David Seideman

LCG LSS and JUC

The pervasive fibrotic tendency in Oshtoran Syndrome represents a fundamental aspect of its pathophysiology, deeply intertwined with its features of autonomic dysfunction, immune dysregulation, and NTBI (iron) accumulation. Understanding these mechanisms is crucial for developing effective management strategies and improving patient outcomes.

In most practices, clinics and professional societies, a homozygous H63D gene mutation was and is generally considered relatively harmless, since carriers of this mutation very rarely develop classic ferritin-related hemochromatosis. Ferritin levels are usually normal or even rather low in these patients, so everything seems fine. Due to the fragme...

This case report explores the diagnosis and effective management of a mid-aged male patient initially suspected of having Metabolic Syndrome. The use of continuous glucose monitoring (CGM) technology led to a surprisingly bold identification of stress-induced gluconeogenesis associated with PDH cytopathy, necessitating a revision of the initial dia...

Sometimes less is more.

Tramadol might be the most effective drug for patients who are suffering from atypical, catecholamine driven high blood glucose levels. Further research is needed.

In my career as a neuroendocrinologist, focusing on rare and complex cases, I have identified unique patterns in patients suffering from mitochondriopathies, particularly those causing autonomic dysfunctions as a complication. While a comprehensive study is underway to validate these findings scientifically, the urgency of the clinical situation co...

While medical guidelines offer invaluable direction for known diseases, their applicability wanes with rare conditions. The lack of data makes predictions based on known trajectories unfeasible.

While medical guidelines offer invaluable direction for known diseases, their applicability wanes with rare conditions. The lack of data makes predictions based on known trajectories unfeasible. This short paper presents a pragmatic approach.

Flow-chart for a adequate follow-up of patients suffering from rare diseases.

The allure of diagnosing a rare disease cansometimes overshadow the fundamentalprinciples of medical practice.This short paperaims to highlight the challenges and potentialpitfalls of over-diagnosing patients with rarediseases, emphasizing the importance ofexperiential knowledge, intuition, and patient-centered care.

Oshtoran Syndrome, also known as H63D Syndrome Type-3. This rare systemic medical condition is characterized by a cascading progression of various disease processes, leading to a very dangerously broad variety autonomic dysfunctions and consequential structural organ damages. One of its most dangerous aspect is the potential development of a pseudo...

Narcolepsy is a chronic neurological disorder with symptoms that include excessive daytime sleepiness and cataplexy. While the traditional understanding of narcolepsy has been centered on genetic and autoimmune causes, recent studies have begun to explore connections with brain injury and mitochondrial diseases (mitochondriopathies). This paper rep...

In most practices, clinics and professional societies, a homozygous H63D gene mutation was and is generally considered relatively harmless, since carriers of this mutation very rarely develop classic ferritin-related hemochromatosis. Ferritin levels are usually normal or even rather low in these patients, so everything seems fine. Due to the fragme...

The phenomenon of a doctor unknowingly killing a patient due to sociopathic traits is a serious issue that has been reported in the medical field. A sociopath is a person who has a personality disorder characterized by a lack of empathy and remorse, and a tendency to manipulate and exploit others. These traits can be difficult to detect, and a doct...

Since H63D syndrome was first described, the authors of this paper systematically investigated for the first time to what extent the adrenal glands, as an integral part of the HPA and SAM axes, are also affected by damage caused by non-transferrin bound iron (NTBI), a hallmark of H63D syndrome. Due to the rarity of the H63D syndrome, the representa...

Update 2.7 We report the case of a patient who suffers from hypotransferrinemia due to a genetic defect, subsequently suffers organ damage due to non-transferrin bound iron (NTBI) and develops a paradoxical reaction of glucose metabolism as a result of treatment with corticosteroids. To our knowledge, this is the first description of such an effect...

We report the case of a patient who suffers from hypotransferrinemia due to a genetic defect, subsequently suffers organ damage due to non-transferrin bound iron (NTBI) and develops a paradoxical reaction of glucose metabolism as a result of treatment with corticosteroids. To our knowledge, this is the first description of such an effect in the med...

After the short-term administration of 20mg/d prednisolone (orally) in a previously non-steroid-treated patient with iron storage disease, the steroid, which is omnipresent in clinical practice, led to paradoxical foudroyant symptoms, but above all to a reduction of 80% in the extreme narcoleptic symptomatology, not however in the cataplectic compo...

A minority of neurologists is convinced that the disease “dementia praecox” first described by Emil Kraepelin in 1899 is still valid and its annexation by psychoanalysis and later by psychiatry has caused severe damage. The psychoanalytic extremist Eugen Bleuler had successfully annexed all conceivable mental conditions for Freud’s couch therapy an...

