Debasis Bagchi

Debasis Bagchi
University of Houston | U of H, UH · Department of Pharmacological and Pharmaceutical Sciences

PhD, MACN, CNS, MAIChE

About

522
Publications
215,641
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25,771
Citations
Citations since 2017
126 Research Items
7235 Citations
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201720182019202020212022202302004006008001,0001,200
201720182019202020212022202302004006008001,0001,200

Publications

Publications (522)
Article
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In this nonsystematic review and opinion, including articles primarily selected from PubMed, we examine the pharmacological and nonpharmacological treatments of neonatal abstinence syndrome (NAS) in order to craft a reasonable opinion to help forge a paradigm shift in the treatment and prevention of primarily opioid-induced NAS. Newborns of individ...
Article
Introduction: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder which accounts for infertility around the world. The disease is characterized by elevated secretion of androgens in the women which results in enlargement of ovaries with accumulation of fluid filled cysts, irregular menstrual cycles, and hirsutism. This study reports the effi...
Article
Full-text available
Scientific studies have provided evidence that there is a relationship between violent and aggressive behaviors and addictions. Genes involved with the reward system, specifically the brain reward cascade (BRC), appear to be associated with various addictions and impulsive, aggressive, and violent behaviors. In our previous research, we examined th...
Article
Full-text available
Scientific studies have provided evidence that there is a relationship between violent and aggressive behaviors and addictions. Genes involved with the reward system, specifically the brain reward cascade (BRC), appear to be associated with various addictions and impulsive, aggressive, and violent behaviors. In our previous research, we examined th...
Article
Full-text available
Since 1990, when our laboratory published the association of the DRD2 Taq A1 allele and severe alcoholism in JAMA, there has been an explosion of genetic candidate association studies, including genome-wide association studies (GWAS). To develop an accurate test to help identify those at risk for at least alcohol use disorder (AUD), a subset of rew...
Article
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Reward Deficiency Syndrome (RDS) is defined as a breakdown of reward neurotransmission that results in a wide range of addictive, compulsive, and impulsive behaviors. RDS is caused by a combination of environmental (epigenetic) influences and DNA-based (genetic) neurotransmission deficits that interfere with the normal satisfaction of human physiol...
Article
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The onset of inflammation takes place in a human body due to an injury or infection during which the tissue becomes inflamed/reddened, swollen, hot, and painful. Basically, it is a collection of host defenses that occurs during an injury and infection in which the white blood cells protect the body from infection from bacteria, fungi, parasites, or...
Article
Introduction: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenemia, a quite common heterogenous endocrine/hormonal disorder, and accompanied by elevated androgen level, menstrual irregularity, and hirsutism. The consequences include infertility or miscarriage. It is a challenging problem to the physicians. In a one-arm, non-rando...
Article
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The current addiction crisis has destroyed a multitude of lives, leaving millions of fatalities worldwide in its wake. At the same time, various governmental agencies dedicated to solving this seemingly never-ending dilemma have not yet succeeded or delivered on their promises. We understand that addictive behavioral seeking is a multi-faceted neur...
Article
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Pediatric autoimmune neuropsychiatric disorders associated with group A streptococcal infections (PANDAS) is a concept that is used to characterize a subset of children with neuropsychiatric symptoms, tic disorders, or obsessive-compulsive disorder (OCD), whose symptoms are exacerbated by group A streptococcal (GAS) infection. PANDAS has been known...
Article
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Addiction is a complex multifactorial condition. Established genetic factors can provide clear guidance in assessing the risk of addiction to substances and behaviors. Chronic stress can accumulate, forming difficult to recognize addiction patterns from both genetic and epigenetic (environmental) factors. Furthermore, psychological/physical/chemica...
Article
Full-text available
Since 1990, when our laboratory published the association of the DRD2 Taq A1 allele and severe alcoholism in JAMA, there has been an explosion of genetic candidate association studies, including GWAS. To develop an accurate test to help identify those at risk for at least Alcohol Use Disorder (AUD), Blum’s group developed the Genetic Addiction Risk...
