David Hupin

Centre Hospitalier Universitaire de Saint-Étienne | CHU St Etienne · Department of Clinical Physiology and Exercise

Letter Re: Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013 http://www.bmj.com/content/354/bmj.i3857/rr-9

Introduction The importance of exercise electrocardiogram (ECG) is still controversial in the prevention of cardiovascular events among sportsmen and sportswomen. The aim of this study was to assess the relevance of exercise ECG as a screening tool to prevent cardiovascular events when any cardiovascular disease (CVD) risk factors are present. Met...

Aims The importance of exercise electrocardiogram (ECG) is still controversial in the prevention of cardiovascular events among sportsmen. The aim of this study was to assess the relevance of exercise ECG as a screening tool for cardiovascular events when any cardiovascular disease (CVD) risk factors are present. Methods The study included leisure...

Background Individually optimising the training programme of cardiac rehabilitation (CR) remains a major concern among young coronary artery disease (CAD) patients. Among effective tools, the power-force-velocity profile (PFVP) is usually assessed to improve performance in athletes through individualised training. Therefore, assessing PFVP may allo...

Rationale Screening the general population aged 65 for atrial fibrillation (AF) has been proposed as a preventive measure against potential complications. The dysfunction of the autonomic nervous system (ANS) plays an important role in atrial fibrillation (AF). Short-term HRV is conceptually attributed to physiologic vagal tone modulation. But rece...

Aim Investigate the various roles played by nurses in the care of patients afflicted with Long COVID. Background Effectively managing Long Covid requires a multidisciplinary approach - a healthcare pathway that necessitates collaboration among various members of the medical profession to monitor the patient. Among these professions, nursing plays a...

Background Although the health benefits of physical activity (PA) are recognized, prostate cancer patients do not follow PA recommendations. Barriers to PA, whether physical, environmental or organizational, are known. Furthermore, even when these barriers are overcome, this achievement is not systematically accompanied by lifestyle change. Many st...

Although moderate-to-vigorous physical activity has been proven to be effective in preventing major chronic diseases, the most recent epidemiological studies now focus on low-intensity physical activity, due to the need to promote all activities. However, the evidence currently remains weak. The objective of the study is to clarify the effects of d...

Exercise in long COVID is poorly studied. Nevertheless, exerciserehabilitation could improve cardiorespiratory, muscular and autonomic functions. We aimed to investigate improvement in physical and autonomic performances of long COVID patients (n = 38) after a 4-week exercise rehabilitation program (3 sessions/week) compared to two control groups c...

Objective To systematically review randomised controlled trials (RCTs) using a wearable physical activity monitoring device as an intervention to increase daily walking activity and improve physical capacities in patients with cardiovascular disease (CVD). Design Systematic review and meta-analysis of RCTs. Data sources PubMed, Embase and Web of...

Background It is well documented that moderate-to-vigorous intensity physical activity (MVPA) is effective in the prevention of major chronic diseases. Even though the current international physical activity (PA) guidelines still mainly focus on MVPA, the topic of the most recent epidemiological studies has shifted from MVPA to light intensity phys...

Objective: This study tested whether the subjective age tends to decrease after following a fall preventive program. This study also examines whether physical abilities and psychological resources at baseline are associated with this decrease in subjective age. Finally, this study tested to what extent the evolution of subjective age is concomitan...

Background/objectives Obesity is a complex health issue in which the brain plays a role yet to be determined, especially in the elderly. Indeed, in the ageing population, the balance between fat and lean mass is different; thus, the co-influence between the brain and obesity may differ between the elderly and younger subjects. Our main goal is thus...

Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Unrestricted grant for fellowship support - Abbott Medical Background The dysfunction of the autonomic nervous system (ANS) plays an important role in atrial fibrillation (AF). However, the meaning of high heart rate variability (HRV) in predicting AF is sti...

Funding Acknowledgements Type of funding sources: None. Background Despite the known benefits of physical activity, patients with cardiovascular disease do not practice enough nor maintain a regular physical activity for their health [1-4] . Walking is one of the easiest ways to stay physically active and can be implemented easily in everyday life...

Funding Acknowledgements Type of funding sources: None. Background Cardiovascular autonomic dysfunction (CVAD) is a major complication for a large proportion of Long COVID (LC) patients. The main phenotype of CVAD is postural orthostatic tachycardia syndrome (POTS), commonly observed as a sequalae of COVID infection, thus defining a subset of LC p...

