Debasish Maiti

• Doctor of Philosophy
• Tripura University

Six novel nickel(II) complexes have been synthesized using Nickel(II) nitrate hexahydrate, ortho-phenanthroline (o-phen), or 2,2ʹ-bipyridine (bipy) and 1-cyano-1-carboethoxyethylene-2,2-dithiolate (CED2-) ligands in various stoichiometric ratios, showing good solubility across organic solvents. Weight loss experiments suggest water of crystallizati...

Leptin, an adipokine related to obesity, is mainly known for its role in regulating energy homeostasis and appetite by working via the leptin receptor. Recently, different groups have demonstrated that apart from adipocytes, specific cell types associated with cancer and tumor microenvironments express leptin and leptin receptors. This tumor microe...

A new mesogenic L-Alanyl-glycine peptide-based Schiff base ligand and its Ni(II), Cu(II), and Zn(II) complexes have been successfully synthesised and characterised through various spectroscopic techniques and elemental analysis. The anticancer potential of these peptide-based Schiff base complexes was assessed against the A-549 lung adenocarcinoma...

Despite significant advancements in cancer treatment in recent decades, the high mortality rate associated with lung cancer remains a significant concern. The development and proper execution of new targeted therapies needs more deep knowledge regarding the lung cancer associated tumour microenvironment. One of the key component of that tumour micr...

Four new transition metal complexes (1-4) were successfully synthesized through the reaction of M(NO3)2·nH2O (M = Ni, Co, Cd or Zn; n = 6 for Ni, Co, Zn; n = 4 for Cd) with 1,1-dicyanoethylene-2,2-dithiolate (i-MNT2–) and p-phenylenediamine (PPD) ligands. The syntheszed metal complexes were characterized by CHN-analysis, electronic, FTIR and 1H NMR...

Aims: To investigate the autophagy-inducing and tumoricidal efficacy of Theaflavins on Ehrlich’s Ascites Carcinoma (EAC) cells. Background: The apoptosis-inducing role of Theaflavins against cancer is reported. Autophagy, a cellular mechanism under stress, occurs either as a survival process or Type-II programmed-cell death in the presence/absence...

Two transition metal complexes viz. [Cd(2-mcpH)4](NO3)2 (1) and [Zn(2-mcpH)4](NO3)2 (2) were synthesized by the reaction of cadmium(II) nitrate tetrahydrate or zinc(II) nitrate hexahydrate with 2-mercaptopyridine (2-mcpH) in 1:4 M ratio. These complexes have been fully characterized by UV–Vis, IR, NMR–spectroscopy and Single crystal X-ray analysis....

Staphylococcusaureus causes a range of chronic infections in humans by exploiting its biofilm machinery and drug-tolerance property. Although several strategies have been proposed to eradicate biofilm-linked issues, here, we have explored whether piperine, a bioactive plant alkaloid, can disintegrate an already existing Staphylococcal biofilm. Towa...

Cu2(μ‐2‐chlorobenzoato‐O,O’)4Cl2].2(4‐DMAPH) (1) and [Zn2(μ‐2‐chlorobenzoato‐O,O’)4(4‐DMAP)2] (2) (4‐DMAP=4‐Dimethylaminopyridine) were synthesized from CuCl2/Zn(NO)3)2 . 6H2O, 2‐chlorobenzoic acid and 4‐dimethylaminopyridine in methanol under reflux. Compounds were comprehensively characterized by elemental analyses, conductance measurement, spect...

Introduction Current anti-leukemic chemotherapies with multiple targets suffer from side effects. Synthetic drugs with huge off-target effects are detrimental to leukemic patients. Therefore, natural plant-based products are being increasingly tested for new anti-leukemic therapy with fewer or no side effects. Herein, we report the effect of ethano...

Availability of safe drinking water at the railway stations is a basic passenger amenity. To maintain the quality of drinking water, the Ministry of Railways, Government of India, follow the Uniform Drinking Water Quality Monitoring Protocol, 2013, with a benchmarking standard of Bureau of Indian Standards, 2012. The quality of drinking water varie...

Gram-positive and Gram-negative bacteria often develop biofilm through different mechanisms in promoting pathogenicity. Hence, the antibiofilm molecule needs to be examined separately on both organisms to manage the biofilm threat. Since the antibiofilm activity of piperine against Staphylococcus aureus was already reported; here, we aimed to exami...

