David Hupin

David Hupin
Centre Hospitalier Universitaire de Saint-Étienne | CHU St Etienne · Department of Clinical Physiology and Exercise

MD, PhD
Post-doc in Karolinska Institutet, Stockholm, Sweden & Assistant Professor in Saint-Etienne University Hospital, France

About

108
Publications
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864
Citations
Additional affiliations
November 2013 - August 2015
Université Jean Monnet
Position
  • Medical Doctor

Publications

Publications (108)
Article
Letter Re: Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013 http://www.bmj.com/content/354/bmj.i3857/rr-9
Article
Full-text available
ContextAfter a COVID-19 infection, some patients have persistent symptoms, the most common is fatigue. To prevent it from becoming chronic (post-COVID-19 syndrome), early management before 3 months could be useful. Exercise and education are recommended.Objective To assess fatigue in patients with prolonged symptoms after COVID-19 infection and who...
Article
Objectives Falls are a common and serious health problem. The present study examined the association between subjective age (i.e., feeling younger or older than one’s chronological age) and falls in two large national samples. Method Participants, aged 65 to 105 years old, were drawn from the National Health and Aging Trends Study (NHATS) and the...
Article
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Funding Acknowledgements Type of funding sources: Other. Main funding source(s): Doctoral contract 2018-2022 Background Several studies have shown the importance of the relationship between the power-force-velocity profile (PFVP) and sport performance in elite athletes through optimised exercise training.[1] Optimising the training programme is co...
Article
Funding Acknowledgements Type of funding sources: None. Background The importance of exercise electrocardiogram (ECG) is still controversial in the prevention of cardiovascular events among sportsmen. The aim of this study was to assess the relevance of exercise ECG as a significant prognostic marker for cardiovascular events when any CVD risk fac...
Article
Full-text available
Background Obstructive sleep apnea (OSA) affects 5% of the adult population and its prevalence is up to 13 times higher in coronary artery disease (CAD) patients. However, OSA in this population is less symptomatic, leading to lower adherence to positive airway pressure (CPAP). While oropharyngeal exercise showed a significant decrease in apnea-hyp...
Article
Background: Cardiac vagal dysfunction was documented in middle-aged patients with migraine. However, vagal activity depends on several psychophysical or physiological factors such as anxiety, depression, lifestyle or age. In this work, we studied cardiac parasympathetic activity in elderly volunteers with past or current migraine. Methods: Among PR...
Article
Baroreflex sensitivity (BRS) is known to be a predictor of morbidity and mortality in metabolic and cardiovascular diseases. However, although we know that BRS decreases with age, we do not know whether BRS is predictive of mortality in general elderly population. The objective of this work is to study the predictive value of BRS in the mortality o...
Article
Objectif Le ticagrelor est connu pour provoquer de la dyspnée mais également des désordres respiratoires centraux lors du sommeil. Nous avons voulu évaluer le retentissement qu’il pouvait avoir sur le comportement ventilatoire à l’exercice et son impact sur le plan fonctionnel et métabolique. Méthodes C’est une étude rétrospective, monocentrique,...
Article
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Background The COVID-19 pandemic led to the closure of most cardiac therapy centers. One of the solutions was to adapt the existing cardiac rehabilitation (CR) program in an institute to a remote approach offered by home-based telerehabilitation. The aim of this study was to measure the cardiorespiratory effects of telerehabilitation compared to co...
Article
Full-text available
Background Although the benefits of physical activity (PA) on health are recognised, prostate cancer patients do not follow PA recommendations. The barriers to PA, whether physical, environmental or organisational, are known. Furthermore, even when such barriers are overcome, this achievement is not systematically accompanied by a change in lifesty...
Article
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Background: Chronic inflammation leads to autonomic dysfunction, which may contribute to the increased risk of cardiovascular diseases (CVD) in patients with rheumatoid arthritis (RA). Exercise is known to restore autonomic nervous system (ANS) activity and particularly its parasympathetic component. A practical clinical tool to assess autonomic fu...
Article
Background: Exercise-induced laryngeal obstruction (EILO) is an exercise-dependent dyspnoea, linked to a laryngeal closure during physical effort. It may concern from 5% to 7% of adolescents and young athletic adults. EILO is a quite recently described condition: standardized diagnostic criteria and consensual management are still to come. Formal...
