Debajyoti Chatterjee

• Senior Researcher at Post Graduate Institute of Medical Education and Research

Background: Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disease presenting with lichenoid papules and plaques and tense blisters. There is a paucity of literature on LPP globally. Objective: To report the clinico-demographic profile, histopathology, immunological features, and associated comorbidities in LPP pat...

Background Primary autoimmune hypothalamitis is an exceptionally rare inflammatory condition of the hypothalamus. Its etiology, clinical presentation, and management are not well established, with significant overlap and distinctions from hypophysitis. Material and methods This study presents management and outcomes of patients with autoimmune hyp...

Introduction Localizing the source of adrenocorticotropic hormone (ACTH) in patients with ACTH-dependent Cushing’s syndrome (CS) poses significant challenges. There is a pressing need for novel imaging modalities that provide both anatomical delineation and functional confirmation of corticotropinomas. Methods This study utilized a modified form o...

IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory disorder. This report presents a case involving a 35-year-old female patient who exhibited symptoms of headaches and secondary amenorrhea. Upon evaluation, she was diagnosed with hyperprolactinemia, in addition to exhibiting low cortisol levels and inappropriately low adrenocorticotropi...

Comedonal discoid lupus erythematosus (DLE) is a rare variant of chronic cutaneous lupus erythematosus, often posing diagnostic challenges due to its atypical acneiform presentation. We report a case of a 52-year-old male presenting with alopecia and hypertrophic plaques on the scalp, characterized by follicular plugging, open comedones, and dermat...

Background and methods: While leprosy primarily affects adults, childhood leprosy poses unique challenges because of its potential to cause lifelong disabilities and stigma. This is a retrospective record review of all patients aged 15 or below, diagnosed with leprosy, who were registered at the leprosy clinic of our tertiary care center from June...

Autoinflammatory disorders are characterized by dysregulated and disproportionately heightened response of innate immune system (IIS) to molecular patterns associated with damage and pathogens/microbes (DAMPs/PAMPs) with crucial role played by neutrophils and macrophages in disease pathogenesis. They closely resemble connective tissue diseases (CTD...

Background Autoimmune blistering disorders (AIBD) result from the formation of auto-antibodies against adhesion proteins of the skin/mucosa(e). These auto-antibodies can be detected in the bound form in the tissue using direct immunofluorescence (DIF) or blood circulation using enzyme-linked immunosorbent assay (ELISA) or other methods. Objectives...

Introduction Autoimmune bullous diseases (AIBDs) are a group of illnesses characterized by autoantibodies targeting adhesion molecules in the skin and mucosa. Accurate diagnosis of the specific subtype of AIBD is crucial for effective management and predicting prognosis, especially in cases with an increased risk of malignancy. However, differentia...

A painful red eye can be extremely distressing and can be caused by various ophthalmological or dermatological disorders. We hereby report a case of a red, painful eye in a 55-year-old woman suspected to have pemphigus or ocular cicatricial pemphigoid. Acantholytic cells were seen on conjunctival biopsy, and treatment with prednisolone 60 mg/day wi...

BACKGROUND For low-grade Gliomas (LGG), total surgery remains the cornerstone of treatment; recent studies have demonstrated a remarkable improvement in overall survival (OS) when PCV chemotherapy is added to the radiation therapy treatment regimen for patients with low-grade Gliomas. In clinical practice, multi-agent PCV chemotherapy is being repl...

The abuse of illicit drugs causes a myriad of systemic complications. Intravenous (IV) injection of such drugs poses various additional threats, primarily due to the use of excipient materials in them. Pulmonary artery embolism with foreign material and granulomatosis may be encountered in the lungs on histopathological examination in such cases. I...

We present the case of a female in her 70s who presented with a solitary verrucous plaque on her left leg accompanied by painful oral erosions. Various differential diagnoses were considered, like lichen simplex chronicus, hypertrophic lichen planus, and chromoblastomycosis. We diagnosed pemphigus vegetans (PVeg) on a nonintertriginous site through...

Introduction Epidermolysis bullosa (EB) encompasses rare hereditary skin conditions marked by skin fragility, nail dystrophy, and minor trauma-induced skin blisters. This study aims to identify genetic variants in Indian EB patients and examine the relationship between genotypic and phenotypic manifestations. Material and Method EB patients seen c...

