Debasmita Dubey

Siksha O Anusandhan University | SOA · Microbiology PhD Programme

The binding interactions between bovine serum albumin (BSA) and three pyridine derivatives, i.e., 2-(5-bromopyridin-3-yl) acetic acid (L1), 3-bromo-5-nitropyridine (L2) and 2-chloro-4-nitropyridine (L3), have been carried out using UV-Vis and fluorescence spectroscopic methods. Fluorescence intensity quenching is observed by adding L2 and L3 to the...

Oral squamous cell carcinoma (OSCC) is a disease of significant concern with higher mortality rates. Conventional treatment approaches have several drawbacks, leading to the opening of new research avenues in the field of nanoparticle-based cancer therapeutics. The study aimed at the synthesis of gold nanoparticles (Pm-AuNPs) from the aqueous bark...

is a pernicious opportunistic bacterium causing several human infections due to its ubiquitous presence and adaptability to various environmental conditions. Primarily, β-lactamase producing strains are the most prevalent ones, especially chronic suppurative otitis media (CSOM) infections. This research was conducted to find the pervasiveness of β-...

Dioscorea alata belongs to Dioscoreaceae or the yam family. Around 600 Dioscorea species are consumed in various regions of the world. Dioscorea alata is well known cultivated tuber consumed by both rural and urban people. In this study, we have investigated the nutrient composition, phytochemicals, and antioxidant and antimicrobial activity of the...

The relationship between the human host and the intestinal microbiota is dynamic and symbiotic. This review examines whether there is a correlation between a disruption in host-microbial interactions caused by an alternative composition of gut microbiota and an increased susceptibility to peptic ulcer disease, mainly when hazardous bacteria are pre...

BACKGROUND Woodfordia fruticosa is a well‐known medicinal plant traditionally used for various treatment methods. Green synthesis of silver nanocomposite with woodfordia flower extract is well‐investigated. However, the therapeutic potential of Woodfordia fruticosa leaf extract silver nanoparticles against various diseases has yet to be investigate...

Plastics, a form of synthetic polymers have a major role to play in the healthcare sector. The recalcitrant nature of plastics has discouraged their use in several nations so as to maintain a sustainable ecosystem. However, the large-scale use of plastics in hospital equipment and other healthcare-related essentials cannot be ignored owing to their...

Human health is directly related to the environment and its various components. Healthcare is one sector that witnesses maximum footfalls in terms of patients, thus giving rise to a large scale of microbial waste. These microbial wastes are mostly hazardous and risk polluting the environment and putting public health at stake. Safe disposal of thes...

Artificial intelligence (AI) is gaining popularity in modern business and everyday life and is increasingly applied in healthcare settings. AI can help healthcare providers with various clinical tasks, including patient care, administration and many different ways. However, the ways that they support might be pretty diverse. While some articles on...

Artificial intelligence (AI) is gaining popularity in modern business and everyday life and is increasingly applied in healthcare settings. AI can help healthcare providers with various clinical tasks, including patient care, administration and many different ways. However, the ways that they support might be pretty diverse. While some articles on...

Biotechnology is one of the emerging fields that can add new and better application in a wide range of sectors like health care, service sector, agriculture, and processing industry to name some. This book will provide an excellent opportunity to focus on recent developments in the frontier areas of Biotechnology and establish new collaborations in...

Pterocarpus marsupium (Roxb.) is an important plant for its diverse pharmacological attributes, including anti-microbial and anti-cancerous effects. The multidrug-resistant (MDR) microbes found in head and neck infections can lead to cancer. Recently, the use of nanoparticles has emerged as an alternative to regular drugs to combat the MDR microbes...

Background Head and neck infections (HNI) associated with multidrug resistance (MDR) offer several health issues on a global scale due to inaccurate diagnosis. Background Head and neck infections (HNI) associated with multidrug resistance (MDR) offer several health issues on a global scale due to inaccurate diagnosis. Objectives This study aimed...

Biosurfactants, fascinating molecules originating from microbial sources, have captivated researchers' imaginations for their escalating potential across a spectrum of healthcare applications. This comprehensive review explores the multifaceted world of biosurfactants, elucidating their diverse nature and exceptional physicochemical properties, pro...

