Debby Klooster

Debby Klooster
Eindhoven University of Technology | TUE · Department of Electrical Engineering

MSc PDEng

About

27
Publications
2,608
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
284
Citations

Publications

Publications (27)
Article
Full-text available
Conventional transcranial electric stimulation(tES) using standard anatomical positions for the electrodes and standard stimulation currents is frequently not sufficiently selective in targeting and reaching specific brain locations, leading to suboptimal application of electric fields. Recent advancements in in vivo electric field characterization...
Article
Full-text available
Repetitive transcranial magnetic stimulation (rTMS) is a tool that can be used to administer treatment to neuropsychiatric disorders such as major depressive disorder (MDD). Though, the clinical efficacy is still rather modest. Overly general stimulation protocols that neither consider patient-specific depression symptomology nor individualized bra...
Article
Objectives As a potential treatment for epilepsy, transcutaneous auricular vagus nerve stimulation (taVNS) has yielded inconsistent results. Combining transcranial magnetic stimulation with electromyography (TMS-EMG) and electroencephalography (TMS-EEG) can be used to investigate the effect of interventions on cortical excitability by evaluating ch...
Article
Full-text available
Objectives Accelerated intermittent theta burst stimulation (aiTBS) is a promising treatment option for depressed patients. However, there is a large interindividual variability in clinical effectiveness and individual biomarkers to guide treatment outcome are needed. Materials and Methods Here, the relation between cortical thickness and clinical...
Article
Full-text available
Background: Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for major depressive disorder (MDD), but its clinical efficacy remains rather modest. One reason for this could be that the propagation of rTMS effects via structural connections from the stimulated area to deeper brain structures (such as the cingulate cor...
Article
Non-invasive brain stimulation (NIBS) techniques, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have shown high treatment potential for a broad variety of neuropsychiatric disorders. However, the application of ‘standard’ protocols results in high inter-individual differences in the responses and...
Article
Full-text available
Graph analysis was used to study the effects of accelerated intermittent theta burst stimulation (aiTBS) on the brain's network topology in medication‐resistant depressed patients. Anatomical and resting‐state functional MRI (rs‐fMRI) was recorded at baseline and after sham and verum stimulation. Depression severity was assessed using the Hamilton...
Article
Full-text available
Accelerated intermittent theta burst stimulation (aiTBS) is a noninvasive neurostimulation technique that shows promise for improving clinical outcome in patients suffering from treatment-resistant depression (TRD). Although it has been suggested that aiTBS may evoke beneficial neuroplasticity effects in neuronal circuits, the effects of aiTBS on b...
Article
Transcranial direct current stimulation (tDCS) involves positioning two electrodes at specifically targeted locations on the human scalp. In neuropsychiatric research, the anode is often placed over the left dorsolateral prefrontal cortex (DLPFC), while the cathode is positioned over a contralateral cephalic region above the eye, referred-to as the...
Article
Introduction Thetaburst stimulation (TBS) is a repetitive transcranial magnetic stimulation (rTMS) protocol that may induce long lasting neuroplasticity. Continuous TBS (cTBS), a cortical excitability reducing protocol, would be the stimulation protocol of choice for the treatment of epilepsy. The lower stimulation intensity and number of pulses co...
Article
Objectives: "Epileptic dementia" is reported in adults with childhood-onset refractory epilepsy. Cognitive deterioration can also occur in a "second-hit model". Materials and methods: We studied the clinical and neuropsychological characteristics of patients with cognitive deterioration (≥1 SD discrepancy between current IQ and premorbid IQ). Me...
Article
Full-text available
Introduction: Repetitive transcranial magnetic stimulation (rTMS) is an established non-invasive neurostimulation technique that is able to induce neuromodulatory effects outlasting the duration of the stimulation train. The cortical excitability disturbance in epilepsy provides a rationale for investigating the efficacy of low-frequency rTMS as a...
Article
Neuromodulation is a field of science, medicine, and bioengineering that encompasses implantable and non-implantable technologies for the purpose of improving quality of life and functioning of humans. Brain neuromodulation involves different neurostimulation techniques: transcranial magnetic stimulation (TMS), transcranial direct current stimulati...
Article
A long-standing concern has been whether epilepsy contributes to cognitive decline or so-called 'epileptic dementia'. Although global cognitive decline is generally reported in the context of chronic refractory epilepsy, it is largely unknown what percentage of patients is at risk for decline. This review is focused on the identification of risk fa...
Article
Full-text available
Objective Many forms of epilepsy are associated with aberrant neuronal connections, but the relationship between such pathological connectivity and the underlying physiological predisposition to seizures is unclear. We sought to characterize the cortical excitability profile of a developmental form of epilepsy known to have structural and functiona...
Article
Introduction Epilepsy is one of the most common neurological diseases. The diagnosis of epilepsy is currently based on clinical history together with EEG recordings. However, low sensitivity is a major disadvantage of the standard EEG recording. Therefore, patients with unclassified spells often undergo multiple EEG registrations before a diagnosis...

Questions

Question (1)
Question
Dear researchers,
I would like to apply graph analysis on 40 rs-fMRI datasets. However, I would preferably calculate graph metrics over a density range from approx 20 to 50%. However, if I investigate the minimal density in which the connectivity matrices of all datasets remain unfragmented, it is in the order of 50 already... I tried using different preprocessing steps but nothing really helps. Also, I have calculated my densities using only positive edges (setting negative ones to 0) or both positive and negative edges included (using absolute values).
Does anyone have a solution how I can still perform the graph analysis in the desired density range?
Thank you very much in advance!
Best, Debby

Network

Cited By

Projects

Project (1)
Project
Depression is a major mental health problem and current treatments are frequently insufficiently effective. Based on our earlier projects we will develop and test innovative ways to combine psychological interventions with neurostimulation targeting mechanisms involved in anhedonia and resilience, to increase sustainable well-being in depression.