Chronic fatigue is a frequent complaint, expressed at all levels of the healthcare system. It is perceived as disabling in a high proportion of cases, and internists are frequently called upon to find "the" cause. The etiological diagnostic approach of an unexplained state of fatigue relies on the careful search for more specific clues by questioni...

Elderly represents a growing population and cardiovascular diseases (CVD) is one of the leading causes of mortality in this population. Sex differences are involved in CVD with middle-aged males being at higher risk than females. After menopause, females are no longer protected by hormones and the role of sex on cardiovascular parameters involved i...

Fatigue is a major symptom in many diseases, often among the most common and severe ones and may last for an extremely long period. Chronic fatigue impacts quality of life, reduces the capacity to perform activities of daily living, and has socioeconomical consequences such as impairing return to work. Despite the high prevalence and deleterious co...

Background: It is well documented that moderate-to-vigorous intensity physical activity (MVPA) is effective in the prevention of major chronic diseases. Even though the current international physical activity (PA) guidelines still mainly focus on MVPA, the topic of the most recent epidemiological studies has shifted from MVPA to light intensity phy...

Background The dysfunction of the autonomic nervous system (ANS) plays an important role in the initiation and maintenance of atrial fibrillation (AF). However, the meaning of high heart rate variability (HRV) in predicting AF is still under debate due to conflicting results in population-based studies. Short-term HRV is conceptually attributed to...

Background Several studies have shown the importance of the relationship between the power-force-velocity profile (PFVP) and sport performance in elite athletes through optimised exercise training [1]. Optimising the training programme is constantly sought in rehabilitation among patients always younger with coronary artery disease. To adapt the ex...

Stroke prediction is a key health issue for preventive medicine. Atrial fibrillation (AF) detection is well established and the importance of obstructive sleep apneas (OSA) has emerged in recent years. Although autonomic nervous system (ANS) appears strongly implicated in stroke occurrence, this factor is more rarely considered. However, the conseq...

Reliable immunoassays are essential to early predict and monitor vaccine efficacy against SARS-CoV-2. The performance of an Interferon Gamma Release Assay (IGRA, QuantiFERON® SARS-CoV-2), and a current anti-spike serological test, compared to a plaque reduction neutralization test (PRNT) taken as gold standard were compared. Eighty vaccinated indiv...

Introduction Regular physical activity (PA) is recognised as a positive factor for health, thus doctors are now able to prescribe PA. It is therefore necessary for health professionals to have a solid knowledge on this subject to disseminate the right information. Facts and results In our study, we looked at the knowledge about PA and health of th...

ContextAfter a COVID-19 infection, some patients have persistent symptoms, the most common is fatigue. To prevent it from becoming chronic (post-COVID-19 syndrome), early management before 3 months could be useful. Exercise and education are recommended.Objective To assess fatigue in patients with prolonged symptoms after COVID-19 infection and who...

Objectives Falls are a common and serious health problem. The present study examined the association between subjective age (i.e., feeling younger or older than one’s chronological age) and falls in two large national samples. Method Participants, aged 65 to 105 years old, were drawn from the National Health and Aging Trends Study (NHATS) and the...

Résumé Une conséquence du vieillissement est la diminution progressive des capacités du sujet âgé à faire face aux tâches de la vie quotidienne, qu’elles soient physiques ou intellectuelles. Cette décroissance atteint toutes les grandes fonctions physiologiques de l’organisme, dont le système nerveux autonome. Il parait ainsi pertinent de mettre en...

Funding Acknowledgements Type of funding sources: Other. Main funding source(s): Doctoral contract 2018-2022 Background Several studies have shown the importance of the relationship between the power-force-velocity profile (PFVP) and sport performance in elite athletes through optimised exercise training.[1] Optimising the training programme is co...

Funding Acknowledgements Type of funding sources: None. Background The importance of exercise electrocardiogram (ECG) is still controversial in the prevention of cardiovascular events among sportsmen. The aim of this study was to assess the relevance of exercise ECG as a significant prognostic marker for cardiovascular events when any CVD risk fac...

