Deep Jyoti Bhuyan

Deep Jyoti Bhuyan
Western Sydney University · NICM Health Research Institute

BSc (Bangalore University) MSc (VIT University) PhD (University of Newcastle)

About

60
Publications
37,291
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655
Citations
Introduction
My research is aimed at understanding the role of gut microbiota in the occurrence, treatment and prognosis of cancer to define gut microbiota-focused therapeutic strategies. My group is also investigating the complex synergistic interactions of bioactive compounds with standard drugs on specific biological targets and how these interactions can be utilised as therapeutic strategies against infectious (bacterial, fungal and viral) diseases and cancer.
Additional affiliations
April 2018 - July 2021
Western Sydney University
Position
  • Postdoctoral Research Fellow
August 2014 - December 2017
The University of Newcastle, Australia
Position
  • Casual Academic
March 2014 - January 2018
The University of Newcastle, Australia
Position
  • PhD Student
Education
March 2014 - December 2018
The University of Newcastle, Australia
Field of study
  • Food Science: Anticancer Research
July 2008 - May 2010
VIT University
Field of study
  • Applied Microbiology
June 2005 - May 2008
Bangalore University
Field of study
  • Biotechnology, Genetics, Biochemistry

Publications

Publications (60)
Article
The association between human gut microbiota and cancers has been an evolving field of biomedical research in recent years. The gut microbiota is composed of the microorganisms residing in the gastrointestinal system that interact with the host to regulate behaviours and biochemical processes within the gut. This symbiotic physiological interaction...
Article
Full-text available
Cannabidiol (CBD), a nonpsychoactive phytocannabinoid, has recently emerged as a potential cytotoxic agent in addition to its ameliorative activity in chemotherapy-associated side effects. In this work, the potential interactions of CBD with docetaxel (DOC), doxorubicin (DOX), paclitaxel (PTX), vinorelbine (VIN), and 7-ethyl-10-hydroxycamptothecin...
Article
Full-text available
In recent years, the role of gut microbial metabolites on the inhibition and progression of cancer has gained significant interest in anticancer research. It has been established that the gut microbiome plays a pivotal role in the development, treatment and prognosis of different cancer types which is often mediated through the gut microbial metabo...
Article
Australian native plants have adapted themselves to harsh climatic conditions enabling them to produce unique and high levels of secondary metabolites. Native fruits and vegetables have been an integral part of the Indigenous Australian diet and Bush Medicine for centuries. They have recently gained popularity owing to their rich dietary fibre, min...
Article
Full-text available
The complex association between the gut microbiome and cancer development has been an emerging field of study in recent years. The gut microbiome plays a crucial role in the overall maintenance of human health and interacts closely with the host immune system to prevent and fight infection. This review was designed to draw a comprehensive assessmen...
Conference Paper
Full-text available
Background: The relevance of gut microbiota in the development, treatment and clinical outcome of cancers is an emerging area of translational research that can pave new avenues in cancer therapeutics. Our recently published reviews have underlined the immunomodulatory and anti-tumoural effects of gut microbiota in cancers through the production of...
Article
Full-text available
Allium cepa (onion) and Allium sativum (garlic) are important members of the Amaryllidaceae (Alliaceae) family and are being used both as food and medicine for centuries in different parts of the world. Polysaccharides have been extracted from different parts of onion and garlic such as bulb, straw and cell wall. The current literature portrays sev...
Article
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Cerebral ischemia is a cerebrovascular disease with high morbidity and mortality that poses a significant burden on society and the economy. About 60% of cerebral ischemia is caused by thrombus, and the formation of thrombus proceeds from insoluble fibrin, following its transformation from liquid fibrinogen. In thrombus-induced ischemia, increased...
Article
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The quality control of medicinal cannabis should include quantification of as many cannabinoids as practicable in a routine analytical lab, to accurately reflect the quality of the product. However, the cost and availability of some cannabinoid standards is an impediment to their routine use. This work seeks to overcome this obstacle by analysing s...
Article
Full-text available
Tomato is a member of the Solanaceae family and is a crop that is widely cultivated around the world due to its sweet, sour, salty, juicy, and nutritious berries. The processing of tomato generates a significant amount of waste in the form of tomato pomace, which includes seeds and skin. Tomato seeds are reservoirs of various nutrients, such as pro...
