De-yu Hu

De-yu Hu
West China Collegel of Stomatology · Department of Preventive Dentistry

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171
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Publications

Publications (171)
Article
Full-text available
Background This study aimed to explore the trend and risk indicators for dental caries of children aged 12 years in China based on national oral health survey data in 2005 and 2015. Methods Research data were from the two latest national oral health surveys conducted in mainland China, including 30 and 31 provinces, autonomous regions, and municip...
Article
Objective: The purpose of this study was to assess the associations between the self-reported oral health-related quality of life (OHRQoL) of older Chinese people and their socio-economic status and oral health using data collected in the 4th National Oral Health Survey. Methods: After multistage stratified cluster sampling, 4332 adults aged 65-...
Article
adolescents aged 12 to 15 years based on the 4th National Oral Health Survey and to explore its associated factors. Methods: Students aged 12 to 15 years were recruited using to a multistage stratified random sampling method. All the subjects received oral examination and completed a questionnaire. Information relating to OHRQoL was collected thr...
Article
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Background The relationship between dental caries and periodontal disease is still controversial. The objective of this study was to explore the relationship between different types of caries and periodontal disease severity in middle-aged and elderly people in China. Methods The study population consisted of 4407 middle-aged and 4117 elderly subj...
Article
Full-text available
Background: The relationship between dental caries and periodontal disease is still controversial. The objective of this study was to explore the relationship between different types of caries and periodontal disease severity in middle-aged and elderly people in China. Methods: The study population consisted of 4407 middle-aged and 4117 elderly sub...
Article
Full-text available
Comprehensive research on ethnic disparities in dental caries in China is limited. The aims of this cross-sectional study were to compare the levels of dental caries in adolescents between the Han ethnic group and ethnic minority groups in China and to explore the risk indicators for dental caries within ethnic subgroups. Data from the Fourth Natio...
Preprint
Full-text available
Background: To explore the relationship between different types of caries and periodontal disease severity in middle-aged and elderly people in China. Methods: The study population consisted of 4,387 middle-aged and 3,225 elderly subjects. Caries was divided into three types: type A, crown caries; type B, lesions involving both the crown and root,...
Preprint
Full-text available
Background: The relationship between dental caries and periodontal disease is still controversial. The objective of this study is to explore the relationship between different types of caries and periodontal disease severity in middle-aged and elderly people in China. Methods: The study population consisted of 4,387 middle-aged and 3,225 elderly su...
Article
Background: The objective of this study was to compare a stannous fluoride (SnF2) dentifrice (Colgate TotalSF) stabilized with zinc phosphate with a sodium fluoride control dentifrice for gingivitis and plaque control over a 6-month period. Methods: One hundred adult participants were enrolled in this study conducted in Chengdu, China. After ran...
Article
Full-text available
The current social and economic transformation in China, which includes improved life expectancy, “super-speed” aging, mass urbanization, and the abrogation of the one-child policy, has made health promotion the first priority for sustainable economic and social development of China. Since 2016, the Chinese government has released a series of healt...
Article
Objectives: The objective of this independent, double-blind clinical study was to assess the efficacy of a new Dual Zinc plus Arginine dentifrice (Colgate-Palmolive Co., New York, NY, USA) containing zinc (zinc oxide, zinc citrate) 0.96%, 1.5% arginine, and 1450 ppm F as sodium fluoride in a silica base for the 12-hour overnight oral malodor reduc...
Article
Objective: To investigate the dental caries status and related factors in Chinese elderly people, using data from the 4th National Oral Health Survey of China. Methods: In this cross-sectional study, a multistage, cluster strategy was used to recruit 4,431participants (2,222 male and 2,209 female) aged 65 to 74 years from all 31 provinces, auton...
Article
Objective: To investigate the prevalence and severity of dental caries among pre-school children in China as part of the 4th National Oral Health Survey. Methods: The sampling process was conducted with a multistage stratified cluster method. A total of 40,360 children aged between 3 and 5 years were recruited for this study. Each participant wa...
Article
Objective: To explore the prevalence and associated risk indicators of dental fluorosis in the mainland of China. Methods: Data for this study was obtained from the 4th National Oral Health Survey in China, conducted from 2015 to 2016. The sample population was 12-year-old school students. Study participants were selected using a multi-stage, st...
Article
Objective: To investigate the periodontal health status and associated factors of adolescents aged 12 to 15 years old in China. Methods: A cross-sectional national oral health survey was conducted in 2015-2016. The multi-stage stratified cluster sampling was used to select participants in all 31 provinces, autonomous regions and municipalities i...