A minority of neurologists is convinced that the disease "dementia praecox" first described by Emil Kraepelin in 1899 is still valid and its annexation by psychoanalysis and later by psychiatry has caused severe damage. The psychoanalytic extremist Eugen Bleuler had successfully annexed all conceivable mental conditions for Freud's couch therapy an...

H63D syndrome, now clinically known as Oslo syndrome (synonymous), is considered a very rare disorder that is difficult to recognize due to its multifaceted nature. Even with homozygous mutation of the HFE gene H63D and the simultaneous presence of the typical clinical symptoms, few clinicians dare to care for affected patients. This is inexplicabl...

H63D syndrome, now clinically known as Oslo syndrome (synonymous), is considered a very rare disorder that is difficult to recognize due to its multifaceted nature. Even with homozygous mutation of the HFE gene H63D and the simultaneous presence of the typical clinical symptoms, few clinicians dare to care for affected patients. This is inexplicabl...

The number of diagnoses of mental illness has been increasing for years, especially in the wealthy industrialized nations. What continues to be overlooked is the massive influence of the lobby of the psychotherapeutic "industry", which has long and steadily earned good money from hastily misdiagnosed patients. However, this can be a matter of moder...

Evidence-based medicine has shown for many years that homozygous mutations of the HFE gene H63D are by no means negligible. Not only can it cause, usually after a second hit, rather mild classical hemochromatosis, but it can also cause numerous other disorders of iron metabolism, such as hypotransferrinemia, changes in binding capacity, and others....

King-Kopetzky syndrome (KKS) is a poorly understood neurological disorder which makes it difficult to understand spoken language even though the patient has a normal hearing threshold. There has long been debate about how best to treat patients with King-Kopetzky syndrome. We decided to investigate the effect of hearing aids in this group of patien...

Evidence-based medicine has shown for many years that homozygous mutations of the HFE gene H63D are by no means negligible. Not only can it cause, usually after a second hit, rather mild classical hemochromatosis, but it can also cause numerous other disorders of iron metabolism, such as hypotransferrinemia, changes in binding capacity, and others....

During the development of a vaccine to protect against the Sars-CoV-2 virus, it became apparent that one vaccine in development (Australia) lead to false positive results in the usual tests for HIV1/2 antibodies. The project was subsequently swiftly terminated and the topic disappeared from the attention of science and the media. Howeber, thanks to...

The number of diagnoses of mental illness has been increasing for years, especially in the wealthy industrialized nations. What continues to be overlooked is the massive influence of the lobby of the psychotherapeutic “industry”, which has long and steadily earned good money from hastily misdiagnosed patients. However, this can be a matter of moder...

In 2010, the Iron Disorders Institute published the first seminal article on the underestimated risk of a homozygous HFE gene H63D mutation. This short but important article has lost none of its relevance. Since it is in danger of being forgotten and disappearing from more and more websites, we are publishing a reprint of the still seminal article,...

Vaccinated people think they are completely immune to Covid-19 and cannot infect others. This is a false assumption. In November 2020, Europe was on the brink of a triage situation. Now it's November again, a year later, and the situation has worsened despite vaccination campaigns. What went wrong?

Vaccinated people think they are completely immune to Covid-19 and cannot infect others. This is a false assumption. In November 2020, Europe was on the brink of a triage situation. Now it’s November again, a year later, and the situation has worsened despite vaccination campaigns. What went wrong?

Erectile dysfunction (ED) is what physicians call the inadequate or absent stiffening of the penis despite emotional sexual arousal. More and more men are suffering from such erectile issues. The better we understand the involvement of the central nervous system in various sexual functions, the more we will also understand its determining role in t...

In the case of a suspicious mole on the skin, the question always arises as to whether it is benign or malignant. Is it a harmless mole, a capillary malformation or a basal cell carcinoma, squamous cell carcinoma or even a melanoma? Often the nevus can be assessed just by a close examination of the lesion and a few questions about its origin. Howev...

H63D narcolepsy as a surrogate marker for brain damage in substantia nigra.

A confused public questions whether painkillers and antipyretics have a negative effect in the context of vaccination against Sars-CoV-2. The honest answer is that there is no scientific consensus on this. So what should be communicated to patients in a primary care setting?

Patients suffering from H63D syndrome have a significant incidence of narcolepsy with cataplexy as a symptom. Previous studies have shown that the presence of narcolepsy with cataplexy in the context of H63D syndrome is a surrogate marker for structural brain damage. Now, the aim was to clarify which measures best protect affected patients with cat...

In a study on the prevention of injury in patients with H63D syndrome and cataplexy, statistical analysis revealed an unexpected but clinically highly significant finding. Apparently, in this patient population, an inverse correlation exists between the severity of tic symptomatology on the one hand and narcolepsy with cataplexy on the other hand,...

