Dean A. Haycock

Dean A. Haycock
The National Association of Science Writers

Ph.D.

About

36
Publications
5,299
Reads
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1,007
Citations
Introduction
Science writer; National Assoc. of Science Writers, Authors Guild; Books: “Tyrannical Minds, Psychological Profiling, Narcissism, and Dictatorship;” “Murderous Minds, Exploring the Criminal Psychopathic Brain;” “Characters on the Couch, Exploring Psychology Through Literature and Film;” “Everything Health Guide to Schizophrenia;” “Everything Health Guide to Adult Bipolar Disorder.” Articles: Annals of Internal Medicine, Lancet Neurology, Drug Discover & Development, WebMD, CNN.com; BioWorld International. Peer Reviewed Pubs: Brain Res., J. Pharm. Exp. Therapeutics, J. Biol. Chem., J. Neuroscience, J. Exp. Neuroscience, J. Med. Chem., J. Cell Biol.
Skills and Expertise
Additional affiliations
October 1993 - present
The National Association of Science Writers
Position
  • Science and Medical Writer
Description
  • Author: "Murderous Minds: Exploring the Criminal Psychopathic Brain," Pegasus Books, 2014. "The Everything Health Guide to Adult Bipolar Disorder, 3nd edition," & "The Everything Health Guide to Schizophrenia," Adams Media. 2014.
November 1987 - September 1993
Sterling Winthrop Pharmaceutical Research Division/Sanofi
Position
  • Senior Research Investigator
Description
  • Supervised pharmaceutical research in neuropharmacology.
September 1987 - October 1988
Brown University
Position
  • Guest Lecturer
Description
  • Delivered guest lectures "Neuropharmacology of Mental Disorders," "Pharmacology of Cannabinoids," Pharmacology
Education
September 1982 - January 1986
Brown University
Field of study
  • Neuroscience

