
David LoUniversity of Leicester | LE · Department of Infection, Immunity and Inflammation
David Lo
MB ChB MSc MD(Res) MRCPCH
About
54
Publications
4,089
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Introduction
David Lo currently works at the Department of Respiratory Sciences, University of Leicester. David does research in Paediatric Respiratory Medicine. His current project is 'CHAMPIONS Study'.
Additional affiliations
Education
September 2022 - September 2027
February 2016 - May 2020
University of Leicester
Field of study
- Medicine
September 2015 - August 2018
Publications
Publications (54)
Background
Poor adherence to asthma preventer medication contributes to worse outcomes in children & young people (CYP) with severe asthma.
Aim
Evaluate the Leicester Children’s Difficult Asthma Adherence Monitoring Pathway with Digital Smart Inhalers (DSI) in CYP.
Methods
CYP with uncontrolled severe asthma and new referrals from local DGHs were...
Background
Recent NICE/BTS/SIGN draft guidelines (NG10186) recommend FeNO as first line diagnostic test for asthma in children 5 to 16 years. Children with FeNO <35ppb require further testing with spirometry and BDR. We investigated the potential impact of this change on the outcome of diagnostic testing.
Methods
Data from the ICB funded prospecti...
Background
Children and young people (CYP) with asthma in the UK are at higher risk of poor outcomes compared with other high-income European countries due to factors including poor access to high-quality asthma reviews, diagnostic testing and inconsistent postattack reviews. The Leicester Integrated Care Board funded the first UK pilot asthma hub...
Background
Preschool-aged children have among the highest burden of acute wheeze. We investigated differences in healthcare use, treatment and outcomes for recurrent wheeze/asthma in preschoolers from different ethno-socioeconomic backgrounds.
Methods
Retrospective cohort study using data from the Clinical Practice Research Datalink linked to Hosp...
Introduction:
Complementing recognition of biomedical phenotypes, a primary care approach to asthma care recognizes diversity of disease, health beliefs, and lifestyle at a population and individual level.
Areas covered:
We review six aspects of personalized care particularly pertinent to primary care management of asthma: personalizing support...
Poor adherence to asthma preventer medication is associated with life-threatening asthma attacks. The quality and outcomes framework mandated primary care annual asthma review does not include adherence monitoring and the effect of poor adherence on lung function in paediatric primary care patients is unknown. The aim was to investigate the link be...
Background:
Cystic fibrosis is an inherited recessive disorder of chloride transport that is characterised by recurrent and persistent pulmonary infections from resistant organisms that result in lung function deterioration and early mortality in sufferers. Meticillin-resistant Staphylococcus aureus (MRSA) has emerged not only as an important infe...
Introduction:
Asthma is a chronic airways disease characterised by intermittent or frequent episodes of wheeze, chest tightness, breathlessness, cough, and by evidence of reversible airflow obstruction; classically symptoms are triggered by exercise, exposure to aeroallergens, and/or respiratory viruses. It is the commonest non-communicable respir...
Objectives
Implementation of guidelines into clinical practice is challenging and complex. This study aims to (1) identify the training needs and capacity requirements, and (2) explore the impact on healthcare utilisation and asthma-related quality of life of implementing both spirometry and fraction of exhaled nitric oxide in diagnosis of asthma a...
Ramphul M, Lo DKH, Gaillard EA. J Asthma Allergy. 2021;14:525–538.
The authors have advised that Figures 1 and 2 on pages 528 and 533, respectively are in the reverse order. In the original article, Figure 1 appears as Figure 2, and Figure 2 as Figure 1. The Figures with the correct captions are shown in Download Article.
The authors apologize for...
Asthma is a heterogeneous disease, characterised by different phenotypes and endotypes. Precision medicine in asthma refers to the implementation of a targeted therapy for each individual child, based on the identification of treatable traits, including environmental, immunological and genetic factors. Severe asthma in children is associated with i...
Objective
To identify risk factors for asthma attacks and poor asthma control in children aged 5–16 years.
Methods
Prospective observational cohort study of 460 children with asthma or suspected asthma from 10 UK general practices.
Gender, age, ethnicity, body mass index, practice deprivation decile, spirometry and fraction of exhaled nitric oxide...
Diagnosing asthma in children represents an important clinical challenge. There is no single gold standard test to confirm the diagnosis. Consequently, both over-, and under-diagnosis of asthma are frequent in children.
A Task Force (TF) supported by the European Respiratory Society has developed these evidence-based clinical practice guidelines fo...
Background
The National Institute for Health and Care Excellence recommends the use of spirometry and measuring the fraction of exhaled nitric oxide (FeNO) as part of the diagnostic work-up for children with suspected asthma, and spirometry for asthma monitoring, across all care settings. However, the feasibility and acceptability of these tests wi...
