Deepika . B

St. Pauls College of Pharmacy · Pharmaceutics

The metabolism of most antidiabetic drugs is initiated by Cytochrome P-450 (CYP) enzymes present in the human body. The result of this metabolism can be a formation of either active metabolites or inactive metabolites. There is possibility of alteration in the activity of CYP enzymes due to some phytoconstituents which are present in vegetables, fr...

In the present study, the floating matrix tablets of Nizatidine were prepared by using both synthetic and natural polymers individually and in combination. In this study, an attempt was done to increase the local action of Nizatidine by formulating as floating tablets. Total 12 formulations were developed out of which formulations F1 to F9 were pre...

Research work was design, prepare and characterization of antihypertensive buccal patches. Nefidipine used in treatment of blood pressure, congestive cardiac failure and angina. BDDS can be effectively utilized for the drug which undergoes first pass metabolism. The quality of API with regard to solubility and short half-life makes this drug as a s...

The present investigation was carried out on Mirtazapine mouth dissolving tablets by sublimation method. The estimation of Mirtazapine by UV spectrophotometric method at 288nm in pH 6.8 phosphate buffer had good reproducibility and this method was used in the study. Camphor concentration was optimised as 10mg. The pre and post formulation studies w...

In the present study Loratidine solid dispersions were formulated. The enhancement of its solubility and dissolution profile is expected to significantly improve its bioavailability and reduce its side effects. Loratidine was mixed with various proportions of excipients showed no colour change at the end of two months, proving no drug-excipient int...

In the present research work gastro retentive floating matrix Tablets of Lisinopril by using various polymers such as Sodium alginate, Guar gum and Carbopol 934 were developed. The formulation blend was subjected to various pre formulation studies, flow properties and all the formulations were found to be good indicating that the powder blend has g...

Gymnosperia emarginata (Willd.) grow in moderately fertile, moist but well-drained soil in full sun with midday shade. This study investigated the antiepileptic of the ethanolic leaf extract of the plant. Three widely used animal models of epilepsy namely the pentylenetetrazole, picrotoxin and maximal electroshock-induced seizure tests were used to...

The aim of the present study was to develop Sustained release formulation of Glipizide to maintain constant therapeutic levels of the drug for over 12 hrs. Here different types of polymers (Locust Bean Gum, Gum Cyamposis, Corn Sugar Gum) were used. Glipizide dose was fixed as 10 mg. Total weight of the tablet was considered as 100 mg. Polymers were...

Sustained Release Matrix Tablets of Amoxicillin were prepared by using Different Rate controlling polymers like Sodium Alginate, Chitosan, Guar Gum and Eudragit L100. Developed total four formulations by using Direct Compression method. The prepared sustained release matrix tablets were evaluated for different evaluation tests like weight variation...

Sustained Release Matrix Tablets of Amoxicillin were prepared by using Different Rate controlling polymers like Sodium Alginate, Chitosan, Guar Gum and Eudragit L100. Developed total four formulations by using Direct Compression method. The prepared sustained release matrix tablets were evaluated for different evaluation tests like weight variation...

Oral medicated jellies developed dated back to 20 th century, remain popular among the consumer and hence it has continued commercial production. Oral medicated jellies are palatable solid dosage forms administered in the oral cavity, meant to be dissolved in mouth or pharynx for its local or systemic effect. Oral medicated jellies provide several...

Rate controlled drug delivery systems are developed to overcome physiological adversities like short residence times and unpredictable gastric emptying times. Differences in gastric physiology such as gastric pH and motility exhibit both intra and inter subject variability demonstrating significant impact on gastric residence time and drug delivery...

Zidovudine is Nucleoside Reverse transcriptase inhibitor and widely used in treatment of ART. In present study Zidovudine matrix tablets were formulated and evaluated using various natural and synthetic polymers. Sustained release matrix tablets were prepared by using HPMC k15m, Eudragit S100, Xanthan gum and Guar gum alone as rate controlling poly...

In the present research work floating matrix tablet formulation of Cefpodoxime Proxetil was prepared by using different polymers. Initially analytical method development was done for the drug molecule. An absorption maximum was determined based on the calibration curve developed by using different concentrations. Gas generating agent sodium bicarbo...

Ramipril is a new Anti hypertensive agent especially for the treatment of Hypertension. The main objective of the study was to formulate and evaluate bioadhesive buccal tablets to avoid the first pass metabolism in liver. Bioadhesive buccal tablets were prepared by direct compression method using bioadhesive polymers like Gum karaya, Sodium Alginat...

The present investigation was carried out on Mirtazapine mouth dissolving tablets by sublimation method. The estimation of Mirtazapine by UV spectrophotometric method at 288nm in pH 6.8 phosphate buffer had good reproducibility and this method was used in the study. Camphor concentration was optimised as 10mg. The pre and post formulation studies w...