Background Prospective research is lacking on the utility of plucked hair outer root sheath direct immunofluorescence (ORS DIF) in the prediction of relapse in pemphigus vulgaris (PV) and the correlation of ORS DIF positivity with serum desmoglein antibody titers. Methods We performed a prospective cohort study enrolling 80 PV patients in complete...

We present a rare case of glioma presenting as a sellar suprasellar mass in a 44-year-old male. He presented with a 6-month history of significant weight loss and erectile dysfunction and a 2-month history of bilateral decrease in vision. Clinically, he had bitemporal hemianopia. He had secondary hypogonadism without the involvement of another horm...

Background Granuloma annulare (GA) is a necrobiotic granulomatous disorder that may sometimes be resistant to treatment, especially the generalised form. Tofacitinib has recently shown promise in the treatment of non-infective granulomatous dermatosis. Objectives In this study, we aimed to evaluate the response of generalised GA to oral tofacitini...

The presented case of tumor-like LV serves as a noteworthy illustration of the diverse clinical manifestations of cutaneous tuberculosis. The rarity of such lesions emphasizes the importance of considering tuberculosis particularly in regions with a high prevalence of the disease. The diagnostic challenge underscores need for a comprehensive clinic...

Epidermolysis bullosa (EB) is a heterogeneous group of genetic disorders characterized by the formation of blisters and/or at the sites of trauma. These heal with post-inflammatory hypopigmentation, scarring, or milia formation. We hereby present a child who presented with widespread hypopigmented atrophic areas, blistering at trauma-prone sites, a...

Pure neuritic leprosy (PNL) often remains underdiagnosed due to the lack of simple, reliable diagnostic tools to detect Mycobacterium leprae. This study aimed to investigate the utility of multiplex polymerase chain reaction (MPCR) in easily accessible and less invasive biopsy sites, including skin biopsy samples and nasal swabs (NSs), to detect M....

Background Mucous membrane pemphigoid (MMP) is a rare subepidermal autoimmune blistering disorder. The clinical and demographic parameters of this disease in Indian patients have not yet been elucidated in detail. Objective We aimed to study the clinical and demographic characteristics, disease course, and treatment aspects of MMP patients. Metho...

This cross-sectional study examines cutaneous inflammatory presentations of chronic granulomatous disease.

Immunotherapy may be a useful tool in the management of leprosy, especially in highly bacillated patients because of immunological memory. This open-label randomized controlled trial assessed changes in the molecular viability assay (esxA and hsp18 transcript expression) and serology (anti-ND-O-BSA levels) in patients with multibacillary leprosy tr...

Dermatological manifestations in chronic granulomatous disease (CGD) include skin infections and sterile cutaneous inflammatory lesions. The objective of this study was to assess the clinical and histopathological features of noninfectious skin lesions in patients with CGD. This was a cross-sectional observational study from January 2022 to June 20...

An 8-year-old male child presented with a history of multiple vesicles and bullae on the ear, nose, upper trunk, lower legs and feet for the past 4 years. There was no history of photosensitivity. There was no history of similar conditions in family members. On examination, the child had erosions with haemorrhagic crusting on the above-mentioned si...

Background: There is scant data on basal cell carcinoma (BCC) in Indian patients. This retrospective study was conducted to explore epidemiology, risk factors, clinical and pathological aspects, and long-term treatment outcomes of BCC in a cohort of North Indian patients. Methods: Data about patients registered in the dermatosurgery clinic between...

In dermatology, lichenoid describes lesions with a violaceous hue that is a clinical reflection of basal cell damage in the epithelium and dense mononuclear infiltrate in the sub-epithelium. The violaceous color results from pigment incontinence due to basal cell damage and the Tyndall effect. Although classically described in lichen planus, a lich...

Folliculocystic and collagen hamartoma (FCCH) is a rare entity, typically documented in males with tuberous sclerosis complex. Here, we report a unique case of FCCH in a 19-year-old female with an unusual presentation in the external genitalia. The patient presented with a progressively enlarging mass over three years, causing difficulties in walki...

