David Kok

David Kok
Peter MacCallum Cancer Centre · Division of Radiation Oncology and Cancer Imaging

BMedSci MBBS GradCertLing MEd FRANZCR

About

21
Publications
1,609
Reads
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198
Citations
Additional affiliations
February 2010 - present
Peter MacCallum Cancer Centre
Position
  • Moorabbin Campus Director

Publications

Publications (21)
Preprint
The advent of immune checkpoint inhibitors (ICI) in the management of melanoma has revolutionized treatment paradigms; with a significant survival benefit in advanced cutaneous melanoma. Despite this, improvements in survival have not translated to mucosal melanoma (MM). As the understanding of the immunomodulatory effects of radiation therapy (RT)...
Article
Introduction: Melanoma remains a large global burden with a significant proportion of patients succumbing to metastatic disease. The adrenal gland is a common area for metastasis with surgical treatment as the main modality. Radiotherapy is less utilised in this setting with uncertainty over deliverability and efficacy. Here, we present the detail...
Article
Full-text available
Introduction: To describe the pattern of the use of advanced radiation therapy (RT) techniques, including intensity-modulated RT (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body RT (SBRT) for the management of bone metastases (BM), and the associated factors in Victoria. Methods: We used a population-based cohort of patient...
Article
Full-text available
Background Melanoma brain metastases (MBMs) are a challenging clinical problem with high morbidity and mortality. Although first-line dabrafenib–trametinib and ipilimumab–nivolumab have similar intracranial response rates (50%–55%), central nervous system (CNS) resistance to BRAF-MEK inhibitors (BRAF-MEKi) usually occurs around 6 months, and durab...
Article
Aims At diagnosis, <1% of patients with non-small cell lung cancer (NSCLC) have synchronous solitary brain metastasis (SSBM). In prior cohorts without 18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) staging, definitive treatment to intracranial and intrathoracic disease showed a 5-year overall survival (OS) of 11...
Article
Full-text available
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine tumor of the skin with an estimated disease‐associated mortality of 15–33%. Australia has a higher incidence of MCC compared to the rest of the world, thought to be due to a higher ultraviolet index. The Australian MCC population is distinct from the MCC population of the Northern he...
Conference Paper
Introduction: Recent trials have established ipilimumab-nivolumab (I-N) as a robust first line (IL) treatment for patients (pts) with asymptomatic melanoma brain metastases (MBM). However, the efficacy of I-N for symptomatic MBM or after intracranial progression on either a BRAF-MEK inhibitor (BRAF-MEKi) or anti-PD1 is unknown. We performed a sing...
Article
Background: Despite classic teaching that intracranial metastases typically arise at the grey-white matter junction, small intracranial melanoma metastases (IMM) are frequently observed at the interface between the cortex and leptomeninges (i.e. "corticomeningeal interface"), suggesting possible leptomeningeal origin. Methods: MRI brain examinat...
Article
Background: Following the resection of brain metastases, Stereotactic Radiosurgery (SRS) to the post-operative surgical cavity has increasingly replaced Whole Brain Radiotherapy (WBRT) as the standard of practice. There is however tremendous variation in the way SRS can be delivered and outcomes of SRS are yet to be systemically characterized. Me...
Article
Full-text available
Purpose of Review Recent randomized evidence has supported the use of resection followed by stereotactic radiosurgery (SRS) as standard of care for patients with a limited number of brain metastases. However, there are known toxicities, including a relatively high incidence of leptomeningeal disease. Neoadjuvant SRS has been proposed to minimize th...
Article
TPS9600 Background: Nivolumab combined with ipilimumab is active in melanoma brain metastases, with intracranial response rates > 55% and durable survival in treatment naïve patients (pts) (Long GV et al Lancet Onc 2018; Tawbi H et al NEJM 2018). We seek to determine if the addition of stereotactic radiotherapy (SRS) results in improved intracrania...
Article
Background: The Master of Cancer Sciences brings together the academic strength of the University of Melbourne (UoM) and world leading content experts from the Victorian Comprehensive Cancer Centre (VCCC), to develop an innovative, interactive, evidence-based flagship educational program in cancer sciences. This program will enhance the capabilitie...
Article
Meningiomas are the most frequent primary brain tumours and are often managed with surgical excision. We present the case of a young woman with the unusual phenomenon of iatrogenic subcutaneous seeding from an intracranial meningioma. We discuss the risk factors, possible mechanisms and management of this.
Article
Full-text available
The remarkable advances in the systemic therapy of metastatic melanoma have now extended the 1-year overall survival rate from 25% to nearing 85%. Systemic treatment in the form of BRAF-targeted therapy and immunotherapy is slowly but surely proving its efficacy in the treatment of metatstatic brain metastases (MBM). Single-agent BRAF inhibitors pr...
Article
Background and purpose: To compare rates of late gastrointestinal toxicity, late genitourinary toxicity and biochemical failure between patients treated for prostate cancer with implanted fiducial marker image guided radiotherapy (FMIGRT), and those treated without FMIGRT. Methods and materials: We performed a single institution retrospective st...
Article
The fishbowl method is a small group teaching technique in which a number of students engage in a discussion while observers form a circle around them. We use this method to teach medical interviewing skills, with students interviewing a simulated patient (SP) whilst being observed by their peers and a clinical tutor. However, there is little evide...
Article
At least one-third of primary breast cancers in Australia are discovered by population-based mammographic screening. The aim of this study was to determine whether there were any differences in the surgical treatment of women diagnosed with breast cancer by BreastScreen Victoria between urban and rural populations and to investigate temporal change...

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