Deep Dutta

Deep Dutta
CEDAR SUPERSPECIALITY HEALTHCARE DWARKA NEW DELHI · ENDOCRINOLOGY AND METABOLISM

MD (Medicine), DM (Endocrinology), DNB (Endocrinology), MNAMS, Specialty Certificate (Endocrinology Royal College, UK), FRCP (Edinburgh)

About

233
Publications
77,728
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2,140
Citations
Additional affiliations
June 2014 - present
Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital
Position
  • Professor (Assistant)
January 2011 - present
Institute of Post-Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital
Position
  • IPGMER & SSKM Hospital, Calcutta
July 2009 - August 2010
Vardhman Mahavir Medical College and Safdarjung Hospital
Position
  • Medical Doctor

Publications

Publications (233)
Article
Aim: To evaluate the role of fetuin-A levels in predicting glycaemic outcomes (progression to diabetes or reversion to normoglycaemia) in people with prediabetes. Methods: A total of 2119 people were screened, of whom 144 people with prediabetes, 50 people with normoglycaemia and 66 people with newly diagnosed diabetes underwent estimation of fa...
Article
This study aimed to evaluate the relation of albumin creatinine ratio (ACR) with insulin resistance (IR) (HOMA2-IR, QUICKI), inflammatory cytokines (TNFα, IL-6 and hsCRP), dyslipidemia and 25-hydroxy-vitamin-D (25OHD) among individuals with prediabetes (IPD), and study whether it could predict future risk of progression to diabetes. IPD (n=147) wit...
Article
Background: No meta-analysis has analysed efficacy and safety of fast-acting aspart insulin (FIAsp) with insulin pump in type 1 diabetes mellitus (T1DM). Methods: Electronic databases were searched for randomised controlled trials (RCTs) involving T1DM patients on insulin pump receiving FIAsp in intervention arm, and placebo/active comparator in...
Article
Background and aims No meta-analysis has analysed efficacy and safety of semaglutide in metabolic-dysfunction associated fatty-liver disease (MAFLD). Methods Electronic databases were searched for RCTs involving people with MAFLD and/or type-2 diabetes (T2DM) receiving semaglutide. Primary outcome was to evaluate changes in alanine aminotransferas...
Article
Background & aims Pooled systematic analysis of safety and efficacy data of trelagliptin in type-2 diabetes (T2DM) is lacking. We undertook this meta-analysis to address this issue. Methods Electronic databases were searched for RCTs involving people with T2DM receiving trelagliptin in study arm, and placebo/active comparator in control arm. Prima...
Article
Background and aim The field of diabetes reversal is continuously evolving. Stratgies for implementing diabetes care towards diabetes reversal are still being worked out. We aim to analyse data from available literature to ascertain factors allowing patient centric dietary approach to achieve diabetes reversal in clinical practice. Methods In this...
Article
Background & aims No meta-analysis has analysed efficacy and safety of long-acting growth hormone (GH) therapy in adult GH deficiency. We undertook this meta-analysis to address this gap in knowledge Methods Electronic databases were searched for RCTs involving adult GH deficiency patients receiving weekly long-acting GH as compared to daily GH/pl...
Article
Background: Costs are important cause of therapeutic noncompliance in type-2 diabetes mellitus (T2DM). Half-tablet empagliflozin (EMPA)-25 mg has lowest monthly cost among all EMPA preparations; data is unavailable on efficacy of half EMPA-25. This study compared real world weight loss and glycaemic outcomes of 10 mg versus 12.5 mg versus 25 mg of...
Article
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The human coronavirus disease 2019 (COVID-19) pandemic has affected overall healthcare delivery, including prenatal, antenatal and postnatal care. Hyperglycemia in pregnancy (HIP) is the most common medical condition encountered during pregnancy. There is little guidance for primary care physicians for providing delivery of optimal perinatal care w...
Article
Background: Till date, there is no Cochrane meta-analysis available which has analyzed efficacy and safety of tirzepatide in type-2 diabetes. This meta-analysis was undertaken to address this knowledge gap. Methods: Electronic databases were searched for randomized controlled trials (RCTs) involving people with diabetes receiving tirzepatide com...
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Diabetes mellitus (DM) and obesity are interrelated in a complex manner, and their coexistence predisposes patients to a plethora of medical problems. Metabolic surgery has evolved as a promising therapeutic option for both conditions. It is recommended that patients, particularly those of Asian origin, maintain a lower body mass index threshold in...