Aims: Local failure remains the major concern in grade 4 glioma or glioblastoma (GBM). Pilot studies have shown a radiotherapy (RT) doseeresponse relationship in GBM. Here we present our preliminary data of RT dose escalation using 68 Ga-Pentixafor PET scan. High 68 Ga-pentixafor uptake in glioma cells helps in sharp demarcation between tumour and...

Our case presents a rare case of verrucous discoid lupus erythematosus in a pediatric patient, with a focus on clinical and histopathological features. Our manuscript also discusses differential diagnoses, including papulonecrotic tuberculid, verrucous psoriasis, and pityriasis rubra pilaris, with a focus on histopathological clues for differentiat...

Purpose: The purpose of this study is to report ocular cicatricial pemphigoid (OCP) occurring in young patients. Relevant literature is also reviewed. Methods: Medical records of patients aged 30 years or younger who were treated for OCP between August 2021 and May 2023 at a tertiary care eye institute were reviewed. The most common differential di...

Background Congenital ichthyoses are a rare Mendelian group of disorders affecting the integument with a heterogeneous clinical presentation amongst which scaling is a constant feature. There is scanty epidemiologic data regarding the clinical profile and histologic patterns of inherited ichthyosis from resource-poor countries. Aims and Objectives...

Rosai-Dorfman disease (RDD) is characterized by clonal proliferation of S-100 positive histiocytes, and variable emperipolesis. It commonly affects cervical lymph nodes. The central nervous system (CNS) involvement is extremely rare. We attempted to evaluate the Cyclin D1 expression and frequency of KRAS and BRAF mutations in the RDD involving the...

A woman in her late 50s presented with rapidly progressing, painful nodulo-ulcerative lesions on bilateral forearms that ulcerated and bled within two weeks of onset. She reported low-grade fever, productive cough, epistaxis, myalgias, and bilateral mixed hearing loss. Investigations revealed microcytic hypochromic anemia, elevated erythrocyte sedi...

Background: Myocarditis, an inflammatory condition, may result from multifactorial causes but in association with lymphoma is an extremely rare presentation. We report a nodal anaplastic lymphoma kinase (ALK) positive anaplastic large-cell lymphoma (ALCL) case in a young adult who was detected with systemic dissemination and showed findings of myoc...

A 60‐year‐old female with diabetes and hypothyroidism presented with a 2‐year history of asymptomatic elevated lesions on the dorsum of her hands.

Background: Human leukocyte antigen (HLA) allele frequencies have a known association with the pathogenesis of various autoimmune diseases. Methods: We recruited 31 Indian patients of acquired dermal macular hyperpigmentation (ADMH) and 60 unrelated, age-and-gender-matched healthy controls. After history and clinical examination, 5 ml of blood i...

We describe a rare case of severe dermatitis multiple allergies and metabolic wasting (SAM) syndrome with a novel mutation in dsg1 with histology showing psoriasiform pattern. The study underscores the importance of genetic testing for conclusive diagnosis. Treatment challenges, including unresponsiveness to acitretin and subsequent use of cyclospo...

Dear Editor, Leprosy, primarily affecting skin and nerves, is a slowly progressing infectious disease caused by Mycobacterium leprae and Mycobacterium lepromatosis.¹ Diagnosis is typically based on WHO cardinal signs, including hypopigmented or erythematous lesions with sensory loss, nerve thickening with impaired function, and acid fast bacilli (A...

Paget's disease of bone (PDB) usually presents with bone pain and deformities. Herein, we describe a case of PDB who presented with gradually progressive quadriparesis. A man in his forties presented with gradually progressive proximal muscle weakness involving all four limbs. The patient had an elevated serum alkaline phosphatase level and osteosc...

A woman in her 40 s presented with bluish discoloration of palms for 4 years. She also had multiple large joint pains (shoulders and knees) and stiffness of back limiting her mobility. Another woman in her 40 s who presented with bluish discolouration of palms and soles, progressive backache and knee, ankle and shoulder joint pains for 9 years.

Lupus vulgaris manifests with diverse clinical presentations, although the typical pattern involves a plaque that extends at one end and heals at the other, leaving behind characteristic atrophic scarring. Cribriform scarring is classically described after the healing of ulcerative pyoderma gangrenosum. In this case report, we present a noteworthy...