Background The COVID-19 pandemic led to the closure of most cardiac therapy centers. One of the solutions was to adapt the existing cardiac rehabilitation (CR) program in an institute to a remote approach offered by home-based telerehabilitation. The aim of this study was to measure the cardiorespiratory effects of telerehabilitation compared to co...

Background Obstructive sleep apnea (OSA) affects 5% of the adult population and its prevalence is up to 13 times higher in coronary artery disease (CAD) patients. However, OSA in this population is less symptomatic, leading to lower adherence to positive airway pressure (CPAP). While oropharyngeal exercise showed a significant decrease in apnea-hyp...

Background: Cardiac vagal dysfunction was documented in middle-aged patients with migraine. However, vagal activity depends on several psychophysical or physiological factors such as anxiety, depression, lifestyle or age. In this work, we studied cardiac parasympathetic activity in elderly volunteers with past or current migraine. Methods: Among PR...

Baroreflex sensitivity (BRS) is known to be a predictor of morbidity and mortality in metabolic and cardiovascular diseases. However, although we know that BRS decreases with age, we do not know whether BRS is predictive of mortality in general elderly population. The objective of this work is to study the predictive value of BRS in the mortality o...

Objectif Le ticagrelor est connu pour provoquer de la dyspnée mais également des désordres respiratoires centraux lors du sommeil. Nous avons voulu évaluer le retentissement qu’il pouvait avoir sur le comportement ventilatoire à l’exercice et son impact sur le plan fonctionnel et métabolique. Méthodes C’est une étude rétrospective, monocentrique,...

Background Although the benefits of physical activity (PA) on health are recognised, prostate cancer patients do not follow PA recommendations. The barriers to PA, whether physical, environmental or organisational, are known. Furthermore, even when such barriers are overcome, this achievement is not systematically accompanied by a change in lifesty...

Background: Chronic inflammation leads to autonomic dysfunction, which may contribute to the increased risk of cardiovascular diseases (CVD) in patients with rheumatoid arthritis (RA). Exercise is known to restore autonomic nervous system (ANS) activity and particularly its parasympathetic component. A practical clinical tool to assess autonomic fu...

Background: Exercise-induced laryngeal obstruction (EILO) is an exercise-dependent dyspnoea, linked to a laryngeal closure during physical effort. It may concern from 5% to 7% of adolescents and young athletic adults. EILO is a quite recently described condition: standardized diagnostic criteria and consensual management are still to come. Formal...

Previous reports of an association between handgrip strength (HGS) and the risk of hypertension have utilized cross-sectional designs. We aimed to assess the prospective association between HGS and hypertension risk in a general population. Handgrip strength was assessed at baseline in 463 Finnish men and women aged 61-73 years. Handgrip strength w...

Background: Cardiorespiratory optimal point (COP) during exercise, a potentially useful submaximal cardiopulmonary exercise testing (CPET) variable, may be an independent risk factor for cardiovascular disease outcomes. However, the relationship of COP with risk of sudden cardiac death (SCD) has not been previously investigated. We sought to evalu...

The aim of the study was to assess potential associations between obstructive sleep apnea (OSA) and the occurrence of diabetes mellitus and insulin resistance in the elderly. Nondiabetic volunteers (n = 549) with undiagnosed or untreated asymptomatic OSA (66.2+/−1 years at the inclusion) were evaluated as an ancillary study of the PROOF cohort stud...

Introduction: The COVID-19 pandemic implied a period of lockdown for the general population, increasing the risk to develop some physical or mental disorders. In fibromyalgia patients, these disorders are part of the large clinical picture of the syndrome. Fibromyalgia management is especially based on a regular practice of physical activity. Lockd...

Background: Falls affects one of three people after 65 years old, and it can lead to serious consequences. Scientific evidence point out that physical exercise is the most efficient way to prevent falls among older adults. Objective: The main objective of this study is to determine if a social marketing program can increase the attendance rate of p...

Introduction: Fibromyalgia (FM) is characterized by multiple symptoms including pain, fatigue, and sleep disorders, altering patient's quality of life. In the absence of effective pharmacological therapy, the last European guidelines recommend a multidisciplinary management based on exercise and education. Thus, our main objective was to measure th...

Although recent trials have shown promising benefits of exercise on obstructive sleep apnea (OSA) severity, the long‐term effect of these interventions remains unknown. The aim of this study was to assess the effect of a 9‐month community physical activity program on OSA severity one year later in free‐living conditions. OSA patients, previously in...

