David Manset

David Manset
Gnubila / Beys Research

DPhil & MBA

About

67
Publications
8,685
Reads
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608
Citations
Introduction
Founder and CEO of a French innovative company in Cloud computing, I have consolidated experience in setting up a structure, creating a team, devising operational processes and pursuing a long-term vision. I started my journey in 2002 at CERN, where I could forge my multi-cultural working experience in the context of a D. Phil in the Model Driven Engineering of distributed computing infrastructures, strategically aiming at transferring a complex asset from HEP to industry.
Additional affiliations
September 2005 - October 2007
MaatG Knowledge
Position
  • Director of Biomedical Applications
September 2002 - September 2005
CERN
Position
  • UPAS - Staff European Project

Publications

Publications (67)
Article
Neuroscience is increasingly making use of statistical and mathematical tools to extract information from images of biological tissues. Computational neuroimaging tools require substantial computational resources and the increasing availability of large image datasets will further enhance this need. Many efforts have been directed towards creating...
Conference Paper
Full-text available
The MammoGrid project has recently delivered its first proof-of-concept prototype using a Service-Oriented Architecture (SOA)-based Grid application to enable computing spanning national borders. The underlying AliEn Grid infrastructure has been selected because of its practicality and its emergence as a potential open source standards-based soluti...
Article
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The unprecedented growth, availability and accessibility of imaging data from people with neurodegenerative conditions has led to the development of computational infrastructures, which offer scientists access to large image databases and e-Science services such as sophisticated image analysis algorithm pipelines and powerful computational resource...
Article
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The today's public database infrastructure spans a very large collection of heterogeneous biological data, opening new opportunities for molecular biology, bio-medical and bioinformatics research, but raising also new problems for their integration and computational processing. In this paper we survey the most interesting and novel approaches for t...
Article
Full-text available
The MammoGrid project has deployed its Service-Oriented Architecture (SOA)-based Grid application in a real environment comprising actual participating hospitals. The resultant setup is currently being exploited to conduct rigorous in-house tests in the first phase before handing over the setup to the actual clinicians to get their feedback. This p...
Conference Paper
We propose a new healthcare data exchange platform for research centers, hospitals and healthcare institutions. Our model is based on a federated blockchain network that interconnect the healthcare institutions and orchestrate the data life cycle from the data publication to the data consumption. The blockchain is responsabible to keep the traceabi...
Article
Full-text available
Essential Biodiversity Variables (EBV) are fundamental variables that can be used for assessing biodiversity change over time, for determining adherence to biodiversity policy, for monitoring progress towards sustainable development goals, and for tracking biodiversity responses to disturbances and management interventions. Data from observations o...
Chapter
While witnessing the advent of the big data era, the unstoppable propagation of the European Union’s General Data Protection Rule (GDPR) and the launch of the EU–US Privacy Shield will impact the way sensitive data can be accessed, shared, and processed in the near future. This societal evolution will require health-care information systems to make...
Article
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Rethinking the humanitarian model : from efficiency to resilience Today the humanitarian sector is experiencing a major economic and organizational crisis, leading to a refocusing on the ethics of actions through resilience. One can therefore question the current humanitarian model, its underlying principles, and its ability to provide efficient an...
Chapter
Multisite-distributed e-infrastructures can foster computational resources, share brain imaging data, and facilitate data analysis in the study of neurodegenerative diseases. The Global Alzheimer’s Association Interactive Network (GAAIN— https://www.gaain.org) is a platform federating worldwide datasets of the brain. The European side of the GAAIN...
Article
The purpose of this study is to assess the reproducibility of hippocampal atrophy rate measurements of commonly used fully-automated algorithms in Alzheimer disease (AD). The reproducibility of hippocampal atrophy rate for FSL/FIRST, AdaBoost, FreeSurfer, MAPS independently and MAPS combined with the boundary shift integral (MAPS-HBSI) were calcula...
Article
Full-text available
Essential biodiversity variables (EBVs) have been proposed by the Group on Earth Observations Biodiversity Observation Network (GEO BON) to identify a minimum set of essential measurements that are required for studying, monitoring and reporting biodiversity and ecosystem change. Despite the initial conceptualisation, however, the practical impleme...
Conference Paper
Full-text available
AEGLE project targets to build an innovative ICT solution addressing the whole data value chain for health based on: cloud computing enabling dynamic resource allocation, HPC infrastructures for computational acceleration and advanced visualization techniques. In this paper, we provide an analysis of the addressed Big Data health scenarios and we d...
Article
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Background and purpose: The measurement of cortical shrinkage is a candidate marker of disease progression in Alzheimer's. This study evaluated the performance of two pipelines: Civet-CLASP (v1.1.9) and Freesurfer (v5.3.0). Methods: Images from 185 ADNI1 cases (69 elderly controls (CTR), 37 stable MCI (sMCI), 27 progressive MCI (pMCI), and 52 Al...
Chapter
Health surveillance requires access to data and, more importantly, to several data sources. Nowadays, large volumes of health-related data are being gathered and stored in geographically dispersed databases, utilizing heterogeneous technologies, standards and for different purposes. Primarily developed by and for High-Energy Physics (HEP), the Grid...
Conference Paper
Full-text available