Article
Objective: To investigate the differences in distribution of root caries and related factors between middle-aged and elderly people in China. Methods: In this cross-sectional study, a multistage, cluster strategy was used to recruit 4,410 participants (2,197 males and 2,213 females) aged 35 to 44 years and 4,431 participants (2,222 males and 2,2...
Article
Objective: To investigate the dental caries status of teenagers in China by means of analysing national data from the 4th National Oral Health Survey of China. Methods: Data for 12- to 15-year-olds participated in the 4th National Oral Health Survey of China were used for statistical analysis. Children who were recruited in the survey completed...
Article
Full-text available
Oral disease patterns change over time and it is important to conduct epidemiological surveillance population surveys regularly to monitor the situation. The overall objectives of the present survey were: (1) to describe the oral health status of Chinese children and adults in the 2015-2016 4th National Oral Health Survey; (2) to investigate the or...
Article
Objective: To explore the clinical and socio-demographic factors influencing oral health-related quality of life (OHRQoL) of Chinese adults in the 4th National Oral Health Survey. Methods: Multistage stratified cluster sampling and PPS method were used in sampling and 4720 adults aged 35 to 44 years were recruited. The study subjects completed a...
Article
Objective: To investigate the oral health status and related factors of 12-year-olds from regions with and without coverage of the National Oral Health Comprehensive Intervention Program in China by means of analysing national data from the 4th National Oral Health Survey. Methods: Data of 12-year-olds participating in the 4th National Oral Heal...
Article
Objective: To evaluate the use of oral health services, the economic burden of oral diseases and related influential factors in China. Method: Using the multistage, stratified, equal proportion, random sampling method in the 4th National Oral Health Survey of China conducted in 2015 to 2016, residents aged 3 to 5 years, 12 to 15 years, 35 to 44...
Article
Objective: To investigate the current status and distribution of resources for oral health in China, by means of analysing national data from the National Investigation of Resources for Oral Health. Methods: The National Investigation of Resources for Oral Health in China was performed in 2015, in parallel with the 4th National Oral Health Surve...
Article
Objective: To assess the current periodontal status of 35 to 44-year-olds from the Chinese population and to analyse potential influence factors on periodontal disease. Methods: The data of subjects were collected from both urban and rural areas of all 31 provinces, autonomous regions and municipalities of the mainland of China, as part of the 4...
Article
Objective: To understand the oral health knowledge, attitude, behaviour and oral health status of Chinese diabetic patients so as to facilitate the development of oral health education programmes for diabetic patients in China. Method: A face-to-face questionnaire was conducted for 1,024 diabetic patients and 8,030 non-diabetic people aged 55 to...
Article
Objective: To investigate the status of tooth loss and denture restoration in Chinese adults, analyse the changing trend and provide fundamental data for oral health policy. Methods: According to the protocol of the 4th National Oral Health Survey, a multistage stratified random cluster-sampling method was used to enrol adult subjects aged 35 to...
Article
Objective: To investigate the prevalence and intra-oral distribution of dentine hypersensitivity (DH) and to evaluate the related risk factors. Material and methods: A total of 1320 subjects, aged between 20 and 69 years old, were selected from six communities in the urban areas of Xi’an, China. The data were collected by conducting individual inte...
Article
Full-text available
Novel ursolic acid derivatives were synthesized, and their structures were confirmed by MS, IR, 1H NMR and 13C NMR spectral analysis. In vitro antitumor activities of these compounds against MGC-803 (gastric cancer cell) and Bcap-37 (breast cancer cell) human cancer cell lines were evaluated by MTT assay. The pharmacological screening results revea...
Article
Introduction: The objective of this 3-arm parallel randomized trial was to evaluate the effects of a fluoride varnish and a fluoride film on the remineralization of white spot lesions around orthodontic brackets after orthodontic treatment. Methods: Patients who had recently completed orthodontic treatment were randomly assigned to the varnish,...
Article
Objectives Osteochondroma (OC) is rare in the mandibular condyle. The radiographic appearance of this lesion is diverse. Most radiologists and surgeons agree that helical computed tomography (CT) has great diagnostic potential for OC. Cone-beam CT (CBCT) can also afford three-dimensional information, and it is widely used to evaluate oral and maxil...