Objectif L’apnée du sommeil augmente avec l’âge. Cependant l’évolution de l’apnée du sommeil chez la personne âgée est inconnue. L’objectif de cette étude est donc de suivre le devenir de cette pathologie et notamment de ses index polygraphiques. Méthodes Parmi les 1011 sujets sains de l’étude PROOF inclus à l’âge de 65 ans en 2001, 213 sujets ont...

Background: Periodontal diseases (PD) seem to appear today as predictors of some cardiovascular diseases (CVD). There is a lack of data on the oral health among Cameroonian military population, and its relationship with CVD. Purpose: Investigate on the link between oral health of Cameroonian military from the Ngaoundéré garrison and their cardio...

Background The prevalence of small-fiber neuropathy (SFN) is high in patients with hereditary transthyretin amyloidosis (ATTRv) but remains unknown in transthyretin wild-type cardiac amyloidosis (ATTRwt-CA). Objective To determine the prevalence of SFN in patients with ATTRwt-CA using Sudoscan®, a non-invasive method used to provide evidence of SF...

Aims The prevalence of autonomic neuropathy (AN) is high in patients with hereditary transthyretin amyloidosis but remains unknown in transthyretin wild‐type cardiac amyloidosis (ATTRwt‐CA). This study aimed to determine the prevalence of AN in patients with ATTRwt‐CA using Sudoscan®, a non‐invasive method used to provide evidence of AN in clinical...

Background: Previous cohorts studied the association of various types of physical activities with the incidence of cognitive disorders. The objective of this work was to analyze the association of leisure, domestic and professional physical activities with mild and moderate cognitive disorders in older people living in the community. Methods: We us...

Objective Subjective age has been implicated in a range of health outcomes but its associations with Fear of Falling (FoF) are unknown. The present study examined the relation between subjective age and FoF in large national sample. Methods Participants were drawn from the National Health and Aging Trends Study (NHATS, 2011–2017). 1,679 participan...

An amendment to this paper has been published and can be accessed via the original article.

Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. The scientific evidence indicates that physical activity is the most effective method for preventing falls among seniors. Although public health professionals often use social marketing to design and plan successful...

Background. Cardiovascular diseases remain as the leading cause of morbidity and mortality in industrialized countries. Ageing and gender strongly modulate the risk to develop cardiovascular diseases but very few studies have investigated the impact of gender on cardiovascular diseases in the elderly, which represents a growing population. The purp...

Background: Older adults and those with pre-existing medical conditions are at risk of death from severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). In this period of quarantine, one of the reasons for going out is physical activity. This issue is important, as the impact of a sedentary lifestyle might be lower for children and young adu...

Background: Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods: The study used data from the prospective observa...

BACKGROUND Studies agree that we are only at the beginning of an unprecedented health crisis affecting the population and especially older adults. In this period of quarantine, one of the reasons for going out is physical activity. This issue is important because if the problem is lower for adults, it is more complicated for older adults. They need...

Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods The study used data from the prospective observationa...

Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods The study used data from the prospective observationa...

Objectif La mise en place d’un traitement du SAS chez le sujet âgé est toujours débattue. En effet, dans cette population, le lien entre la pathologie et l’augmentation du risque de mortalité n’a pas été clairement établi et les indices de sévérité du SAS utilisés en clinique (AHI et ODI) restent controversés. Méthodes Nous avons suivi la mortalit...

Objectif Évaluer l’effet à long terme d’un programme d’activité physique supervisé de 9 mois en condition de vie réelle chez des patients souffrant d’un syndrome d’apnées obstructives du sommeil (SAOS). Méthodes À l’issue des 9 premiers mois de suivi, les patients randomisés dans le groupe exercice (EXE) ont été encouragés à maintenir une activité...

Objectif Les rythmes professionnels des sapeurs-pompiers (SP) perturbent leur sommeil. Des études chez les SP à l’étranger ont montré que le manque de sommeil pourrait diminuer l’efficacité au travail. L’objectif de l’étude FIRESLEEP était d’évaluer la qualité du sommeil et des troubles du sommeil chez les SP professionnels (SPP) et volontaires (SP...

Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. The scientific evidence indicates that physical activity is the most effective method for preventing falls among seniors. Although public health professionals often use social marketing is to design and plan successfu...