Since the introduction of multidrug therapy (MDT), various disabilities/morbidities due to leprosy have been prevented. However, there is a subset of patients in whom the skin lesions do not resolve completely or remain unchanged despite a full course of MDT, which is a great source of anxiety to the patient and their family members. Hence, we trie...

A woman in her 30s had asymptomatic erythematous scaly plaques over the face and proximal extremities. The lesions started as a erythematous papule on the face, which had progressed to larger plaques within 10 years. What is your diagnosis?

Acute lymphoblastic leukaemia/lymphoma (ALL) is a systemic disease which primarily involves bone marrow or lymphoid organs. Extranodal presentation of ALL is uncommon, and ALL presenting as a dural mass is exceedingly rare. Here we present a case of primary dural B-cell ALL which was preoperatively diagnosed as meningioma on clinico-radiological gr...

Lymphoplasmacyte-rich meningioma (LP meningioma) is a rare form of grade 1 meningioma. It shows dense lymphoplasmacytic infiltrate, mimicking an inflammatory lesion. We present a case of Lymphoplasmacyte-rich (LP) meningioma in the left parasagittal region in a 47-year-old female. On histological examination, it showed dense lymphoplasmacytic infil...

Background Direct immunofluorescence (DIF) is essential for the diagnosis of sub-epidermal immunobullous diseases (SIBD). Bullous pemphigoid (BP), a sub-epidermal immunobullous disease, shows linear IgG and C3 deposition along the dermo-epidermal junction by DIF. However, similar histological and DIF findings are also seen in epidermolysis bullosa...

Acquired dermal macular hyperpigmentation (ADMH) is a chronic disorder characterised by asymptomatic hyperpigmentation of varying shades of brown‑to‑slate‑grey without antecedent inflammatory lesions. ADMH includes disorders of hyperpigmentation, namely, lichen planus pigmentosus, Riehl’s melanosis (pigmented contact dermatitis) and ashy dermatosis...

Bullous pemphigoid (BP) and mucous membrane pemphigoid (MMP) sometimes have overlapping clinical, histopathological, and direct immunofluorescence (DIF) features in the early stages. Complement deposition is an intrinsic component of the patho-mechanism of BP in contrast to MMP. Hence immunohistochemistry (IHC) for C3d and C4d may be helpful in dif...

Pemphigus vulgaris (PV) is a potentially lethal chronically relapsing autoimmune bullous disorder with intraepithelial lesions affecting the skin and mucous membranes. The prediction of clinical relapse has been studied with conventional skin biopsy and plucked hair direct immunofluorescence (DIF; Daneshpazhooh M, Naraghi ZS, Ramezani A et al. Dire...

Background Rheumatoid Arthritis (RA) is a common systemic inflammatory disease that can present with a plethora of extraarticular manifestations. Many patients with RA from low- and middle-income countries do not get timely and adequate treatment with disease-modifying therapies. This results in the perpetuation of a chronic inflammatory state. Fo...

Context.—: Pituitary neuroendocrine tumors/adenomas are common intracranial tumors that require accurate subtyping because each tumor differs in its biologic behavior and response to treatment. Pituitary-specific transcription factors allow for improved lineage identification and diagnosis of newly introduced variants. Objective.—: To assess the...

Extramammary Paget's disease (EMPD) is a rare intraepithelial adenocarcinoma. To increase awareness and knowledge regarding this rare dermatosis, we hereby reported a case of ulcerated plaque on genitalia.

Background: Oral Squamous cell carcinoma (OSCC) often results in unfavorable outcomes due to locoregional relapse. While circulating tumor cells (CTCs) may be attributed to these locoregional metastases, detecting CTCs and their molecular profiling remains challenging. Here we report a novel strategy for isolating CTCs in OSCC. Secondly, we charact...

Background: Primary neuroendocrine tumors (NETs) of the central nervous system (CNS) are rare, primarily seen in the cauda equina region, known as cauda equina NETs. This study was carried out to evaluate the morphological and immunohistochemical characteristics of cauda equina NETs. Material and methods: All cases of histologically proven NETs...