Three new organotin(IV) complexes, [Me3Sn(H2L)]2 (1), Bu3Sn(H2L) (2), and [(Bu2Sn(H2L))2O]2 (3) were synthesized by the reaction of 2-[4-hydroxy-3-((2-hydroxyethylimino)methyl)phenylazo]benzoic acid (H3L) with appropriate alkyltin(IV) precursors. The complexes were characterized by elemental analysis, IR, and multinuclear (1H, 13C and 119Sn) NMR sp...

Cytokine therapies have shown promising results against cancers. Cytokines are secreted naturally from different bodily cells. These have fewer side effects but higher specificity than chemotherapy and radiation therapy. In leukemia, changes in normal hematopoiesis and defective leukocyte production limit the efficacy of immunotherapy by reducing t...

This review is intended to summarize the existing literature on the mutagenicity of N-ethyl-N-nitrosourea (ENU) in inducing hematological malignancies, including acute myeloid leukemia (AML) in mice. Blood or hematological malignancies are the most common malignant disorders seen in people of all age groups. Driven by a number of genetic alteration...

Antioxidant enzyme plays a pivotal role in preventing oxidative stress. Chemical toxicants often exert adverse effects in the biological system by breaking the antioxidant response system leading to severe oxidative stress. N-Ethyl-N-Nitrosourea (ENU) is a DNA alkylating agent and is carcinogenic and neurotoxic in animals. ENU in the nervous system...

Aim Our previous work depicted that benzo(a)pyrene (BaP)-induced lung cancer associated pulmonary redox imbalance and inflammation were effectively regulated by the combinatorial treatment of IL-27 and IL-28B. So in continuation of that finding the present study was designed to reveal the inflammation regulating signaling network modulated by IL-27...

Staphylococcus aureus causes numerous community-acquired and nosocomial infections in humans by exploiting biofilm. In this context, this study aims to impede the formation of Staphylococcus aureus biofilm by exposing the cells to a plant-based alkaloid, piperine. Our study revealed that piperine exhibited considerable antimicrobial activity agains...

Background: Leukaemia is a major health concern affecting peoples of all age groups starting from children to old agers. It is malignant disorder of white blood cells arising from the bone marrow due to gene or chromosomal mutations, exposure to pollutants, carcinogens, radiations and viral infections. The most conventional methods of treating leuk...

Staphylococcus aureus causes several nosocomial and community-acquired infections in human host involving biofilm. Thus, strategies need to be explored to curb biofilm threats by either inhibiting the formation of biofilm or disintegrating the pre-existing biofilm. Towards this direction, we had already revealed the biofilm inhibiting properties of...

Lung cancer is the most aggressive as well as deadly form of cancer and most of the lung cancer cases are involved in direct smoking or passive smoking. Oxidative stress and pulmonary inflammation regulated by some transcription factors like Nrf2, NF-κB etc. play important roles in lung cancer. Various combinations of therapies are currently attrib...

Biofilm, an aggregated form of microbial existence has been a major area of concern in the healthcare units. These sessile microbes not only protect themselves from the host immune system but also exhibit high resistance against several antimicrobials. One such widely reported Gram-positive pathogen is Staphylococcus aureus . This human commensal i...

The Mediterranean diet is appraised as the premier dietary regimen and its espousal is correlated with the prevention of degenerative diseases and extended longevity. The consumption of olive oil stands out as the most peculiar feature of the Mediterranean diet. Olive oil rich in various bioactive compounds like oleanolic acid, oleuropein, oleocant...

Four copper(II) carboxylate complexes, namely [Cu2(μ-3,5-dinitrobenzoate-O,O')4(4-(dimethylamino)-benzaldehyde)2] (1), [Cu2(μ -benzoate-O,O')4(benzoic acid)2] (2), [Cu2(μ -benzoate-O,O')4(H2O)2] [Cu(benzoate-O,O')2(imz)2].2H2O (3) and [Cu(benzoate-O,O')2(2-Me-imz)2] (4) (imz = imidazole, 2-Me-imz = 2-methyl-imidazole), were synthesized and comprehe...

Microbial biofilm indicates a cluster of microorganisms having the capability to display drug resistance property thereby increasing its proficiency in spreading diseases. In the present study, the antibiofilm potential of thymoquinone, a black seed-producing natural molecule was contemplated against the biofilm formation by Pseudomonas aeruginosa....

