David Jeremiah Lubin

State University of New York University Hospital · Radiology and Nuclear Medicine

Background Barium sulfate is utilized for imaging of the gastrointestinal tract and is usually not deposited within the wall of the intestine. It is thought that mucosal injury may allow barium sulfate to traverse the mucosa, and allow deposition to occur uncommonly. Most pathology textbooks describe the typical barium sulfate deposition pattern as...

A collision tumor is a neoplastic lesion comprised of two or more distinct cell populations with distinct borders. Desmoid fibromatosis (DF) is a rare musculoaponeurotic tissue tumor that grows deep in the connective tissue and shows locally aggressive behavior. Only two cases of collision tumors with desmoid fibromatosis are reported in the Englis...

Initial disease presentations are often surprising compared with expected clinical trajectories. We present a case of metastatic lung adenocarcinoma where the initial presentation was masquerading as a musculoskeletal soft tissue mass. Initial concern was for a hematoma after light trauma, but due to a pacemaker, MRI was contraindicated. Workup inc...

Well‑differentiated thyroid carcinoma is predominantly a slow‑growing malignancy, amendable to treatment, and has an excellent prognosis following thyroidectomy and radioiodine ablation (RAI). However, patients who fail the initial RAI treatment attempt may require repeated RAI or other treatments and with this, comes an associated impact on patien...

Radiologic and Nuclear Medicine presentation of Paget's Disease

Skin metastasis from solid and soft tissue primary malignancies overall are rare. However, cutaneous metastases from certain soft tissue malignancies are seen not infrequently in clinic especially by dermatologists. Clinically, the presence of cutaneous metastasis is usually a finding of advanced disease stage and generally indicates a poor prognos...

Ga-prostate-specific membrane antigen 11 (PSMA) PET/CT imaging accurately depicts metastatic prostate adenocarcinoma (PCa). Pulmonary metastases of PCa are often overlooked on follow-up imaging in patients after initial treatment and following androgen deprivation therapy. Here we present a rare case of biopsy-proven PCa pulmonary metastasis with a...

NSC319726 (ZMC1) is a small molecule that reactivates mutant p53 by restoration of WT structure/function to the most common p53 missense mutant (p53-R175H). We investigated the mechanism by which ZMC1 reactivates p53-R175H and provide evidence that ZMC1: 1) restores WT structure by functioning as a zinc-metallochaperone, providing an optimal concen...

TP53 is the most commonly mutated gene in human cancer for which no effective targeted anti-cancer drug exists. We identified NSC319726 (726) as a mutant p53 reactivating compound, and a lead compound for mutant p53 targeted drug development. Prior evidence indicated that the effects of 726 were allele-specific, by restoring wildtype structure and...

The physiologically active form of p53 consists of a tetramer of four identical 393-amino-acid subunits associated via their tetramerization domains (TDs; residues 325-355). One in two human tumors contains a point mutation in the DNA binding domain (DBD) of p53 (residues 94-312). Most existing studies on the effects of these mutations on p53 struc...

Fusion of one protein domain with another is a common event in both evolution and protein engineering experiments. When insertion is at an internal site (e.g., a surface loop or turn), as opposed to one of the termini, conformational strain can be introduced into both domains. Strain is manifested by an antagonistic folding–unfolding equilibrium be...

We present a model of chromosome oscillations during late metaphase based on the postulates of the stochastic detachment/reattachment of kinetochore microtubules and the dynamic instability model for microtubules dynamics. In this approach the motion of the chromosomes is analyzed by treating them as Brownian particles subject to a fluctuating forc...