Article
Objective: Initial results gathered from previously published observations dealing with nondiabetic volunteers reveal that both the fasting blood glucose (FBG) level employed as a surrogate for insulin resistance (IR) and the amount of body fat mass (FM) correlate significantly with the strength and pathological direction of many harmful elements...
Article
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Introduction: Undenatured type II collagen, derived from chicken sternum cartilage, is a novel functional ingredient, which has been demonstrated to improve joint health, flexibility and mobility, and enhancing motor functions. Undenatured type II collagen has been commercially available as functional dietary supplement worldwide for many years. Re...
Article
Data gathered from healthy and non-diabetic volunteers who previously had participated in assorted clinical research trials, reveal that many medical risk factors primarily related to insulin resistance (IR) and the metabolic syndrome (MS) gradually intensify between ages 25 and 70 years. This phase here labeled “Continuum of risks” (CR) is a perio...
Article
Pyrroloquinoline quinone (PQQ), a potent coenzyme antioxidant naturally occurring in foods, has been demonstrated to protect brain cells by enhancing the expression of nerve growth factors (NGF) and NGF receptors, and suppressing the fibril formation and aggression of amyloid β. We developed mnemoPQQ®, a novel PQQ disodium salt and assessed its saf...
Article
Obesity and overweight are now defined as an epidemic. An array of evidence substantiates that existing weight loss strategies and programs have not worked. Fat is the lightest of macromolecules, the highest energy reserve of the body, and the last reservoir of survival insurance to be expended. Conventional weight loss concepts and therapies, for...
Article
Cognitive dysfunctions are increasing alarmingly around the world, and researchers are exploring preventive measures for improving brain performance. Pyrroloquinoline quinone (PQQ), a naturally occurring coenzyme in foods, exhibits potent antioxidant activity, and improves diverse functions which includes mitochondrial activation, growth, repair, p...
Article
Despite the advancement in wound care, the effective therapy of chronic diabetic ulcers continues to be a challenge. Wound healing is a highly controlled process, which involves a sequence of complex overlapping steps. This healing pathway comprises of hemostasis, inflammation, proliferative, and remodeling phases. Recent evidence suggests that phy...
Article
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Background: The prevalence of obesity has increased an astounding 30.5% to 42.2% over the last two decades despite numerous weight loss products and programs, thus qualifying it as an epidemic. Fat is the lightest of macromolecules, the highest energy reserve of the body, and the last reservoir of survival insurance to be expended. Water, muscle, a...
Article
Prevalence of osteoarthritis (OA) is increasing alarmingly worldwide. Slowing down the progression of OA and diverse locomotive organ disorders is gaining interest in improving the quality of life (QOL) and extending healthy life-span. In a pilot study, intake of a small amount of undenatured type II collagen exhibited suppression of damage to the...
Article
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Background: In advancing age population worldwide, joint discomfort and poor locomotive functions are symptoms, which are often detected. Aggravation of such symptoms potentially develops into osteoarthritis (OA) as characterized by the loss of articular cartilage in the joints of the hand, spine, knee, foot, and hip. For joint health complications...
Article
The researchers demonstrate the development of a novel Prodosome technology-derived PL425 PEC phytonutrient-enriched electrolyte formulation and its significant contribution in fluid homeostasis as well as enhanced neuromuscular function, cardio-protection, pulmonary, and other physiological cellular and organ functions. Electrolytes enriched in ph...
Chapter
Recent years have marked food allergy development as a common and major problem with detrimental immune reactions in response to various food proteins. In many cases of food allergy, probiotics and prebiotics have emerged as potential therapeutic agents. This type of treatment is aimed to minimize inflammation and correct diverse allergic symptoms,...
Chapter
The gastrointestinal tract consists of the alimentary canal from mouth cavity to the anus and attached to associated glandular organs that empty their contents into the tract. It absorbs nutrients and water into circulation and eliminates waste materials. Most of the foodstuff in the diet is taken in as solid and as macromolecules; therefore, diges...
