David Hunter

David Hunter
The University of Sydney · Faculty of Medicine (Sydney Medical School)

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810
Publications
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Publications

Publications (810)
Article
Purpose: The magnitude and location of hip contact force influences the local mechanical environment of the articular tissue, driving remodelling. We used a neuromusculoskeletal model to investigate hip contact force magnitudes and their regional loading patterns on the articular surfaces in those with femoroacetabular impingement (FAI) syndrome an...
Article
INTRODUCTION The Foundation for the National Institutes of Health (FNIH) OA Biomarkers Consortium is a nested case-control study based within the larger OAI study. One goal of this study was to determine the association between semiquantitative MRI biomarkers and knee OA progression To date there is a gap in knowledge whether change of non-cartilag...
Article
BACKGROUND Imaging plays an important role in defining structural disease severity and potential suitability of patients recruited to disease-modifying osteoarthritis drug (DMOAD) trials. Three main structural phenotypes in knee OA have been proposed based on MRI, i.e., inflammation, cartilage-meniscus and subchondral bone. The cartilage-meniscus p...
Article
INTRODUCTION Both semi-quantitative (SQ) MOAKS cartilage scores and quantitative (Q) cartilage thickness measurements are used as outcome measures in observational studies and interventional knee osteoarthritis (OA) trials. In order to increase sensitivity to change of SQ instruments in longitudinal observational studies or clinical DMOAD trials, s...
Article
INTRODUCTION Levothyroxine, the primary treatment for hypothyroidism, is prescribed for more than 7% of Americans. Levothyroxine use, or the underlying hypothyroidism can be associated with musculoskeletal symptoms; however, no prior work has investigated this association using sensitive biomarkers. OBJECTIVE We examined the association between le...
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Introduction Trapeziometacarpal joint osteoarthritis (OA) produces significant functional impairment due to pain and loss of strength in both power and precision grips, but few studies have related radiographic scores to functional and pain-based measures. Purpose To investigate the association between markers of radiographic disease and outcomes...
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Background Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both ind...
Article
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BACKGROUND: Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breast cancer patients. METHODS: We performed genome-wide association analyses within 15 subgroups of breast cancer patients based on...
Article
Background The internet is used for information related to health conditions, including low back pain (LBP), but most LBP websites provide inaccurate information. Few studies have investigated the effectiveness of internet resources in changing health literacy or treatment choices. Objective This study aims to evaluate the effectiveness of the MyB...
Preprint
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Background: Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and its interaction with genetic variants are not fully understood. Methods: We conducted a genome-wide interaction analysis between MHT use and genetic variants for breast cancer risk in 27,585 cases and 34,785...
Preprint
BACKGROUND The internet is used for information related to health conditions, including low back pain (LBP), but most LBP websites provide inaccurate information. Few studies have investigated the effectiveness of internet resources in changing health literacy or treatment choices. OBJECTIVE This study aims to evaluate the effectiveness of the MyB...
Article
Objectives: This study examined whether risk factors for knee osteoarthritis (KOA) pain such as age, gender, body mass index (BMI), baseline pain, and other putative risk factors for knee osteoarthritis pain flares (KOAF) (e.g. knee buckling, injury, mood/stress/social support scores, and footwear) could predict KOAF. Method: People with KOA and pr...
Preprint
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Reproductive longevity is critical for fertility and impacts healthy ageing in women, yet insights into the underlying biological mechanisms and treatments to preserve it are limited. Here, we identify 290 genetic determinants of ovarian ageing, assessed using normal variation in age at natural menopause (ANM) in ~200,000 women of European ancestry...
Article
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Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringi...
Article
Objective Establish the impact of pain severity on the cost-effectiveness of generic duloxetine for knee osteoarthritis (OA) in the United States. Design We used a validated computer simulation of knee OA to compare usual care (UC) - intra-articular injections, opioids, and total knee replacement (TKR) - to UC preceded by duloxetine in those no lo...
Article
Background Studies of walking in those with femoroacetabular impingement syndrome have found altered pelvis and hip biomechanics. But a whole body, time-contiuous, assessment of biomechanical parameters has not been reported. Additionally, larger cam morphology has been associated with more pain, faster progression to end-stage osteoarthritis and i...
Article
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Objective: Implementation strategies, such as new models of service delivery, are needed to address evidence practice gaps. This paper describes the process of developing and operationalising a new model of service delivery to implement recommended care for people with knee osteoarthritis (OA) in a primary care setting. Methods: Three developmen...
Article
Objectives Our objective was to evaluate the association of weather factors with the risk of pain exacerbations in people with symptomatic hip osteoarthritis (OA). Method Eligible participants with symptomatic hip OA were instructed to log on to the study website and complete questionnaires every 10 days and additionally whenever they considered t...
