Deboshree Bhattacharyya

Deboshree Bhattacharyya
Netaji Subhash Chandra Bose Cancer Research Institute · Department of Molecular Biology

M.Sc

About

27
Publications
3,072
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69
Citations
Citations since 2017
2 Research Items
33 Citations
201720182019202020212022202302468
201720182019202020212022202302468
201720182019202020212022202302468
201720182019202020212022202302468
Additional affiliations
January 2009 - present

Publications

Publications (27)
Article
Full-text available
Background Philadelphia chromosome, a hallmark of chronic myeloid leukemia (CML), plays a key role in disease pathogenesis. It reflects a balanced reciprocal translocation between long arms of chromosomes 9 and 22 involving BCR and ABL1 genes, respectively. An accurate and reliable detection of BCR-ABL fusion gene is necessary for the diagnosis and...
Article
Full-text available
This study aims to describe the hemoglobin Fannin-Lubbock-I, which has a rare mutation substituting the amino acid glycine with aspartic acid at codon 119 of the β-globin chain. A Bengalee Hindu Brahmin family from Kolkata in West Bengal was the focus of this study. Molecular analysis using ARMS-PCR and direct DNA sequencing revealed the presence o...
Article
The present study was based in a hospital at which 660 individuals have been screened for thalassemia in the past 4 years. The main purposes of the study were to identify different types of beta mutations prevailing among these patients, and to establish a genotype-phenotypic correlation. Complete blood count, high-performance liquid chromatography...
Article
The incidence of breast cancer in India is on the rise and is rapidly becoming the number one cancer in females pushing the cervical cancer to the second position. The mutations in two breast cancer susceptibility genes, BRCA1 and BRCA2, are frequently associated with familial breast cancer. The main objective of the study was to determine the freq...
Article
Toto is one of the smallest tribes in the world. This primitive sub Himalayan, endogamous tribe lives in a small, isolated village called Totopara in the Jalpaiguri district of West Bengal in India. The tribal communities of West Bengal are vulnerable to various genetic disorders such as β-thalassemia (β-thal). We have studied 443 Totos to define t...
Article
Full-text available
Hematopoietic stem cell transplant using human leukocyte antigen (HLA)-matched sibling or unrelated bone marrow, or related or unrelated cord blood has been performed successfully to treat patients with different types of hematological malignancies, genetic disorders and hereditary immune deficiencies. Since 1983, stem cell transplantation has been...
Article
Full-text available
Background TURANDOT is the first prospective trial to compare BEV combined with either paclitaxel (PAC) or capecitabine (CAP). We report the planned interim analysis (IA) of efficacy.
Article
Background In India there are about 2.5 million cancer patients and it increases by 1 million new cancer patients every year, which is 1/10 of total cancer burden in the world. The aim of our state based non-governmental Cancer Control Program is to reduce the cancer burden by proper awareness and screening. We also intended to teach about the earl...
Article
Full-text available
Introduction ATL is a malignancy of mature T-lymphocytes caused by human T-lymphotropic virus type I (HTLV-1), and it is classified into 4 clinical subtypes,i.e. acute, lymphoma, chronic, and smoldering type according to the analysis of the former nationwide survey performed in late 80's. During the 2 decades after this analsysis, treatment for ATL...
Article
Background The search for germline mutations within breast cancer susceptibility genes has been focused on the risk for developing malignancies in specific population. Mutations in the high penetrance breast cancer susceptibility gene BRCA1 account for a significant percentage of hereditary breast cancer cases. As reported earlier, carrier for the...
Article
In India, breast cancer accounts for 25- 33% of all cancers in urban women and over 50% patients are diagnosed at late stages (III & IV), deeply impacting survival-rate. Statistics forecasts rural areas are 10% more likely to be affected with late-stage breast cancer. One of the strongest risk factors for developing breast cancer is preceded by lif...
Article
Breast cancer is second leading cause of cancer deaths among women. In India, total 5lacs breast cancer patients are found with annual increment of 1.25lacs. Human Leukocyte Antigen (HLA) has been reported to be an interesting tool for predisposition and protection of breast cancer. Association of ethnicity specific HLA allele haplotypes has a sign...
Article
Background: Sickle cell disease is an inherited disorder of hemoglobin synthesis. This is due to replacement of Valine for Glutamic Acid in position six of the Beta globin chain of hemoglobin. This genetic alteration yields unstable RBC which lasts for 10–20 days. In stressful conditions the cells become sickle shaped and get lysed. There are about...
Article
4493 Objective Now that imatinib is being used to treat thousands of chronic myeloid leukemia (CML) patients for more than 10 year it is highly probable that many patients will get pregnant during its use. Company warns against any such use. But the fact remains that there is need for planned pregnancies in indicated cases. So we selected few case...
Article
5175 Background India is in the Thalassemia belt of the world. Presently prevalence of Thalassemia carrier in India is 3.7% of its total population. Annual increment of Thalassemia carrier is 50,000. Both Alpha and Beta Thalassemia are found in West Bengal, a state in Eastern part of India. Beta Thalassemia is most common in West Bengal. Annual In...
Article
5170 Background The Thalassemias are a group of anemia that results from a genetic defect whch reduces the rate of synthesis of normal globin chains. Beta Thalassemia results in severe microcytic, hypochromic, haemolytic anaemia among affected patients. It has emerged as one of the most common health problems among the tribal populations in West B...
Article
5113 Background Toto is a primitive Indo-Bhutanese tribe residing in a small enclave called Totopara in the Jalpaiguri district of West Bengal, India. Toto culture and language is totally unique to the tribe, and is clearly distinguished from the neighboring Rajbongshis, Koch or the Bhutanese Sharchop tribes. Totos use to do consanguineous marriag...
Article
5114 BACKGROUND Thalassemia syndromes are a heterogeneous anemia caused by mutation affecting globin chains of the hemoglobin molecule. It is estimated that the average life span of Rabhas (tribal population of North Bengal, Jalpaiguri) range from 42 – 45 years. This raised a concern that they are perishing due to some genetic disease. Hence Scree...

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