Dawid F. Larysz

University of Warmia and Mazury in Olsztyn · Department of Head and Neck Surgery for Children and Adolescents

Frame-based stereotactic radiosurgery (SRS) has an established role in the treatment of tremor in patients with Parkinson’s disease (PD). The low numbers of studies of frameless approaches led to our prospective phase 2 open-label single-arm clinical trial (NCT02406105), which aimed to evaluate the safety and efficacy of CyberKnife frameless SRS. T...

The neonate skull consists of several bony plates, connected by fibrous soft tissue called sutures. Premature fusion of sutures is a medical condition known as craniosynostosis. Sagittal synostosis, caused by premature fusion of the sagittal suture, is the most common form of this condition. The optimum management of this condition is an ongoing de...

Background: Craniosynostosis (CS) represents a highly heterogeneous genetic condition whose genetic background has not been yet revealed. The abnormality occurs either in isolated form or syndromic, as an element of hundreds of different inborn syndromes. Consequently, CS may often represent a challenging diagnostic issue. Methods: We investigated...

Background: Craniosynostosis (CS) represents a highly heterogeneous genetic condition whose genetic background has not been yet revealed. The abnormality occurs either in isolated form or syndromic, as an element of hundreds of different inborn syndromes. Consequently, CS may often represent a challenging diagnostic issue. Methods: We investigated...

Sagittal synostosis is the most occurring form of craniosynostosis, resulting in calvarial deformation and possible long-term neurocognitive deficits. Several surgical techniques have been developed to correct these issues. Debates as to the most optimal approach are still ongoing. Finite element method is a computational tool that’s shown to assis...

The aim of this study was to carry out a retrospective multicenter study comparing the morphological outcome of 8 techniques used for the management of sagittal synostosis versus a large cohort of control patients. Computed tomography (CT) images were obtained from children CT-scanned for non-craniosynostosis related events (n=241) and SS patients...

Purpose The aim of the study was to assess changes in the upper respiratory tract and sleep quality in patients who were suffering from midfacial hypoplasia and treated with the movement of underdeveloped middle segment of the face with an Le Fort III osteotomy and distraction. Methods In this study patients aged 7-19, suffering from Crouzon syndr...

Objective Craniosynostosis (CS) is the premature fusion of the cranial sutures, occurring either in isolated or syndromic form. Syndromic CS, which was described in over 180 genetic syndromes, accounts for 15–30% of all CS cases and usually originates from mutations within the FGFR1 , FGFR2 , FGFR3 , and TWIST1 genes. However, causative alterations...

Obtaining reliable and high fidelity next-generation sequencing (NGS) data requires to choose a suitable sequencing platform and a library preparation approach, which both have their inherent assay-specific limitations. Here, we present the results of successful adaptation of SureSelect hybridisation-based target enrichment protocol for the sequenc...

The article presents statistical research aiming at the formulation of functions of the child’s head growth in the first year of age. The research group consisted of 129 infants, from 0 to 12 months of age, whose heads were subjected to computer tomography tests within a regular diagnosis of neurological and oncological diseases and other condition...

Craniosynostosis (CS) is a frequent congenital anomaly featuring the premature fusion of 1 or more sutures of the cranial vault. Syndromic cases, featuring additional congenital anomalies, make up 15% of CS. While many genes underlying syndromic CS have been identified, the cause of many syndromic cases remains unknown. We performed exome sequencin...

Purpose: To report the outcomes for 76 patients with penile cancer treated with high-dose-rate brachytherapy (HDR-BT) at a single institution. Methods: Seventy-six patients with penile cancer treated with HDR-BT in our department between October 1998 and September 2018 were analyzed. Seventy underwent interstitial HDR-BT (fractionation dose rang...

Background: Indications to Le Fort 3 level advancement distraction osteogenesis include midface hypoplasia, leading to severe obstructive sleep apnea, orbital hypoplasia as evidenced by varying degrees of proptosis complicated by conjunctival and globe irritation, as well as many craniofacial syndromes with orbito-maxillary hypoplasia such as Crouz...

