David Martinez-Lopez

Universidad de La Rioja (Spain) | UNIRIOJA · Chemistry

Donor–Acceptor Stenhouse Adducts (DASAs) are playing an outstanding role as innovative and versatile photoswitches. Until now, all the efforts have been spent on modifying donor and acceptor moieties, to modulate the absorption energy and improve the cyclization and reversion kinetics. However, there is a strong dependence on specific structural mo...

Aminoazobenzene derivatives with four ortho substituents with respect to the N–N double bond are a relatively unexplored class of azo compounds that show promise for use as photoswitches in biology. Tetra- ortho -methoxy-substituted aminoazobenzene compounds in particular can form azonium ions under physiological conditions and exhibit red-light ph...

Aminoazobenzene derivatives with four ortho substituents with respect to the NN double bond are a relatively unexplored class of azo compounds that show promise for use as photoswitches in biology. Tetra- ortho methoxy aminoazobenzenes, in particular, can form azonium ions under physiological conditions and exhibit red-light photoswitching. Here, w...

Photocontrolling the activity of biomolecules is a promising field to selectively target specific cells or tissues. Here, we present a rational design of novel photoactive molecules which combine a metronidazole‐like moiety, responsible of the cytotoxic activity, and a photoswitchable unit. The proposed compounds stand out for their easy synthesis...

A series of photoswitchable compounds based on the antibiotics nalidixic acid and ciprofloxacin has been designed and prepared. Different photoactive moieties have been used as templates in order to allow for the photocontrol of the antimicrobial properties while providing the adequate photophysical features and solubility required for practical ap...

In spite of a considerable interest in the design of molecular switches towards photo-controllable (bio)materials, few studies focused on the major influence of the surrounding environment on the switches photoreactivities. We present a combined experimental and computational study of a retinal-like molecular switch linked to a peptide, elucidating...

The synthesis and photophysical behavior of an unexplored family of GFP-like chromophore analogs is reported. The compound p-HBDNI (2a) exhibits significantly enhanced fluorescence properties relative to the parent compound p-HBDI (1). p-HBDNI was considered as a model system and the photophysical properties of other novel 2-amino-3,5-dihydro-4H-im...

The synthesis and photophysical behavior of an unexplored family of green fluorescent protein (GFP)-like chromophore analogues is reported. The compound (Z)-4-(4-hydroxybenzylidene)-1-propyl-2-(propylamino)-1H-imidazol-5(4 H)-one (p-HBDNI, 2 a) exhibits significantly enhanced fluorescence properties relative to the parent compound (Z)-5-(4-hydroxyb...

The synthesis, photochemical and photophysical properties, and photoisomerization mechanism of the title compounds are reported.

Neutral rhodopsin-based molecular photoswitches can be activated by using low-energy visible light through sensitized irradiation. The triplet state of the neutral and protonated forms are studied and compared by the use of different experimental conditions, laser flash photolysis, and theoretical calculations. The use of common, visible light abso...

A new family of molecular photoswitches based on arylidenehydantoins is described together with their synthesis, photochemical and photophysical studies. A series of hydantoin derivatives have been prepared as single isomers using a simple and versatile chemistry in good yields. Our studies show that the photostationary states of these compounds ca...

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