Lung cancer is the leading cause of cancer-related deaths and is responsible for one-quarter of all cancer deaths. The pulmonary diseases that are associated with the greatest risk for lung cancer are characterized by abundant and deregulated inflammation. Pulmonary disorders such as COPD are characterized by profound abnormalities in inflammatory...

Reactive oxygen species (ROS) are generated as the by-product of cellular respiration and also due to the exposure of various xenobiotics whereas the mitochondrial electron transport chain is being considered as the main source of ROS generation. Due to the sequential addition to molecular oxygen give rise to the various form of ROS like superoxide...

Aims The major cause behind lung cancer development is exposure to various polycyclic aromatic hydrocarbons like benzo(a)pyrene (BaP) present in tobacco smoke, motor vehicle, and industrial exhaust. BaP is reported to induce the expression of various pro-inflammatory cytokines and matrix remodeling proteins. It is also responsible for dysfunction a...

Two new neutral bimetallic and trimetallic mixed-ligand complexes of Cd(II) and Hg(II) were obtained by using potential flexible molecular building blocks, 1,1-dicyanoethylene-2,2-dithiolate dipotassium salt (K2i-mnt) and polyamines. X-ray diffraction analysis revealed that dithiolate (i-mnt ⁻²) acts as a bridging unit in the slightly distorted squ...

Cadmium telluride (CdTe) and silver-doped CdTe (CdTe/Ag) nanocrystals have been used to study the antibacterial activity against gram-positive bacteria (Streptococcus pneumoniae and Staphylococcus aureus) and gram-negative bacteria (Klebsiella pneumoniae and Escherichia coli) by disc diffusion method. Here, CdTe and CdTe/Ag nanocrystals have been p...

Murine splenic macrophage plays a decisive role in host immunity through phagocytosis against pathogens. It was reported that, macrophages also involves in phagocytosis of some tumour cells upon its activation initiated by certain cytokines produced by other immune cell or by indigenously treated. In this study, we have investigated the killing of...

Aim: Pineapple (Ananas comosus (L.) Merr.) is a good source of bromelain (B) and also contain peroxidase. The objective of this study is isoaltion of bromelain plus peroxidase (BP) from the pineapple fruit to evaluate the anticancer activity of BP from the pineapple fruit of Tripura, compared to commercial bromelain against ascitic Dalton’s lymphom...

Olive (Olea europaea L.) leaf extract (OLE) have shown therapeutic activity against different types of cancer. However, it is less known that olive leaf extract has anti myeloma activity. The in vitro cytotoxic activity of OLE was evaluated against mouse metastatic melanoma B16F10 cell lines. The extracts were analyzed for their antioxidant activit...

Biofertilizer happens to be a promising alternative of chemical fertilizer in the establishment of sustainable agricultural practices. Following this observation, several nitrogen-fixing bacteria were isolated from the soil in which an isolate (AKS7) was selected for further studies as AKS7 showed considerable competence in growth on nitrogen-free...

A highly substituted imidazole‐based colorimetric and fluorogenic chemosensor, 2‐methoxy‐4‐(4,5‐diphenyl‐1H‐imidazol‐2‐yl)phenol (L), for the detection of Cu²⁺ ion and subsequent colorimetric detection of an amino acid, cysteine, was investigated. L exhibited a distinct color change from colorless to red in the presence of Cu²⁺ in an aqueous medium...

Bromelain is a protease present in pineapple fruit and stem. It is reported that commercially available pure bromelain has anticancer, anti-inflammatory and other therapeutic effects. But there are few reports available on the biological activity of bromelain along with peroxidase which is present in pineapple fruit extract. The aim of the present...

Abstract: Alkaloids are plant secondary metabolite. They are well known nitrogen-containing natural bioactive compounds. Cutting edge research is going on alkaloids to unravel novel therapeutic approaches. Literature reveals that alkaloids contribute multiple biological activities and some alkaloids transform into active metabolites too. In this re...

Abstract: Alkaloids are plant secondary metabolite. They are well known nitrogen-containing natural bioactive compounds. Cutting edge research is going on alkaloids to unravel novel therapeutic approaches. Literature reveals that alkaloids contribute multiple biological activities and some alkaloids transform into active metabolites too. In this re...

Abstract: Alkaloids are plant secondary metabolite. They are well known nitrogen-containing natural bioactive compounds. Cutting edge research is going on alkaloids to unravel novel therapeutic approaches. Literature reveals that alkaloids contribute multiple biological activities and some alkaloids transform into active metabolites too. In this re...