Article
Background and aims No meta-analysis has analysed efficacy and safety of remogliflozin. We undertook this meta-analysis to address this gap in knowledge Methods Electronic databases were searched for RCTs involving diabetes patients receiving remogliflozin as compared to controls. Primary outcome was to evaluate changes in HbA1c. Secondary outcome...
Article
Position Statement: The current coronavirus disease (COVID‑19) pandemic is showing no signs of abatement and result in significant morbidity and mortality in the infected patients. Many therapeutic agents ranging widely between antivirals and anti‑inflammatory drugs have been used to mitigate the disease burden. In the deluge of the drugs being use...
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Background Macroprolactinemia is an analytic laboma encountered as a part of prolactin assay. No data are available on the burden of macroprolactinemia in Indians. This study aimed to determine the prevalence and predictors of macroprolactinemia among people with hyperprolactinemia. Methods Consecutive patients detected to have serum prolactin > 18...
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Background: No meta-analysis has holistically analysed and summarised the efficacy and safety of gemigliptin in type 2 diabetes. The meta-analysis addresses this knowledge gap. Methods: Electronic databases were searched for randomised controlled trials (RCTs) involving diabetes patients receiving gemigliptin in the intervention arm and placebo/...
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Problem considered Type 2 diabetes mellitus (T2DM) is a global pandemic with increasing prevalence worldwide. Hearsay, or reported speech, is an important contributor to diabetes care related behavior and may influence the outcomes of diabetes treatment. An emerging concept in preventive medicine is Quinary prevention which aims at preventing healt...
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Aims: No meta-analysis is available which has holistically analyzed efficacy and safety of once weekly thyroxine (OWT) vs. standard daily therapy (SDT) with regards to managing primary hypothyroidism. We undertook this meta-analysis to address this knowledge gap. Methods: Electronic databases were searched for clinical trials involving hypothyro...
Chapter
Nonalcoholic fatty liver disease (NAFLD) is growing at pandemic proportions worldwide, following closely on the heels of the rising prevalence of obesity and type 2 diabetes mellitus (T2DM). It has an intricate association with metabolic risk factors and thus control of these metabolic risk factors remains the mainstay of the treatment. Dyslipidemi...
Article
PurposePrior systematic reviews on yoga and diabetes have given conflicting results. They have been limited by inclusion of uncontrolled unblinded single group observational studies. No reviews are available which have used the Cochrane methodology and GRADE (Grades of Recommendation, Assessment, Development and Evaluation) approach. This meta-anal...
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Background and aims The ongoing pandemic of coronavirus disease 2019 (COVID-19) is rapidly evolving, thereby posing a profound challenge to the global healthcare system. Cardiometabolic disorders are associated with poor clinical outcomes in persons with COVID-19. Healthcare challenges during the COVID-19 pandemic are linked to resource constraints...
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Type 2 diabetes mellitus (T2DM) is a global epidemic. According to international guidelines, the management protocol of T2DM includes lowering of blood glucose, along with preventing disease-related complications and maintaining optimal quality of life. Further, the guidelines recommend the use of a patient-centric approaches for the management of...
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Background and aims: The impact of altered cholesterol metabolism on post-prandial lipids in Indians with hypothyroidism is not known. This study evaluated the impact of overt primary hypothyroidism (OPH) and subclinical hypothyroidism (ScH) on post-prandial lipids after a standardised, carbohydrate-rich, mixed meal. Methods: Endocrinology outpa...
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Hydroxychloroquine has been used in rheumatology for decades. This review highlights the mechanistic, clinical and safety data with regards to hydroxychloroquine use in novel coronavirus disease (COVID-19) in people with or without metabolic syndrome. PubMed and Medline were searched for articles published from January 1970 to March 2020 using the...
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Therapeutic advances have revolutionised cancer treatment over the last two decades, but despite improved survival and outcomes, adverse effects to anticancer therapy such as dyselectrolytaemias do occur and need to be managed appropriately. This review explores essential aspects of sodium homeostasis in cancer with a focus on alterations arising f...
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Novel coronavirus disease 2019 is a dreaded pandemic that is going to persist, and diabetic people with poor glycemic control are at high risk of complications and death from it. Social distancing being the only way to prevent infection spread, it is very difficult to continue usual clinic-based diabetes care. So, in this review, we focus to discus...