Publications

Publications (36)
Chapter
It is now clear that many ambitious athletes are motivated to cheat, but unions and employers have reasons not to push too hard for rigorous testing. . . the terms under which these players are tested are negotiated. The results of these negotiations hinder the ability of drug testers to detect drugs.
Chapter
Gender roles are arguably one of the most important elements of society—especially for teens and young adults who are learning roles that are fraught with conflicting expectations, have changed considerably in recent years, and are continuing to evolve. Films and television programs can both reflect and influence our perception of history and socia...
Book
Providing intriguing insights for students, film buffs, and readers of various genres of fiction, this fascinating book delves into the psychology of 100 well-known fictional characters. • Provides an engaging and entertaining way to learn about both positive psychology and mental health issues through the behavior of interesting and often familia...
Book
Today, neuroscientists are imaging, mapping, testing and dissecting the source of the worst behavior imaginable in the brains of the people who lack a conscience: psychopathic individuals. Neuroscientist Dean Haycock examines the behavior of real life psychopathic persons and discusses how their actions can be explained in scientific terms, from re...
Book
If you or a loved one has been diagnosed with bipolar disorder, it can be confusing and overwhelming. What are the most effective treatments? Will therapy help? When will life return to normal? With The Everything Health Guide to Adult Bipolar Disorder, 3rd Edition, you can take charge and manage your condition, or learn the best ways to support yo...
Article
Available in film copy from University Microfilms International. Computer-produced copy. Thesis (Ph. D.)--Brown University, 1985. Vita. Bibliography: leaves 70-79.
Book
Every year in the United States, around 1.3 million people have laser vision correction surgery. Three months after their surgeries, 70 percent of these people feel amazed and delighted with the results. The remaining 30 percent, however, experience side effects that leave them feeling dissatisfied to varying degrees. They may have uncomfortably dr...
Book
The effects of schizophrenia can be devastating for both the 3.3 million adults living with the disease as well as their families and friends. This guide offers help to those who suffer from schizophrenia and their loved ones, including information on how to: Get a correct diagnosis Understand the various types of schizophrenia Handle resulting pr...
Article
Full-text available
Research into bacterial signal transduction could improve antimicrobial drug discovery now and in the future.
Article
Full-text available
Review of "Typhoid Mary: An Urban Historical" by Anthony Bourdain Bloomsbury, 2001
Article
Integration of Damage Signals before Commitment to Death Programmed cell death (apoptosis) is controlled in part by the Bcl-2 family of apoptosis-promoting (Bak, Bax, Bid) and apoptosis-inhibiting (Bcl-2, Bcl-xL) proteins. Beginning on page 903, Griffiths et al. examine what may be one of the earliest events in apoptosis: the effects of damage sig...
Article
Aminoalkylindoles (AAIs) with potent cannabinoid agonist activity have been synthesized where the aminoalkyl chain is attached to the indole ring via a carbon atom of the cyclic amine.
Article
Full-text available
Indence analogs of pravadoline exhibited antinociceptive activity in several animal models. The inhibition of prostaglandin (PG) synthesis in mouse brain microsomes was diminished in these pravadoline analogs, but they were potent in inhibiting electrically stimulated contractions in the mouse vas deferens (MVD) preparations. Binding studies with l...
Article
Full-text available
WIN 64821, a secondary metabolite produced by Aspergillus sp. (ATCC 74177) was found to inhibit radiolabeled substance P (SP) binding in a variety of tissues, including those of human origin. This compound inhibited, in a competitive manner, the binding of SP with Ki values ranging from 0.24 microM in human astrocytoma U-373 MG cells to 7.89 microM...
Article
A binding assay for WIN 55212-2, an aminoalkylindole (AAI) with antinociceptive activity in rodents, is described. [3H]WIN 55212-2 bound to rat cerebellar membranes with a Kd of 2 nM and a maximum binding of 1.2 pmol/mg of protein. Specific binding in this filtration assay was greater than 90%, saturable, reversible, stereospecific, pH sensitive an...
Article
[3H]Bradykinin binds to intact human IMR-90 fetal lung fibroblasts in a time and dose-dependent manner. Binding equilibrium was attained by 120 minutes at 4 degrees C. [3H]Bradykinin binding was saturable; Scatchard analysis of saturation binding data demonstrated a single binding site having a KD = 1.8 +/- 0.2 nM and a receptor concentration of 17...
Article
Extensive mapping of the cannabinoid receptor in rat brain has been reported recently using synthetic cannabinoids. Another class of compounds, the aminoalkylindoles (AAIs), does not resemble the cannabinoids structurally. Ligand binding data on isolated membranes, however, indicate that AAIs bind to the cannabinoid receptor. The present experiment...
Article
Pravadoline (1) is an (aminoalkyl)indole analgesic agent which is an inhibitor of cyclooxygenase and, in contrast to other NSAIDs, inhibits neuronally stimulated contractions in mouse vas deferens (MVD) preparations (IC50 = 0.45 microM). A number of conformationally restrained heterocyclic analogues of pravadoline were synthesized in which the morp...
Article
Full-text available
Tyrosine hydroxylase, which catalyzes the initial step in catecholamine biosynthesis, is phosphorylated at serines 8, 19, 31, and 40 in intact pheochromocytoma (PC12) cells (Haycock, J.W. (1990) J. Biol. Chem. 265, 11682-11691). After 32Pi labeling of rat corpus striata in vivo or rat corpus striatal synaptosomes, 32P incorporation into tyrosine hy...
Article
We have compared catecholamine synthesis regulation in rat brain olfactory tubercle and hypothalamic synaptosomes with regard to: calcium-dependency of stimulant drug-induced synthesis activation; tyrosine-dependency of amphetamine-induced synthesis stimulation, and the effects of the calcium chelator, ethylene glycol-bis-(beta-aminoethyl ether)N,N...
Article
By inhibiting aromatic L-amino-acid decarboxylase (EC 4.1.1.28) in rat brain striatal synaptosomes, we have been able to measure dihydroxyphenylalanine production via high performance liquid chromatography-electrochemical oxidation. This dihydroxyphenylalanine assay was compared to a standard radioisotopic assay of catecholamine synthesis (14CO2 pr...
Article
A number of investigators have recently used osmotic minipumps to continuously deliver the neurotoxin 6-hydroxydopamine (6-OHDA) to kitten cerebral cortex for periods up to 7 days. Because this compound is known to be particularly labile, we studied the stability of 6-OHDA stored under conditions similar to those found in an osmotic minipump. In 0....
Article
Each segmental ganglion of the leech nervous system has two pairs of lateral roots extending to the body wall and viscera. A cluster of about eight neuron cell bodies is located proximal to the first major branch of each anterior root and is termed the anterior root ganglion (ARG). Only one of these eight cells is vitally-stained by Neutral Red dye...
Article
Each segmental ganglion of the leech nervous system has two pairs of lateral roots extending to the body wall and viscera. A cluster of about eight neuron cell bodies is located proximal to the first major branch of each anterior root and is termed the anterior root ganglion (ARG). Only one of these eight cells is vitally-stained by Neutral Red dye...
Article
In order to characterize the properties of synaptosomal catecholamine formation in a predominantly noradrenergic preparation, we have studied catecholamine synthesis in rat brain hypothalamic synaptosomes. Kinetic analysis revealed an apparent Km for tyrosine of 2.5 microM and an apparent Vmax of 2.1 nmol/h/g. In the hypothalamus, norepinephrine-in...

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Projects (3)
Project
Book publication scheduled for April 3, 2017 (Pegasus Books)
Archived project
Archived project