In this study, the determination of secondary metabolites, anti-oxidant and cytotoxic activity of seed coat of Macrotyloma uniflorum were carried out in different solvents (petroleum ether, chloroform, ethanol, and water), according to their increasing polarity. Alkaloid and tannin content was analyzed by simple titrimetric method. Colorimetric met...

Melanoma is a predominant cause of skin cancer-related deaths. It was reported that, the methanolic extract of Pouzolzia Indica (P. indica) on chromatography gave five compounds (1-hentriacontanyl palmitate, myricyl alcohol, 6,7-dimethoxycoumarin, trichadonic acid and friedelane), which inhibited the acute promyelocytic leukemia cell lines, NB4, an...

Microbial biofilms are factions of surface-colonized cells encompassed in a matrix of extracellular polymeric substances. Profound application of antibiotics in order to treat infections due to microbial biofilm has led to the emergence of several drug-resistant microbial strains. In this context, a novel type of 3,6-di(pyridin-2-yl)-1,2,4,5-tetraz...

Ameliorative effect of bromelain along with olive leaf extract on benzo(a)pyreneinduced lung carcinogenesis associated MMP-2, MMP-9 and mast cell density(MCD).

Biofilms are structured consortia of microbial cells that grow on living and non living surfaces and surround themselves with secreted polymers. Infections with bacterial biofilms have emerged as a foremost public health concern because biofilm growing cells can be highly resistant to both antibiotics and host immune defenses. Zinc oxide nanopartic...

Introduction: Pineapple juice contains a number of enzymes including bromelain, which is a cysteine protease. Apart from bromelain, other enzymes including peroxidase & trace amount of different proteolytic enzymes like ananine and comasin are also present. It has been reported that pure commercial bromelain have anticancer, anti-inflammatory and o...

Reaction of N,N′-bis(2-pyridylmethyl)oxamide (H2L), and copper(II)nitrate trihydrate in 1:2 M proportion in methanol generates oxamido bridged dimeric copper(II) compound, [Cu2L(H2O)2(NO3)2]H2O (1a.H2O) in good yield. 1a.H2O has been characterized by C, H and N microanalyses, copper estimation, FT-IR, UV–Vis and room temperature magnetic susceptibi...

Leukemia is often accompanied by enhanced susceptibility to infection due to compromised B cell and T cell functions. The alterations in macrophage functions in leukemia remain less investigated. Herein, we examined macrophages for their functions and responsiveness to IL-3 and GM-CSF in ENU-induced leukemia in BALB/c mice. We observed that the mac...

Pineapple contains a protease enzyme called bromelain. Along with bromelain, pineapple extract also contains endopeptidase like peroxidase. It is reported that commercially available bromelain has anticancer, anti-inflammatory and other therapeutic benefits. But there are few reports available about activity of peroxidase i.e. how peroxidase enhanc...

In leukaemia, secondary infection is common and after chemotherapy the number of normal active neutrophil reduced significantly. Therefore, to avoid side effects of chemotherapy and to induce neutrophil activity and number, in this study, we have treated with G-CSF plus IL-15 in combination to N-N’ Ethylnitrosourea (ENU) induced leukemia in BALB/c...

Objective: Objective of the present work was qualitative and quantitative estimation of alkaloids and phenolics of five edible cucurbitaceous plants and to evaluate their antibacterial activity against some human pathogenic bacteria. Methods: Total alkaloid present was determined by acid-based titrimetric methods using methyl red as an indicator an...

Aim: The enrolment of blood progenitor cells from the bone marrow into peripheral blood or mobilization is required in leukemia following treatment with chemotherapy and/or cytokines. In this experiment, we examined the mobilization of lymphocytes from bone marrow to peripheral blood using interleukin-3 (IL-3) and granulocyte monocyte-colony stimul...

Central nervous system (CNS) drug development will be biology driven. Due to absence of functional platform for CNS drug targeting since, the large molecules pharmaceuticals cannot be delivered to brain. About 1.5 billion people worldwide are suffering from various type of central nervous system (CNS) disorders. Overcome to this problem modern phar...

Objectives: Murine macrophages were playing a key role against microbes and foreign particles as well as help in solid tumorigenesis in the host body. In this experiment we were trying to evaluate the protein tyrosine kinase (PTK) activity in macrophages from experimentally induced leukemic animal model. Methods: Balb/C mice were divided into four...