Chapter
Enzymes play a vital role in biometabolic functions. Insufficient enzyme availability leads to impaired metabolism including digestive and immune dysfunctions. Digestive enzymes enable disintegration, dissolution, and absorption of foods, significantly improving gastro-intestinal integrity, immunity, cellular functionality, and overall health. An a...
Chapter
A growing body of research suggests that elevated circulating levels of glucose and insulin, even in their nondiabetic ranges but still relatively high, can over time accelerate risk factors for a wide range of disorders linked to the metabolic syndrome and the aging process. Accordingly, low-risk interventions that could reduce circulating glucose...
Chapter
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) reports that approximately 60–70 million people are affected by a plethora of chronic digestive disorders and problems, including irritable bowel syndrome, bloating and gas, constipation, diarrhea, lactose intolerance, fecal incontinence, acid reflux, Crohn’s disease, celi...
Chapter
The gut microflora plays a significant role in host human health. Alteration in these microflora influences the setting in of diseases such as metabolic disorders, cardiovascular health, and obesity. The composition of our gut microbiota and its functions are highly influenced by diet. Changes in the gut microbial composition (dysbiosis) have been...
Chapter
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A variety of behavioral disorders are associated with addictions, impulsivity, obsessive-compulsive behaviors, and some personality disorders, which are collectively known as reward deficiency syndrome. These disorders are also associated with diverse digestive disorders. The enteric nervous system, a complex subdivision of the peripheral nervous s...
Article
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Kenneth Blum,1– 5 Bruce Steinberg,6 Marjorie C Gondre-Lewis,7 David Baron,1 Edward J Modestino,6 Rajendra D Badgaiyan,8– 10 B William Downs,11 Debasis Bagchi,11 Raymond Brewer,5 Thomas McLaughlin,12 Abdalla Bowirrat,13 Mark Gold14 1Center for Psychiatry, Medicine & Primary Care, Division of Addiction Research & Education, Graduate College, Western...
Article
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Metabolic competence in conjunction with well-balanced nutritional support is extremely important for normal biochemical and physiological functions, as well as for enhanced athletic performance. Research-affirmed nutraceuticals enriched in structurally diverse phytonutrients including bioflavonoids may help to boost athletic, functional, and bioph...
Article
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An increase in anaerobic (oxygen-deprived) pathogenesis significantly increases the generation of reactive oxygen species (ROS) inflicting damage on cell membranes and intracellular constituents. Generation of ROS and concomitant inflammatory response is the two hallmarks of cellular damage caused by cellular injury or invasion by pathogens. Oxygen...
Article
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Alcohol and other substance use disorders share comorbidity with other RDS disorders, i.e. a reduction in dopamine signaling within the reward pathway. RDS is a term that connects addictive, obsessive, compulsive, and impulsive behavioral disorders. An estimated 2 million individuals in the United States have opioid use disorder related to prescrip...
Article
Background The medicinal herb fenugreek (Trigonella foenum-graecum) seeds, fortified with dietary fibers and furostanolic saponins including protodioscin, have demonstrated a significant contribution to human health. In our laboratories, Furosap®, a patented 20% protodioscin-enriched extract was developed from fenugreek seeds. Objective In an open...
Article
Background While a consistent, gradual decline in the renal glomerular filtration rate (GFR) is a characteristic occurrence over the human life span, the exact pathophysiology behind this event remains unresolved. Evidence to date suggests that the endogenous glucose-insulin system could be involved at some level. Diabetic-induced nephropathy, one...
Article
SARS-COV2 has emerged as the second biggest threat to humanity of all times, after the Spanish Flu massacre. Due to its brisk rate of mutation, especially that of the host receptor docking Spike protein, a safe immunization is still questioned by some, and protection or recovery has been dependent largely on immune system competence and overall bio...
Article
Full-text available
Background: The United States Centers for Disease Control and Prevention (CDC) estimates a total obesity rate of 30% for 12 states and a 20% obesity rate nationwide. The obesity epidemic continues to increase in spite of preventative measures undertaken worldwide. Pharmacological treatments promise to reduce total fat mass. However, medications may...