Article
Guava processing industries generate peel and seeds as primary waste fractions. Guava seeds obtained after fruit processing possess untapped potential in the field of food science due to the presence of a diversity of nutritional and bioactive compounds. Along with offering a detailed understanding of the nutritional attributes of guava seeds, the...
Article
Full-text available
Cannabis is well-known for its numerous therapeutic activities, as demonstrated in pre-clinical and clinical studies primarily due to its bioactive compounds. The Cannabis industry is rapidly growing; therefore, product development and extraction methods have become crucial aspects of Cannabis research. The evaluation of the current extraction meth...
Article
The lack of a gold standard synergy quantification method for chemotherapeutic drug combinations warrants the consideration of different synergy metrics to develop efficient predictive models. Furthermore, neglecting combination sensitivity may lead to biased synergistic combinations, which are ineffective in cancer treatment. In this paper, we pro...
Article
In the present study, the attitudes of heterosexual individuals toward same-sex attracted individuals were investigated. Heterosexual Indian and Australian participants (n = 472; 254 males) completed a series of measures indexing participants’ attitudes toward lesbians, gay men and bisexual individuals. Overall, compared to Australians, Indians hel...
Article
Full-text available
Depression, anxiety, and insomnia are common in cancer patients. Mind-body therapies (MBTs) are promising forms of treatment for cancer patients living with depression, anxiety, and insomnia. The objective of this study is to assess the effectiveness and acceptability of MBTs in cancer patients living with depression, anxiety, or insomnia. EMBase,...
Conference Paper
Full-text available
The combination of natural products with standard chemotherapeutic agents offers a promising strategy to enhance the efficacy or reduce the side effects of standard chemotherapy. We explored the synergistic interactions between Australian propolis extract (AP−1) and doxorubicin (DOX) in the MCF7 cells. Five prenylated stilbenes were identified as t...
Article
Full-text available
The processing of tomato fruit into puree, juices, ketchup, sauces, and dried powders generates a significant amount of waste in the form of tomato pomace, which includes seeds and skin. Tomato processing by-products, particularly seeds, are reservoirs of health-promoting macromolecules, such as proteins (bioactive peptides), carotenoids (lycopene)...
Article
Full-text available
The combination of natural products with standard chemotherapeutic agents offers a promising strategy to enhance the efficacy or reduce the side effects of standard chemotherapy. Doxorubicin (DOX), a standard drug for breast cancer, has several disadvantages, including severe side effects and the development of drug resistance. Recently, we reporte...
Article
MMEO (3′-methoxy-3′,4″(methylenedioxy)-2,5-epoksilignan-4′ol-6-on) is a derivative of DMEO (3′-methoxy-3″,4″(methylenedioxy)-2,5-epoksilignan-4′,6-diol) synthesized through demethylation using dimethylsulfoxide-acetic anhydride reagent. MMEO inhibits Hedgehog signaling at a concentration of 4.1 μ M. The current study aimed to formulate MMEO as soli...
Article
Propolis is a by-product of honeybee farming known for its broad therapeutic benefits around the world and is extensively used in the health food and beverage industry. Despite Australia being one of the world's megadiverse countries with rich flora and fauna, Australian propolis samples have not been explored adequately with most in vitro and in v...
Article
Full-text available
The outbreak of the novel coronavirus, severe acute respiratory syndrome (SARS)–CoV-2, has gained unprecedented global attention. SARS-CoV-2, which causes the newly described coronavirus disease 2019 (COVID-19), has affected millions of people and led to over 1.9 million deaths worldwide by the beginning of January 2021. Several governments have op...
Article
Neuroinflammation is believed to play a primary role in the pathogenesis of most neurodegenerative diseases including Alzheimer's disease, Parkinson's and schizophrenia. Currently, suitable in vitro neuroinflammation models for studying cellular interactions and inflammatory mechanisms at the neurovascular unit are still scarce. In this study, we e...
Conference Paper
Thanks to their complexity and diversity, viral infections represent one of the biggest disease burdens in the world. According to the World Health Organisation, currently, 16 out of 20 pandemic and epidemic diseases are caused by viruses. Despite the recent advancement in immunization and drug development, many viruses lack vaccines and effective...
Conference Paper