Article
A series of novel hydrazone derivatives containing pyridine amide moiety were designed, synthesized, and evaluated for their insecticidal activity. Bioassays indicated that some of the target compounds exhibited good insecticidal activities against Nilaparvata lugens (N. lugens), Plutella xylostella (P. xylostella), Mythimna separata (M. separata),...
Article
To assess the ability of fluorescence imaging with reflectance enhancement (FIRE) to quantify early enamel demineralization in vitro. A total of 30 bovine enamel specimens were immersed in demineralizing solution to produce artificial caries. Specimens were examined by FIRE, quantitative light-induced fluorescence (QLF), and polarized light microsc...
Article
This longitudinal study aimed to investigate the caries status of primary and permanent teeth among 6-year-old children in Sichuan Province from 2010 to 2012. A sample that comprised 652 6-year-old children from six different elementary schools (three represented the urban areas, and the other three represented the rural areas) were examined accord...
Article
Purpose: To investigate the clinical efficacy in controlling established gingivitis and dental plaque of a 1450 ppm fluoride as sodium monofluorophosphate (SMFP)/zinc-based dentifrice, as compared to a zinc-free dentifrice with 1450 ppm fluoride as SMFP after six months product use. Methods: A six-month clinical study, with eighty-six (86) subjects...
Article
In this study, a series of 2-mercapto-5-substituted-1,3,4-oxadiazole/thiadiazole derivatives were synthesized and evaluated for their antibacterial activities against rice bacterial leaf blight and tomato bacterial wilt caused by Xanthomonas oryzae pv. oryzae (Xoo) and Ralstonia solanacearum (R. solanacearum) via the turbidimeter test in vitro. Ant...
Article
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To determine whether sugar-free gum can provide remineralization and caries control of active enamel caries lesions compared to baseline (before gum chewing) and to a no-gum group, following daily chewing for 12 weeks by school children; to determine whether chewing frequency can affect the extent of remineralization. A pragmatic cluster-randomized...
Article
Background This in vitro study aimed to assess the ability and efficacy of HX-BGC, a novel bioactive glass-ceramic (SiO2-P2O5-CaO-Na2O-SrO), to reduce dentine tubule permeability.Methods Dentine discs from human third molars were etched and randomly allocated into five groups: Group 1 - distilled water; Group 2 - Sensodyne Repair toothpaste (contai...
Article
Full-text available
The co-infection of rice caused by southern rice black-streaked dwarf virus (SRBSDV) and rice ragged stunt virus (RRSV) was widely found at many regions, such as Yunnan Province, China, and North and Central Vietnam. These rice viral diseases lead to seriously yield loss of rice. In this study, the proteomics technology of shotgun and label free co...
Conference Paper
Objective: To compare the clinical efficacy of Colgate 360 Toothpaste containing 5% small particle silica and 2% Zinc Citrate (test) to Colgate Cavity Protection Toothpaste (negative control) in reducing dentin hypersensitivity after 8-week twice daily brushing. Method: Prior to the study the clinical protocol was reviewed and approved by IRB. Th...
Conference Paper
Objective: The aim of this longitudinal study was to investigate the eruption and dental caries of first permanent molars among schoolchildren in Chengdu, China. Method: A sample of 715 children (mean age 6.7 years) from 6 different elementary schools (3 of them represented urban areas and another 3 represented rural areas) was examined at baseli...
Conference Paper
Objective: Tissue engineering is a potential approach for the repair of damaged tissues or organs. Aligned nanofiber 3D scaffold made it particularly useful for various artificial tissues or organs, such as blood vessel, tendon, nerve, etc, in which cell orientation was crucial for their performance. In this study, aligned cellulose nanofiber 3...
Article
A series of 2,5-substituted-1,3,4-oxadiazole/thiadiazole sulfone derivatives were synthesized and evaluated for their antibacterial activities against rice bacterial leaf blight and leaf streak caused by Xanthomonas oryzae pv. oryzae and Xanthomonas oryzae pv. oryzicolaby via the turbidimeter test in vitro. Antibacterial bioassay results indicated...
Article
The aim of this study was to determine the caries removal effectiveness (CRE) and minimal invasiveness potential (MIP) of four dentine caries removal methods. After carious molars were scanned using micro-computerized tomography (micro-CT), dentine caries were removed by fluorescence aided caries excavation (FACE) technology, laser induced fluoresc...
Article
To investigate whether the long term use of two dentifrices containing arginine, an insoluble calcium compound, and fluoride: (1) 1.5% arginine and 1450 ppm F as sodium monofluorophosphate (NaMFP) in a dicalcium phosphate dihydrate (dical) base, and (2) 8.0% arginine and 1450 ppm F as NaMFP in a calcium carbonate base, results in an increase in ora...