Article
Previous reports of an association between handgrip strength (HGS) and the risk of hypertension have utilized cross-sectional designs. We aimed to assess the prospective association between HGS and hypertension risk in a general population. Handgrip strength was assessed at baseline in 463 Finnish men and women aged 61-73 years. Handgrip strength w...
Article
Background: Cardiorespiratory optimal point (COP) during exercise, a potentially useful submaximal cardiopulmonary exercise testing (CPET) variable, may be an independent risk factor for cardiovascular disease outcomes. However, the relationship of COP with risk of sudden cardiac death (SCD) has not been previously investigated. We sought to evalu...
Article
Full-text available
Although recent trials have shown promising benefits of exercise on obstructive sleep apnea (OSA) severity, the long‐term effect of these interventions remains unknown. The aim of this study was to assess the effect of a 9‐month community physical activity program on OSA severity one year later in free‐living conditions. OSA patients, previously in...
Article
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Background: Falls affects one of three people after 65 years old, and it can lead to serious consequences. Scientific evidence point out that physical exercise is the most efficient way to prevent falls among older adults. Objective: The main objective of this study is to determine if a social marketing program can increase the attendance rate of p...
Article
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Introduction: The COVID-19 pandemic implied a period of lockdown for the general population, increasing the risk to develop some physical or mental disorders. In fibromyalgia patients, these disorders are part of the large clinical picture of the syndrome. Fibromyalgia management is especially based on a regular practice of physical activity. Lockd...
Article
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The aim of the study was to assess potential associations between obstructive sleep apnea (OSA) and the occurrence of diabetes mellitus and insulin resistance in the elderly. Nondiabetic volunteers (n = 549) with undiagnosed or untreated asymptomatic OSA (66.2+/−1 years at the inclusion) were evaluated as an ancillary study of the PROOF cohort stud...
Article
Full-text available
Introduction: Fibromyalgia (FM) is characterized by multiple symptoms including pain, fatigue, and sleep disorders, altering patient's quality of life. In the absence of effective pharmacological therapy, the last European guidelines recommend a multidisciplinary management based on exercise and education. Thus, our main objective was to measure th...
Article
Objectif L’apnée du sommeil augmente avec l’âge. Cependant l’évolution de l’apnée du sommeil chez la personne âgée est inconnue. L’objectif de cette étude est donc de suivre le devenir de cette pathologie et notamment de ses index polygraphiques. Méthodes Parmi les 1011 sujets sains de l’étude PROOF inclus à l’âge de 65 ans en 2001, 213 sujets ont...
Article
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Background: Periodontal diseases (PD) seem to appear today as predictors of some cardiovascular diseases (CVD). There is a lack of data on the oral health among Cameroonian military population, and its relationship with CVD. Purpose: Investigate on the link between oral health of Cameroonian military from the Ngaoundéré garrison and their cardio...
Article
Background The prevalence of small-fiber neuropathy (SFN) is high in patients with hereditary transthyretin amyloidosis (ATTRv) but remains unknown in transthyretin wild-type cardiac amyloidosis (ATTRwt-CA). Objective To determine the prevalence of SFN in patients with ATTRwt-CA using Sudoscan®, a non-invasive method used to provide evidence of SF...
Article
Full-text available
Aims The prevalence of autonomic neuropathy (AN) is high in patients with hereditary transthyretin amyloidosis but remains unknown in transthyretin wild‐type cardiac amyloidosis (ATTRwt‐CA). This study aimed to determine the prevalence of AN in patients with ATTRwt‐CA using Sudoscan®, a non‐invasive method used to provide evidence of AN in clinical...
Article
Full-text available
Background: Previous cohorts studied the association of various types of physical activities with the incidence of cognitive disorders. The objective of this work was to analyze the association of leisure, domestic and professional physical activities with mild and moderate cognitive disorders in older people living in the community. Methods: We us...
Article
Objective Subjective age has been implicated in a range of health outcomes but its associations with Fear of Falling (FoF) are unknown. The present study examined the relation between subjective age and FoF in large national sample. Methods Participants were drawn from the National Health and Aging Trends Study (NHATS, 2011–2017). 1,679 participan...