Turmeric (Curcuma longa) has known to be one of the most commonly used Chinese herb termed Jiang Huang for the promotion of blood and relieving pain. Even though turmeric has been accessible for almost thousands of years, research involving turmeric as an active medicinal entity has gained recognition only over the last four decades. Modern researc...
Conference Paper
Invited talk at the National Agricultural Higher Education Project, India sponsored International Webinar on Food Safety Policies and Regulations Organized by the Department of Food Science and Nutrition, College of Community Science, Assam Agricultural University, India.
Thesis
Full-text available
The poorest prognostic outcome for pancreatic cancer (PC) patients, among all gastrointestinal malignancies, can be attributed to the molecular heterogeneity and lack of specific therapeutic strategies. The emergence of resistance against the common chemotherapeutic drug gemcitabine has also been widely reported. Several studies have demonstrated i...
Chapter
Full-text available
Chinese Herbal Medicine (CHM), an integral part of Traditional Chinese Medicine, has been implementing complex herbal formulae usually consisting of two or more medicinal herbs for the prevention and treatment of various diseases since antiquity. The key mechanisms of action of CHM for the systematic management of many diseases largely rely on the...
Article
Full-text available
Background: A large amount of mushroom waste is generated during mushroom production (accounting for up to 20% of total production) and is mainly composed of mushrooms that do not meet the specifications set by retailers because of misshapen caps and/or stalks. Mushrooms are notable for their ergosterol (a precursor of vitamin D2) content which is...
Article
Full-text available
Persea americana, commonly known as avocado, has recently gained substantial popularity and is often marketed as a "superfood" because of its unique nutritional composition, antioxidant content, and biochemical profile. However, the term "superfood" can be vague and misleading, as it is often associated with unrealistic health claims. This review d...
Chapter
Full-text available
Phenolic compounds are perhaps the most explored natural compounds due to their potential health benefits as demonstrated in a number of studies. In the last few years, phenolic compounds derived from natural sources have been linked to antioxidant, anti-inflammatory, anti-allergic, anti-carcinogenic, antihypertensive, cardioprotective, anti-arthri...
Conference Paper
OBJECTIVE To elucidate the phytochemical, anticancer, antibacterial and antifungal properties of crude aqueous freeze-dried extract of Angophora floribunda leaves. METHODS The phytochemical profile was studied by analyzing the total phenolic content (TPC), total flavonoid content (TFC), proanthocyanidins and antioxidant properties of the extract. T...
Conference Paper
Lay summary: Pancreatic cancer (PC) is one of the most devastating forms of human cancers in the world with no improvement of the overall survival rate over the last five decades. Australian eucalypts have been linked with anticancer activity in a number of studies, but not specifically against PC. This study investigated the anti-pancreatic cancer...
Article
Full-text available
Australia is home to over 800 different species of Eucalyptus and traditionally, many Eucalyptus species have been utilised to heal wounds and treat fungal infections by the Indigenous people of Australia. In view of this, our study was designed to investigate the phytochemical, antibacterial and antifungal properties of crude aqueous extract of E....
Article
Full-text available
In spite of the recent advancements in oncology, the overall survival rate for pancreatic cancer has not improved over the last five decades. Eucalypts have been linked with cytotoxic and anticancer properties in various studies; however, there is very little scientific evidence that supports the direct role of eucalypts in the treatment of pancrea...
Article
Full-text available
This study was designed to develop ultrasonic conditions as an advanced technique for optimal recovery of phenolics and antioxidants from E. robusta leaf and to evaluate the impact of solvents, temperature, sonication time and power on ultrasound-assisted extraction of these compounds. Temperature had the greatest impact on the total phenolic conte...
Article
The individual and interactive impacts of guar gum and glycerol on the pea starch-based edible film characteristics were examined using three factors with three level Box–Behnken response surface design (BBD). The results showed that density and elongation at break were only significantly (p < 0.05) affected by pea starch and guar gum in a positive...
Article
Background: Pancreatic cancer (PC) is a disastrous disease with a dismal survival rate of only 5%. The current standard of care for PC patients consists of surgery and/or treatment with gemcitabine, a natural productderived chemotherapeutic which has been shown to have a modest effect for some patients, however it is not a long-term curative treatm...