Endothelial cells play a major role in the initiation and perpetuation of the inflammatory process in health and disease, including their pivotal role in leukocyte recruitment. The role of pro-inflammatory transcription factors in this process has been well-described, including NF-κB. However, much less is known regarding transcription factors that...

Abstract Caesalpinia mimosoides Lamk, a climbing shrub of Caesalpiniaceae family, shoots and leaf contains gallic acid, caffeine, vanillic acid, ferulic acid etc. These compounds are cytotoxic in nature. In this study we have investigated the anticancer properties of the methanol extract from the shoots and leaves of the plant. For anticancer activ...

ARTICLE INFO ABSTRACT Protein tyrosine kinase (PTK) is an enzyme which mediates cell function, growth, metabolism and apoptosis. The present work has an objective to evaluate the involvement of PTK activity on neutrophil population in the peripheral blood upon stimulati animal. N where in combination with were treated. To determine assay kit were u...

Abstract: Chemotherapy has huge side effects in leukemia. Immunotherapy may be better approach for the consequences in leukemia patient. Carcinogen induced leukaemia was developed in BALB/C mice to test the hypothesis that protein tyrosine kinase (PTK) activity is impaired in leukemia and can be improved after treatment in combination with Granuloc...

Purpose: Leukaemia, the cancer of blood forming cells causes appearance of large number of abnormal white blood cells. Natural killer cells are a major component of the innate immune system, can kill cancer cells and hold potential for cell based therapies targeting malignancies. Cytokines secreted from different immune cells play a very important...

Leukaemia, the cancer of blood forming cells causes appearance of large number of abnormal white blood cells. Carcinogen induced leukaemia was developed in BALB/C mice to test the hypothesis that in combination with IL-15 and GCSF can increase the number and can improve functional activity of neutrophil from spleen. N-N’-Ethyl-nitrosourea was used...

Purpose: Leukaemia is a cancer of blood-forming tissues including bone marrow and lymphatic system. These immature cells accumulate in blood and organs but all of them are not able to carry out the normal functions of blood. Natural killer cells are a major component of the innate immune system, can kill cancer cells in the absence of prior stimula...

Oxides of copper have been investigated for decades due to their unique semiconductor and optical properties. The review of literature revealed that very few reports are available on the synthesis of copper oxide nanoparticles using microorganisms and plant extracts. In this paper, we have reported the synthesis of copper oxide nanoparticles (CuO)...

Objective: The persent investigation is carried out to assess in vitro antimicrobial, antioxidant and anti-alphaglucosidase activity of the crude and fraction extracts of both leaf and fruits of the plant Dillenia pentagyna Roxb. (Dilleniaceae). Methods: Extracts prepared from leaf and fruits by drying and fractionation process. Antibacterial activ...

Context: The genus Mussaenda (Rubiaceae) includes 200 species distributed in hilly tracks of north eastern India and in tropics of the old world. Mussaenda roxburghii Hook. f. mainly grown in Tripura and other north eastern states of India has been used as traditional medicine.

Context: Ichnocarpus frutescens (Linn) (Family-Apocynaceae) is an evergreen plant and this plant is used in traditional Indian medicine for centuries to treat several illness including fever, dyspepsia, skin troubles and headache. The possible antitumor activity and antioxidant role of I. frutescens in the mice transplanted with Ehrlich ascites car...

Background: Dillenia penagyna Roxb. is a plant of Dilliniaceae family (Karmal family), locally known as ‘Hargaza’, is widely distributed randomly in hilly areas of north east states of India and Bangladesh. Local tribal peoples use different parts of this plant for various ailments like dirrhoea, dysentery etc. The aim of the present study is to de...

The various parts of Dillenia pentagyna Roxb. (dilliniaceae), are used as medicine for various ailments like anal fistula, wounds, neuritis etc. in eastern India and south east Asia. We have isolated the betulinic acid from ethyl acetate fraction of fruit by running column chromatography with 20% ethyl acetate in chloroform. It is a naturally occur...

The extract of the plant, Artocarpus chaplasa, (family Moraceae; Local name: Chamal) is used as traditional medicine for treatment of various ailments and skin diseases in north eastern India. The antimicrobial, antioxidant and antidiabetic properties of the crude stem bark methanol extract of the plant have been evaluated. The extract showed antim...