Aims: To compare the differences in bone mineral density (BMD) at loaded and non-loaded skeletal sites in professional ballet dancers. We hypothesized that in both male and female elite ballet dancers, a significant difference in BMD will be observed between impact and non-impact sites. Methods: 44 elite ballet dancers, 22 men (age 26.4±5.9 yrs)...

Introduction Empirical studies show that belonging to a support group contributes to patient and caretaker empowerment. They also show that support groups significantly help parents and caretakers of ill children reduce stress and better handle the illness. Aim The aim of the study is to expand knowledge of how social media support groups function,...

Background: Craniosynostoses are congenital defects in the construction of the skull involving premature fusion of one or more cranial sutures. Premature fusion of sutures causes characteristic skull deformation(s). This affect the structure and thus the appearance of the entire head and face. The aim of this study was to analyze parents' subjecti...

This article was originally published electronically on 29 May 2018 with incorrect copyright line in the Publisher's internet portal (currently SpringerLink). The copyright line of the article should be "

Craniosynostosis (CS) refers to the group of craniofacial malformations characterized by the premature closure of one or more cranial sutures. The disorder is clinically and genetically heterogeneous and occurs usually as an isolated trait, but can also be syndromic. In 30–60% of patients, CS is caused by known genetic factors; however, in the rest...

This paper presents a morphological analysis of the skull shape in infants under one year of age. Three-dimensional measurements were performed on models generated from images in Mimics software. Subsequently, a multivariate statistical analysis of the measured dimensions was performed to determine key indicators of the skull shape. Eventually it w...

Significance Craniosynostosis is a common congenital malformation resulting from premature fusion of the bones that comprise the cranial vault, requiring surgery in infancy to prevent adverse neurologic outcomes. Eighty-five percent of cases are non-syndromic and of unknown cause. By exome sequencing of families with non-syndromic midline craniosyn...

Introduction The correction of adolescent idiopathic scoliosis (AIS) using the posterior approach is the most common and well-documented technique in medical literature. As with any invasive procedure, it carries the risk of potential neurological complications (NCs). Aim Evaluation of NCs after surgical treatment of AIS and patient satisfaction a...

Introduction Superior mesenteric artery (SMA) syndrome (SMAS) is a relatively rare disease that the etiology is closely related to the anatomy and the topography of the duodenum, aorta, and SMA. Aim To present and analyze the case of a patient who was diagnosed and treated for SMAS after scoliosis surgery. Case study A 13-year-old girl was admitt...

Craniosynostosis is a congenial malformation caused by premature fusion of one or more cranial sutures, leading to abnormal shape of the skull. Non-syndromic craniosynostoses can result in developmental disorders, including speech acquisition delay. The authors have carried out neurologopaedic research on a group of 124 children aged 3 to 59 months...

Introduction: Mechanism of pathogenesis of pituitary adenomas is still unknown and it shows differences in pituitary cells of different origin. The aim of our study was to analyze gene expression profile of pituitary hormone and their precursor genes: PRL, GH, POMC, TSHb, LHb, FSHb and CGA by QPCR in particular types of pituitary adenomas and evalu...

This chapter describes a method of engineering support of preoperative planning of surgical procedureswith the use of engineering tools, such as state-of-the art software formedical image processing, or a finite elementmethod. The procedure of pre-operative planning consists in matching individual cases of incision sites and directions, visualizati...

This article is a continuation of theoretical reflections on discourse disorders in persons with schizophrenia. The theoretical part was presented in Logopedia Silesiana 2. Working with a person suffering from schizophrenia relies on frequent relapses, medical prognosis, no schematic disorders, making it difficult to capture the moment of stabiliza...

Background and purpose: The pathogenesis of cerebral aneurysms still raises some controversies. The aim of this study was to identify morphological, hemodynamic, and clinical independent risk factors for anterior communicating artery (ACoA) aneurysm development. Methods: Computed tomography angiography and transcranial color-coded sonography wer...

Introduction: Mechanism of pathogenesis of pituitary adenomas is still unknown. Gene expression differences in pituitary cells of different origin are not extensively described. Identification of genes specific for pituitary adenomas should enable better understanding of differences in their response to therapy, especially to radiotherapy. Aim: The...

