David Meiri

David Meiri
Technion - Israel Institute of Technology | technion · Faculty of Biology

PhD

About

59
Publications
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1,176
Citations

Publications

Publications (59)
Article
Full-text available
The therapeutic use of medical Cannabis is growing, and so is the need for standardized and therapeutically stable Cannabis products for patients. The therapeutic effects of Cannabis largely depend on the content of its pharmacologically active secondary metabolites and their interactions, mainly terpenoids and phytocannabinoids. Once harvested and...
Article
Full-text available
Phytocannabinoids possess a wide range of immune regulatory properties, mediated by the endocannabinoid system. Monocyte/macrophage innate immune cells express endocannabinoid receptors. Dysregulation of macrophage function is involved in the pathogenesis of different inflammatory diseases, including inflammatory bowel disease. In our research, we...
Article
CD8+ T cell proliferation and differentiation into effector and memory states are high-energy processes associated with changes in cellular metabolism. CD28-mediated costimulation of T cells activates the PI3K/AKT/mammalian target of rapamycin signaling pathway and induces eukaryotic translation initiation factor 4E-dependent translation through th...
Article
Full-text available
The use of medical cannabis (MC) to treat cancer-related symptoms is rising. However, there is a lack of long-term trials to assess the benefits and safety of MC treatment in this population. In this work, we followed up prospectively and longitudinally on the effectiveness and safety of MC treatment. Oncology patients reported on multiple symptoms...
Article
Full-text available
Medical Cannabis and its major cannabinoids (−)-trans-Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are gaining momentum for various medical purposes as their therapeutic qualities are becoming better established. However, studies regarding their efficacy are oftentimes inconclusive. This is chiefly because Cannabis is a versatile plant rathe...
Article
Background Poor sleep is associated with adverse health consequences and was shown to be associated with subclinically active inflammatory bowel diseases (IBD). Altered sleep patterns in IBD patients were associated with frequent disease flares and lower quality of life. The aim of this study was to assess the effect of cannabis use on sleep qualit...
Article
Full-text available
In the last decades, growing evidence showed the therapeutic capabilities of Cannabis plants. These capabilities were attributed to the specialized secondary metabolites stored in the glandular trichomes of female inflorescences, mainly phytocannabinoids and terpenoids. The accumulation of the metabolites in the flower is versatile and influenced b...
Article
The conversion of solar energy into electrical current by photosynthetic organisms has the potential to produce clean energy. Bio-photoelectrochemical cells (BPECs) utilizing unicellular photosynthetic microorganisms have been studied, however similar harvesting of electrons from more evolved intact photosynthetic organisms has not been previously...
Article
Full-text available
Background: Little research has tested associations of pain and MC use after long-term treatment and through methods that have external validity outside experimental settings. The study examined associations of pain, associated painful experiences, and long-term medical cannabis (MC) use in chronic pain (CP) patients using a naturalistic daily diar...
Article
Full-text available
Background Inflammatory bowel diseases (IBDs) are chronic, idiopathic, inflammatory, gastrointestinal disorders. The endocannabinoid system may have a role in the pathogenesis of IBD. We aimed to assess whether cannabis treatment influences endocannabinoids (eCBs) level and clinical symptoms of IBD patients. Methods Blood samples and biopsies were...
Article
Full-text available
Studies have shown that females are more susceptible to adverse effects (AEs) from conventional drugs. This study aimed to investigate the differences of Medical Cannabis (MC) related AEs between females and males in chronic non-cancer pain (CNCP) patients. This is a cross-sectional study of adult patients licensed for MC treatment who were also di...
Article
Medical cannabis (MC) treatment for chronic pain is increasing, but evidence regarding short-and long-term efficacy and associated adverse effects (AEs) of the different cannabis plant components is limited. Most reports focus on two phytocannabinoids, (-)-Δ 9-trans-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). This study, aimed to identify...
