David Luck

David Luck
CHU Sainte-Justine · Department of Neonatology

PhD

About

90
Publications
10,571
Reads
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793
Citations
Additional affiliations
September 2018 - present
CHU Sainte-Justine
Position
  • Senior Researcher
April 2011 - September 2018
Université de Montréal
Position
  • Professor (Assistant)

Publications

Publications (90)
Article
If disturbance of binding in long term memory is well established in schizophrenia, data concerning working memory maintenance are less clear. Feature binding in working memory was investigated in 19 patients with schizophrenia and 19 healthy controls. Binding was assessed by comparing two conditions in which participants had to retain four letters...
Article
Alterations of binding in long-term memory in schizophrenia are well established and occur as a result of aberrant activity in the medial temporal lobe (MTL). In working memory (WM), such a deficit is less clear and the pathophysiological bases remain unstudied. Seventeen patients with schizophrenia and 17 matched healthy controls performed a WM bi...
Article
Memory is one of the cognitive functions most affected in schizophrenia, but the severity of deficits varies from one task to another. In particular, greater impairments have been reported for pair recognition than item recognition. However, decision biases and how they could affect memory dysfunction in schizophrenia have received scant attention....
Article
Full-text available
Integrating information in space and time is a central feature of episodic memory. Although disturbance of the binding processes in episodic memory is well established in patients with schizophrenia, data on working memory (WM) remain discrepant. In a change detection procedure, two target displays of pairs of letters located in cells of grid were...
Article
Full-text available
Resting state functional MRI (rsfMRI) has been shown to be a promising tool to study intrinsic brain functional connectivity and assess its integrity in cerebral development. In neonates, where functional MRI is limited to very few paradigms, rsfMRI was shown to be a relevant tool to explore regional interactions of brain networks. However, to iden...
Article
Full-text available
Congenital heart disease (CHD) has been associated with structural brain growth and long-term developmental impairments, including deficits in learning, memory, and executive functions. Altered functional connectivity has been shown to be altered in neonates born with CHD; however, it is unclear if these early life alterations are also present duri...
Preprint
Full-text available
Resting state fMRI (rsfMRI) has been shown to be a promising tool to study intrinsic functional connectivity and assess its integrity in cerebral development. In neonates, where fMRI is limited to few paradigms, rsfMRI was shown to be a relevant tool to explore regional interactions of brain networks. However, to identify the resting state networks...
Article
Full-text available
13,15 ✉ 16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging data from 101 CNV carr...
Article
Full-text available
13,15 ✉ 16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging data from 101 CNV carr...
Conference Paper
As the diagnostic power of medical imaging technologies continues to develop, its utilization in healthcare research has proliferated (Sandoval et al. 2018). Consummate with such proliferation has been the aggregation of a large amount of high-quality research medical imaging data across research centres. Henceforth, there is a rising need for an a...
Article
Full-text available
IntroductionDeep learning neural networks are especially potent at dealing with structured data, such as images and volumes. Both modified LiviaNET and HyperDense-Net performed well at a prior competition segmenting 6-month-old infant magnetic resonance images, but neonatal cerebral tissue type identification is challenging given its uniquely inver...
Preprint
Full-text available
16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. We analyzed resting-state functional magnetic resonance imaging data from 101 CNV carriers, 755 individuals wi...
Article
Background Brain injury and abnormal maturation in the neonatal period is associated with long-term changes underlying significant cognitive, motor, language and behavioural deficiencies. Our understanding of clear cerebral disruptors of brain development and the extent of their impact are still limited, mostly due to the lack of robust non-invasiv...
Article
Full-text available
With increasing advances in the field of medical brain imaging, the known spectrum of white matter lesions has expanded, and we can now assess the presence of punctate white matter lesions (PWML). These focal small lesions are quite frequently detected in the preterm infant and in full-term infants with congenital heart malformations with, some stu...
Article
Full-text available
Among healthy volunteers in psychiatric brain functional magnetic resonance imaging (fMRI) research studies, the prevalence of incidentalomas can be as high as 34%, of which 10% show clinical significance. An incidentaloma is a lesion found by coincidence without clinical symptoms or suspicion. Like lesions and other types of accidental findings, i...
Poster
Full-text available
présentation d'une affiche décrivant la plateforme canadienne du cerveau néonatal, dont ses 3 objectifs.
Article
Psychotic symptoms (PS) are experienced by a substantial proportion of the general population. When not reaching a threshold of clinical relevance, these symptoms are defined as psychotic experiences (PEs) and may exist on a continuum with psychotic disorders. Unfavorable socio-environmental conditions, such as ethnic minority position (EMP) and mi...
Article
Full-text available
Recent studies have shown that transcranial direct current stimulation (tDCS) may reduce craving and smoking. However, little is known regarding brain correlates of these behavioral changes. We aimed to evaluate whether 10 sessions of tDCS modulate cigarette consumption, craving and brain reactivity to smoking cues in subjects with tobacco use diso...
Article
We designed an fMRI study to pinpoint the neural correlates of active and passive binding in working memory. Participants were instructed to memorize three words and three spatial locations. In the passive binding condition, words and spatial locations were directly presented as bound. Conversely, in the active binding condition, words and spatial...
Presentation
Full-text available
Le syndrome de Gilles de la Tourette (SGT) est un trouble neuropsychiatrique caractérisé par la présence de tics moteurs et phoniques. À cela s’ajoute souvent de nombreuses comorbidités, certaines impliquant des comportements impulsifs : trouble déficitaire de l’attention avec ou sans hyperactivité (TDAH), trouble oppositionnel avec provocation, ép...
Article