Article
Objetivo Evaluar la capacidad de un nuevo dentífrico con arginina al 1.5% y 1450 ppm de fluoruro para detener y revertir las lesiones naturales de caries vestibular en niños. Diseño del estudio Participantes de Chengdu, en la Provincia de Sichuan en China, probaron tres dentífricos: un nuevo dentífrico con arginina al 1.5%, un compuesto de calcio...
Article
To investigate the expression of transient receptor potential vanilloid 3 (TRPV3) ion channel protein in human odontoblasts (OD). Twenty intact and healthy third molars extracted for orthodontic purpose were included. The quality of dental tissue sections was determined through HE staining, and the OD layer was further determined by dentin sialopho...
Article
Full-text available
The purpose of this study was to assess the ability of a new dentifrice containing arginine, an insoluble calcium compound, and fluoride to arrest or reverse naturally occurring buccal caries lesions measured using Quantitative Light-induced Fluorescence (QLF). Three study groups used dentifrices which contained 1) 1.5% arginine and 1450 ppm fluori...
Article
Full-text available
The purpose of this six-month study was to assess the ability of a new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride, as sodium monofluorophosphate, to arrest and reverse primary root caries lesions in adults. Three test groups used dentifrices which contained either: 1) 1.5% arginine and 1450 ppm fluorid...
Conference Paper
Objective: The aim of this longitudinal study was to investigate the dental caries trend of deciduous teeth among children in kindergarten in Western China. Method: A sample of 600 children (mean age 3.2 years) from 6 different kindergarten (3 of them represented urban areas and another 3 represented rural areas ) was examined at baseline. 361...
Conference Paper
Full-text available
Objective: This study aimed at assessing the effect of chewing-gums (CG) sweetened with SweetPearl® maltitol on tooth mineralisation using the Quantitative Laser induced Fluorescence (QLF) method. Method: In a four-group, double-blinded, randomized controlled clinical trial, 420 children aged 8 to 13 years, with at least one white spot on anterio...
Article
Full-text available
Introduction: Some inevitable problems, such as concentrated bite force and lacked ability of self-renewal, are proved to be the major challenge in the management of implants failures. Thus, it is meaningful to find an ideal dental implant harboring its own peri-implant periodontium, just as the natural teeth. Various studies attempted to reconstru...
Conference Paper
Objective: The objective of this independent, double-blind, overnight and 12 hours daytime clinical study was to assess the efficacy of a dentifrice containing 2% Zinc Citrate (Darlie Expert Fresh, DEF) for the overnight and 12 hours daytime control of oral malodor, relative to a regular fluoride dentifrice (RF) Methods: After a seven-day period...
Article
Full-text available
Objective: To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest and reverse naturally occurring buccal caries lesions in children relative to a positive control dentifrice containing 1450 ppm fluoride alone. Study design: Participants from Chengdu, Sichuan Province, C...
Article
To examine the imaging characteristics of extra-abdominal desmoid-type fibromatosis. The clinical data and imaging findings of 15 patients with extra-abdominal demoid-type fibromatosis confirmed by pathology were retrospectively analyzed, among whom 5 cases were examined by plain CT scan and 4 by contrast-enhanced CT scan; 11 cases were examined by...
Article
To evaluate longitudinally ART sealants placed in Chinese school children under field conditions. 191 ART sealants were placed in 140 children, aged 11-14 years, by five assistant dentists in four secondary schools in Deyang, Sichuan Province, China. Teeth selected for sealing were those with pits and fissures that were deep or showing early enamel...
Conference Paper
Objectives: In a newly developed technology called fluorescence imaging with reflectance enhancement (FIRE), back-scattered reflectance light is used to enhance the fluorescence image of tooth tissue for detecting early dental caries. This research was aimed to assess the ability of FIRE technology quantifying early enamel demineralization in vit...
Conference Paper
Objective: To evaluate dental caries experience among adolescents in Chengdu, China and determine its influnce on oral-health-related quality of life (OHRQoL) among adolescents. Method: A random sample of 768 12-year-old children was selected in rural schools of Chengdu, the capital of Sichuan Province in South-West China and first examined i...
Article
Full-text available
The current study targets the chemical constituents of Caesalpinia decapetala (Roth) Alston and investigates the bioactivities of the isolated compounds. Fourteen known compounds were isolated using column chromatography, and structural identification was performed by physical and spectral analyses. The biological activities of the compounds were a...