The medico folklore use of medicinal plants is the mainstay healthcare system of the tribals in and around the Gandhamardan, Western Odisha. These people depend on the forest and traditional Vaidyas to treat various health ailments, including bacterial infections. While documenting folklore claims, we found the acute dependency of traditional diarr...

In the present study, we have investigated the differences in the composition of proximate minerals, vitamins bioactive compounds, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity between the raw and boiled tubers of Dioscorea bulbifera. The results showed that both the raw and boiled tubers have rich sources of carbohydrates (31.62% an...

The relationship between the human host and the intestinal microbiota is dynamic and symbiotic. This review examines whether there is a correlation between a disruption in host-microbial interactions caused by an alternative composition of gut microbiota and an increased susceptibility to peptic ulcer disease, mainly when hazardous bacteria are pre...

Candida is one of the most common problems faced these days which require timely medical attention. We have aimed to identify the Candida albicans and non-albicans species of upper aerodigestive fungal infections and their antifungal drug's susceptibility using various antifungal. Swab samples were collected from the upper aerodigestive area and by...

Background Nasolabial cysts are non-odontogenic cysts that arise from the nasal alar area. Sublabial resection of the nasolabial cyst is considered an effective surgical modality of treatment. Objective This study aimed to evaluate the clinical presentation, diagnosis and treatment of nasolabial cyst at a tertiary care teaching hospital in eastern...

Schwannoma is a slow-growing benign tumor that originates from the nerve sheath consisting of the Schwann cells. It is an encapsulated nerve sheath tumor of neuroectodermal origin. This is an encapsulated and well-circumscribed lesion composed of different cellular patterns. Schwannoma usually originates from the superior vestibular nerve in the in...

The lichen Anzia ornatoides was identified by its morpho-anatomical and chemical features. The hexane, diethyl ether, ethyl acetate, methanol, and water extracts of the lichen were assessed for their antioxidant capacities. The presence of various phyto-compounds of the methanol extract were run through a GC�MS and identified three major compounds...

Vulvovaginal Candidiasis (VVC) is a significant public health concern, and current article focuses primarily on understanding this infection's molecular processes. The hosts defence mechanisms and their dysregulation, such as the innate immune response and the genetic susceptibility factors, play a crucial role in determining the susceptibility to...

Background Nasosinus mucoceles are expansile cystic masses originating at the paranasal sinuses by chronic retention of the mucus in a sinus cavity due to ostial obstruction. Aim This study aims to evaluate the risk factors, clinical presentations, and management of nasosinus mucoceles. Materials and Methods This is a retrospective study carried...

Head and neck infection (HNI) can lead to life-threatening complications, including death. The purpose of this study is to look at the entire clinico-demographic profile of patients with HNI as well as the microbio-logic profile of recurring bacterial infection cases with a variety of symptoms. A retrospective cross-sectional study was conducted on...

The cyanobacteria are the promising candidate for synthesizing gold nanoparticles (AuNPs), due to their ability to accumulate heavy metals from the cellular environment and additionally contain varied bioactive compounds as reducing and stabilizing agents. This study describes the N 2-fixing cyanobacterium Nostoc calcicola-mediated bioreduction of...

Rationale: Presenting this case report is of essential importance to shed the light on this rare clinical situation. Patient Concerns: A 68-year-old man presented with generalised weakness, shortness of breath, mild fever and loss of smell and taste for three days. Diagnosis: A filling deficiency of the cavernous sinus was detected by contrast-enha...

Introduction: Paranasal sinus mucoceles are benign, expansile and cystic lesions lined with respiratory epithelium containing the mucoid substance. It may happen because of chronic obstruction of the ostia of the paranasal sinus. Mucus accumulation causes enlargement of the mucocele which is thought to be a sine qua non for a such clinical conditio...

Cancer is a terrifying disease that has become one of the world’s most challenging health concerns, necessitating a proactive approach to its treatment. Nature is a rich source of new chemical entities and a promising avenue for cancer research. Because of their different modes of action on target events in many ways, nature-derived chemicals are c...

Head and neck infections (HNI) are dangerous illnesses caused by a variety of bacterial species. Due to either incorrect diagnosis or excessive antibiotic usage, multidrug resistance (MDR) poses a problem on a global scale. We aimed this study to identify and compare their relationship with eastern Indian MDR bacteria.We collected 264 HNI clinical...