Tourette syndrome (TS) is a neuropsychiatric disorder involving motor and phonic tics. Inhibitory control is a key issue in TS, and many disruptive or impulsive behaviors might arise from inhibitory deficits. However, conflicting findings regarding TS patients’ inhibitory performance in neuropsychological tasks have been reported throughout the lit...
Article
Full-text available
Functional and structural brain changes associated with the cognitive processing of emotional visual stimuli were assessed in schizophrenic patients after 16 weeks of antipsychotic treatment with ziprasidone. Forty-five adults aged 18 to 40 were recruited: 15 schizophrenia patients (DSM-IV criteria) treated with ziprasidone (mean daily dose = 120 m...
Presentation
Full-text available
conférence donnée à la Société Québécoise de Schizophrénie
Poster
Full-text available
A meta-analysis of inhibitory deficits during neuropsychological tasks in Tourette syndrome patients
Conference Paper
Background Tobacco use disorder (TUD) is one of the leading causes of disease and premature death in the world. Despite several approaches to help smokers quit (e.g., substitution therapy), about 80% of patients will relapse in the 3 months after a quit attempt. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation tech...
Article
Context: Patients with schizophrenia display abnormalities in pitch discrimination of non-verbal tones as revealed by the Tone-Matching Task (TMT). It may lead to deficits in higher-order cognitive functions and clinical symptoms. Objectives: We conducted a systematic review and meta-analysis pooling data about TMT score differences between patient...
Article
Source memory deficits have been widely reported in schizophrenia, and may result from inefficient binding processes in working memory (WM). Thus, we designed an fMRI study aimed at investigating the neural correlates of both incidental and intentional binding in working memory in schizophrenia. Nineteen patients with schizophrenia and 23 matched c...
Conference Paper
Introduction: Working memory (WM) is particularly affected in schizophrenia, however, some processes are more altered than others. For example, patients with schizophrenia have more difficulties holding in memory the association of multiple pieces of information than the information itself. This type of associative process is commonly referred to a...
Article
De nombreuses etudes en neuroimagerie fonctionnelle (IRMf) menees chez les adultes presentant un trouble de personnalite limite (TPL) convergent pour identifier un patron d’activation neuronale, notamment fronto-limbique, different de celui active chez les adultes sans TPL lors des tâches de visualisation d’images emotionnelles. A ce jour, aucune e...
Article
Full-text available
Jusqu’au début du 20e siècle, l’étude de la cognition et des émotions était principalement l’affaire des philosophes. Le débat typiquement cartésien autour de la dualité émotion versus raison, ou raison versus passion a animé les chercheurs ainsi que l’imaginaire collectif jusqu’à nos jours. Les philosophes ont ainsi historiquement divisé l’étude d...
Article
Full-text available
Auditory verbal hallucinations (AVH) of schizophrenia are associated with a disrupted connectivity between frontal and temporoparietal language areas. We hypothesized that this dysconnectivity is underpinned by white matter abnormalities in the left arcuate fasciculus, the main fiber bundle connecting speech production and perception areas. We ther...
Data
Activations elicited by encoding when contrasting the emotional and neutral conditions in FES patients and healthy controls.
Data
Activations elicited by encoding when contrasting the neutral and emotional conditions in FEP patients and healthy controls.
Article
Alterations of associative memory, resulting from perturbations within the medial temporal lobe, are well established in schizophrenia. So far, all the studies having examined associative memory in schizophrenia have limited ecological validity, as people experience various emotional stimuli in their life. As such, emotion must be taken into accoun...
Article
Different test types lead to different intelligence estimates in autism, as illustrated by the fact that autistic individuals obtain higher scores on the Raven’s Progressive Matrices test (RSPM) than they do on the Wechsler IQ, in contrast to relatively similar performance on both tests in non-autistic individuals. However, the cerebral processes u...
Article
Establishing associations between pieces of information is related to the medial temporal lobe (MTL). However, it remains unclear how emotions affect memory for associations and, consequently, MTL activity. Thus, this event-related fMRI study attempted to identify neural correlates of the influence of positive and negative emotions on associative m...
Article
Full-text available
In schizophrenia (SZ), a specific binding deficit in working memory (WM) has not yet been demonstrated, given that studies with various methodologies were conducted and the results obtained were heterogeneous. Thus, a meta-analysis of 10 WM studies was performed. Effect sizes were calculated for binding and control conditions. Analyses disclosed si...
Article
Clinical evidence and structural neuroimaging studies linked cerebellar deficits to cognitive-related symptoms in schizophrenia. Yet, in functional neuroimaging literature to date, the role of the cerebellum in schizophrenia was not explored in a systematic fashion. Here, we reviewed 234 functional magnetic resonance imaging studies indexed by PubM...
Article
Full-text available
Cognitive dysfunction is a well recognized symptom of schizophrenia, as well as patients having poor insight into their illness. The subjective scale to investigate cognition in schizophrenia (SSTICS) is one of several scales that have been developed to study subjective cognitive dysfunction and has been compared to patients' objective cognitive le...
Article
We explore the mechanisms sub-tending the re-organization and memorization of visual information by studying how these mechanisms fail in patients with schizophrenia. Several studies have suggested that patients have difficulties in organizing information in perception and memory. We explore to what extent prompting patients to group items influenc...
Article
Full-text available
. Second-generation antipsychotics treatment is associated with weight gain and metabolic disturbances. Although much research has been done on the topic, the precise mechanisms underlying such side effects are still not well understood. Method . We followed over 16 weeks a group of 17 schizophrenia patients who were treated with olanzapine and mon...
Article
Working memory is devoted to the temporary storage and on-line manipulation of information. Recently, an integrative system termed the episodic buffer has been proposed to integrate and hold information being entered or retrieved from episodic memory. Although the brain system supporting such an integrative buffer is still in debate, the medial tem...