Debjit Bhowmik

Debjit Bhowmik
HIMACHAL PHARMACY COLLEGE · PHARMACEUTICAL SCIENCES

M.PHARM,PHD

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206
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Publications

Publications (206)
Article
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The pharmacy students, either of under graduate or doctor of pharmacy, have greater role in patient care and subsequent counselling , awareness among the people along with subjective knowledge and instruments handling. So, productive modern active learning-teaching methods are very necessary for the pharmacy students to fulfil their demand in the s...
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Aims: Bone complications (also known as skeletal-related events [SREs]) pose significant health and financial burdens on patients with bone metastases. Denosumab demonstrated superiority over zoledronic acid in delaying the time to first SRE. We examined the lifetime cost-effectiveness of denosumab versus zoledronic acid from both US payer and soci...
Book
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The use of cosmetics is a long practice. Since the ancient time the cosmetics are being used in the society. The interest towards cosmetics has been increased day-by-day. The word ‘Cosmetics’ was derived from the Greek word ‘kosmeticos’, which bears the meaning of embellishment. The type of materials used for the preparation of cosmetics also devel...
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Acute encephalitis syndrome is a clinical condition caused by infection with Japanese encephalitis virus or other infectious and noninfectious causes. Acute poses a great public health problem in India, occurring both in epidemics and sporadically. Seasonal outbreaks of acute encephalitis syndrome occur with striking regularity in India and lead to...
Article
Objective: Bone metastases are common among patients with advanced breast cancer, putting patients at increased risk of skeletal-related events (SREs). This study described impact of bone metastases, utilization of bone-targeted agents (BTAs) and physicians’ decision processes for BTA use in advanced breast cancer. Methods: Data were collected usin...
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Background Bone metastases (BMs) are common in patients with prostate cancer and can lead to skeletal-related events (SREs), which are associated with increased pain and reduced quality of life (QoL). Bone-targeted agents (BTAs), such as zoledronic acid and denosumab, reduce the incidence of SREs and delay progression of bone pain. Methods We eval...
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Disintegrating agents are substances routinely included in the tablet formulations to aid in the break up of the compacted mass when it is put into a fluid environment. They promote moisture penetration and dispersion of the tablet matrix. In recent years, several newer agents have been developed known as "Superdisintegrants". These newer substance...
Article
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Extended release means the pill is formulated so that the drug is released slowly over time. This has the advantage of taking pills less often. Also means that there may be fewer side effects as the levels of the of drug in the body are more consistent in extended release formulations. Extended-release dosage consists of sustained-release and contr...
Book
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Book
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Osteomyelitis is an infection and inflammation of the bone or the bone marrow. It can happen if a bacterial or fungal infection enters the bone tissue from the bloodstream, due to injury or surgery. Around 80 percent of cases develop because of an open wound. Symptoms include deep pain and muscle spasms in the inflammation area, and fever. Bone inf...
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Gastro-retentive drug delivery technology is designed to retain a drug in the upper gastrointestinal tract for a prolonged period of time to allow efficient absorption. This is important because almost 40% of all new drugs have poor bioavailability from the lower gastrointestinal tract. Gastric retention will provide advantages such as the delivery...
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In the present work an attempt has been made to formulate tablet containing immediate release Atorvastatin and sustained release Gliclazide using retardant namely hydroxypropyl methyl cellulose. Two different grade of hydroxypropyl methylcellulose in different concentrations were used. In the preformulation study, compatibility evaluation was perfo...
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ABSTRACT The aim of the study was to evaluate ciprofloxacin-hydrochloride loaded microspheres using copolymers synthesized from acrylic and methacrylic acid esters as a the retardant material for nasal administration.. Microspheres prepared by emulsion solvent diffusion method using an acetone and dichloro methane system. Formulation parameters and...
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ABSTRACT The aim of the present study is to formulate and evaluate Captopril micro-encapsules. Microspheres and micropellets of captopril prepared with different polymers through the techniques of microencapsulation were found to have a good spherical shape, and were nonaggregated exhibiting good flow properties. In addition, all the formulations...
Article
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The present study comprises of an investigation of captopril a potent ACE inhibitors used orally to treat hypertension, as a feasible candidate for transdermal drug delivery. The present research work was undertaking to formulate a Transdermal drug delivery system of captopril, to investigate the effect of different penetration enhancers, and to s...
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Buccal delivery is defined as drug administration through the mucosal membranes lining the cheeks (buccal mucosa).The main impediment to the use of many hydrophilic macromolecular drugs as potential therapeutic agents is their inadequate and erratic oral absorption. The future challenge of pharmaceutical scientists is to develop effective non-paren...
Conference Paper
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National Seminar on “Current Status and Future Scope for Nanomaterials and Nanotechnology In Drug Discovery and Development” on dated 23-24 February 2018 sponsored by Indian Council of Medical Research (ICMR) and Himachal Pradesh Technical University(HPTU), Hamirpur, Himachal Pradesh
Article
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Background Bone metastases (BMs) are common in patients with breast cancer and can lead to skeletal-related events (SREs), which are associated with increased pain and reduced quality of life (QoL). Bone-targeted agents (BTAs), like zoledronic acid and denosumab, reduce the incidence of SREs and delay progression of bone pain. Materials and method...
