David Skoloudik

David Skoloudik
University of Ostrava · Faculty of Medicine

Prof., MD, PhD, FESO

About

275
Publications
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Publications

Publications (275)
Article
In the last decade, ultrasound examination in neurology has been undergoing a significant expansion of its modalities. In parallel, there is an increasing demand for rapid and high-quality diagnostics in various acute diseases in the prehospital setting, the emergency room, intensive care unit, and during surgical or interventional procedures. Due...
Article
Background Despite all the gains that have been achieved with endovascular mechanical thrombectomy revascularization and intravenous thrombolysis logistics since 2015, there is still a subgroup of patients with salvageable brain tissue for whom persistent emergent large vessel occlusion portends a catastrophic outcome. Objective To test the safety...
Article
Objectives The morphology and histological structure of the atherosclerotic plaque seem critical to its stability. Our study aimed to identify the epidemiological, morphological and histological parameters associated with stable and unstable plaques. Materials and Methods The study included 280 plaques harvested from 269 consecutive patients. Epid...
Article
Full-text available
Background and aim Carotid plaque progression contributes to increasing stroke risk. The study aims to identify factors influencing carotid plaque thickness progression after changing the preventive treatment to the ‘treating arteries instead of risk factors’ strategy, that is, change in treatment depending on the progression of atherosclerosis. M...
Article
Shear-wave elastography (SWE) is a novel ultrasound technique for quantifying tissue elasticity. The aim of this study was to identify differences in atherosclerotic plaque elasticity measured using SWE among individuals with symptomatic, asymptomatic progressive and asymptomatic stable carotid plaques. Consecutive patients from the Atherosclerotic...
Article
Introduction Knowledge of the implementation gap would facilitate the use of intravenous thrombolysis in stroke, which is still low in many countries. The study was conducted to identify national implementation targets for the utilisation and logistics of intravenous thrombolysis. Material and Method Multicomponent interventions by stakeholders in...
Article
Objectives Transcranial color‐coded duplex sonography (TCCS) enables to measure blood flow characteristics in cerebral vessels, including vascular resistance and pulsatility. The study aims to identify factors influencing pulsatility (PI) and resistance (RI) indices measured using TCCS in patients with carotid atherosclerosis. Methods Self‐suffici...
Article
Aim: Early identification of patients at higher risk of unstable atherosclerotic plaque development is essential for successful preventive treatment. The aim of the study was to identify the duplex sonography carotid atherosclerotic plaque risk characteristics for plaque progression. Methods: All patients who underwent regular sonographic examinati...
Article
This article describes policy processes that have led to the re-organisation of stroke care in the Czech Republic since 2011, which has been part of a broader process of care concentration in several medical fields. Currently, stroke care is provided by 13 Comprehensive and 32 Primary Stroke Centres. The paper explains factors that supported the re...
Article
Aim: Atherosclerotic carotid artery disease is one of the most common causes of ischemic stroke. As the study of the progression and development of instability of atherosclerotic plaques in vivo is limited, data from in vitro studies can be used to clarify these processes. For these reasons, the authors constructed a hemodynamic model with the poss...
Article
Purpose Cerebral blood flow volume is an important factor for the accurate diagnosis of neurovascular diseases and treatment indication. This study aims to assess correlations of blood flow volume measurements in cervical and intracranial arteries between duplex sonography and quantitative magnetic resonance angiography (qMRA). Materials and Method...
Article
Objectives Hyperechogenicity of the substantia nigra (SN) and abnormal dopamine transporter-single-photon emission computed tomography (DAT-SPECT) are biomarkers commonly used in the assessment of prodromal synucleinopathy. Our goal was: 1) to compare echogenicity of SN in idiopathic REM behavior disorder (iRBD), PD without RBD (PD-noRBD), PD with...
Article
Full-text available
Aim: The aim of a prospective multicenter study was to determine whether the risk of developing a new ischemic brain lesion on control MRI is dependent on some of the characteristics of atherosclerotic plaque detected by duplex sonography, MRI and CTA. Materials and methods: Patients with internal carotid artery stenosis (70–95%) indicated for caro...
