David Moser

SoniModul AG

Objective: Bilateral stereotactic neurosurgery for advanced Parkinson's disease (PD) has a long history beginning in the late 1940s. In view of improved lesioning accuracy and reduced bleeding risk and in spite of long-standing caveats about bilateral approaches, there is a need to investigate bilateral MR-guided focused ultrasound (MRgFUS) interve...

Background: Trigeminal neuralgia (TN) is a recognized pain condition the treatment of which can be very challenging. Various surgical interventions can be applied in cases of therapy-resistance to drug treatments. The central lateral thalamotomy (CLT) against neurogenic (or neuropathic) pain is based on multiarchitectonic histological as well as ph...

OBJECTIVE In addition to the well-recognized ventral intermediate nucleus (Vim) thalamotomy for the treatment of chronic therapy-resistant essential tremor (ET), an alternative approach targeting the posterior part of the subthalamus was proposed in the 1960s and early 1970s and then was reactualized as cerebellothalamic tractotomy (CTT) with the a...

Background: There is a long history, beginning in the 1940s, of ablative neurosurgery on the pallidal efferent fibers to treat patients suffering from Parkinson's disease (PD). Since the early 1990s, we undertook a re-actualization of the approach to the subthalamic region, and proposed, on a histological basis, to target specifically the pallidoth...

Background: MR-guided focused ultrasound (MRgFUS) offers the possibility of safe and accurate lesioning inside the brain. Until now, most MRgFUS thermal applications have been based on temperature or energy protocols. Experimental studies support however an approach centered on thermal dose control. Objective: To show the technical feasibility and...

Background: MR-guided focused ultrasound (MRgFUS) offers new perspectives for safe and efficient lesioning inside the brain. The issue of target coverage remains primordial and sub-optimally addressed or solved in the field of functional neurosurgery. Objective: To provide an optimized planning and operative strategy to perform a pallidothalamic tr...

Background After 60 years of history in the field of functional neurosurgery, the issue of target coverage remains primordial and sub-optimally addressed and solved. The possibility of intraoperative visualization and monitoring of a selected target heated with MR-guided high intensity focused ultrasound (MRgFUS) offers new perspectives for safe an...

OBJECTIVE Since the first clinical application of the incisionless magnetic resonance–guided focused ultrasound (MRgFUS) technology only small series of patients have been reported, and thus only extrapolations of the procedure-related risks could be offered. In this study, the authors analyze side-effects and targeting accuracy in 180 consecutive...

Already in the late 1960s and early 1970s, targeting of the “posterior subthalamic area (PSA)” was explored by different functional neurosurgical groups applying the radiofrequency (RF) technique to treat patients suffering from essential tremor (ET). Recent advances in magnetic resonance (MR)-guided focused ultrasound (MRgFUS) technology offer the...

Les récentes avancées de la technologie des ultrasons focalisés permettent depuis 2008 la réalisation de lésions cérébrales thérapeutiques sans incision avec une précision et une sécurité jamais atteintes par les techniques stéréotaxiques avec pénétration cérébrale. Elle permet actuellement de proposer aux patients atteints de tremblement essentiel...

Die neuen Entwicklungen der intrakraniellen fokussierten Ultraschalltechnologie erlauben seit 2008 die Durchführung von therapeutischen, inzisionslosen Eingriffen am Gehirn mit einer Präzision und Sicherheit, die durch stereotaktische Methoden mit Penetration des Gehirns niemals erreicht werden konnten. Sie bietet Patienten, die unter chronischen u...

Radiofrequency (RF) subthalamotomies have been proposed since the 1960s to treat patients suffering from Parkinson's disease (PD). Recently, the magnetic resonance (MR)-guided focused ultrasound technology (MRgFUS) offers the possibility to perform subthalamic thermocoagulations with reduced risks and optimized accuracy. We describe here the initia...

The authors would like to highlight the overlap in the Background, Methods and Discussions sections between their article in the Journal of Therapeutic Ultrasound [1] and their previous publication in Neurosurgical Focus [2], published and copyrighted by the American Association of Neurosurgeons. The novel aspects of this article [1] are the demons...

Background The purpose of this study was to describe targeting accuracy in functional neurosurgery using incisionless transcranial magnetic resonance (MR)-guided focused ultrasound technology. Methods MR examinations were performed before and 2 days after the ultrasound functional neurosurgical treatment to visualize the targets on T2-weighted ima...

The object of this study was to describe a method of measuring targeting accuracy in functional neurosurgery using MR imaging and the Stereotactic Atlas of the Human Thalamus and Basal Ganglia. This method should be useful for any functional procedure using these tools or similar ones, and is described here in the specific context of focused ultras...

In this paper an active way linear synchronous motor with multiphase independent supply is presented. The paper is mainly focused on the power electronics and control structure. The whole system, motor, power electronics and control has been built and successfully tested. The obtained results show that the chosen multi DSP master-slave structure al...

In ac-supplied traction systems (e.g., 15 kV, 16.7 Hz), the energy supplied by a conventional transformer results in large volume, high weight, and relatively low efficiency. In this paper, an ac-dc multilevel converter is presented that allows the use of a medium-frequency transformer in the input section of a traction drive. The proposed solution...