David Han

The University of Texas at San Antonio | UTSA · Department of Management Science and Statistics

Chronic neck pain (cNP) is one of the leading causes of disability worldwide, often being refractory to conventional forms of treatment. Various forms of electrical stimulation have been proposed to decrease pain and improve function. Patient-reported outcome measures (PROMs) for treatment of cNP have rarely been published. An independent retrospec...

Chronic low back pain (cLBP) is a problem globally, creating a tremendous economic burden. Since conventional treatments often fail, various forms of electrical stimulation have been proposed to improve function and decrease pain. Patient-reported outcome measures (PROMs) have not been adequately reported in the electrical stimulation literature. A...

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is...

The North American opioid epidemic has resulted in over 800,000 related premature overdose fatalities since 2000, with the United States leading the world in highest opioid deaths per capita. Despite increased federal funding in recent years, intended to address this crisis, opioid overdose mortality has continued to increase. Legally prescribed op...

ince the seminal discovery reported by Drs Kenneth Blum & Ernest P. Nobles in JAMA 1990 of the association of the DRD2 Taq A1 allele and severe alcoholism, the field of Psychiatric Genetics was born, and the understanding of the relationships between DNA polymorphisms and epigenetic insults exploded [1]. Nature vs. nurture is now thought to be 50/5...

Thanks to continuously advancing technology and manufacturing processes, the products and devices are becoming highly reliable but performing the life tests of these products at normal operating conditions has become extremely difficult, if not impossible, due to their long lifespans. This problem is solved by accelerated life tests where the test...

Since 1990, when our laboratory published the association of the DRD2 Taq A1 allele and severe alcoholism in JAMA, there has been an explosion of genetic candidate association studies, including genome-wide association studies (GWAS). To develop an accurate test to help identify those at risk for at least alcohol use disorder (AUD), a subset of rew...

Since 1990, when our laboratory published the association of the DRD2 Taq A1 allele and severe alcoholism in JAMA, there has been an explosion of genetic candidate association studies, including GWAS. To develop an accurate test to help identify those at risk for at least Alcohol Use Disorder (AUD), Blum’s group developed the Genetic Addiction Risk...

Background There is a shortage of clinical studies examining the efficacy of Nicotinamide Adenine Dinucleotide and Enkephalinase infusions (IV1114589NAD) in treating Substance Use Disorder (SUD). Objective This study aims to provide evidence that IV1114589NAD infusions significantly attenuate substance craving behavior. Methods The study cohort c...

For highly reliable products and devices, conducting the life tests at normal usage conditions demands a great deal of time and cost, which can result in missed opportunities to introduce the product to the market in a timely manner and eventually loss of the market share. By subjecting test units at higher stress levels than normal operating condi...

With the engineering technology and manufacturing processes continuously improving, modern products and devices are becoming more sophisticated and reliable. On the other hand, conducting traditional life tests for these products at normal operating conditions has become almost impossible because of their extremely long lifespans. In this competing...

A step‐stress accelerated life test is a special life test where test units are subjected to higher stress levels than normal operating conditions so that the information on the lifetime parameters of a test unit can be obtained more quickly in a shorter period of time. Also, progressive Type‐I censoring is a generalized form of time censoring wher...

Thanks to continuously advancing technology and manufacturing processes, the products and devices are becoming highly reliable. However, performing the life tests of these products at normal operating conditions becomes extremely difficult, if not impossible, due to their long life spans. This can result in missed opportunities to introduce the pro...

In reliability engineering, the accelerated life test is not only getting increasingly popular but also necessary as it quickly yields information on the lifetime distribution of a highly reliable product in a short period of time by conducting the life test at more extreme stress levels than normal operating conditions. Through extrapolation, the...

Using an array of sensors with well calibrated but different tuning curves, it is possible to appreciate a wide range of stimuli. In this work, we first revisit the statistical estimation of the stimuli concentrations given the responses of a sensor array, discussed in Sanchez-Montanes & Pearce [18]. Since it is not a typical regression problem, th...

The primary aim of our study was to compare the preoperative diagnostic accuracy of plain radiographic findings with the accuracy of magnetic resonance imaging (MRI) findings for diabetic foot osteomyelitis in hospitalized patients who underwent first-time partial foot amputations with confirmed histopathological specimens positive for osteomyeliti...

Background: Buprenorphine and naloxone (bup/nal), a combination partial mu receptor agonist and low-dose delta mu antagonist, is presently recommended and used to treat opioid-use disorder. However, a literature review revealed a paucity of research involving data from urine drug tests that looked at compliance and abstinence in one sample. Metho...

