David Rojas

David Rojas
University of Chile · Departamento de Ciencias Neurologicas Oriente

MD

About

47
Publications
14,737
Reads
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179
Citations
Citations since 2016
6 Research Items
90 Citations
201620172018201920202021202205101520
201620172018201920202021202205101520
201620172018201920202021202205101520
201620172018201920202021202205101520
Additional affiliations
August 2017 - present
University of Chile
Position
  • Professor (Associate)
August 2006 - August 2017
University of Chile
Position
  • Professor (Assistant)

Publications

Publications (47)
Article
Full-text available
The classification of primary tumors of the Central Nervous System (CNS) has its origin in the morphological description whose histopathological analysis has allowed to identify the cell line involved in these tumors and obtain the recognition of certain characteristics of these lesions and their clinical evolution. The molecular study has come to...
Article
Full-text available
In 2000, Chile introduced profound health reforms to achieve a more equitable and fairer system (GES plan). The reforms established a maximum waiting time between diagnosis and treatment for a set of diseases, described as an opportunity guarantee within the reform. If the maximum waiting time is exceeded , the patient is referred to another (priva...
Article
[Prognostic Value of Granular Pattern of Growth Hormone Secreting Tumors] [Article in Spanish] Felipe Valenzuela 1 , Pablo Villanueva 2 , David Rojas Z 3 , Roger Gejman 4 , Isidro Huete 5 , Romina Zunino 5 , René E Díaz 6 , Nelson Wohllk 6 , Claudia Tissera 7 , Carmen A Carrasco 8 Affiliations PMID: 31859983 DOI: 10.4067/S0034-98872019000700852...
Article
Background: Classification of growth hormone (GH) - secreting tumors by the granular pattern might predict their clinical behavior in acromegalic patients. There are several other prognostic factors. Aim: To compare the features at presentation and cure rates of patients with GH secreting tumors according to the granular pattern, and to define i...
Article
Full-text available
Background Functional recovery after aneurysmal subarachnoid hemorrhage (SAH) remains a significant problem. We tested a novel therapeutic approach with long-chain omega-3 polyunsaturated fatty acids (n-3 PUFAs) to assess the safety and feasibility of an effectiveness trial. Methods We conducted a multicentre, parallel, randomized, open-label pilo...
Article
Full-text available
Los tumores hipofisiarios son un conjunto de lesiones que ocupan la silla turca, siendo el adenoma hipofisiario por lejos la lesión más frecuente. Los adenomas hipofisiarios se manifiestan clínicamente por compresión de las estructuras vecinas y por hiper o hipofunción hormonal. Dependiendo de estas características, su manejo puede ser variable des...
Research
Full-text available
Una guia para el manejo enfocado especialmente en tumores hipofisarios funcionantes y no funcionantes
Article
Introduction: Vestibular Schwannomas (VS) are benign intracranial tumors, for which their current management is a matter of debate, although microsurgical treatment remains the mode of choice in the majority of cases. Objective: To describe the surgical outcome of patients operated on for a VS in a Chilean Public Hospital. Material and method:...
Article
Full-text available
Background: Dopamine agonists (DA) effectively reduce tumor size of macroprolactinomas, with the consequent improvement of eventual visual impairment. Aim: To study the visual outcomes in patients with macroprolactinoma treated with DA. Material and Methods: Retrospective cohort study which included patients with macroprolactinoma controlled at a N...
Article
Full-text available
Background: Dopamine agonists (DA) effectively reduce tumor size of macro-prolactinomas, with the consequent improvement of eventual visual impairment. Aim: To study the visual outcomes in patients with macroprolactinoma treated with DA. Material and Methods: Retrospective cohort study which included patients with macroprolactinoma controlled at a...
Article
Full-text available
Primary pituitary lymphoma in immunocompetent patients is a rare disease and has been described in less than 20 cases. Moreover, low-grade lymphomas constitute only 3% of all primary central nervous system lymphoma. The objective of this report is to report a low-grade primary pituitary lymphoma, diagnostic problems and to give more evidence about...
Article
Full-text available
Study of resistance to chemotherapy mediated by abc transporters in biopsies of glioblastoma multiforme Background: Mortality rate is dramatically high in high-grade brain tumors. The presence of multiple drug resistance transporters in glioblastoma multiforme, has contributed largely to the poor efficacy of targeted therapy against cancer in the c...
Article
Full-text available
Mortality rate is dramatically high in high grade brain tumors. The presence of multiple drug resistance transporters in glioblastoma multiforme, has contributed largely to the poor efficacy of targeted therapy against cancer in the central nervous system. To analyze the percentage of survival and mortality of patients with glioblastoma multiforme...