Article
Full-text available
Introduction: Chronic non-cancer pain (CNCP) is one of the most prevalent indications for medical cannabis (MC) treatment globally. In this study, we investigated CNCP parameters in patients during prolonged MC treatment, and assessed the interrelation between CNCP parameters and the chemical composition of MC chemovar used. Methods: A cross-sectio...
Preprint
Conversion of solar energy into electrical current by photosynthetic organisms has the potential to produce clean energy. Previously reported living-organism based bio-photoelectrochemical cells (BPECs) have utilized unicellular photosynthetic microorganisms. In this study, we describe for the first time BPECs that utilize intact live marine macroa...
Article
Aims: Despite reports that medical cannabis improves symptoms in Crohn's disease (CD), controlled studies evaluating disease response are lacking. This study assessed the effect of cannabidiol (CBD)-rich cannabis oil for induction of remission in CD. Methods: In a double-blind, randomized, placebo-controlled single center trial, patients receive...
Article
The marine macroalgae Ulva sp. is considered an ecosystem engineer in rocky shores of temperate waters worldwide. Ulva sp. harbors a rich diversity of associated microbial epibionts, which are known to affect the algae's typical morphological development and 'health'. We examined the interaction between airborne microbes derived from atmospheric ae...
Article
Medical cannabis (MC) policies are currently undergoing rapid changes, with increasingly more jurisdictions around the world legalizing MC for various indications, including chronic pain. These developments make it increasingly likely that the general population, and in particular older populations, will consume cannabis regularly. Indeed, MC treat...
Article
Full-text available
In the last decade the use of medical cannabis (MC) for palliative cancer treatment has risen. However, the choice between products is arbitrary and most patients are using Tetrahydrocannabinol (THC)-dominant cannabis products. In this study, we aimed to assess the short-term outcomes of MC treatment prescribed by oncologists in relation to the typ...
Article
Background: Although studied in a few randomized controlled trials, the efficacy of medical cannabis (MC) for chronic pain remains controversial. Using an alternative approach, this multicentre, questionnaire-based prospective cohort was aimed to assess the long-term effects of MC on chronic pain of various aetiologies and to identify predictors f...
Article
Full-text available
Introduction and aims: Cannabis exposure is becoming more common in older age but little is known about how it is associated with brain health in this population. This study assesses the relationship between long-term medical cannabis (MC) use and cognitive function in a sample of middle-aged and old chronic pain patients. Design and methods: A...
Article
Full-text available
Cannabis or its derivatives are widely used by patients with cancer to help with cancer symptoms and treatment side effects. However, cannabis has potent immunomodulatory properties. To determine if cannabis consumption during immunotherapy affects therapy outcomes, we conducted a prospective observatory study including 102 (68 immunotherapy and 34...
Article
Full-text available
Increasing evidence for the therapeutic potential of Cannabis in numerous pathological and physiological conditions has led to a surge of studies investigating the active compounds in different chemovars and their mechanisms of action, as well as their efficacy and safety. The biological effects of Cannabis have been attributed to phytocannabinoid...
Article
Full-text available
Background: Medical cannabis (MC) treatment for migraine is practically emerging, although sufficient clinical data are not available for this indication. This cross-sectional questionnaire-based study aimed to investigate the associations between phytocannabinoid treatment and migraine frequency. Methods: Participants were migraine patients lic...
Presentation
Full-text available
Proceedings of The 68th ASMS Reboot Conference on Mass Spectrometry and Allied Topics, 2020 June 1st-12th, Online Reboot Conference due to the COVID-19 pandemic.
Article
Full-text available
The therapeutic effect of the Cannabis plant largely depends on the presence and specific ratio of a spectrum of phytocannabinoids. While prescription of medicinal Cannabis for various conditions constantly grows, its consumption is mostly limited to oral or respiratory pathways, impeding its duration of action, bioavailability and efficacy. Herein...