Gymnosperia emarginata (Willd.) grow in moderately fertile, moist but well-drained soil in full sun with midday shade. This study investigated the antiepileptic of the ethanolic leaf extract of the plant. Three widely used animal models of epilepsy namely the pentylenetetrazole, picrotoxin and maximal electroshock-induced seizure tests were used to...

In the present study Loratidine solid dispersions were formulated. The enhancement of its solubility and dissolution profile is expected to significantly improve its bioavailability and reduce its side effects. Loratidine was mixed with various proportions of excipients showed no colour change at the end of two months, proving no drug-excipient int...

The aim of the present study was to develop sustained release formulation of Tramadol Hydrochloride to maintain constant therapeutic levels of the drug for over 24hrs. By using different ratios of synthetic polymers like Ethyl cellulose, Eudragit RL100, Natural polymers like Moringa gum and Tamarind gum were employed as polymers. All the formulatio...

In the present research work gastro retentive floating matrix Tablets of Lisinopril by using various polymers such as Sodium alginate, Guar gum and Carbopol 934 were developed. The formulation blend was subjected to various pre formulation studies, flow properties and all the formulations were found to be good indicating that the powder blend has g...

In the present research work floating matrix tablet formulation of Cefpodoxime Proxetil was prepared by using different polymers. Initially analytical method development was done for the drug molecule. An absorption maximum was determined based on the calibration curve developed by using different concentrations. Gas generating agent sodium bicarbo...

In the present study Loratidine solid dispersions were formulated. The enhancement of its solubility and dissolution profile is expected to significantly improve its bioavailability and reduce its side effects. Loratidine was mixed with various proportions of excipients showed no colour change at the end of two months, proving no drug-excipient int...

The aim of the present study was to develop Sustained release formulation of Glipizide to maintain constant therapeutic levels of the drug for over 12 hrs. Here different types of polymers (Locust Bean Gum, Gum Cyamposis, Corn Sugar Gum) were used. Glipizide dose was fixed as 10 mg. Total weight of the tablet was considered as 100 mg. Polymers were...

Ramipril is a new Anti hypertensive agent especially for the treatment of Hypertension. The main objective of the study was to formulate and evaluate bioadhesive buccal tablets to avoid the first pass metabolism in liver. Bioadhesive buccal tablets were prepared by direct compression method using bioadhesive polymers like Gum karaya, Sodium Alginat...

The aim of the present study was to develop sustained release formulation of Tramadol Hydrochloride to maintain constant therapeutic levels of the drug for over 24hrs. By using different ratios of synthetic polymers like Ethyl cellulose, Eudragit RL100, Natural polymers like Moringa gum and Tamarind gum were employed as polymers. All the formulatio...

The present investigation was carried out on Mirtazapine mouth dissolving tablets by sublimation method. The estimation of Mirtazapine by UV spectrophotometric method at 288nm in pH 6.8 phosphate buffer had good reproducibility and this method was used in the study. Camphor concentration was optimised as 10mg. The pre and post formulation studies w...

In the present research work gastro retentive floating matrix Tablets of Lisinopril by using various polymers such as Sodium alginate, Guar gum and Carbopol 934 were developed. The formulation blend was subjected to various pre formulation studies, flow properties and all the formulations were found to be good indicating that the powder blend has g...

Gymnosperia emarginata (Willd.) grow in moderately fertile, moist but well-drained soil in full sun with midday shade. This study investigated the antiepileptic of the ethanolic leaf extract of the plant. Three widely used animal models of epilepsy namely the pentylenetetrazole, picrotoxin and maximal electroshock-induced seizure tests were used to...

In terms of formulation, a orally disintegrating tablet (ODT) differ from an conventional tablet by modification of normal disintegrants with a superdisintegrant which is highly sensitive to aqueous environment (saliva) and disintegrates in fraction of time enhancing disintegration followed by immediate dissolution .This unique property helps rapid...

The purpose of the present investigation was to prepare oral microspheres of levetiracetam with a view to reduce the frequency of dosing and to attain steady state drug levels in addition to masking the bitter taste and faint odor of drug. Levetiracetam is a second-generation antiepileptic agent useful in the treatment of partial onset and myocloni...

The aim of study was to prepare and characterize buccoadhesive tablets of Metoprolol tartrate using different Mucoadhesive polymers such as Carbopol 934, Sodium alginate and HPMC K4M in combination. Ten formulations were prepared with varying concentrations of polymers using combination of two polymers in each formulation. Formulations F1 to F5 wer...

Buccoadhesive tablets of piroxicam were prepared by using HPMC K4M and carbopol 934 as mucoadhesive polymers. Ten formulations were developed with varying concentrations of polymers. H1 to H5 formulations were composed of HPMC K4M in ratios of 1:1 to 1:5 whereas in C1 to C5 formulations Carbopol 934 were used in ratios of 1:0.25 to 1:1.5. The formu...