Dealmy Delgadillo Guzmán

Autonomous University of Coahuila, Unidad Torreón, Mexico. · Pharmacology

Background Mexico has the largest number of the genus salvia plant species, whose main chemical compounds of this genus are diterpenes, these chemical compounds have shown important biological activities such as: antimicrobial, anti-inflammatory and immunomodulatory. Objective This study aimed to evaluate the immunomodulatory activity of three dit...

Background An antigen is a small foreign substance, such a microorganism structural-protein, that may trigger an immune response once inside the body. Antigens are preferentially used rather than a complete attenuated microorganism to develop safe vaccines. Unfortunately, not all antigens are able of inducing an immune response. Thus, new adjuvants...

Metabolic alterations, resulting from factors such as obesity or infections (HIV), generate inflammation in the body, affecting the immune system and causing oxidative stress. Prolonged exposure to antiretroviral therapy (ART) conditions the appearance of alterations considered risk factors for metabolic syndrome (MetS), affecting the quality of li...

Chronic endemic regional hydroarsenicism (CERHA) occurs worldwide, with millions of people exposed to arsenic (As) in drinking water. CERHA is present in north-central Mexico, where As typically exceeds the WHO guideline (10 µg L − 1 ) and Mexican limits (25 µg L − 1 ). Biochemical alterations related to the human As metabolism may increase the ris...

Dengue fever is a disease with a high mortality rate around the world, which is an important issue for the health authorities of many countries. As a result of this, the search for new drugs that are effective to combat this disease has become necessary. Medicinal plants have been used since ancient times to treat a wide list of diseases, including...

Este libro se divide en tres capítulos que guían al estudiante a aplicar los métodos estadísticos para analizar información (de una investigación cuantitativa o cualitativa recopilada, organizada y presentada a través de métodos gráficos o numéricos) con la finalidad de que el estudiante sea capaz de caracterizar y pronosticar el comportamiento de...

Background Immunization or vaccination is the process of inducing artificial immunity against an antigen taking advantage of the mechanisms of immunological memory. Current vaccines include substances known as adjuvants, which tend to improve the immunogenicity of the antigen, reduce the antigen quantity employed, and boost the immune response in w...

Exposure to organophosphorus pesticides is an important public health issue due to a large number of occupationally exposed populations, as well as their effects mainly at the level of the nervous, reproductive, and immune systems. It has been reported that one of the molecular mechanisms by which adverse effects of exposure to organophosphorus pes...

People with HIV face multiple illnesses derived from psychological, social, behavioral and medical factors ., the health problems they face include sleep disturbances, anxiety, depression, malnutrition and tuberculosis. Thus, they resort to the use of substances as an alternative to solve these problems or to improve their quality of life. There is...

Background: The COVID-19 pandemic had infected more than 3.5M people around the world and more than 250K people died in 187 countries by May 2020. The causal agent of this disease is a coronavirus whose onset of symptoms to death range from 6 to 41 days with a median of 14 days. This period is dependent on several factors such as the presence of c...

Leptin levels and oxidative stress are implicated in obesity risk. Reports of association of leptin gene (LEP) and leptin receptor gene (LEPR) polymorphisms with leptin elevation are contradictory in diverse population. Only a few studies report linkage of obesity with biochemical markers and genetic factors. Objetive: The aim of this study was to...

Leptin levels and oxidative stress are implicated in obesity risk. Reports of association of leptin gene (LEP) and leptin receptor gene (LEPR) polymorphisms with leptin elevation are contradictory in diverse population. Only a few studies report linkage of obesity with biochemical markers and genetic factors. Objective The aim of this study was to...

Background Type 2 diabetes (T2DM) has been associated with deficiencies in serum magnesium level, decreasing insulin sensitivity and glucose metabolism. Glycosylated hemoglobin (Hb1Ac) is a biomarker of glucose values within the half-life of the erythrocyte, that is, 3 months. Low circulating and intracellular magnesium levels can modify glucose me...

Few pharmacological and toxicological studies have been conducted to demonstrate the usefulness and safety of using the Jatropha dioica extract. The aim of this study was to update the state of the art on the chemical composition, pharmacology, and toxicology of the species J. dioica, to find new possible applications. A search of different databas...

Combined antiretroviral therapy has improved quality and life expectancy of people living with human immunodeficiency virus (HIV). However, this therapy increases oxidative stress (OS), which in turn causes alterations in lipid and carbon metabolism, kidney disease, liver cirrhosis, and increased risk of cardiovascular disease. The Klotho gene has...

ANTECEDENTES: De 6 a 14% de las mujeres padecen síndrome de ovario poliquístico. En la práctica clínica este síndrome se subdianostica, circunstancia que deriva en complicaciones propias del padecimiento que incluyen: obesidad, resistencia a la insulina, alteraciones metabólicas e infertilidad. La fisiopatología no se ha definido por completo y en...

People with Diabetes Mellitus often use medicinal plants to treat this metabolic disease that frequently reports complications, such as impaired wound healing. Coriandrum sativum has a wide range of healing properties: antibiotics, antifungals, hypoglycemics and antioxidants to name a few. However, no studies have been conducted on its potential as...