The plant Artocarpus chaplasa, family Moraceae (Local name: Chamal) plant extract is used in treatment of various ailments and skin diseases in north eastern India. The α-glucosidase inhibitory activity of four fractions viz. aqueous, butanol, chloroform, and ethyl acetate of the stem bark extract of the plant has been tested comparing with acarbos...

Herbal medicines are getting popular in India as well as all around the world due to its minimum adverse effects. In north eastern region of India especially in the state of Tripura, deliver varieties of endemic plants of versatile medicinal properties are explored for their bioefficacies. From that aspect, the aim of the present study is to evalua...

Ischemic retinopathies, including retinopathy of prematurity and diabetic retinopathy, are major causes of blindness. Both have two phases, vessel loss and consequent hypoxia-driven pathologic retinal neovascularization, yet relatively little is known about the transcription factors regulating these processes. Myocyte enhancer factor 2 (MEF2) C, a...

The various parts of the plant Mussaenda roxberghii (rubiaceae), are used as medicine for various ailments in eastern India and south east Asia. We have studied antimicrobial activity, in vitro superoxide radical scavenging activity, Nitric oxide radical scavenging activity and in vitro biochemical anti-diabetic activity (viz. alpha-amylase inhibit...

The plant Dellenia pentagyna , locally known as ‘Hargaza’, is widely distributed randomly in hilly areas of north east states of India and Bangladesh. Haque et al revealed that the extract of the bark of this plant has antibacterial and cytotoxic activity. The purpose of this study in our lab is to evaluate the medicinal properties of other portion...

Vascular endothelial growth factor is a key regulator of physiological and pathologic angiogenesis. Although much is known about the major upstream signaling pathways of VEGF in endothelial cells, less is known about key transcription factors involved in VEGF action. The transcription factor myocyte enhancer factor (MEF)-2C is thought to play an im...

The purpose of this study is to investigate the expression and regulation of type-2 tissue factor pathway inhibitor (TFPI-2) in endothelial cells, as well as the regulation of human endothelial cell (EC) function by TFPI-2. Real-time polymerase chain reaction (PCR) and Western blot analysis revealed that vascular endothelial growth factor (VEGF) in...

Microvascular endothelial cells involved in angiogenesis are exposed to an acidic environment that is not conducive for growth and survival. These cells must exhibit a dynamic intracellular (cytosolic) pH (pHcyt) regulatory mechanism to cope with acidosis, in addition to the ubiquitous Na+/H+ exchanger and HCO3--based H+-transporting systems. We hy...

Glial cells exhibit distinct cellular domains, somata, and filopodia. Thus the cytoplasmic pH (pH(cyt)) and/or the behavior of the fluorescent ion indicator might be different in these cellular domains because of distinct microenvironments. To address these issues, we loaded C6 glial cells with carboxyseminaphthorhodafluor (SNARF)-1 and evaluated p...

The lung endothelium layer is exposed to continuous CO(2) transit which exposes the endothelium to a substantial acid load that could be detrimental to cell function. The Na(+)/H(+) exchanger and HCO(3)(-)-dependent H(+)-transporting mechanisms regulate intracellular pH (pH(cyt)) in most cells. Cells that cope with high acid loads might require add...

Tyrosine kinase has an important role with regard to self-renewal and as a comitogen in the movement of stem cells out of the haemopoietic stem cell pool into the progeny pool. The present investigation has an objective to evaluate the protein tyrosine kinase (PTK) activity of bone marrow derived pluripotent cells before and after application of bi...

We have shown that a specific cytosolic pH (pHcyt) regulatory mechanism, i.e., vacuolar type H+-ATPases at the plasma membrane (pmV-ATPases), allows angiogenic and metastatic cells to survive in an acidic and hostile environment. However, a functional evaluation of this pump's activity in situ (i.e., in living animal models) has not been attempted....

Biological Response Modifiers (BRMs) including interleukin-2 (IL-2), interferon-gamma (IFN-γ) and sheep erythrocytes (SRBC) protected N,N′-ethylnitrosourea (ENU) induced leukaemic mice. Two cell types from the bone marrow were isolated in density specific gradient representing two distinct compartments, the low density cells being more CD34 positiv...

Efforts in prevention and control of tuberculosis suffer from the lack of detailed knowledge of the mechanisms used by pathogenic mycobacteria for survival within host cell macrophages. The exploitation of host cell signaling pathways to the benefit of the pathogen is a phenomenon that deserves to be looked into in detail. We have tested the hypoth...