Article
Full-text available
Objective: The aim of this cross-sectional questionnaire-based study was to identify associations between the doses of cannabinoids and terpenes administered, and symptoms of attention deficit hyperactivity disorder (ADHD). Methods: Participants were adult patients licensed for medical cannabis (MC) treatment who also reported a diagnosis of ADHD b...
Article
Full-text available
Objectives Medical cannabis (MC) is increasingly being used for treatment of chronic pain symptoms. Among patients there is also a growing preference for the use of MC to manage sleep problems. The aim of the current study was to examine the associations between use of whole plant cannabis and sleep problems among chronic pain patients. Methods A...
Poster
Full-text available
Background and aims: Although the use of Herbal Cannabis (HC) for chronic pain is rising, scientific evidence for its associations with reduction in analgesics reduction is scarce. The aim of this study is to present the changes from baseline in analgesics consumption during one year of HC treatment. Methods: Patients with chronic pain for whom an...
Article
Full-text available
The therapeutic effect of Cannabis largely depends on the content of its pharmacologically active secondary metabolites, mainly phytocannabinoids, flavonoids and terpenoids. Recent studies suggest of therapeutic effects of specific terpenoids, as well as synergistic effects with other active compounds in the plant. Although Cannabis contains an ove...
Article
Full-text available
The Cannabis plant contains over 100 phytocannabinoids and hundreds of other components. The biological effects and interplay of these Cannabis compounds are not fully understood and yet influence the plant's therapeutic effects. Here we assessed the antitumor effects of whole Cannabis extracts, which contained significant amounts of differing phyt...
Presentation
Full-text available
Proceedings of the 67th ASMS Conference on Mass Spectrometry and Allied Topics, Atlanta, Georgia, June 2-6, 2019.
Article
Full-text available
Background: There has been a significant increase in the use of immunotherapy and cannabis recently, two modalities that have immunomodulatory effects and may have possible interaction. We evaluated the influence of cannabis use during immunotherapy treatment on response rate (RR), progression-free survival (PFS), and overall survival (OS). Subje...
Article
Full-text available
Most clinical studies of Cannabis today focus on the contents of two phytocannabinoids: (-)-Δ9-trans-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), regardless of the fact that the plant contains over 100 additional phytocannabinoids whose therapeutic effects and interplay have not yet been fully elucidated. This narrow view of a complex Canna...
Conference Paper
Full-text available
Introduction The use of medical cannabis (MC) for chronic pain is rising in many parts of the world. In Israel, approximately 32,000 patients are currently licensed to use of medical cannabis, mostly for the relief of chronic pain and 2,000 new licenses are expected to be issued yearly. Although some prospective cohorts on the effectiveness and saf...
Conference Paper
Full-text available
Introduction The use of medical cannabis (MC) for chronic pain is rising in many parts of the world. In Israel, approximately 32,000 patients are currently licensed to use of medical cannabis, mostly for the relief of chronic pain and 2,000 new licenses are expected to be issued yearly. Although some prospective cohorts on the effectiveness and saf...
Article
Full-text available
Background: Although the use of medical cannabis (MC) for chronic pain is rising, scientific evidence on its long-term effectiveness and safety is scarce. Study Aims: The aim of this study was to set up a patient registry on the treatment of MC for the relief of chronic pain in Israel, by prospectively collecting data on the effectiveness and safet...
Poster
Full-text available
The aim of this study was to set up a patient registry on the treatment of MC for the relief of chronic pain in Israel. By prospectively collecting data on the effectiveness and safety of MC.
Conference Paper
Full-text available
Current results from the findings of the Israeli medical cannabis registry for chronic pain treatment: effectiveness and safety measures.
Conference Paper
Full-text available