Article
Background Cognitive dysfunctions are increasing alarmingly around the world, and researchers are exploring preventive measures for improving brain performance. Pyrroloquinoline quinone (PQQ), a naturally occurring coenzyme in foods, exhibits potent antioxidant activity, and improves diverse functions which include mitochondrial activation, growth,...
Article
Background Conventional medical therapies for neurodegenerative diseases primarily target anti-inflammatory interventions, immune suppression of autoimmune pathologies, and, depending on the diagnosed pathological mechanisms, neurotransmitter reuptake inhibition, among other tactics. However, the incidence of neuroinflammatory pathologies appears t...
Article
Background A gradual upward progression of blood pressure (BP) occurs regularly in most humans during aging. This is unfortunate, because it is generally recognized that elevation of BP, even when relatively mild, is eventually detrimental to human health. Accordingly, considerably more understanding of the pathophysiology behind such a phenomenon...
Article
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This article describes a unique therapeutic precision intervention, a formulation of enkephalinase inhibitors, enkephalin, and dopamine-releasing neuronutrients, to induce dopamine homeostasis for detoxification and treatment of individuals genetically predisposed to developing reward deficiency syndrome (RDS). The formulations are based on the res...
Article
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Saving lives and flattening the curve are the foremost priorities during the ongoing pandemic spread of SARS-CoV-2. Developing cutting-edge technology and collating available evidence would support frontline health teams. Nutritional adequacy improves general health and immunity to prevent and assuage infections. This review aims to outline the pot...
Article
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In 2019, the US Center for Disease Control and Prevention provided vital statistics related to drug overdoses in the United State1. They concluded that in the USA the number of deaths at almost 72,000 was due to 66.6% of opioid overdoses. In fact, the rate is alarming and increasing yearly. To make 2021 even more scary is the daunting effect on inc...
Book
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This chapter discusses the particular function of lipids and fatty acids and their metabolism are discussed in light of metabolomic, lipidomic, and observational studies of the elderly population with and without diagnosed neurodegenerative diseases. The major mechanistic and dietary conclusions are examined in the light of potential prevention and...
Article
Introduction Polymorphic gene variants, particularly the genetic determinants of low dopamine function (hy-podopaminergia), are known to associate with Substance Use Disorder and a predisposition to PTSD. Addiction research and molecular genetic applied technologies supported by the National Institutes of Health (NIH) have revealed the com-plex fun...
Chapter
Nutrition plays an important role in maintaining the normal physiological functions of human body. Healthy food habit and balanced lifestyle can reduce the risk of several diseases, including neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease, which are mainly due to environmental factors, age-related issues, and unhea...
Article
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We hypothesize that Iron-Deficiency Anemia (IDA) has been misconceptualized. In the body, low blood iron is not caused by a deficiency. The primary cause of low iron, appearing to be IDA, is the expenditure of alkalinizing histidine, from heme protein, which requires the cleavage of iron and its repartitioning to other storage depots. As an alkalin...
Article
Background: Significant inverse correlations between circulating vitamin D3 and the presence and strength of common clinical entities influenced by insulin resistance (IR) have been reported. Among these entities are common maladies such as the metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD). Since hypovitaminosis D3 is conside...
Article
Vitamin D deficiency (VDD) partly explains geographical differences in COVID-19 susceptibility, severity, and mortality. VDD among African-Americans, diabetics, hypertensive, and aged populations possibly explain the higher death rate, aggravated by cocooning. Vitamin D is pleiotropic, mediating bone metabolism, calcium homeostasis, and immune func...
Article
Objective Many medical disorders comprising the metabolic syndrome (MS) are becoming increasingly prominent worldwide. Accordingly, much more knowledge is necessary to design the best preventive and therapeutic regimens to combat them effectively. This investigation examines the manner and magnitude of any interplay between body fat mass (FM) and i...