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Background: The Patient Activation Measure (PAM-13) was developed using Rasch analysis to assess knowledge, skills and confidence in the management of one's health. Previous studies report positive relationships between PAM-13 scores, self-management behaviours and longitudinal health outcomes in adults with chronic disease. There is little extant...
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Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly genotyped) and 375,188 controls identified 54 significant (P < 5 × 10−8) loci with 68 independent single nucleotide polymorphisms. Analysis of risk estimates across geographical region...
Article
Purpose: prevalence of knee osteoarthritis has been associated with work-related repetitive joint movements and excess knee load, but little is known of the relationship between specific job titles and risk of knee osteoarthritis; especially light to moderate physically demanding occupations. This review aims to assess the association between occup...
Article
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Introduction Hand osteoarthritis (HOA) is a highly prevalent disabling joint disease. The current management regimens are limited. Potentially as a consequence, many people turn to complementary and alternative medicines for symptomatic relief. A combination of two or more supplements is common in clinical practice; however, evidence for the effica...
Article
Objective: Weight loss has beneficial effects on clinical outcomes in knee osteoarthritis (OA), but the mechanism is still unclear. Since meniscus extrusion is associated with knee pain, this study assessed whether weight loss by diet and/or exercise is associated with less progression in meniscus extrusion measures over time. Design: The Intens...
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Objective: This paper aims to (i) identify differences in measures of hip morphology between four racial groups using anteroposterior (AP) hip x-rays, and (ii) examine whether these differences vary by sex. Methods: 912 hip x-rays (456 individuals) from four racial groups (European Caucasians, American Caucasians, African Americans and Chinese)...
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Objective ‘Environmental’ factors associated with colorectal cancer (CRC) risk include modifiable and non-modifiable variables. Whether those with different non-modifiable baseline risks will benefit similarly from reducing their modifiable CRC risks remains unclear. Design Using 7945 cases and 8893 controls from 11 population-based studies, we co...
Article
Background Previous gene-environment interaction studies of breast cancer risk have provided sparse evidence of interactions. Using the largest available dataset to date, we performed a comprehensive assessment of potential effect modification of 205 common susceptibility variants by 13 established breast cancer risk factors, including replication...
Conference Paper
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Background/Purpose: To investigate the construct validity of Outcome Measures in Rheumatology (OMERACT) ultrasound scores for knee osteoarthritis (OA) with pain, other symptoms, and OA severity on radiographs and magnetic resonance imaging (MRI) counterparts. Methods: A subgroup of community-recruited participants with symptomatic and mild-moderat...
Article
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A disease-modifying osteoarthritis drug (DMOAD) is a drug that modifies the underlying OA pathophysiology and potentially inhibits the structural damage to prevent or reduce long-term disability with potential symptomatic relief. The focus of this narrative review is on describing the state of the field for disease-modifying pharmacologic agents th...
Preprint
BACKGROUND Osteoarthritis (OA) is a chronic, disabling and prevalent disorder. As there is no cure for OA, long-term self-management is paramount. Support groups can facilitate self-management among people living with OA. Understanding preferences in design and features of support groups, including online support groups (OSGs), among people with OA...
Article
Background: Osteoarthritis (OA) is a chronic, disabling, and prevalent disorder. As there is no cure for OA, long-term self-management is paramount. Support groups (SGs) can facilitate self-management among people living with OA. Understanding preferences in design and features of SGs, including online SGs (OSGs), among people with OA can inform f...
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Full-text available
Genome-wide association study–identified prostate cancer risk variants explain only a relatively small fraction of its familial relative risk, and the genes responsible for many of these identified associations remain unknown. To discover novel prostate cancer genetic loci and possible causal genes at previously identified risk loci, we performed a...
Article
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Background Ultrasound can visualize both structural and inflammatory changes of osteoarthritis (OA) with greater accessibility. Therefore, the Outcome Measures in Rheumatology (OMERACT) Ultrasound Task Force recently proposed a semi-quantitative knee ultrasound scoring system1 which requires further validation. Objectives To investigate inter-rate...
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Background In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear. Methods We co...
Article
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Background: Thumb-base osteoarthritis (OA) is a common cause of pain and disability This study aimed to investigate the associations of musculoskeletal ultrasound OA pathologies with the extent of pain, function, radiographic scores, and muscle strength in symptomatic thumb-base osteoarthritis. Methods: This is a cross-sectional study of an ongo...
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Full-text available
Introduction Despite the prevalence of low back pain (LBP) worldwide, many people with the condition do not receive evidence-based care or achieve the best possible outcomes. There is a gap in the dissemination of evidence-based information across the globe. The advent of the internet has changed the way people obtain health information. As such, t...