Article
Transcranial sonography (TCS) can reveal pathology in brain structures including insula. This study compared insula echogenicity among 22 patients with Wilson's disease (WD), 21 patients with early-onset Parkinson's disease (EO-PD) and 24 healthy patients. Echogenicity of predefined brain structures (insula, lentiform nucleus, caudate nucleus, subs...
Article
Objectives: This study explored the quality of life (QoL) and attitudes to aging in older adults with and without dementia, and ascertained the main factors that predict QoL and attitude to ageing. Methods: A cross-sectional study involving 563 community-dwelling adults with (PwD) and without dementia (PwoD) >60 years of age was conducted in three...
Article
Aim: Intraplaque hemorrhage (IPH) belongs to potential mechanisms of plaque instability subsequently leading to ischemic stroke. Study aims to compare the IPH occurrence in patients with symptomatic (SS), asymptomatic stable (AS) and asymptomatic progressive (AP) internal carotid artery (ICA) stenosis ≥ 50%. Materials and methods: Serial duplex ult...
Article
Full-text available
Introduction: A fear of falling marks an important psychological factor connected with a reduction in the life space of people with dementia. The Czech version of the Falls Efficacy Scale-International (FES-I) has not been validated in patients with early-stage dementia. Methods: The tests were administered to 282 patients with early-stage demen...
Article
Full-text available
Background and Purpose— Many patients with acute ischemic stroke are not eligible for thrombolysis or mechanical reperfusion therapies due to contraindications, inaccessible vascular occlusions, late presentation, or large infarct core. Sphenopalatine ganglion (SPG) stimulation to enhance collateral flow and stabilize the blood-brain barrier offers...
Article
BACKGROUND: Clinical examination, including preand postoperative assessment of olfaction function, should be included in evaluating surgical outcomes in patients with pituitary adenomas. Most of the studies are lacking assessment of olfactory function. - METHODS: A prospective study of 143 patients who underwent surgical resection of pituitary aden...
Article
Background Sphenopalatine ganglion stimulation increased cerebral collateral blood flow, stabilised the blood–brain barrier, and reduced infarct size, in preclinical models of acute ischaemic stroke, and showed potential benefit in a pilot randomised trial in humans. The pivotal ImpACT-24B trial aimed to determine whether sphenopalatine ganglion st...
Article
Full-text available
Aim: Nerve injuries, wound complications and poor cosmetic results still have an important impact on the patient’s outcome after carotid endarterectomy (CEA). The study aimed to compare 30-day morbidity and cosmetic outcome between patients undergoing CEA using short longitudinal incision (SLI) and transverse skin incision (TSI). Patients and meth...
Article
OBJECTIVE: Silent and symptomatic cerebral infarctions occur in up to 34% of patients after carotid endarterectomy (CEA). This prospective study compared the risk of new brain infarctions detected by magnetic resonance imaging (MRI) in patients with internal carotid artery stenosis undergoing CEA with local anesthesia (LA) vs general anesthesia (G...
Article
Background Atrophy of the medial temporal lobe is one of the anatomical hallmarks of Alzheimer's disease (AD). Transcranial sonography (TCS) is able to visualize and measure the MTL. Purpose Study aims to test digital image analysis of MTL image in AD compared to healthy controls. Methods Patients with AD and healthy controls underwent TCS. The m...
Article
Full-text available
Background Cerebral blood flow volume (BFV) is important factor for accurate diagnosis of neurovascular diseases and treatment indication. Study aims to assess correlations of BFV measurements in cervical and intracranial arteries between quantitative magnetic resonance angiography (qMRA) and duplex sonography. Methods Consecutive patients with su...
Article
Full-text available
Abstract Introduction:The presence of silent cerebral infarction (SCI) might cause cognitive dysfunction, psychiatric disorders, clinical stroke and increase mortality. Exact incidence and prevalence of SCI is still not clear. The results of previous published clinical trials vary. The aims of our study were to detect acute and subacute SCI using m...