Patients suffering from H63D syndrome have a significant incidence of narcolepsy with cataplexy as a symptom. Previous studies have shown that the presence of narcolepsy with cataplexy in the context of H63D syndrome is a surrogate marker for structural brain damage. Now, the aim was to clarify which measures best protect affected patients with cat...

A confused public questions whether painkillers and antipyretics have a negative effect in the context of vaccination against Sars-CoV-2. The honest answer is that there is no scientific consensus on this. So what should be communicated to patients in a primary care setting?

In a study on the prevention of injury in patients with H63D syndrome and cataplexy, statistical analysis revealed an unexpected but clinically highly significant finding. Apparently, in this patient population, an inverse correlation exists between the severity of tic symptomatology on the one hand and narcolepsy with cataplexy on the other hand,...

Patients suffering from H63D syndrome have a significant incidence of narcolepsy with cataplexy as a symptom. Previous studies have shown that the presence of narcolepsy with cataplexy in the context of H63D syndrome is a surrogate marker for structural brain damage. Now, the aim was to clarify which measures best protect affected patients with cat...

H63D syndrome is a serious and clinically progressive disorder of iron metabolism caused by non-transferrin-bound iron (NTBI). In 2019, after scientists from around the world joined together to form the H63D Syndrome Research Consortium (a non-profit entity), a consensus paper “H63D Syndrome” was adopted at a meeting in Oslo in December 2019. With...

Multiple sclerosis (MS) is a progressive inflammatory disease of the central nervous system that normally leads to impairment and persistent disability at a rather early age. The observation that physical stress can lead to the onset of reversible neurological symptoms has in the past led to patients being discouraged from doing sports. We investig...

Based on an analysis of anonymized medical records from four hospitals in Asia and Africa, we succeeded in identifying symptoms typical for narcolepsy (with cataplexy) that are regularly overlooked because they are masked by the two severe leading symptoms. Our results do not differ between primary and secondary cases of narcolepsy.

Based on an analysis of anonymized medical records from four hospitals in Asia and Africa, we succeeded in identifying symptoms typical for narcolepsy (with cataplexy) that are regularly overlooked because they are masked by the two severe leading symptoms. Our results do not differ between primary and secondary cases of narcolepsy.

Narcolepsy with cataplexy is an often underestimated disorder in both its primary and secondary forms. As with epilepsy, narcolepsy and cataplexy pose a high risk of injury to the patient. Yet, narcoleptics have historically received poorer care than epileptics with regard to non-pharmacological aids. This “White Paper” informs both professionals a...

Post-inflammatory hyperpigmentation is the most benign cause of brownish discolorations of the skin. For this reason it has been little researched. In times of increasing treatments in the field of cosmetic medicine and simultaneous increased attention to the issue of skin cancer, a lack of knowledge may lead to over-treatment of post-inflammatory...

The majority of seborrheic keratoses can be reliably differentiated clinically from a melanocytic nevus. In case of difficult findings, for example at unusual localization, dermatoscopy is the key method for diagnosis. In the near future, developments in artificial intelligence (A.I.) might help to classify the findings. Initial results from studie...

Narcolepsy is a model disease for many sleep-wake disorders, a dyssomnia. Diagnostically important is the so-called “narcoleptic tetrad”: Daytime sleepiness, cataplexy, sleep paralysis, and hypnagogic hallucinations. Common differential diagnoses are epilepsy, psychoses, pharmacological influences and sleep disorders. The correct diagnosis is often...

H63D syndrome is a phenotype of a homozygous mutation of the HFE gene H63D, which is otherwise known to cause at most mild classical hemochromatosis. H63D syndrome leads to an iron overload in the body (especially in the brain, heart, liver, skin and male gonads) in the form of non-transferrin bound iron (NTBI) poisoning. Hallmark symptoms and caus...

H63D syndrome is a phenotype of a homozygous mutation of the HFE gene H63D, which is otherwise known to cause at most mild classical hemochromatosis. H63D syndrome leads to an iron overload in the body (especially in the brain, heart, liver, skin and male gonads) in the form of non-transferrin bound iron (NTBI) poisoning. Hallmark symptoms and caus...

H63D syndrome is a unique phenotype (clinical picture) of a homozygous mutation of the HFE gene H63D, which is otherwise known to cause at most mild classical hemochromatosis. H63D syndrome is associated with iron overload in the body (especially in the brain, heart, liver, skin and male gonads), but in the form of non-transferrin bound iron (NTBI)...

H63D syndrome is a phenotype of a homozygous mutation of the HFE gene H63D, which is otherwise known to cause at most mild classical hemochromatosis. H63D syndrome leads to an iron overload in the body (especially in the brain, heart, liver, skin and male gonads) in the form of non-transferrin bound iron (NTBI) poisoning. Hallmark symptoms and caus...