David Osterbur- Ph.D.
- Managing Director at Harvard Medical School
David Osterbur
- Ph.D.
- Managing Director at Harvard Medical School
About
34
Publications
2,369
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870
Citations
Introduction
Current institution
Additional affiliations
January 2006 - present
January 1988 - present
Publications
Publications (34)
Background: Ensuring the strength of the physician workforce is essential to optimizing patient care. Challenges that undermine the profession include inequities in advancement, high levels of burnout, reduced career duration, and elevated risk for mental health problems, including suicide. This narrative review explores whether physicians within f...
Background:
Evidence-based guidelines and recommendations can be transformed into "If-Then" Clinical Evidence Logic Statements (CELS). Imaging-related CELS were represented in standardized formats in the Harvard Medical School Library of Evidence (HLE).
Objective:
We aimed to (1) describe the representation of CELS using established Systematized...
AIM: To determine the association between dementia and age-related macular degeneration (AMD) using meta-analysis.
METHODS: We searched in the MEDLINE, EMBASE, Web of Knowledge, PsycInfo and Cochrane database of systematic reviews for studies published from March 1959 to March 2018. We included cross-sectional, case-control and cohort studies that...
AIM: To determine the association between dementia and age-related macular degeneration (AMD) using meta-analysis.
METHODS: We searched in the MEDLINE, EMBASE, Web of Knowledge, PsycInfo and Cochrane database of systematic reviews for studies published from March 1959 to March 2018. We included cross-sectional, case-control and cohort studies that...
Objective:
To describe types of recommendations represented in a curated online evidence library, report on the quality of evidence-based recommendations pertaining to diagnostic imaging exams, and assess underlying knowledge representation.
Materials and methods:
The evidence library is populated with clinical decision rules, professional socie...
Objective:
For health information technology tools to fully inform evidence-based decisions, recommendations must be reliably assessed for quality and strength of evidence. We aimed to create an annotation framework for grading recommendations regarding appropriate use of diagnostic imaging examinations.
Methods:
The annotation framework was cre...
Purpose: Clinical decision support tools provide recommendations based on decision rules. A fundamental challenge regarding decision rule-sharing involves inadequate expression using standard terminology. We aimed to evaluate the coverage of three standard terminologies for mapping imaging-related decision rules. Methods: 50 decision rules, randoml...
We posed the question of what services an academic library can best provide to support the NIH Public Access Policy. We approached the answer to this question through education, collaboration, and tool-building. As a result, over the last four years we have engaged over 1500 participants in discussions of public access to research results, forged a...
We posed the question of what services an academic library can best provide to support the NIH Public Access Policy. We approached the answer to this question through education, collaboration, and tool-building. As a result, over the last four years we have engaged over 1,500 participants in discussions of public access to research results, forged...
The paper gives examples of the bioinformatics services provided in a variety of different libraries by librarians with a broad range of educational background and training.
Two investigators sent an email inquiry to attendees of the "National Center for Biotechnology Information's (NCBI) Introduction to Molecular Biology Information Resources" or...
The paper describes collaborations and partnerships developed between library bioinformatics programs and other bioinformatics-related units at four academic institutions.
A call for information on bioinformatics partnerships was made via email to librarians who have participated in the National Center for Biotechnology Information's Advanced Works...
Abstract
Background
Nocturnin was originally identified by differential display as a circadian clock regulated gene with high expression at night in photoreceptors of the African clawed frog, Xenopus laevis . Although encoding a novel protein, the nocturnin cDNA had strong sequence similarity with a C-terminal domain of the yeast transcription fa...
ISI Document Delivery No.: WN215
Histochemical procedures can be used to detect the cellular distribution of iron in the brain. The objective of the present study was to determine if the cellular distribution of iron enrichment is conserved between animals on different branches of the phylogenetic tree. This information can facilitate our understanding of the role of iron enrichme...
In Drosophila melanogaster the yolk protein (YP) genes are normally expressed only in the fat body and follicular epithelium of adult females--never in males or in larvae. We describe here a first step toward a genetic examination of the developmental controls that restrict the activity of the YP genes to adult female tissues. A YP1 promoter that c...
We describe our analysis of IMP-L2, one of a set of six ecdysone-inducible genes in imaginal discs of Drosophila whose transcripts are associated with membrane-bound polysomes. The spatial and temporal patterns of expression of the IMP-L2 transcript were analyzed. This transcript is first expressed in imaginal discs in areas that are precursors of...
ISI Document Delivery No.: G8226
ISI Document Delivery No.: A6643
An extracellular matrix (ECM) lies between the upper and lower epithelial layers of the wing imaginal discs of moths. Organization and composition of this extracellular matrix, as revealed by staining with ruthenium red, tannic acid, and alcian blue, changes in concert with levels of hormones in the haemolymph. The ECM of the wing imaginal disc is...
Ecdysterone stimulates a 2- to 15-fold increase in the synthesis of four small heat-shock proteins (hsp) in Drosophila line S3 cells. This is accompanied by a rapid and coincident increase in the abundance of small hsp transcripts. A parallel in vivo situation is now described in imaginal discs isolated from pupariating larvae. In neither system ar...
Ecdysteroid binding proteins have been found in nuclei of Drosophila melanogaster embryos. Comparison of results derived from Scatchard analysis, analogue binding competition, and sucrose gradient centrifugation has revealed no significant differences between the properties of the putative embryonic receptor and those of the receptor found in imagi...
ISI Document Delivery No.: HF947
ISI Document Delivery No.: HW638
ISI Document Delivery No.: HF947
1.1. Eleven protein systems were investigated via electrophoresis in three color morphs of Asellus brevicauda.2.2. Genetic variability was present in all but two protein systems.3.3. The variability is strongly color dependent with fixed differences occurring at two α-gpdh loci between the white and dark color types.4.4. These and other differences...
Thesis (Ph. D. in Genetics)--University of California, Berkeley, May 1986. Includes bibliographical references (leaves 166-184).