Preprint
Full-text available
Background: Integrity of hemoglobin is a crucial determining factor for the overall health functions. Nutrient repletion therapy should be a fundamental strategy to restore the healthy properties of blood. A unique patent-pending iron-free VMP35 formulation was engineered by our laboratory to restore iron-dependent hemoglobin in anemic cells using...
Article
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Background: A common neurological condition worldwide is Reward Deficiency Syndrome (RDS) leading to both substance and non-substance addictive behaviors, that must be combatted by integrating both central nervous system and peripheral nervous system biological approaches. Integrity of hemoglobin is a crucial determining factor for the overall hea...
Article
Objectives Optimal nutrition and natural digestive enzymes play a critical role in enhancing healthy digestion. N-SORB, a novel KD120 liquid multienzyme complex was developed and encapsulated using a SK713 SLP absorption technology (Prodosome®). A randomized, double-blind placebo-controlled investigation over a period of 90 consecutive days was con...
Article
Objectives NHLBI announced that anemia is one of the most common blood disorders, which affects more than 3 million Americans, while the Global Burden of Disease 2016 reported that anemia affects 1.93 billion people worldwide. Anemia is associated with chronic inflammatory conditions and autoimmune disorders. Hemorrhagic anemia results in substanti...
Article
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In the face of the global pandemic of COVID 19, approaching 1.75 Million infected worldwide (4/12/2020) and associated mortality (over 108, 000 as of 4/12/2020) as well-as other catastrophic events including the opioid crisis, a focus on brain health seems prudent [1] (https://www.coronavirus.gov). This manuscript reports on the systemic benefits o...
Chapter
Despite the variations in age, gender, and ethnicity among subjects, important significant correlations are found between fasting blood glucose (FBG) as a surrogate for insulin resistance (IR) and many elements of the metabolic syndrome (MS). It is quite reasonable to believe that maintaining relatively low levels of FBG representing the optimal st...
Chapter
• Modestly elevated blood pressure (BP) readings, even in the so-called normal range, provide serious cardiovascular complications throughout the world. • Among dietary constituents, just excess intake of table salt (NaCl) for the most part and to a lesser extent lack of sufficient dietary potassium are consistently linked to BP elevations. • Nev...
Chapter
Findings from earlier clinical studies indicated that the triglycerides/HDL-cholesterol ratio (Tri/HDL) is a practical surrogate for insulin resistance (IR) and a suitable means to approximate the activity of many associated components of the metabolic syndrome (MS). However, analyses of later-gathered data implied that despite utility in American-...
Chapter
World statistics indicate that approximately 1.93 billion people suffer from anemia. Anemia is intricately linked to overindulgence of dietary fat, salt, and sugar-induced chronic inflammation, chronic kidney disease, gastrointestinal and gynecological malignancies, and autoimmune disorders. Hemorrhagic anemia results in substantial loss of blood w...
Chapter
The general consensus among many health professionals is for most individuals to decrease dietary intake of sodium from table salt but increase potassium to improve overall health. Body sodium content correlates directly with fluid volume. Keeping this in mind, many from all over the globe consume far more sodium than generally recommended leading...
Chapter
Background: In recent, limited-in-size, cross-sectional studies employing nondiabetic subjects, fasting blood glucose (FBG) levels were used to estimate status of insulin resistance (IR) and found to correlate significantly with various components of the metabolic syndrome (MS). However, while FBG values rose gradually within the generally accepted...
Chapter
Background: Over the past two decades, numerous reports have implied that the ratio triglycerides/HDL-cholesterol is a convenient, reasonable surrogate to approximate the intensity of insulin resistance (IR) and associated maladies. Also a similar prognostic potential has been promoted for fasting blood glucose (FBG) levels. Objective: The present...
Chapter
Nutritional status plays a major role in determining the fate of wound healing and its complications, especially in diabetes. Nutritional factors are often ignored as a problem in the management of chronic wound patients. A wide range of macronutrients, micronutrients, and food supplements and their combinations are instrumental in orchestrating wo...