Article
Background/aims: The aim of this study was to perform a psychometric validation of the Czech version of the Quality of Life - Alzheimer's Disease scale (QoL-AD) for patients with early-stage dementia. Methods: The sample included 212 patient-proxy pairs. For convergent validity, the Czech version of the Bristol Activities of Daily Living Scale (...
Article
Mitochondrial membrane protein-associated neurodegeneration (MPAN) is an autosomal recessive disorder caused by mutation in the C19orf12 gene. We report a compound heterozygous c.[32C>T];[205G>A;424A>G] (p.[Thr11Met];[Gly69Arg;Lys142Glu]) Czech patient who manifested with right foot dystonia, impaired handwriting, attention deficit, and signs of ir...
Article
Carotid stenosis is well-known risk factor for ischaemic stroke or transient ischaemic attack. Plaque features, such as intraplaque haemorrhage, neovascularization, large lipid core, thin or ruptured fibrous cap or inflammation seems to play important role in plaque instability and are related to higher risk of stroke. At present, no single modalit...
Article
Full-text available
Background After a transient ischemic attack (TIA) or minor stroke, the long-term risk of stroke and other vascular events is not well known. In this follow-up to a report on 1-year outcomes from a registry of TIA clinics in 21 countries that enrolled 4789 patients with a TIA or minor ischemic stroke from 2009 through 2011, we examined the 5-year r...
Article
Background: Silent brain infarcts can be detected on magnetic resonance imaging (MRI) in ~22% of patients after coronary angioplasty and stenting (CS). The effect of periprocedural sonolysis on the risk of new brain infarcts during CS was examined. Methods: Patients undergoing elective CS were allocated randomly to a bilateral sonolysis group (7...
Article
Full-text available
Background Quality of life (QoL) is one of the main endpoints in stroke prevention or acute stroke treatment studies. The aim of the current study was to identify risk factors affecting the QoL of patients with carotid stenosis in stroke prevention. Methods Self-sufficient patients (50–80 years of age) with ≥20% carotid artery stenosis followed in...
Poster
Full-text available
The aim of this prospective study was to evaluate the frequency and subtype of microembolic signals (MES) detected using transcranial Doppler monitoring (TCD) in patients undergoing elective coronary angiography, angioplasty, and/or stenting, and examine their correlation with asymptomatic and symptomatic brain ischemic lesions detected on control...
Conference Paper
Full-text available
Background: Silent brain ischemic lesions can bedetected on magnetic resonance imaging (MRI) in as many as 22% of patients after coronary angioplasty and stenting (CS). The effect of periprocedural sonolysis on the risk of new brain ischemic lesions during CS was examined. Material and Methods: Patients undergoing elective CS were allocated randoml...
Article
Full-text available
Background: Endovascular therapy (EVT) with stent retrievers has been shown to be superior and safe (in the anterior circulation) in comparison to intravenous thrombolysis (IVT) alone or no specific therapy. We compared clinical outcome between patients undergoing EVT admitted directly to comprehensive stroke centers (CSCs) and patients transferred...
Article
Context: The Patient Dignity Inventory (PDI) is a valid, reliable screening tool to assess a range of issues that have been reported to affect the sense of dignity in patients with life-limiting conditions. Objectives: We investigated the item characteristics, factor structure, and reliability of the Czech version of the PDI (PDI-CZ) among cance...
Article
Purpose: Comfort promotion plays a significant role in end-of-life patient care. The objective of this study was to determine the utilization rate of comfort supporting nursing activities in end-of-life patients in an institutionalized environment in the Czech Republic in relation to the age of the registered nurses (RNs), length of work experienc...
Article
Full-text available
Introduction: Mechanical thrombectomy (MT) has been established as a standard of care in acute ischaemic stroke. We systematically evaluated all stroke centres conducting MT i. The Czech Republic. Methods: An online questionnaire based. The International Multi-Society Consensus Document was distributed to all such centres to monitor al. The procedu...