The substantial therapeutic properties of the Cannabis plant have been known since antiquity, while recently it has been “rediscovered” and applied in many diseases. The most studied active constituent in Cannabis is THC, which was the first cannabinoid to be identified and isolated. This discovery paved the way for research focused on the molecul...
Article
Full-text available
Cellular transformation by oncogenic RAS engages the MAPK pathway under strict spatiotemporal regulation by the scaffold protein KSR-1. Here, we find using a whole genome functional shRNA-based screen, that the guanine nucleotide exchange factor GEF-H1 plays a critical role in a positive feedback loop for the RAS/MAPK pathway independently of its R...
Article
Full-text available
The RhoGEF GEF-H1 can be sequestered in an inactive state on polymerized microtubules by the dynein motor light-chain Tctex-1. Phosphorylation of GEF-H1 Ser885 by PKA or PAK kinases creates an inhibitory 14-3-3-binding site. Here we show a new mode of GEF-H1 activation in response to the G-protein-coupled receptor (GPCR) ligands lysophosphatidic ac...
Article
Cellular transformation by oncogenic RAS engages the MAPK pathway under strict regulation by the scaffold protein KSR-1. Here, we report that the guanine nucleotide exchange factor GEF-H1 plays a critical role in a positive feedback loop for the RAS/MAPK pathway independent of its RhoGEF activity. GEF-H1 acts as an adaptor protein linking the PP2A...
Article
Full-text available
The protein ROF2 from the plant Arabidopsis thaliana acts as a heat stress modulator, being involved in the long-term acquired thermotolerance of the plant. Here we investigate the relationship between the biological function and the structure of ROF2, inferred by circular dichroism (CD) spectroscopy. The far-UV CD spectra, analyzed with the CDPro...
Article
Actin-based stress fiber formation is coupled to microtubule depolymerization through the local activation of RhoA. While the RhoGEF Lfc has been implicated in this cytoskeleton coupling process, it has remained elusive how Lfc is recruited to microtubules and how microtubule recruitment moderates Lfc activity. Here, we demonstrate that the dynein...
Article
Full-text available
Post-translational modification of target proteins by the small ubiquitin-like modifier protein (SUMO) regulate many cellular processes. In this work we show SUMOylation of the heat shock transcription factor, AtHsfA2, in connection with the plant's response to heat stress and acquired thermotolerance. Using the Yeast two hybrid and the bimolecular...
Article
Full-text available
The ROF2 (FKBP65) is a heat stress protein which belongs to the FK506 Binding Protein (FKBP) family. It is homologous to ROF1 (FKBP62) which was recently shown to be involved in long term acquired thermotolerance by its interaction with HSP90.1 and modulation of the heat shock transcription factor HsfA2. In this study, we have demonstrated that ROF...
Article
Full-text available
Lfc is a guanine nucleotide exchange factor (GEF) for Rho that demonstrates an unusual ability to associate with microtubules. While several phosphorylated residues have been detected in the Lfc polypeptide, the mechanism(s) by which phosphorylation regulates the exchange activity of Lfc remains unclear. We confirm that Lfc is a phosphorylated prot...
Article
Full-text available
Arabidopsis ROF1 (AtFKBP62) is a peptidyl prolyl cis/trans isomerase and a member of the FKBP (FK506 binding protein) family. ROF1 expression is induced by heat stress and developmentally regulated. In this study, we show that ROF1 binds heat shock proteins HSP90.1 via its tetratricopeptide repeat domain, and localizes in the cytoplasm under normal...

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Projects (3)
Project
The use of medical cannabis for therapeutic applications among cancer patients, predominantly for nausea, pain relief, and loss of appetite, becomes highly prevalent in the last decade. Though cannabis has immunomodulatory effects, and its consumption among cancer patients needs to be carefully considered due to its potential effects on the immune system. The aim of this project is to evaluate the overall impact of chronic use of cannabis on the immune system and to understand its therapeutic use in better and safer clinical and Medical indications .
Project
In this project, we aim to investigate the effectiveness and safety of herbal medical cannabis (MC) in the treatment of a large and heterogeneous population of oncology patients. Additionally, we will try to identify predictors for treatment success.
Project
To asses the pain reduction properties and safety for the tretment of medical cannabis for chronic pain patients and to identify predictors for success\failure of medical cannabis treatment.