The antigens used in vaccines are usually attenuated or inactivated microorganisms, toxoids or purified particles. The purified particles have a better biosecurity but their capacity to generate an immune response is low, therefore vaccines include adjuvants that seek to improve immunogenicity. Unfortunately, adjuvants have side effects so only alu...

Background Pathogens use multiple mechanisms to disrupt cell functioning in their host and allow pathogenesis. These mechanisms involve communication between the pathogen and the host cell through protein-protein interactions. Protein-protein interactions chains referred to as signal transduction pathways are the processes by which a chemical or ph...

Type 2 diabetes (T2DM) and depression are widespread pathologies throughout the world, with increasing growth. The diagnosis and treatment of both pathologies is affected by their silent presentation and by the lack of adherence to treatment. The molecular pathways involved in its pathogenesis seem to be associated with each other, not only due to...

All TransRetinoic Acid (ATRA) has been extensively studied as an integrating component of endocrine functions in the pancreas. The aim of this study was to evaluate the effects of ATRA on physiopathological biomarkers in an experimental model of rat with type 1 diabetes induced by alloxan (T1D). Twenty Wistar rats were divided equally into five gro...

BACKGROUND. The cesarean surgery is still a commonly used alternative to ending a pregnancy. Nevertheless, the risk of inherent complications during the surgical process makes the use of antibiotics necessary. The purpose of the antibiotic prophylaxis in the surgical procedure is reducing the colonization of microorganisms during the intervention u...

El abuso de sustancias psicotrópicas en el personal médico, frecuentemente es poco abordado por las connotaciones sociales y profesionales implicadas. Más aún, se convierte en un problema que afecta no solo al individuo que lo consume, sino que traspasa hacia el quehacer médico en la toma de decisiones en el tratamiento de sus pacientes. Los mé...

Jatropa dioica (J. dioica) is a plant used in traditional medicine in Mexico. Resins, saponins, an alkaloid and acid oxalic have been found. From stems or roots chewed emanates a latex rich in tannins, which has had in ancestral medicine use as a fixative of teeth. Similarly it has been shown that aqueous extract of the root exerts antibiotic activ...

La farmacología es la rama de la enseñanza de la medicina en la que se enlazan los conocimientos de las llamadas ciencias básicas con los principios de aplicación terapéutica, con el siguiente objetivo: el conocimiento de los mecanismos que los fármacos poseen para la prescripción racional de medicamentos para el tratamiento de patologías. Deberá d...

El término “glucocorticoides” se refiere a la vez las hormonas esteroides naturales como por ejemplo el cortisol y las hormonas sintéticas por ejemplo la dexametasona. La acción fisiológica de los glucocorticoides implica dinamizar los recursos del organismo, para que se pueda adaptar a cambios internos o del medio ambiente que puedan perturbar la...

Resumen: Los plaguicidas organofosforados (POF) poseen una acción anticolinesterásica utilizada como indicador de intoxicación crónica del trabajador agrícola por POF. En esta población, los POF pueden actuar como pro-oxidantes, afectando la actividad de las enzimas antioxidantes y probablemente generar daños crónicos. Objetivo. Determinar la influ...

Organophosphate pesticides (OPs) are considered as negative risk factors for the health POF farm workers. The anticholinesterase action these compounds have been used as an indicator POF chronic OP poisoning. Some authors have suggested that agricultural workers in the Ops can act as pro-oxidants, affecting the activity POF antioxidant enzymes and...

La obesidad es una alteración metabólica multifactorial que incluye los efectos de citocinas como la leptina, la lipoperoxidación (LPX) y la activación de sistemas antioxidantes para contrarrestar los daños celulares. Objetivo: Evaluar la asociación de las concentraciones de leptina y estrés oxidativo en poblaciones mestiza e indígena tepehuana de...

Osteoarthritis (OA), the most common form of arthritis around the world, is a multifactorial degenerative joint disorder characterized by articular cartilage degradation, subchondral bone sclerosis, osteophyte formation, synovial membrane inflammation and afection of extraarticular tissue as tendon, ligaments and articular capsule. Although various...

Background: Obesity is a multifactorial metabolic disorder that involves lipid peroxidation (LPX), activating the antioxidant systems to counteract cellular damage. Objective: To evaluate the correlation between the antioxidant capacity and LPX levels of /eptin, in indigenous Tepehuan and Mestizo populations of the State of Durango. Methods: We...

Ischemic heart disease is a life threatening condition whose prognosis remains poor as current treatments are palliative and the loss of cardiac tissue is not restored. Stem cell therapy appears to be a promising option for myocardial repair after myocardial infarction (MI). Recent experimental and clinical work has suggested that stem cell therapy...

The aim of this study was to assess differences in nutritional status and their association with circulating leptin levels in the indigenous Tepehuán people of Mezquital Durango and Mestizo populations of Durango City, Mexico. A group of 128 volunteers aged 18 through 59 years were recruited for the study: 60 indigenous Tepehuán from Mezquital and...

End-stage renal disease is a cause for death worldwide. Renal transplant is a therapeutic alternative, restricted by the scant number of donors. Function of the donor kidney is under risk of adverse circumstances such as fibrosis, where profibrotic effect of transforming growth factor beta 1 (TGF-β1) plays a key role. Efforts to diminish risks of d...