With aging, there is decline in both short-term and long-term memory. This effect is magnified by epigenetic insults on specific, dopamine- related genes (e.g., DRD2, DAT1) as well as by impaired or reduced mRNA transcription. In addition, long-term memory ability is positively correlated with dopamine function and there is evidence that aging is a...

To collect the information about the lifetime distribution of a product, a standard life testing method at normal working conditions is impractical when the product has a substantially long lifespan. Accelerated life testing solves this problem by subjecting the test units at higher stress levels for quicker and more failure data. Due to constraine...

By running life tests at higher stress levels than normal operating conditions, accelerated life testing quickly yields information on the lifetime distribution of a test unit. The lifetime at the design stress is then estimated through extrapolation using a regression model. To conduct an accelerated life test efficiently with constrained resource...

The aim of this study was to determine the lower extremity amputation and mortality rates of a group of patients who underwent reconstructive surgery using circular external fixation for treatment of diabetic Charcot neuroarthropathy (CN) of the foot and/or ankle. Existing studies regarding lower extremity amputation or mortality rates for diabetic...

To our knowledge, this is the largest study evaluating relationships between 3T Magnetic Resonance Imaging (MRI) and P300 and memory/cognitive tests in the literature. The 3T MRI using NeuroQuant has an increased resolution 15 times that of 1.5T MRI. Utilizing NeuroQuant 3T MRI as a diagnostic tool in primary care, subjects (N=169; 19-90 years) dis...

In a reliability experiment, accelerated life-testing allows higher-than-normal stress levels on test units. In a special class of accelerated life tests known as step-stress tests, the stress levels are increased at some pre-planned time points, allowing the experimenter to obtain information on the lifetime parameters more quickly than under norm...

Abstract Recently, Willuhn et al. reported that cocaine use and even non-substance-related addictive behavior increases as dopaminergic function is reduced. Chronic cocaine exposure has been associated with decreases in D2/D3 receptors and was also associated with lower activation of cues in occipital cortex and cerebellum, in a recent PET study by...

Various studies have demonstrated that increased leptin levels and obesity are inversely related to cognitive decline in menopausal women. It is hypothesized that adiposity is inversely correlated with cognitive decline, as women with increased weight are less vulnerable to diminishing cognition. However, it is increasingly observed that menopausal...

This is the first quantitative analysis of data from urine drug tests for compliance to treatment medications and abstinence from drug abuse across "levels of care" in six eastern states of America. Comprehensive Analysis of Reported Drugs (CARD) data was used in this post-hoc retrospective observational study from 10,570 patients, filtered to incl...

Background: Following the first association between the dopamine D2 receptor gene polymorphism and severe alcoholism, there has been an explosion of research reports in the psychiatric and behavioral addiction literature and neurogenetics. With this increased knowledge, the field has been rife with controversy. Moreover, with the advent of Whole G...

By running the life tests at higher stress levels than normal operating conditions, accelerated life testing quickly yields information on the lifetime distribution of a test unit. The lifetime at the design stress is then estimated through extrapolation using a regression model. In constant-stress testing, a unit is tested at a fixed stress level...

It is well known that athletes and other individuals who have suffered painful injuries are at increased risk for all reward deficiency syndrome (RDS) behaviors, including substance use disorder (SUD). Comparing patient demographics and relapse rates in chemical dependence programs is pertinent because demographics may affect outcomes. Increased ri...

Various trials have been conducted on the management and treatment of androgenic alopecia (AGA) or male pattern hair loss using a variety of laser and light sources. For this feasibility study, the population was composed of males between the ages of 20 and 60 years who have been experiencing active hair loss within the last 12 months and the diagn...

In accelerated step-stress life tests, the stress levels are allowed to increase at some pre-determined time points to obtain information on the lifetime parameters more quickly than under normal operating conditions. Understanding that there are often more than one cause of failure of a test unit such as mechanical or electrical, in this article,...

The mounting endemic of prescription iatrogenic opioid dependence in pain patients provoked this treatise about an alternative method that can be used to treat pain, improve function and reduce the risk of opioid dependence. It is well known that as well as the side effects reported for chronic opioid therapy, genetically predisposed individuals ar...

By running life tests at higher stress levels than normal operating conditions, accelerated life testing (ALT) quickly yields information on the lifetime distribution of a test unit. The lifetime at the design stress is then estimated through extrapolation using a regression model. In constant-stress testing, a unit is tested at a fixed stress leve...