Article
Full-text available
An amendment to this paper has been published and can be accessed via the original article.
Article
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Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. The scientific evidence indicates that physical activity is the most effective method for preventing falls among seniors. Although public health professionals often use social marketing to design and plan successful...
Article
Full-text available
Background: Cardiovascular diseases remain as the leading cause of morbidity and mortality in industrialized countries. Ageing and gender strongly modulate the risk to develop cardiovascular diseases but very few studies have investigated the impact of gender on cardiovascular diseases in the elderly, which represents a growing population. The pur...
Article
Full-text available
Background: Older adults and those with pre-existing medical conditions are at risk of death from severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). In this period of quarantine, one of the reasons for going out is physical activity. This issue is important, as the impact of a sedentary lifestyle might be lower for children and young adu...
Article
Full-text available
Background: Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods: The study used data from the prospective observa...
Preprint
BACKGROUND Studies agree that we are only at the beginning of an unprecedented health crisis affecting the population and especially older adults. In this period of quarantine, one of the reasons for going out is physical activity. This issue is important because if the problem is lower for adults, it is more complicated for older adults. They need...
Preprint
Full-text available
Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods The study used data from the prospective observationa...
Preprint
Full-text available
Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods The study used data from the prospective observationa...
Article
Objectif La mise en place d’un traitement du SAS chez le sujet âgé est toujours débattue. En effet, dans cette population, le lien entre la pathologie et l’augmentation du risque de mortalité n’a pas été clairement établi et les indices de sévérité du SAS utilisés en clinique (AHI et ODI) restent controversés. Méthodes Nous avons suivi la mortalit...
Article
Full-text available
Objectif Évaluer l’effet à long terme d’un programme d’activité physique supervisé de 9 mois en condition de vie réelle chez des patients souffrant d’un syndrome d’apnées obstructives du sommeil (SAOS). Méthodes À l’issue des 9 premiers mois de suivi, les patients randomisés dans le groupe exercice (EXE) ont été encouragés à maintenir une activité...
Article
Objectif Les rythmes professionnels des sapeurs-pompiers (SP) perturbent leur sommeil. Des études chez les SP à l’étranger ont montré que le manque de sommeil pourrait diminuer l’efficacité au travail. L’objectif de l’étude FIRESLEEP était d’évaluer la qualité du sommeil et des troubles du sommeil chez les SP professionnels (SPP) et volontaires (SP...
Preprint
Full-text available
Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. The scientific evidence indicates that physical activity is the most effective method for preventing falls among seniors. Although public health professionals often use social marketing is to design and plan successfu...
Article
Full-text available
Background The force-velocity-power (FVP) profile is used to describe dynamic force production capacities, which is of great interest in training high performance athletes. However, FVP may serve a new additional tool for cardiac rehabilitation (CR) of coronary artery disease (CAD) patients. The aim of this study was to compare the FVP profile betw...
Preprint
Full-text available
Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods The study used data from the prospective observationa...
Article
Le cancer de la prostate est le cancer le plus fréquent en France. Bien que les bénéfices de l’activité physique chez les patients atteints de cancer soient actuellement bien établis, cette population reste insuffisamment active. Renforcer l’adhésion des patients à l’activité physique est l’enjeu principal d’une prise en charge personnalisée en can...
Preprint
Full-text available
Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. Physical activity represents the most effective method for preventing falls among seniors. Social marketing has already shown its utility in the construction of prevention programs. Its use and evaluation in preventio...
Preprint
Full-text available
Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. The scientific evidence indicates that physical activity is the most effective method for preventing falls among seniors. Although public health professionals often use social marketing to design and plan successful i...
Preprint
Full-text available
Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. The scientific evidence indicates that physical activity is the most effective method for preventing falls among seniors. Although public health professionals often use social marketing to design and plan successful i...
Preprint
Full-text available
Background: Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. The scientific evidence indicates that physical activity is the most effective method for preventing falls among seniors. Although public health professionals often use social marketing to design and plan successful i...
Preprint
Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods The study used data from the prospective observationa...