Mucoceles are benign and slow-growing lesions of the paranasal sinus that develop following blockage of the sinus ostium. It slowly enlarges and fills the paranasal sinus completely. If the mucocele content is infected, the lesion is called a mucopyocele. Most of the mucoceles are found in the frontal and anterior ethmoidal sinuses. It may expand t...

Plant-derived essential oils are natural sources of antimicrobial and pharmaceutical agents besides their broad spectrum of use in the cosmetic, food, and perfume industries. The essential oil from the flowers of P. odorifer was extracted using the hydro distillation method. The major compound from the essential oil was identified by high-resolutio...

Head and neck infection (HNI) is more complicated, as most of the sites of infection in the head and neck regions are very complex. Bacterial head and neck infections can usually originate through the upper airway, sinusitis, and dental or oral cavity and then extend deeper into other head and neck compartment sites. Both aerobic and anaerobic bact...

Nature derived product drew a lot of interest because of their potential nutritional and therapeutics value. Most natural compounds are now processed and developed as possible antioxidative, antimitotic, antimicrobial, anti-inflammatory, antiangiogenic, and anti-carcinogenic pharmaceutical agents. Indeed, several natural products have been used as...

Tinnitus is the phantom perception of sound. The pathophysiology of tinnitus is poorly understood in medicine. It is a highly prevalent disorder and treatment is still elusive. Tinnitus is a common otologic symptom presented by patients in the outpatient department of otolaryngology. In some people, tinnitus is a fairly minor irritation but for man...

Diabetic foot ulcers (DFUs) are a common complication of poorly controlled diabetes and often become infected, termed diabetic foot infection. Despite using several multidisciplinary techniques, no significant cure is still achievable. So, it needs an alternative therapeutic approach to treat diabetic foot ulcers. So, it needs to search for alterna...

A ranula is a pseudocystic lesion of the sublingual salivary gland, found in the floor of the mouth. Ranula is classified into types such as simple and plunging type. Plunging ranula arises when a simple ranula extends beyond the floor of the mouth into the neck. A simple ranula is seen above the level of the mylohyoid muscle and is often the res...

Objective: To investigate the interaction of p53 with docetaxel and berberine and their anticancer activities against oral squamous cell carcinoma. Methods: The interaction between p53 with docetaxel and berberine was investigated and their mechanisms of action against oral squamous cell carcinoma were studied. Toxicity studies were performed...

Application of nanorobotics in high density pharmaceutical assay process

A method for advanced tumor recognition based on IOT and AI Image processing

Background Schwannomas are neoplasms that are rarely found in the sinonasal tract and pterygopalatine fossa (PPF). The objective of this study is to evaluate the schwannoma in the sinonasal tract and PPF including its effectiveness of endoscopic surgical excision of the lesion. Methods This retrospective study was done between March 2018 and April...

Chronic otitis media (COM) is a major health problem in the world, particularly in the underdeveloped and developing countries. COM is typically persistent, insidious in onset, and usually capable to manifest deafness and otorrhea. The common microorganisms isolated from COM include Staphylococcus aureus , Pseudomonas aeruginosa , Klebsiella pneumo...

Vocal fold cysts are benign lesions of the larynx. Vocal fold cysts can be unilateral or bilateral and often confused with vocal nodules, particularly when symmetrical. The most common clinical presentation of this lesion is hoarseness of voice. The vocal fold cyst is usually secondary to vocal abuse. Endoscopic examination or videostroboscopy is a...

Background Aspiration of an open safety pin in the airway is an extremely rare and critical condition that needs immediate and safe removal of the foreign body (FB). An open safety pin in the airway of the pediatric patient requires urgent recognition. Imaging will confirm the exact site of the open safety pin in the airway. Rigid bronchoscopy with...

The Heat shock proteins (HSP) play an important role in controlling the apoptosis and inflammatory response. These proteins are released into the extracellular environment and act as mediators of inflammation. Protein folding accuracy is ensured by chaperone activity, which also prevents the accumulation of abnormal isoforms. In the current work, S...

This present study evaluates the in vitro antimicrobial activity of the selected Indian medicinal plant Coccinia grandis (C. grandis) against this isolated multidrug-resistant bacteria causing chronic suppurative otitis media infection (CSOM) along with their in vivo toxicity test using a rat model. The minimum inhibitory concentration (MIC) and mi...