Zaburzenia czynności językowych w przypadku uszkodzeń prawopółkulowych na przykładzie pacjentów po udarach niedokrwiennych Abstract: This article presents the results of researches related to linguistic actions at patients after ischaemia apoplexy having various linguistic disorders of various degree in case of right cerebral hemisphere damages. Th...

Authors of the article undertook an important subject of the correlation of conditions of Down syndrom (its genetic syndrome) with the latest reports from medical world literature. Fragments relating to relationships between Down syndrom and dementative syndroms deserve specialattention (particularly at adults and older people) as well as the indic...

In this article the authors present one of the most frequent clinical syndroms connected with complex dyscranias – the acroce phalosyndactylia of A type, i.e. Apert syndrom. Authors present cases of three children touched by this illness and they will show the disorders of cognitive and communicative functions that aresignificant as regards the wor...

Le Fort III osteotomy is the procedure which is performed In mid-face hyoplasia. This involves the lower parts of the orbit. This condition occures in severe sleep apnea and exophtalmous of the eye globe. The main group of patients are Crouzon , Apret, Pfaifer syndrom and achondroplazya. Each of them has mid-face hyoplasia and breathing problems....

Craniosynostosis is a skull malformation because of premature fusing of one or more cranial sutures. The most common types of craniosynostosis are scaphocephaly (with the sagittal suture fused) and trigonocephaly (with the metopic suture fused). In this paper we describe and discuss how finite element analysis and three-dimensional modeling can be...

The aim of the study was to compare the radiological indicators of effectiveness for hydrocephalus treatment in children operated on under the third year of age with the use of shunt insertion (SI) and endoscopic third ventriculostomy (ETV). The effectiveness was considered in terms of postoperative neurodevelopment in correlation to pre- and posto...

The treatment of large arteriovenous malformations (AVMs) or AVMs involving eloquent regions of the brain remains a challenge. For inoperable lesions, observation, volume-staged radiosurgery or hypofractionated stereotactic radiotherapy (HFSRT) are proposed. The aim of our study was to assess the safety and efficiency of HFSRT for large AVMs locate...

Purpose The aim of our study was to evaluate treatment results and toxicity of stereotactic irradiation for arteriovenous malformations (AVMs) in children. Methods A group of ten consecutive children (four boys and six girls) irradiated between 2002 and 2010 at our institution was included into the study. The mean age at the time of treatment was...

Introduction: The mechanism of pathogenesis of adenomas pituitary is still unknown; differences between pituitary cells of different origin are observed. Identification of genes specific to pituitary adenomas should give better understanding of differences in their response to therapy, especially to radiotherapy. The aim of our study was to indepe...

Craniosynostosis is a birth defect that causes one or more sutures on a baby's head to close earlier than normal. In effect the growing brain determines an abnormal skull shape and, which is more important and more dangerous, it causes an elevated intracranial pressure. The only treatment for children with craniosynostosis is surgical cranioplasty....

Pituitary adenomas are primary, benign CNS tumors. Sporadically, they metastasize or become malignant. However, they can infiltrate adjacent structures even if they are benign and without hormonal activity. Moreover, by compressing adjacent tissues they cause their gradual degradation and, as a result, irreversible CNS damage. Pure endoscopic trans...

Speech therapy should be an integral part of the support for children with craniosynostosis. Knowledge and research pathological deformation of the head in children are presented in this article. Needs should not only focus on the improvement of cranial distortion that results from premature closure of the sutures between the bone of the skull, but...

Scaphocephaly is a type of non-syndromic craniosynostosis with premature fusion of sagittal suture. It is the most common type of craniosynostosis [5]. In the paper the technique of finite element analysis was used to analyze cranial deformation and changes in intracranial pressure, after surgical correction of scaphocephaly. With methods of finite...

Stereotactic radiosurgery is a widely accepted method of treatment for small, surgically inaccessible arteriovenous malformations (AVMs) of the brain. Treatment of large AVMs however is more complicated because of dose-limiting volume of the lesion. Staged-volume or hypofractionated radiosurgery can be the way to deliver a curative dose to an AVM w...

