David Ramos Valcárcel

University of Vigo | UVIGO

Ambient Intelligence has emerged lately as the integrating concept which includes Ubiquitous Computing, Ubiquitous Communication and Intelligent User Interfaces. The real implementation of such concepts is based on the use of new technology and innovative ways of development. Agent Oriented Software Engineering techniques and concepts have been use...

This chapter introduces the definition of an agile process for the INGENIAS methodology. It is based on a well-known development process: Scrum. The process adopts the iterative and fast plan presented originally by the methodology and uses some of the activities and most of the work products of the INGENIAS proposal with the Unified Development Pr...

This chapter introduces the definition of an agile process for the INGENIAS methodology. It is based on a well-known development process: Scrum. The process adopts the iterative and fast plan presented originally by themethodology and uses some of the activities and most of the work products of the INGENIAS proposal with the Unified Development Pro...

Urothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological and genetic levels. Tumor invasiveness (T) and grade (G) are the main factors associated with outcome and determine patient management. A discovery exome sequencing screen (n = 17), followed by a prevalence screen (n = 60), identified new genes mutated in this tumor codi...

Requirements elicitation is a very difficult task when designing multimedia systems because of its special characteristics. The usual requirements specification process in multimedia development starts with the codification of prototype. After, it is analyzed by the customer to decide whether the application is to be constructed or not. This paper...

Association studies are the choice approach in the discovery of the genomic basis of complex traits. To carry out such analysis, researchers frequently need to (1) select optimally informative sets of Single Nucleotide Polymorphisms (SNPs) in candidate regions and (2) annotate the results of associations found by means of genome-wide SNP arrays. Th...

Vertebrates have two cohesin complexes that consist of Smc1, Smc3, Rad21/Scc1 and either SA1 or SA2, but their functional specificity is unclear. Mouse embryos lacking SA1 show developmental delay and die before birth. Comparison of the genome-wide distribution of cohesin in wild-type and SA1-null cells reveals that SA1 is largely responsible for c...

Within the European Higher Education Area (EHEA), the assessment of transversal skills is a major problem, since this assessment is often difficult to quantify and must be done without neglecting the traditional evaluation of specific skills. This paper presents an alternative for this kind of assessment based on the use of a competition among peer...

Multimedia systems, and in particular games, have special characteristics that make the process of obtaining system requirements very difficult. In most cases, an important work of codification is needed in order to obtain a prototype that can be analyzed by the customer and make requirements elicitation easier. This paper proposes a way of facilit...

Lately, serious games are a useful tool to learn how humans interact with each other and their environment. The best serious games are simulations that have the appearance of a game, but whose events and / or processes are non-game. Usually they include business domains and military operations (many games are popular entertainment on the basis of b...

Transcription factors are common targets of epigenetic inactivation in human cancer. Promoter hypermethylation and subsequent silencing of transcription factors can lead to further deregulation of their targets. In this study, we explored the potential epigenetic deregulation in cancer of Ikaros family genes, which code for essential transcription...

Chronic lymphocytic leukaemia (CLL), the most frequent leukaemia in adults in Western countries, is a heterogeneous disease with variable clinical presentation and evolution. Two major molecular subtypes can be distinguished, characterized respectively by a high or low number of somatic hypermutations in the variable region of immunoglobulin genes....

Bisulfite sequencing is a technique that can be combined with next-generation sequencing approaches to analyze DNA methylation patterns in a genome wide scale. The GATK framework is a new Java framework for fast-developing NGS applications including capabilities for automatic shared-memory parallelization. This work presents the design and initial...

Usually people make a visual representation of what they read. This is a fact inherent to their nature. Many efforts have been done in the last years to try to find a direct method to translate a text wrote on a natural language to a graphical representation. Some solutions try to represent mainly a static scene with the objects appearing in the te...

In the development of multimedia environments, it is necessary to create rapid interactive prototypes, which could validate the interface and functionality in a natural way by the production manager. In the world of video game we work with characters (agents), that play a role (roles), interact and perform actions and/or tasks according to their ne...

Nowadays, there is a considerable improvement of development tools in the field of multimedia, although it is not accompanied by the progress in software engineering processes that support it. In the developments based on video games, the concepts used on video games development, are closely related and properly grounded in Agent-Oriented Software...

Traditional development processes do not include dynamic and creative aspects that exist in multimedia development environments. In these domains, creativity, design and animation are non-functional requirements that have great relevance in the final product and are often not considered in the implementation of traditional software. In this article...

Modelos de comportamiento de las redes vehiculares en sus escenarios más representativos, utilizando simulación en la herramienta NCTUns RESUMEN La adaptación al espacio europeo de educación superior es un hecho que debe ser asumido por todos y cuyo proceso se está llevando a cabo. Para proceder a esta adaptación será necesaria la adopción de nuevo...

La adaptación al espacio europeo de educación superior es un hecho que debe ser asumido por todos y cuyo proceso se está llevando a cabo. Para proceder a esta adaptación será necesaria la adopción de nuevos sistemas pedagógicos apoyados en la utilización de nuevas tecnologías informáticas. En este artículo se ofrece una propuesta basada en el desar...

Biological pathways are crucial to much of the scientific research today including the study of specific biological processes related with human diseases. PathJam is a new comprehensive and freely accessible web-server application integrating scattered human pathway annotation from several public sources. The tool has been designed for both (i) bei...

Rap1 is a component of the shelterin complex at mammalian telomeres, but its in vivo role in telomere biology has remained largely unknown to date. Here we show that Rap1 deficiency is dispensable for telomere capping but leads to increased telomere recombination and fragility. We generated cells and mice deleted for Rap1; mice with Rap1 deletion i...

The EMBRACE ( European Model for Bioinformatics Research and Community Education) web service collection is the culmination of a 5-year project that set out to investigate issues involved in developing and deploying web services for use in the life sciences. The project concluded that in order for web services to achieve widespread adoption, standa...

The EMBRACE (European Model for Bioinformatics Research and Community Education) web service collection is the culmination of a 5-year project that set out to investigate issues involved in developing and deploying web services for use in the life sciences. The project concluded that in order for web services to achieve widespread adoption, standar...

Cells have the ability to respond and adapt to environmental changes through activation of stress-activated protein kinases (SAPKs). Although p38 SAPK signalling is known to participate in the regulation of gene expression little is known on the molecular mechanisms used by this SAPK to regulate stress-responsive genes and the overall set of genes...

Gene-expression profiling in B-cell lymphomas has provided crucial data on specific lymphoma types, which can contribute to the identification of essential lymphoma survival genes and pathways. In this study, the gene-expression profiling data of all major B-cell lymphoma types were analyzed by unsupervised clustering. The transcriptome classificat...

Activated B cells reshape their primary antibody repertoire after antigen encounter by two molecular mechanisms: somatic hypermutation (SHM) and class switch recombination (CSR). SHM and CSR are initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues on the immunoglobulin loci, which leads to the genera...

The BioMoby project was initiated in 2001 from within the model organism database community. It aimed to standardize methodologies to facilitate information exchange and access to analytical resources, using a consensus driven approach. Six years later, the BioMoby development community is pleased to announce the release of the 1.0 version of the i...

There is a huge quantity of information generated in Life Sciences, and it is dispersed in many databases and repositories. Despite the broad availability of the information, there is a great demand for methods that are able to look for, gather and display distributed data in a standardized and friendly way. CARGO (Cancer And Related Genes Online)...