Antimicrobial-resistant (AMR) bacterial infections remain a significant public health concern. The situation is exacerbated by the rapid development of bacterial resistance to currently available antimicrobials. Metal nanoparticles represent a new perspective in treating AMR due to their unique mechanisms, such as disrupting bacterial cell membrane...

Background Antrochoanal polyps (ACPs) are benign polypoidal mass originating from the maxillary sinus and they extend into the choana. The etiopathogenesis of ACP is not clear. These are found more commonly in children and young adults. ACP is almost always unilateral and common symptoms include nasal obstruction and nasal discharge. These lesions...

Nine actinobacteria were isolated from the mangrove soil of Bhitarkanika and screened for their bioactive metabolites and antimicrobial property. Out of the nine actinobacterial isolates, the bacterial isolateBAB-7 showed positive activity towards most of the enzymes screened, i.e., Cellulase, phosphate solubilization, L-asparaginase, protease, and...

Nine actinobacteria were isolated from the mangrove soil of Bhitar kanika and screened for their bioactive metabolites and antimicrobial property. Out of the nine actinobacterial isolates, the bacterial isolateBAB-7 showed positive activity towards most of the enzymes screened, i.e., Cellulase, phosphate solubilization, L-asparaginase, protease, an...

Oral biofilm is a major problem in almost all individuals as they cause dysbiosis of the oral cavity and lead to various microbial infections and related ailments. Currently, antibiotics and antifungal drugs are the major way to control oral biofilm, but the rapid increase in antibiotic-resistant bacterial strains has limited the treatment options...

Post the industrial revolution, there has been a rapid development in almost all the fields of science and technology, providing a better standard of living. We the humans in the quest for a luxurious life have either knowingly or unknowingly brought about disturbances in the environmental homeostasis. Environmental pollution, climate change, outbr...

Recent Developments in genome editing technology, Gene cloning and selecting a suitable host as an expression system for Mass production of desired protein have simplified the therapeutic product development to treat both communicable and non communicable diseases as well as it's become a most emerging technology today. The most fundamental goal of...

Respiratory tract infections are common ailments in man and pig. Several species of bacteria are associated with the infection. Considering the uses of Typhonium trilobatum(L.) in both Unani and Ayurvedic medicinal systems, we approached to investigate its efficacy against selected respiratory tract bacterial pathogens associated with both man and...

Biofilms are formed by the congregation of one or more types of microorganisms that can grow on a firm surface. Dental plaque is one of the most commonly forming biofilms in the oral cavity and appears as a slimy layer on the surface of the teeth. In general, the formation is slow, but biofilms are very adaptive to the changing environment, and a m...

Background: The COVID-19 pandemic has resulted in about 75.2M cases and 1.67M deaths

Aim: To evaluate the antibacterial efficacy, the presence of different phytoconstituents of the leaf extracts of Indian plant Celastrus paniculatus against 6 antibiotic-resistant bacteria along with the evaluation of their antioxidant potentiality. Methods: The leaf extracts were prepared using 4 solvents, water, methanol, n-butanol, and acetone. T...

From the time of second world war, the field of medical microbiology has witnessed emergence of multidrug resistant (MDR) strains of bacterial pathogens, due to many obvious factors. Moreover, empiric therapy also adds ‘fuel to the fire’ the MDR problem. Unfortunately, there are genetic recombination method, transformation, conjugation and transduc...

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Objective: To do surveillance for vancomycin and inducible clindamycin resistance of Enterococcus faecalis, a Gram-positive bacterium in a teaching hospital. Materials and methods: E. faecalis strains isolated from clinical samples were screened for vancomycin and inducible clindamycin resistance, i.e., D-test positivity, using vancomycin screen ag...

Objective: To monitor in vitro antibacterial activities of leaf extracts of 30 common and noncommon plants used by aborigines in Kalahandi district, Odisha, against 6 clinically isolated multidrug resistant (MDR) Gram-positive bacteria of 3 genera, Staphylococcus, Streptococcus, and Enterococcus. Methods: The antibiotic sensitivity patterns of 6 ba...

Objectives To locate a plant with suitable phytochemicals for use as antimicrobials for controlling multidrug resistant (MDR) bacteria as complementary medicine without host toxicity as monitored through cultured lymphocytes from human cord blood. Methods The methanol crude leaf-extract of the plant Woodfordia fruticosa was subjected to antimicrob...