Article
Eucalyptus species have found their place in traditional medicine and pharmacological research and they have also been shown to possess a large number of phenolic compounds and antioxidants. The present study sought to implement conventional extraction to yield maximal total phenolic content (TPC), total flavonoid content (TFC), proanthocyanidins,...
Article
The genus Eucalyptus (Myrtaceae) is mainly native to Australia; however, some species are now distributed globally. Eucalyptus has been used in indigenous Australian medicines for the treatment of a range of ailments including colds, flu, fever, muscular aches, sores, internal pains, and inflammation. Eucalyptus oils containing volatile compounds h...
Conference Paper
Conference proceeding: Eucalyptus robusta (E. robusta) has been shown to possess many pharmacological properties in vitro in addition to its significance in traditional medicine. This study utilised microwave-assisted extraction (MAE) to yield optimal total phenolic content (TPC) and total antioxidants from E. robusta. Response surface methodology...
Article
Full-text available
Euphorbia tirucalli (E. tirucalli) is now widely distributed around the world and is well known as a source of traditional medicine in many countries. This study aimed to utilise response surface methodology (RSM) to optimise ultrasonic-assisted extraction (UAE) conditions for total phenolic compounds (TPC) and antioxidant capacity from E. tirucall...
Article
Full-text available
Biochemical properties of five different rice varieties of North East India and a starter culture cake (ASC1) collected from Arunachal Pradesh used in the process of rice beer preparation were analyzed. Further, microbial count of the starter culture cake and nutritional composition of the five laboratory prepared rice beer samples were evaluated....
Book
In recent years, concerns have been raised about the environmental impact and the potential health risk related to the use of chemical fungicides in agriculture. Interests have been generated in the development of safer antifungal agents such as plant based essential oils and extracts. In the present study, crude methanol extracts from leaves of tw...
Conference Paper
The concept of “Probiotic Chocolate” is an interesting aspect of Food microbiology that combines the goodness of probiotics with chocolate which is one of the most popular and heavenly foods of all times. Food scientist and industries around the globe have made many attempts in finding creative ways of maintaining the viability of probiotic bacte...
Article
Use of plant derived bioactive compounds as biopesticides is an emerging trend in today's world. Although, the research on various indigenous plant species is still in its infancy, the plant extracts and the bioactive compounds of many traditionally important plants have tremendous potential to serve as biofungicide in agriculture. This review high...
Article
In the present study, the antifungal and antibacterial properties of three selected plants namely Amphineuron extensus, Hedyotis diffusa and Vitex negundo used in the preparation of rice beer starter culture cakes were evaluated against Aspergillus niger, Aspergillus flavus and E. coli. A. extensus showed the highest inhibition zone against A. nige...
Conference Paper
In vitro sensitivity of Sclerotinia sclerotiorum towards methanol extracts from 12 plant species namely Allamanda cathartica, Clerodendron infortunatum, Cactus species, Drymaria cordata, Mimosa pudica, Ocimum sanctum, Piper betle, Piper longum, Piper betleoides, Polygonum hydropipper, Solanum melongena, Vitex negundo tested by agar well diffusion...
Thesis
In the present study, crude methanol extracts from twelve different medicinal plant species (leaves) were evaluated in vitro using agar well diffusion method for their efficacy against phytopathogenic fungus Sclerotinia sclerotiorum, the causal agent of white mold disease in French bean. All the plant extracts showed efficacy against the pathogen w...

Questions

Question (1)
Question
I am interested to find out the interactions between 2 drugs in terms of their inhibitory effects on various mediators of inflammation. We have earlier used combination index and Isobologram models in this context and now want to try RSM.

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Projects

Projects (6)
Project
Holistic exploration of the chemical space of pharmacologically active natural products extracts or fractions. Chemometrics-driven identification of key marker metabolites among closely related species or extracts for QC purposes. Biochemometric and active molecular networking-driven identification of active compounds in potential extracts.
Project
1- Predict synergistic anticancer combinations in-silico against different synergy quantitation models. 2- Explore the interaction of chemotherapeutic agents with natural products, including cannabinoids, propolis...etc. 3-Proteomic identification of underlying synergistic and cytotoxic mechanisms.