Article
Background and aims: Saroglitazar is commonly used in India for managing hypertriglyceridemia in diabetes. This meta-analysis evaluated the efficacy and safety of saroglitazar in hypertriglyceridemia. Methods: Electronic databases were searched for RCTs involving diabetes patients receiving saroglitazar in intervention arm, and placebo/lipid/dia...
Article
Aims: No meta-analysis is available which has summarized and holistically analyzed the efficacy and safety of evogliptin. We undertook this meta-analysis to address this gap in knowledge. Methods: Electronic databases were searched for RCTs involving diabetes patients receiving evogliptin in intervention arm and placebo/active comparator in cont...
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The use of ketogenic diets (KDs) for the management of type 2 diabetes mellitus (T2DM) and in weight-loss programs is long established, but high-quality data supporting them are limited and they remain controversial. In recent years there has been a trend towards individual, patient-centered medical nutrition therapy in which KD regimens have been...
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Novel coronavirus disease (COVID-19) infection is a global pandemic, of high infectivity, variable mortality, with currently no established treatment. This review summarizes different molecules which are being evaluated for COVID19 treatment. PubMed and Medline, search for articles published to March 2020 was done using terms "COVID19" OR "corona-v...
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The anterior and posterior hypophyseal hormones alter glucose metabolism in health and disease. Secondary diabetes may occur due to hypersecretion of anterior pituitary hormones like adrenocorticotrophic hormone in Cushing's disease and growth hormone in acromegaly. Other hormones like prolactin, gonadotropins, oxytocin and vasopressin, though not...
Article
Introduction: This review focuses on currently available injectable combination therapies (ICT) for managing diabetes. Areas covered: References were identified through searches of PubMed, Medline, and Embase for articles published till July 2019 using terms “insulin” [MeSH Terms] OR “glucagon like peptide 1 analogue” [All Fields] OR “combination t...
Chapter
The world is currently facing a diabesity and hypertension pandemic. Increased per capita calorie intake, especially refined sugars, are driving this pandemic, especially in the developing world. Replacement of saturated fats with unsaturated fats or carbohydrates especially refined sugars reduces cardiovascular (CV) risk. Very low intake of satura...
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Aims: The knowledge, awareness, and practice with regards to the management of polycystic ovary syndrome (PCOS) among doctors from India is not currently known. This study aimed to determine current clinical practice with regards to managing PCOS. Methods: Local doctors from New Delhi attending an international-led endocrinology conference in New D...
Article
Drug-induced bone disorders are a group of disorders characterized by osteomalacia or osteoporosis, with the common denominator being the iatrogenic nature of the disease. Drug-induced bone disorders are either due to the drug directly effecting the bone microarchitecture (osteoblastic or osteoclastic activity) or indirectly by interfering with Vit...
Article
Diabetes is a multisystemic and multifaceted syndrome, and its clinical impact is wide ranging and varied. The musculoskeletal complications of diabetes, too cover a broad spectrum of joints and presentations. Relatively less attention is paid, however, to the diabetic knee. This communication describes the bidirectional relationship between diabet...
Article
Hydroxychloroquine (HCQ) has been extensively used in the treatment of different autoimmune disorders by rheumatologists for several decades now. Studies on rheumatoid arthritis, lupus and Sjogren syndrome have highlighted the mild anti‐hyperglycaemic benefits of this molecule [1–3]. In rheumatoid arthritis 14‐month use of HCQ was associated with d...
Article
Background and aims: In spite of large volume of data linking Vitamin D with cardiovascular morbidity, autoimmunity, cancer, and virtually every organ system, Vitamin D and thyroid is a lesser-known aspect of Vitamin D in clinical practice. This article intends to highlight the current literature on the impact of Vitamin D status and supplementati...
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Introduction: The Palaeolithic diet is designed to resemble that of human hunter-gatherer ancestors thousands to millions of years ago. This review summarises the evidence and clinical application of this diet in various disorders. An empiric vegan variant of it has been provided, keeping in mind vegan food habits. Review of the literature: diff...
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Background and objectives There is no data regarding knowledge, attitude, and practices (KAP) of fasts in subjects with type 2 diabetes (T2DM) among different religions in India. Study was done to assess KAP regarding fasts among subjects with T2DM from various religions. Material and methods A total of 300 consecutive participants with T2DM (age...