Article
Thespesia populnea is a reputed ever green tree belonging to the family malvaceae; commonly known as Indian tulip tree. The plant is distributed tropical regions and coastal forest in India. It is well known and all the parts are used in traditional system of medicine. The plant has been used as astringent, antibacterial, hepatoprotective, haemosta...
Article
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BSTRACT: Telmisartan is a ACE inhibitor anti-hypertensive drug. Hence, in the present work, Telmisartan fast dissolving tablets will be prepared by using different super disintegrating agents. The amount of drug that is subject to first pass metabolism is reduced as compared to mouth dissolving tablets. Orally disintegration tablets contain wide va...
Article
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An Oral Dosage Form is the physical form of a dose of a chemical compound used as a drug or medication intended for administration or consumption by oral route. Common oral dosage forms are tablets or capsules.Tablets are solid preparations each containing a single dose of one or more active substances with or without excipients usually obtained by...
Article
Introduction During cancer progression, more than half of patients develop renal insufficiency, including chronic kidney disease. The primary and secondary objectives of this study were to estimate healthcare resource use and costs, respectively, associated with renal impairment in patients with bone metastases from solid tumors in the United State...
Article
Full-text available
Thespesia populnea is a reputed ever green tree belonging to the family Malvaceae; commonly known as Indian tulip tree. The plant is distributed tropical regions and coastal forest in India. It is well known and all the parts are used in traditional system of medicine. The plant has been used as astringent, antibacterial, hepatoprotective, haemosta...
Article
Full-text available
The free radical scavenging activity of Thespesia populnea bark (TPBE) and leaves (TPLE) has been studied using the methanolic extracts. In vitro antioxidant potential of leaves and stem bark were evaluated in three different models viz superoxide radical scavenging activity, lipid peroxide radical scavenging activity and hydroxyl radical scavengin...
Article
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Methyl phenidate is a medication that belongs to the drug class called central nervous system stimulants. Methylphenidate is prescribed for treating narcolepsy (uncontrollable sleepiness), and attention-deficit hyperactivity disorder (ADHD). The aim of the current investigation is to design oral twice a daily sustained release matrix tablets of met...
Article
Methods: Data were extracted from the Adelphi Breast Cancer Disease-Specific Programme (DSP), a cross-sectional survey of 98 US oncologists conducted from February to May 2015 in the USA. Each physician completed comprehensive record forms capturing the following information about the next 12 patients being treated for advanced breast cancer: Pres...
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Introduction Dispersible tablets are uncoated or film coated tablets intended to be dispersed in water before administration giving a homogeneous dispersion or a stabilized suspension, so, it's preferred in cases where patients cannot swallow a dosage form and the drug substance is unstable if formulated in liquid medication. The faster the drug in...
Article
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The main aim of proposed work was to develop Vildagliptin matrix tablets, sustained release dosage form, for the treatment anti-diabetic drug. Sustained release formulation is the drug delivery system that is designed to achieve a prolonged therapeutic effect by contineously releasing medication over an extended period of time after administration...
Article
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Orodispersible Tablets disintegrate and/or dissolve rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fa...
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The presentation deals with formulation of immediate release tablet of levofloxacin using super disintegrant such as Croscarmelose sodium and crospovidone. To enhance the rapid absorption rate to treat the case of bacterial infection. The study had been carried out by formulating 8 formulations by varying the concentration of disintegrating agent....
Article
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Introduction The oral route of drug administration is the most important method of drug administration for systemic effects. The Parenteral route of administration is important in treating the medical emergencies in which subject is comatose or can not swallow and in providing various types of maintenance therapy. Nevertheless, about 90% of all the...
Article
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Introduction Little is known about the health risks of working in the pharmaceutical industry. On the surface, the industry looks clean. The production of medicinals demands a carefully maintained and sterile working environment and the white lab coats worn by workers add to the illusion of safety. The appearances are deceptive, though. Producing d...
Article
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Introduction Pharmacoeconomics has been defined as the description and analysis of the costs of drug therapy to health care systems and society. Pharmacoeconomic research identifies, measures, and compares the costs (ie, resources consumed) and consequences (ie, clinical, economic, humanistic) of pharmaceutical products and services. Within this fr...
Article
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Introduction Ayurveda, the oldest health science has eight branches. Rasayana (rejuvenation) is one of them. Rasa has different meanings like juice, taste, essence, flavor or emotion, but is not limited to any of these in itself. In therapeutic process Rasa is concerned with the conservation, transformation, and revitalization of energy. Rasa nouri...
Article
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Introduction Ayurveda, the oldest health science has eight branches. Rasayana (rejuvenation) is one of them. Rasa has different meanings like juice, taste, essence, flavor or emotion, but is not limited to any of these in itself. In therapeutic process Rasa is concerned with the conservation, transformation, and revitalization of energy. Rasa nouri...