The implementation of a grid network to support large-scale epidemiology analysis (based on distributed medical data sources) and medical data sharing require medical data integration and semantic alignment. In this paper, we present the GINSENG (Global Initiative for Sentinel e-Health Network on Grid) network that federates existing Electronic Hea...
Article
Full-text available
From n-Tier client/server applications, to more complex academic Grids, or even the most recent and promising industrial Clouds, the last decade has witnessed significant developments in distributed computing. In spite of this conceptual heterogeneity, Service-Oriented Architectures (SOA) seem to have emerged as the common underlying abstraction pa...
Article
The brain of a patient with Alzheimer's disease (AD) undergoes changes starting many years before the development of the first clinical symptoms. The recent availability of large prospective datasets makes it possible to create sophisticated brain models of healthy subjects and patients with AD, showing pathophysiological changes occurring over tim...
Article
Purpose To compare the reproducibility of the hippocampal atrophy rates over one year generated by the fully automated FreeSurer/ReconAll and FSL/FIRST software packages using a back-to-back (BTB) reproducibility test based on the ADNI1 data set [1] . Conclusions Study funding was provided by neuGRID4you (N4U), an European Community FP7 project (gr...
Chapter
In recent times, innovative new e-Infrastructures have materialized all around the globe to address the compelling and unavoidably increasing demand on computing power and storage capacity. All fields of science have entered an era of digital explosion and thus need to face it with appropriate and scalable instruments. Amongst century’s cutting-edg...
Conference Paper
Full-text available
The GINSENG (Global Initiative for Sentinel E-health Network on Grid) project aims to implement a grid infrastructure for ehealthand epidemiology in Auvergne. A distributed medical database is created upon a secure network for epidemiologicalstudies. Our goal is to create a decentralized information system using grid technologies. The medical sites...
Conference Paper
Full-text available
The GINSENG (Global Initiative for Sentinel E-health Network on Grid) project aims to implement a grid infrastructure for e-health and epidemiology in Auvergne. A distributed medical database is created upon a secure network for epidemiological studies. Our goal is to create a decentralized information system using grid technologies. The medical si...
Article
Full-text available
Neuroimaging is a field that benefits from distributed computing infrastructures (DCIs) to perform data- and compute-intensive processing and analysis. Using grid workflow systems not only automates the processing pipelines, but also enables domain researchers to implement their expertise on how to best process neuroimaging data. To share this expe...
Thesis
From n-Tier client/server applications, to more complex academic Grids, or even the most recent and promising industrial Clouds, the last decade has witnessed significant developments in distributed computing. In spite of this conceptual heterogeneity, Service-Oriented Architecture (SOA) seems to have emerged as the common and underlying abstractio...
Conference Paper
Full-text available
A relentless trend of massive data generation is happening across all human activities. It is estimated that the amount of data produced each year is greater than the sum of all that previously created, thus exceeding ICT tools and capacities. Although the challenges may seem daunting and ambi-tious to address, the opportunities are immense. With a...
Article
Full-text available
Background Cortical thickness is a promising marker for Alzheimer's disease. Research groups worldwide are recently carrying out brain atrophy analysis using different automated tools for cortical thickness extraction from MRI data. For future clinical exploitation, performances and results of these tools must be compared to establish their trustwo...
Article
Full-text available
Aim of DECIDE (Diagnostic Enhancement of Confidence by an International Distributed Environment) is to design, implement, and validate a GRID-based e-Infrastructure building upon neuGRID and relying on the Pan-European backbone GEANT and the NRENs. Over this eInfrastructure, a service will be provided for the computer-aided extraction of diagnostic...
Article
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Emerging challenge concerning public health statistics is the ability to provide real time information on population health. It is especially relevant in case of emergency scenarios: pollution through toxic gas emission or radioactivity, heat waves, pandemic flu viruses. The daily improvement of care practice can also benefit of any real time infor...
Conference Paper
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This paper presents the architecture of the Virtual Imaging Platform sup- porting the execution of medical image simulation workflows on multiple comput- ing infrastructures. The system relies on the MOTEUR engine for workflow execu- tion and on the DIRAC pilot-job system for workload management. The jGASW code wrapper is extended to describe appli...
Article
Full-text available
This document is the first external deliverable of the SALTY project (Self-Adaptive very Large disTributed sYstems), funded by the ANR under contract ANR-09-SEGI-012. It is the result of task 1.1 of the Work Package (WP) 1 : Requirements and Architecture. Its objective is to identify and collect requirements from use cases that are going to be deve...
Chapter
Full-text available
In recent times, innovative new e-Infrastructures have materialized all around the globe to address the compelling and unavoidably increasing demand on computing power and storage capacity. All fields of science have entered an era of digital explosion and thus need to face it with appropriate and scalable instruments. Amongst century"s cutting-edg...
Conference Paper
Full-text available
Despite significant efforts to achieve reliable grid middlewares, grid infrastructures still encounter important difficulties to implement the promise of ubiquitous, seamless and transparent computing. Identified causes are numerous, such as the complexity of middleware stacks, dependence to many distributed resources, heterogeneity of hardware and...
Article
Full-text available
Grid technologies have proven their capabilities to settle challenging problems of medical data access. The grid ability to access distributed databases in a secure and reliable way while preserving data ownership opened new perspectives in medical data sharing and disease surveillance. This paper focuses on the implementation challenges of grid-po...