Article
Background Previous cohorts have been notably criticized for not studying the different type of physical activity and not investigating household activities. The objective of this work was to analyse the relation between physical activity and cognitive decline in older people living in community. Impact of type of physical activity on the results h...
Conference Paper
Full-text available
BACKGROUND : Falls are the leading cause of mortality in people aged 65 and over, affecting one in three people in this population. Physical activity (PA) is recognized as the most effective method to prevent falls in the elderly. Yet despite there being a consensus now that PA is effective in practice, there remain many obstacles to participation....
Article
Full-text available
While obstructive sleep apnea (OSA) increases chemoreflex, leading to an autonomic dysfunction in the long‐term, no studies have yet assessed the potential benefit of exercise on cardiac autonomic activity in these patients. The aim of this study was to evaluate potential improvement in cardiac autonomic function (CAF) measured through heart rate v...
Article
Full-text available
Introduction: Obstructive sleep apnea/hypopnea (OSAH) affects more than 15% of the general population and increases the occurrence of cardiovascular (CV) and metabolic events. Continuous positive airway pressure (CPAP) treatment is currently the gold standard treatment of OSAH and could prevent the occurrence of such events. However, long-term adhe...
Article
Full-text available
Background Previous studies have suggested that exercise training improves cardiac autonomic drive in young and middle-aged adults. In this study, we discuss the benefits for the elderly. Objectives We aimed to establish whether exercise still increases heart rate variability (HRV) beyond the age of 60 years, and to identify which training factors...
Article
Full-text available
Introduction: Several studies suggest in middle-aged subjects a relationship between arterial stiffness, a cardiovascular risk marker, and moderate to severe obstructive sleep apnea (OSA). No extensive data are present in older subjects. This study explores this association in a sample of healthy older subjects suffering OSA. Methods: A total of...
Article
Objectif Évaluer l’activité autonomique cardiaque mesurée par la variabilité de la fréquence cardiaque (VFC) après un programme d’activité physique de 9 mois chez des patients atteints de Syndrome d’apnées obstructives du sommeil (SAOS). Méthodes 74 patients ayant un SAOS modéré, âgés de 40 à 80 ans, ont été randomisés dans un groupe exercice (n =...
Article
Objectif Le syndrome d’apnée du sommeil (SAS) est la cause la plus fréquente de somnolence excessive diurne. La prévention et la prise en charge des personnes atteintes du SAS peut contribuer à la diminution du risque d’AVC. L’objectif de cette étude est d’expérimenter un dépistage du risque d’apnée du sommeil par les pharmaciens d’officine. Métho...
Article
Obstructive sleep apnea (OSA) has been linked to altered cardiovascular response to exercise. A systematic review and individual patient data (IPD) meta-analysis were conducted to assess whether OSA patients present reduced exercise capacity. PubMed, Embase and Web of Science were searched until September 2018. Studies which performed sleep recordi...
Article
Full-text available
Background: Work may contribute significantly to daily physical activity (PA) and sedentary behavior (SB). Physical inactivity and SB at work might be two major risk factors for premature morbidity. Therefore, the aim of this research was to describe self-reported past PA and SB at work and during leisure time within the PROOF cohort subjects, and...
Article
Full-text available
Idiopathic hypersomnia (IH) is a rare central hypersomnia of unknown physiopathology. In this study, we determine if the presence of infectious mononucleosis evaluated by serological markers of Epstein Barr virus infection plays a role in this hypersomnia. Ten patients with a suspicion of IH underwent to clinical assessment, 24 h polysomnography, a...
Article
Supported by grants from the National Association of Research and Technology (ANRT) and the Federation Francaise d'Education Physique et de Gymnastique Volontaire (FFEPGV) through the CIFRE Convention #2014/0391, from the University Hospital of Saint-Etienne (AOL #2015/150833), and from the Adene group. The University Hospital of Saint-Etienne was...
Conference Paper
Full-text available
Impact of Inspiratory Muscle Training on Obstructive Sleep Apnea in Coronary Artery Disease Patients. The RICAOS study: preliminary results. INTRODUCTION Obstructive Sleep Apnea (OSA) affects 5% of the adult population and its prevalence is up to 13 times higher in coronary artery disease (CAD) patients. However, OSA in this population is less sym...