Article
Full-text available
Objective: The objective of this eight week, single-center, two-cell, double-blind, and randomized clinical study was to evaluate the dentin hypersensitivity reduction efficacy of a mouthwash using Pro-Argin™ Mouthwash Technology containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride in an alcohol-free base ("Arginin...
Article
Aim: The aim of this paper was to investigate the predictive value of ankle-brachial index (ABI) and blood glucose to estimate mortality in Chinese type 2 diabetes patients. Methods: Chinese type 2 diabetes patients (1706 subjects) were followed up for about 6 years, Results: One thousand four hundred fourteen were included in the final statis...
Article
Summary  Dentine hypersensitivity (DH) is a common condition that is frequently encountered in dental practice. The aim of this multi-centre and cross-sectional study was to establish the prevalence of DH in the general population in China. A total of 6843 subjects were questioned and examined using a triple syringe with a blast of cold air to conf...
Conference Paper
Objective: To evaluate and compare the efficacy in reducing dentine hypersensitivity of a 5% potassium nitrate/ 1450 ppm sodium fluoride dentifrice to a marketed control containing 1450ppm F as sodium monofluorophosphate in a Chinese population. Method: This was a single center, randomised, stratified, examiner-blind, two-arm, parallel group stud...
Article
The present study aims to examine the distribution and gender- and age-specific reference ranges of brachial-ankle pulse wave velocity (baPWV) in Chinese population. A total of 21094 subjects were recruited into a cross-sectional study from June 2007 to June 2008 in China. Participants were divided into three clinical subgroups: 1) subgroup 1: subj...
Article
Pyrazole and hydrazone derivatives possess good insecticidal activities; their substructural units are widely used in pesticide design. In an effort to discover new molecules with good insecticidal activities, a series of pyrazole amide derivatives containing hydrazone substructures were synthesised and bioassayed. Bioassays demonstrated that some...
Article
Full-text available
There have been few studies conducted on the oral health status of illegal drug users in China, affecting the development of preventive and therapeutic approaches. The aim of the present study was to investigate and analyze the oral health status of former heroin users treated with methadone in Chengdu, the capital of Sichuan Province in southweste...
Article
To investigate caries status of primary and permanent teeth among 6-year-old children in Sichuan Province and correlation between caries of deciduous molars and first permanent molars. Referenced to the sampling programme of the third national epidemiological survey of oral health status, a total of 714 children aged 6 were randomly sampled in clus...
Article
Full-text available
To assess the oral debris removal efficacy of two commercial sugar-free chewing gums, based on a newly developed oral debris scoring system. A randomized, examiner-blinded, three-arm crossover study was conducted, with a 1-week washout period between the crossover phases. 42 healthy adults were randomly assigned to sugar-free stick gum (Wrigley's E...
Article
The synthesis of a series of novel α-aminophosphonate derivatives containing benzothiazole and thiourea moieties from substituted 2-aminobenzothiazoles and synthetic intermediates O,O′-dialkylisothiocyanat-(phenyl)methylphosphonates under microwave irradiation has been demonstrated. Several salient features, such as good to excellent yields, shorte...
Article
A series of new sulfone compounds containing the 1,3,4-oxadiazole moiety were designed and synthesized. Their structures were identified by (1)H and (13)C nuclear magnetic resonance and elemental analyses. Antibacterial bioassays indicated that most compounds exhibited promising in vitro antibacterial bioactivities against tobacco bacterial wilt at...
Article
The study was designed to investigate the relationship between ankle-brachial index (ABI) and carotid intima-media thickness (IMT), and provide scientific basis for primary and secondary prevention of atherosclerotic diseases. Participants were recruited for this investigation from Inner Mongolia in China through cluster multistage and random sampl...
Article
To investigate the clinical characteristics and risk factors of dentine hypersensitivity in smaller cities and rural area in Sichuan province. The examinee aged 20 - 69 years old were interviewed and divided into five age groups (20 - 29, 30 - 39, 40 - 49, 50 - 59 and 60 - 69). The random sampling methods were performed in this study. A total of ei...
Article
The aim of this systematic review was to compare the effectiveness of laser therapy with that of topical desensitising agents in treating dentine hypersensitivity. A secondary objective was to determine the safety of laser application according to the relevant studies. A systematic search was performed in the MEDLINE, EMBASE, the Cochrane Central R...