Article
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Carvedilol a poorly water soluble drug undergoes extensive first pass metabolism, which reduces its bioavailability to 25-30%. Fast dissolving tablets of Carvedilol were prepared with the purpose of delivering the drug directly into the systemic circulation and bypassing the hepatic first pass metabolism with a concomitant increase in bioavailabili...
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Data
Cefditoren is a semi-synthetic cephalosporin antibiotic for oral administration. It is a product, which is hydrolyzed by esterases during absorption, and the drug is distributed in the circulating blood as active Cefditoren. Formulation and development was carried by following different processes such as wet granulation (FWG), fluid bed process (FB...
Article
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A good Transdermal patch containing can be formulated by solvent casting technique using as film former and propylene glycol as plasticizer such Transdermal patches are advantages in providing effective treatment for Hypertension with enhanced patient compliance. From the in-vitro release results observed that the films prepared by using different...
Article
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Metoprolol tartrate is effective β-blocker which is having antianginal properties and used in the treatment of myocardial infarction. Oral bioavailability of metoprolol tartrate is around 40%. In present work an attempt has been made to prepare fast dissolving tablets of metoprolol tartrate to enhance the dissolution rate. Sublimation method. The v...
Article
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ABSTRACT Transdermal drug delivery system is being extensively investigated as a viable alternative to drug delivery with improved bioavailability. The aim of the present investigation is to develop membrane type Transdermal drug delivery patches of antihypertensive agent Carvedilol. Transdermal patches of Carvedilol were prepared by using polymer...
Article
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The present research work is an attempt to develop and evaluate matrix-type transdermal therapeutic system of metoprolol succinate. It has a relatively greater blocking effect on beta 1-receptors.Transdermal patches of metoprolol succinate were developed with different ratios of hydrophilic-HPMC and hydrophobic –EC polymer combinations by solvent e...
Article
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Transdermal therapeutic systems have been designed to provide controlled continuous delivery of drugs via the skin to the systemic circulation. The relative impermeability of skin is well known, and this is associated with its functions as a dual protective barrier against invasion by microorganism and the prevention of the loss of physiologically...
Article
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Sonophoresis (phonophoresis) has been shown to increase skin permeability to various low and high molecular weight drugs, including insulin and heparin. However, its therapeutic value is still being evaluated. Some obstacles in transdermal sonophoresis can be overcome by combination with other physical and chemical enhancement techniques. Use of ul...
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Transdermal patches delivers drug across skin to the circulatory system to achieve therapeutic effects or to provide local effect of drugs. As one of the fastest growing drug administration routes, it has several advantages compared to other traditional delivery methods: controlled release rate, more stable plasma concentration, noninvasive admini...
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The main objective of the present work is to find out good pharmacological activities in herbal source with their preliminary phytochemical study, and also it is aimed to investigate of ethanol and aqueous extracts of dried stem of plant 'Kalanchoe pinnata(lam.)Pers.' against with Anti-inflammatory and in rats and Analgesic activity in mice.Normall...
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Food poisoning occurs when you swallow food or water that contains bacteria, parasites, viruses, or toxins made by these germs. Most cases of food poisoning are from common bacteria such as Staphylococcus or E. coli. Food poisoning, also known as acute gastroenteritis, is an acute inflammation of the lining of the stomach and small bowel. Food pois...
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Introduction Pharmacoeconomics has been defined as the description and analysis of the costs of drug therapy to health care systems and society. Pharmacoeconomic research identifies, measures, and compares the costs (ie, resources consumed) and consequences (ie, clinical, economic, humanistic) of pharmaceutical products and services. Within this fr...
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Micro emulsions are isotropic, thermodynamically stable transparent system of oil, water and surfactant, frequently in combination with a co-surfactant. These versatile systems are currently of great technological and scientific interest to the researchers because of their potential to incorporate a wide range of drug molecules (hydrophilic and hyd...
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The main objective of present work is to find out good pharmacological activities in herbal source with their preliminary phytochemical study, and also it is aimed to investigate anti-diabetic activity of ethenolic and aqueous extracts of dried stem of plant Kalanchoe pinnata (LAM)PERS against CNS-Depressant activity in rats. Normally herbal produc...
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The controlled or sustained release dosage forms are designed to complement the pharmaceutical activity of the medicament in order to achieve better selectivity and longer duration of action.The aim of this study is to formulate and evaluate the extended release tablets of Pentoxifylline.Pentoxifylline is prescribed to patients who are suffering fr...
Article
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A recent approach to drug delivery is to deliver the drug into systemic circulation at predetermined rate using skin as a site of application. Transdermal drug delivery is one of the most promising methods for drug application. Increasing numbers of drugs are being added to the list of therapeutic agents that can be delivered to the systemic circul...
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Dengue fever is an infectious disease carried by mosquitoes. It is found mostly during and shortly after the rainy season in tropical and subtropical areas of: Africa ,
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