Article
Full-text available
Introduction: Mechanical thrombectomy (MT) has been established as a standard of care in acute ischaemic stroke. We systematically evaluated all stroke centres conducting MT in the Czech Republic. Methods: An online questionnaire based on the International Multi-Society Consensus Document was distributed to all such centres to monitor all the proce...
Article
Full-text available
Background: Patients with minor acute ischemic stroke or transient ischemic attack are at high risk for subsequent stroke, and more potent antiplatelet therapy in the acute setting is needed. However, the potential benefit of more intense antiplatelet therapy must be assessed in relation to the risk for major bleeding. The SOCRATES trial (Acute St...
Article
Aim: The study aimed to as sess the quality of life of self-sufficient post-stroke patients compared to control group. Material and methods: Self-sufficient patients examined in a neurosonology laboratory for carotid stenosis, aged 50-80 years, without stroke or severe disease during the last 12 months, without dementia or psychiatric disease inclu...
Article
Early diagnosis of anxiety and depression may be facilitated by the use of neurobiological markers. In depression and panic disorder, transcranial sonography (TCS) has revealed decreased echogenicity of the brainstem raphe (BR). The aim of the present study was to detect whether decreased echogenicity of the BR correlates with personality features...
Article
Introduction: An effective treatment of mental disorders and it'fs development require seeking for their neurobiological markers. Transcranial ultrasonography (TCS) is a brain imaging method, which is able to depict certain brain structures with a high accuracy. In depressive and selected anxiety disorders, it revealed a reduced echogenicity of the...
Article
Transcranial sonography (TCS) enables displaying of intracranial structures in the B-mode. Recently, TCS has been established mostly as a tool for the diagnosis and monitoring of degenerative brain disorders, less frequently also for the diagnosis and monitoring of other intracranial pathologic processes. Transtemporal and transfrontal approaches a...
Article
Full-text available
Background: Carotid endarterectomy (CEA) is a beneficial procedure for selected patients with an internal carotid artery (ICA) stenosis. Surgical risk of CEA varies from between 2 and 15%. The aim of the study is to demonstrate the safety and effectiveness of sonolysis (continual transcranial Doppler monitoring, TCD) using a 2-MHz diagnostic probe...
Article
Full-text available
RNF213/Mysterin has been identified as a susceptibility gene for moyamoya disease, a cerebrovascular disease characterized by occlusive lesions in the circle of Willis. The p.R4810K (rs112735431) variant is a founder polymorphism that is strongly associated with moyamoya disease in East Asia. Many non-p.R4810K rare variants of RNF213 have been iden...
Data
Native brain computed tomography of II-2 in Family 1. (DOCX)
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Repeated MRI imaging (DWI) of II-2 in Family 1. (DOCX)
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CT angiography of II-1 in Family 2 from 2015. (DOCX)
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RNF213 exonic varinats found in total 19 Slovakian or Czech MMD patients. (DOCX)
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MRI imaging (diffusion-weighted imaging, DWI) of II-2 in Family 1. (DOCX)
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MRI imaging (T2-weighted) of II-2 in Family 1. (DOCX)
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Perfusion-computed tomography of II-2 in Family 1. (DOCX)
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MRI imaging (T1-weighted image) of II-2 in Family 1 coronal scan. (DOCX)
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Duplex ultrasound image of II-2 in Family 1. (DOCX)
Data
MRI imaging (FLAIR) of II-1 in Family 2 from 2009 and 2015. (DOCX)
Article
Full-text available
Aim: The aim of the pilot study was to assess correlation between three diagnostic methods contrast transesophageal echocardiography (cTEE), contrast transcranial Doppler (cTCD) and Flow detection system Anazen TM (FDS) - in detecting right-to-left shunts in young patients aged under 55 years with ischemic stroke or transient ischemic attack (TIA)....
Article
Purpose: Transcranial B-mode sonography (TCS) of brain parenchyma is increasingly used as a diagnostic tool for movement disorders. Accordingly, experimental B-Mode Assist software was developed to enable digitized analysis of the echogenicity of predefined brain regions. The aim of the study was to assess the reproducibility of digitized TCS image...