W pracy przedstawiono badania modelowe dotyczące inżynierskiego planowania endoskopowych zabiegów neurochirurgicznych w przypadku patologicznego kształtu głowy u dzieci. Przedwczesne zarośnięcie szwów czaszkowych, czyli kraniosynostoza, wymaga przeprowadzenia zabiegu korygującego ważnego zarówno dla zmiany kształtu czaszki jak i dla prawidłowego ro...

Kraniosynostoza to choroba najczęściej o charakterze wrodzonym, polegająca na nieprawidłowym kształcie główki dziecka. Kraniosynostoza jest spowodowana przedwczesnym zrośnięciem jednego lub kilku szwów czaszkowych. W artykule przedstawiono współczesne metody komputerowego wspomagania leczenia kraniosynostozy polegające na planowaniu zabiegu neuroch...

Epidermal growth factor receptor (EGFR) gene amplification and protein expression in malignant gliomas (anaplastic astrocytoma, AA and glioblastoma, GBL) were suggested to be correlated with the degree of malignancy. Large deletions within the EGFR gene occur frequently in glioma patients. The aim of our study was to analyse EGFR gene expression by...

Craniosynostosis represents premature suture fusion of the fetal and neonatal skull. Pathogenesis of craniosynostosis is complex and probably multifactorial. Growth of skull bones is strictly connected with the expanding growth of the brain and cranial malformations or prematurely fused sutures cause abnormal head shape. In order to diagnose the cr...

The attempt to a new methodology creation, supported neurosurgical correction of trigonocephaly by engineers is presented in this paper. Trigonocephaly is an example of skull deformity, that wrong influence on child physical and psychological development. Conventional procedures in such cases are connected with invasive operation. Up to now neurosu...

The aim of this study was to evaluate the metabolic profile of uninvolved brain tissue after treatment for pediatric brain tumors. A group of 24 patients aged 4-18 years was analyzed after combined treatment for brain tumors. In this group, there were nine medulloblastomas, seven low-grade gliomas, three high-grade gliomas, two ependymomas and thre...

The aim of the study was to evaluate the incidence of postirradiation imaging changes after stereotactic radiosurgery for arteriovenous malformations (AVM) and cerebral cavernous malformations (CCM). A group of 85 patients treated for arteriovenous malformations (62 patients, 73%) and cavernomas (23 patients, 27%) between October 2001 and December...

There are still many important questions about algorithms and clinical scenarios in the context of children with clinical intracranial hypertension symptoms (IHS) without radiological findings. Such conditions could appear in different clinical situations, including slit ventricle syndrome, overdrainage syndrome, normal volume hydrocephalus, or idi...

The aim of the study was the functional neurodevelopmental assessment of children with posterior fossa tumors, specifically examining whether tumor location in particular cerebellar structures determines particular neuropsychological deficits. The examined group consisted of 34 children treated between 1999 and 2007 at the Division of Pediatric Neu...

The attempt to methodology creation supported neurosurgical procedures of deformed skull correction, connected with craniosynostosis is presented in this paper. Typical treatment in such cases is connected with invasive operation. Up to now neurosurgeons during pre-operation planning of bones correction based on their own knowledge and experience s...

The researches supporting neurosurgical correction of children head deformations are presented in this paper. On the basis of computer tomography CT two models were created. Scans helped to generate two models of craniosynostoses: first scaphocephaly and second trigonocephaly. Three-dimensional models of deformed skull were created with use of Mimi...

The attempt to a new methodology creation, supported neurosurgical correction of trigonocephaly by engineers is presented in this paper. Trigonocephaly is an example of skull deformity, that wrong influence on child physical and psychological development. Conventional procedures in such cases are connected with invasive operation. Up to now neurosu...

The aim of the study was to evaluate the effectiveness and skills in BLS and use of automatic external defibrillators (AED) by paramedics from units of the National Fire and Rescue System. One hundred and fifty-eight rescuers participated in the study. They included both volunteers and professionals, and were recruited from 40 different rescue orga...

Multiple injuries are the most frequent cause of death among patients under 40 years of age. Authors present their experiences based on anulysis of 112 patients referred to the Emergency Department of the Specialist Hospital in Sosnowiec by EMS or HEMS as multiply injured patients. The median ISS of this group was 29 and the mean age of the patient...