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Publications
Publications (141)
Chikungunya patients may develop chronic joint pain that can persist for months to years. This study aimed to determine the factors associated with Chikungunya chronicity. This case–control study involved data from patients with laboratory-confirmed Chikungunya reported from March 2016 to December 2020 in Vitória, Espírito Santo state, Brazil. The...
Long COVID (LC) is a condition where the patient experiences sequelae for at least two months after a period of three months following the initial SARS-CoV-2 infection, and these sequelae cannot be attributed to any other pathological condition. Possible explanations for the condition include the identification of genetic polymorphisms that may und...
Background
Espírito Santo state, in Brazil, is a dengue-endemic region predicted to suffer from an increase in temperature and drought due to climate change, which could affect the areas with active dengue virus transmission.
Objectives
Modeling climatic factors and climate change effects in zones suitable for dengue virus transmission in Espírito...
Cancer therapy is facing increasingly significant challenges, marked by a wide range of techniques and research efforts centered around somatic mutations, precision oncology, and the vast amount of big data. Despite this abundance of information, the quest to cure cancer often seems more elusive, with the “war on cancer” yet to deliver a definitive...
Brazil is the world leader in pesticide consumption, and its indiscriminate use puts farmers’ health at risk. The CYP2C9 gene stands out for encoding the CYP2C9 enzyme, which metabolizes several endogenous substrates and specific xenobiotics, especially pesticides. Our goal is to study the risk of pesticide use, espe-cially the herbicide glyphosate...
Palavra-chave 1: Single-Cell Tracking Palavra-chave 2: Glioblastoma Palavra-chave 3: Ploidy Variation Palavra-chave 4: Tumor Resistance Palavra-chave 5: CellProfiler
Palavra-chave 1: Computational Biology Palavra-chave 2: Systems Biology Palavra-chave 3: Single Cell Biology Palavra-chave 4: Oncology Palavra-chave 5: Network Biology
Since December 2019, a new form of Severe Acute Respiratory Syndrome (SARS) has emerged worldwide, caused by SARS coronavirus 2 (SARS-CoV-2). This disease was called COVID-19 and was declared a pandemic by the World Health Organization in March 2020. Symptoms can vary from a common cold to severe pneumonia, hypoxemia, respiratory distress, and deat...
Biotechnology constitutes a realm of inquiry that extends its benefits across diverse domains of knowledge, ranging from agricultural sciences to clinical applications. This field leverages technology to address challenges frequently entailing living organisms. Of current significance is the endeavor to elucidate the process of animal regeneration,...
O câncer/neoplasias de mama (CM) é uma doença altamente incidente em mulheres com milhões de novos casos a cada ano. Dentre os avanços tecnológicos destaca-se a tecnologia de RNA-seq que permitiu compreender melhor a expressão gênica, possibilitando desvendar as interações proteicas entre tumores de mama em estágio inicial e recorrente (pós-mastect...
Glycosylation is the most common protein and lipid post-translational modification in humans. Congenital disorders of glycosylation (CDG) are characterized by both genetic and clinical heterogeneity, presenting multisystemic manifestations, and in most cases are autosomal recessive in inheritance. The PIGN gene is responsible for the addition of ph...
Polyploid/Multinucleated giant cancer cells (PGCCs/MNGCs) represent subpopulations of cancer cell relevant for tumor evolution and adaptation to therapeutic stress. PGCCs/MNGCs are characterized by nuclear alterations including micronucleation, multinucleation and nuclear enlargement. Understand the PGCCs/MNGCs phenotype in glioblastoma (GB), we em...
Biotechnology is the term given to the branch of science that employs knowledge, techniques, and genetic engineering methods for creating various products using living organisms as raw material. Although this term has been recently adopted, humans have long been manipulating biological processes for their own benefit. Biotechnology is multidiscipli...
O farmacêutico oncológico clínico tem um importante papel no manejo farmacoterapêutico de pacientes que realizam quimioterapia. Atualmente, este profissional faz uso de alguns métodos para facilitar o emprego do Acompanhamento Farmacoterapêutico em Oncologia, como o Método Dáder. A Inteligência Artificial surge como uma nova ferramenta para auxilia...
O Transtorno de Ansiedade Generalizada (TAG) é um distúrbio mental caracterizado por preocupações excessivas e persistentes, juntamente com sintomas físicos e cognitivos. Para melhor entender seu impacto na pandemia de COVID-19, este estudo empregou a pesquisa bibliográfica em bases de dados, buscando artigos que investigaram os efeitos da pandemia...
Patologia Digital. Rastreamento de Célula Única. Variação de Ploidia. Glioblastoma. Resistência Tumoral.
A regeneração celular e tecidual, muito abordada em diversas áreas da medicina e da biologia, ainda permanece com lacunas sobre seus processos e funcionamento. Na última década, elucidou-se o papel da epigenética na referida função, dando-se ênfase para RNAs não codificantes, e entre eles, os piRNAs (PIWI-interacting RNAs), antes conhecidos por sua...
Short tandem repeat (STR) markers on the X chromosome have a high potential for solving complex kinship analysis and individual identification cases. To achieve such purposes, allele and haplotype frequencies for the specific population are necessary. Nonetheless, such frequencies are not always available. Therefore, we obtained haplotypes from 520...
Há muito o câncer vem se destacando como um compilado de desafios complexos e instigantes, os quais vêm orientando novas descobertas terapêuticas e teóricas, rompendo barreiras e fronteiras de um conhecimento mutável na pesquisa biomédica. Por muito tempo, o pilar científico foi o reducionismo dividindo mares turbulentos como o conhecimento complex...