Article
Full-text available
La acromegalia es una enfermedad crónica causada en la mayoría de los casos por un adenoma hipofisario. Su manejo es complejo por la gran variabilidad de la lesión causante y su repercusión clínica. Los resultados quirúrgicos son pobres, con tasas de remisión de la enfermedad en promedio de un 80% en microadenomas y 50% en macroadenomas. Se present...
Article
Full-text available
Acromegaly is a chronic disease caused in most cases by hypophysiary adenoma. It is of complex management due to the high variability of the causing lesion and its clinical repercussion. Surgical outcomes are poor with remission rates of 80% for microadenomas and 50% for macroadenomas. The author's experience in treating 38 patients with this patho...
Article
Cisternal and ventricular blood predisposes to hydrocephalus and cerebral ischemia after high-grade aneurysmal subarachnoid hemorrhage (HGSAH). We studied the role of lamina terminalis fenestration combined with cisternal blood evacuation in HGSAH. A clinical, prospective, non-randomized study of a series of HGSAH patients (Modified Fisher>or=3) tr...
Article
Full-text available
Melanotic schwannoma is a rare neoplasm, classifiable as a peripheral nerve sheath tumor, and differentiated from a typical schwannoma by heavy pigmentation. Psammoma bodies can be visualized in more than 50% of melanotic schwannomas. Half of patients with such "psammomatous melanotic schwannomas" have Carney complex, a dominantly transmitted autos...
Article
Full-text available
The treatment of choice for acromegaly is surgery that, according to the literature, is curative in 91% of pituitary microadenomas and 73% of macroadenomas. To report the results of surgical treatment in 53 patients with acromegaly. Retrospective review of medical records of all patients with acromegaly, operated between 1984 and 2004. When necessa...
Article
Full-text available
Background: The treatment of choice for acromegaly is surgery that, according to the literature, is curative in 91016 of pituitary microadenomas and 7396 of macroadenomas. Aim: To report the results of surgical treatment in 53 patients with acromegaly. Material and methods: Retrospective review of medical records of all patients with acromegaly, op...
Article
Full-text available
Background: The treatment of choice for acromegaly is surgery that, according to the literature, is curative in 91% of pituitary microadenomas and 73% of macroadenomas. Aim: To report the results of surgical treatment in 53 patients with acromegaly. Material and methods: Retrospective review of medical records of all patients with acromegaly, opera...
Article
Full-text available
We discuss revascularization techniques for complex skull base lesions utilizing high-flow arterial bypass. At present, the radial artery is the donor graft utilized in most circumstances at our institution. The knowledge of revascularization techniques is very important to achieve radical resection in lesions where arterial compromise is documente...
Article
Arterial embolization with cyanoacrylate is commonly used for the treatment of arteriovenous malformations. We report the case of a 40 years old man who four days after an embolization with cyanoacrylate, begins with cough, bloody sputum, and right hemithorax pleuritic pain. Pulmonary embolism was confirmed with chest X ray, CT scan and scyntigraph...
Article
Full-text available
Arterial embolization with cyanoacrylate is commonly used for the treatment of arteriovenous malformations. We report the case of a 40 years old man who four days after an embolization with cyanoacrylate, begins with cough, bloody sputum, and right hemithorax pleuritic pain. Pulmonary embolism was confirmed with chest X ray, CT scan and scyntigraph...
Article
Cavernomas, or cavernous angiomas, are benign vascular hamartomatous malformations; they are almost always located supratentorially in the brain. The prevalence is about 0.1 to 4% of the general population, and they may arise in sporadic or familial forms. The present study analyzes the epidemiological, clinical and outcome characteristics of a ser...
Article
Cavernomas, or cavernous angiomas, are benign vascular hamartomatous malformations; they are almost always located supratentorially in the brain. The prevalence is about 0.1 to 4% of the general population, and they may arise in sporadic or familial forms. The present study analyzes the epidemiological, clinical and outcome characteristics of a ser...

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Projects

Projects (5)
Project
We are developing and implementing prescriptive analytics tools in hospitals in Chile, focusing on scheduling patients in operating rooms.
Project
To detect potential limiting factors for surgical treatment and predict functional outcome. To describe new surgical approaches that provide the optimal exposure. To systematize and homogenize the study and classification of these complex tumors