double emulsion method was used to increase the entrapment efficiency of hydrophilic drug and formulation was optimized by central composite design to achieve critical quality attributes namely particle siz...