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Background: This study evaluated the real-world weight loss and glycemic outcomes of multidrug therapy (MDT) according to various combinations of metformin, sodium-glucose cotransporter -2 inhibitor (SGLT2i), glucagon-like peptide-1 receptor analogs (GLP1a), and orlistat in diabesity. Methods: Data retrospectively captured from medical records o...
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Background: Data on prevalence and burden of end-organ damage in fibrocalculous pancreatic diabetes (FCPD) from eastern India is scant. This study investigated the burden of end-organ damage and exocrine pancreatic defect in FCPD patients in Eastern India. Materials and methods: Consecutive FCPD patients underwent evaluation of glycemic control,...
Chapter
Musculoskeletal complications are perhaps the most neglected aspect of diabetes management. Musculoskeletal complications are a diverse and common disorder observed in 30–50% of patients in diabetes from different parts of the globe. This chapter highlights the different musculoskeletal complications of diabetes and the challenges associated with t...
Chapter
Cigarette smoking is a well-known risk factor for many chronic diseases, including cardiovascular diseases and various malignancies. Smoking is associated with higher insulin resistance, chronic inflammation, and dyslipidemia. Smoking is strongly linked with both increased incidence as well as severity of diabetes. Smoking has also shown to be asso...
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The past three decades have seen a quadruple rise in the number of people affected by diabetes mellitus worldwide, with the disease being the ninth major cause of mortality. Type 2 diabetes mellitus (T2DM) often remains undiagnosed for several years due to its asymptomatic nature during the initial stages. In India, 70% of diagnosed diabetes cases...
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Objective: This study aimed to determine the clinical and biochemical profile of patients with severe primary hypothyroidism (SPH) (TSH ≥40 μIU/ml) as compared to milder forms of hypothyroidism and document improvement in hypothyroidism symptoms in SPH. Methods: Thyroid symptomatology and biochemistry were evaluated in SPH, non-severe overt prim...
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Background and aims: Knowledge of therapeutic lifestyle interventions is one of the most important pillars of diabetes care; however, its incorporation in real-world settings is poor. This review evaluates the role of partner and family support in diabetes management. Methods: Literature searches were performed in PubMed, Medline and Embase for art...
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The aim of this study was to evaluate clinical practice among doctors in India, in the diagnosis and management of bone health disorders, with a special focus on vitamin D deficiency and osteoporosis. Methods: During an academic program attended by 394 doctors, all participants were given questionnaires to evaluate the practice patterns. Questions...
Article
Knowledge, awareness, and practices with regard to diabetes management in south Asia are not known. This study aimed to determine current clinical practices with regard to managing diabetes in Nepal and India. Doctors attending conferences in Delhi, Guwahati, and Kathmandu were evaluated regarding their diabetes treatment preferences using a standa...
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Background & objectives: Dyslipidaemia is a major contributor to cardiovascular morbidity, which is increased in HIV. Data on dyslipidaemia in Indians with HIV are scant. This study was undertaken to determine the predictors of dyslipidaemia and lipoatrophy in Indians with HIV infection and their relation with body composition parameters. Methods:...
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Introduction Data on ultrasound elastography (USE) are scant from India. This study aimed to compare the sensitivity and specificity of USE with thyroid ultrasonography (USG) and fine-needle aspiration (FNA) as preoperative predictor of malignancy, using postoperative histopathology as gold standard. Materials and Methods Consecutive patients with...
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BACKGROUND: No data is available evaluating the difference in serum versus plasma sample assay of commonly tested parameters in the emergency department, where the sample processing time can be significantly reduced if plasma is used for analysis instead of conventionally used serum. Hence, this study aimed to evaluate the differences in serum vers...
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India has the dubious distinction of being a hotspot for both diabetes and hypertension. Increased salt and sugar consumption is believed to fuel these two epidemics. This review is an in-depth analysis of current medical literature on salt and sugar being the two white troublemakers of modern society. The PubMed, Medline, and Embase search for art...
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Background and Objectives Nonalcoholic fatty liver disease (NAFLD) and dysglycemia are public health challenges. There is urgent need for anthropometric surrogates for NAFLD screening. This study evaluated role of neck circumference (NC) and neck-height ratio (NHtR) as predictors of liver stiffness measure (LSM) in individuals with prediabetes (IPD...
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Background & objectives: Data on bone mineral density (BMD) and sarcopenia are scant from young females with HIV. This study was conducted to determine occurrence, predictors and impact of body composition alterations on osteoporosis in pre-menopausal women with HIV. Methods: A total of 214 females with serologically documented HIV infection wer...