At the start of the school year, there is an influx of children with attacks of viral wheeze and asthma who present to children’s emergency departments. In the UK, the COVID-19 pandemic has resulted in extensive school lockdowns and the implementation of social distancing measures within schools. We aimed to determine the extent that SARS-CoV-2 has...
In this article, the Group Chairs and the Early Career Members of the Paediatric Assembly of the European Respiratory Society (ERS) highlight some of the most interesting findings in the field of paediatrics presented at the 2019 ERS International Congress, which was held in Madrid, Spain. The main findings from each group are summarised at the end...
Background
Spirometry and fraction of exhaled nitric oxide (FeNO) are commonly used in specialist centres to monitor children with asthma. The National Institute for Health and Care Excellence recommends spirometry for asthma monitoring from 5 years in all healthcare settings. There is little spirometry and FeNO data in children managed for asthma...
Background:
Chest computed tomography (CT) scans have a recognised role in investigating adults with severe asthma to exclude alternative diagnoses, but its role in children is less clear. The objective of this study was to review the CT findings of our local cohort of children with severe asthma and to explore whether clinical or pathobiological...
In many healthcare settings asthma in children is a clinical diagnosis based on parental reported symptoms. These include intermittent episodes of wheezing, breathlessness and periodic nocturnal dry cough. Increased symptoms often coincide with colds. Confirming a diagnosis of asthma in children can be difficult and recent reports highlight that mi...
The Royal College of Physicians three questions (RCP3Q) is widely used for assessing asthma control within primary care in the UK, despite limited evidence in children. This study compared the RCP3Q as a tool for assessing asthma control in children (5-16 years) against the validated Asthma Control Test (ACT), Childhood Asthma Control Test (C-ACT),...
Background:
Cystic fibrosis is an inherited recessive disorder of chloride transport that is characterised by recurrent and persistent pulmonary infections from resistant organisms that result in lung function deterioration and early mortality in sufferers.Meticillin-resistant Staphylococcus aureus (MRSA) has emerged as, not only an important infe...
Transformational leadership theory has been at the centre of health-care leadership research for the past three decades, has had a tangible influence on the evolution of NHS leadership development strategies, and is still evident in current frameworks. This article provides an overview of the key concepts and weaknesses of transformational leadersh...
Introduction and Objectives
The UK Quality Outcomes Framework (QOF) rewards primary-care practices for completing the Royal College of Physicians “Three Questions” (RCP3Q) score for all patients listed on their asthma register. Almost no validation data currently exists, however, to support its use in children. This study aimed to investigate the p...
Leadership development for health-care professionals is a priority within the NHS. Training is generally targeted at individual staff groups in isolation, even though contemporary leadership thinking recognizes the benefts of collaborative leadership between different clinical disciplines. Focussing on the attitudes and perceived training needs of...
Introduction
Despite the common nature of asthma there is no gold standard test for diagnosis. Both under- and over-diagnosis of childhood asthma in primary care have been reported but there is no UK data.1,2 Diagnostic algorithms including objective tests have been proposed but not implemented following a recent NICE consultation. Concerns regardi...
Diagnosing asthma in children is challenging, but information obtained from clinical history and objective lung function testing should help nurses determine probability and adopt a stepwise approach, write Dr David Lo, Dr Brigitte Gaillard, Louise Bullous and Dr Erol Gaillard
Diagnosing asthma in children is challenging, but information obtained from clinical history and objective lung function testing should help nurses determine probability and adopt a stepwise approach, write Dr David Lo, Dr Brigitte Gaillard, Louise Bullous and Dr Erol Gaillard
Although asthma is the most common non-communicable disease of childhood...
Background:
Cystic fibrosis is an inherited recessive disorder of chloride transport that is characterised by recurrent and persistent pulmonary infections from resistant organisms that result in lung function deterioration and early mortality in sufferers.Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as, not only an important inf...
This is the protocol for a review and there is no abstract. The objectives are as follows:
To evaluate the effectiveness of treatment regimens designed to eradicate MRSA and to determine whether the eradication of MRSA confers better clinical and microbiological outcomes for patients with CF.
To ascertain whether attempts at eradicating MRSA can le...
Background
The UK antibiotic guidelines for cystic fibrosis (CF) recommend that all infants should be prescribed a prophylactic narrow spectrum antibiotic, such as flucloxacillin, from diagnosis until 3?years of age. We wished to evaluate the prevalence of prophylactic antibiotic use in the UK and the effect this had on the microbiological outcome...
The use of inhaled therapies for chronic respiratory infections in cystic fibrosis represents a substantive treatment burden to patients. In this paper, we review the evidence supporting two commonly used inhaled antibiotic regimens for chronic respiratory infections - continuous vs. intermittent (28 days on followed by 28 days off) therapy. We inc...
Background According to the Advanced Paediatric Life Support (APLS) guidelines, the weight of children between the ages of 1 and 10 years can be safely estimated using the formula: weight=2 × (age +4). Although several alternative methods have been proposed to be more accurate, they are not widely used. In this study we compare the accuracy of the...