Addictions to illicit drugs are among the nation's most critical public health and societal problems. The current opioid prescription epidemic and the need for buprenorphine/naloxone (Suboxone®; SUBX) as an opioid maintenance substance, and its growing street diversion provided impetus to determine affective states ("true ground emotionality") in l...

We have entered the genomics era with hope for the future of medicine including psychiatry. Understanding the role of DNA and polymorphic associations with brain reward circuitry has led to a new understanding of all addictive behaviors. We present here a brief review of the role of both neurogenetics and nutrigenomics as cornerstones that link mor...

Addictions to illicit drugs are among the nation's most critical public health and societal problems. The current opioid prescription epidemic and the need for buprenorphine/naloxone (SuboxoneH; SUBX) as an opioid maintenance substance, and its growing street diversion provided impetus to determine affective states (''true ground emotionality'') in...

Addictions to illicit drugs are among the nation’s most critical public health and societal problems. The current opioid prescription epidemic and the need for buprenorphine/naloxone (Suboxone®; SUBX) as an opioid maintenance substance, and its growing street diversion provided impetus to determine affective states (“true ground emotionality”) in l...

It is well established that inherited human aldehyde dehydrogenase 2 (ALDH-2) deficiency reduces the risk for alcoholism. Kudzu plants and extracts have been used for 1,000 years in traditional Chinese medicine to treat alcoholism. Kudzu contains daidzin, which inhibits ALDH-2 and suppresses heavy drinking in rodents. Decreased drinking due to ALDH...

Background and aims: Many patients presenting multiple behaviors including drug and food abuse as well as other pathological repetitive unwanted activities such as gambling, self-mutilation and paraphilias may not be appropriately diagnosed. Here we present a case of a male presenting many of these seemingly diverse behaviors and finally diagnosed...

Background: Split-thickness skin grafts can be used for foot wound closure in diabetic and nondiabetic patients. It is unknown whether this procedure is reliable for all diabetic patients, with or without comorbidities of diabetes, including cardiovascular disease, neuropathy, retinopathy, and nephropathy. Methods: We retrospectively reviewed 203 p...

While numerous studies support the efficacy of methadone and buprenorphine for the stabilization and maintenance of opioid dependence, clinically significant opioid withdrawal symptoms occur upon tapering and cessation of dosage. We present a case study of a 35 year old Caucasian female (Krissie) who was prescribed increasing dosages of prescriptio...

Importantly, research from our laboratory in both in-patient and outpatient facilities utilizing the Comprehensive Analysis of Reported Drugs (CARD)™ found a significant lack of compliance to prescribed treatment medications and a lack of abstinence from drugs of abuse during active recovery. This unpublished, ongoing research provides an impetus t...

In accord with the new definition of addiction published by American Society of Addiction Medicine (ASAM) it is well-known that individuals who present to a treatment center involved in chemical dependency or other documented reward dependence behaviors have impaired brain reward circuitry. They have hypodopaminergic function due to genetic and/or...

While there is a considerable body of literature correlating the role of dopaminergic genes and obesity, body mass index, body type, overeating, carbohydrate binging, energy expenditure and low dopamine D2 receptor (D2R) receptor density, there is a paucity of research concerning the dopamine D2 receptor gene (DRD2) variants and percent body fat. W...

For reasons of time constraint and cost reduction, censoring is commonly employed in practice, especially in reliability engineering. Among various censoring schemes, progressive Type-I right censoring provides not only the practical advantage of known termination time but also greater flexibility to the experimenter in the design stage by allowing...

In reliability analysis, accelerated life-testing allows for gradual increment of stress levels on test units during an experiment. In a special class of accelerated life tests known as step-stress tests, the stress levels increase discretely at pre-fixed time points, and this allows the experimenter to obtain information on the parameters of the l...

In this paper, a k-step-stress accelerated life-testing is considered with an equal step duration τ. For small to moderate sample sizes, a practical modification is made to the model previously considered by Gouno et al. [2004. Optimal step-stress test under progressive Type-I censoring. IEEE Trans. Reliability 53, 383–393] in order to guarantee a...

In reliability analysis, accelerated life-testing allows for gradual increment of stress levels on test units during an experiment. In a special class of accelerated life tests known as step-stress tests, the stress levels increase discretely at pre-fixed time points, and this allows the experimenter to obtain information on the parameters of the l...

In this article, optimal progressive censoring schemes are examined for the nonparametric confidence intervals of population quantiles. The results obtained can be universally applied to any continuous probability distribution. By using the interval mass as an optimality criterion, the optimization process is free of the actual observed values from...

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