Chapter
Full-text available
The Health-e-Child project started in January 2006 with the aim of developing a Grid-based healthcare platform for European paediatrics and providing seamless integration of traditional and emerging sources of biomedical information. The objective of this chapter is to share experiences, and present major issues faced, solutions found and a roadmap...
Chapter
Full-text available
There is a proliferation of research and industrial organizations that produce sources of huge amounts of biological data issuing from experimentation with biological systems. In order to make these heterogeneous data sources easy to use, several efforts at data integration are currently being undertaken based mainly on XML. Starting from a discuss...
Article
Full-text available
Recent developments of grid services for secured distributed data management open new perspectives for disease surveillance. In this paper, we report on our initiative to develop a surveillance network for breast cancer in the Auvergne region. The network gathers cytopathology laboratories, structures in charge of cancer screening and institutes in...
Article
Full-text available
The Health-e-Child (HeC) project [1], [2] is an EC Framework Programme 6 Integrated Project that aims to develop a grid-based integrated healthcare platform for paediatrics. Using this platform biomedical informaticians will integrate heterogeneous data and perform epidemiological studies across Europe. The resulting Grid enabled biomedical informa...
Conference Paper
Full-text available
The integration of heterogeneous biomedical information is one important step towards providing the level of personalization required in the next generation of healthcare provision. In order to provide the computer-based decision support systems needed to access this integrated healthcare information it will be necessary to handle the semantics of...
Conference Paper
Full-text available
Grids enable the aggregation, virtualization and sharing of massive heterogeneous and geographically dispersed resources, using files, applications and storage devices, to solve computation and data intensive problems, across institutions and countries via temporary collaborations called virtual organizations (VO) as described in [1]. Most implemen...
Article
Full-text available
Nowadays, technological developments have led to the possibility of using distributed computing facilities as a single, unified computing resource, a so-called Grid, following the analogy of a power Grid providing consistent, per-vasive, dependable and transparent access to electricity, irrespective of its source or its delivery. Grids implement nu...
Conference Paper
Full-text available
The Health-e-Child project aims to develop an integrated healthcare platform for European paediatrics. In order to achieve a comprehensive view of children’s health, a complex integration of biomedical data, information, and knowledge is necessary. Ontologies will be used to formally define this domain knowledge and will form the basis for the medi...
Article
Full-text available
The Health-e-Child project aims to develop an integrated healthcare platform for European paediatrics. In order to achieve a comprehensive view of childrens health, a complex integration of biomedical data, information, and knowledge is necessary. Ontologies will be used to formally define this domain knowledge and will form the basis for the medic...
Article
Full-text available
This paper presents an overview of the MammoGrid project and some of its achievements. In terms of the global grid project, and European research in particular, the project has successfully demonstrated the capacity of a grid-based system to support effective collaboration between physicians, including handling and querying image databases, as well...
Article
Full-text available
The MammoGrid project has delivered the first deployed instance of a healthgrid for clinical mammography that spans national boundaries. During the last year, the final MammoGrid prototype has undergone a series of rigorous tests undertaken by radiologists in the UK and Italy and this paper draws conclusions from those tests for the benefit of the...
Article
Full-text available
This paper discusses the concept of model-driven software engineering applied to the Grid application domain. As an extension to this concept, the approach described here, attempts to combine both formal architecture-centric and model-driven paradigms. It is a commonly recognized statement that Grid systems have seldom been designed using formal te...
Conference Paper
Full-text available
This paper presents an overview of the MammoGrid project and some of its achievements. In terms of the global grid project, and European research in particular, the project has successfully demonstrated the capacity of a grid-based system to support effective collaboration between physicians, including handling and querying image databases, as well...
Article
Full-text available
The MammoGrid project has delivered the first deployed instance of a healthgrid for clinical mammography that spans national boundaries. During the last year, the final MammoGrid prototype has undergone a series of rigorous tests undertaken by radiologists in the UK and Italy and this paper draws conclusions from those tests for the benefit of the...
Conference Paper
Full-text available
As a consequence to the hype of Grid computing, such systems have seldom been designed using formal techniques. The complexity and rapidly growing demand around Grid technologies has favour the use of classical development techniques, resulting in no guidelines or rules and unstructured engineering processes. This paper advocates a formal approach...
Conference Paper
Full-text available
The MammoGrid project aims to prove that grid infrastructures can be used for collaborative clinical analysis of database-resident but geographically distributed medical images. This requires: a) the provision of a clinician-facing front-end workstation and b) the ability to service real-world clinician queries across a distributed and federated da...
Article
Full-text available
The MammoGrid project aims to prove that Grid infrastructures can be used for collaborative clinical analysis of database-resident but geographically distributed medical images. This requires: a) the provision of a clinician-facing front-end workstation and b) the ability to service real-world clinician queries across a distributed and federated da...