David Orestes Guarin Bedoya

Massachusetts General Hospital | MGH · Athinoula A. Martinos Center for Biomedical Imaging

We report dissolution Dynamic Nuclear Polarization (d-DNP) of [15N3]metronidazole ([15N3]MNZ) for the first time. Metronidazole is a clinically approved antibiotic, which can be potentially employed as a hypoxia-sensing molecular probe using 15N hyperpolarized (HP) nucleus. DNP process is very efficient for [15N3]MNZ with an exponential build-up co...

We report dissolution Dynamic Nuclear Polarization (d‐DNP) of [ ¹⁵ N 3 ]metronidazole ([ ¹⁵ N 3 ]MNZ) for the first time. Metronidazole is a clinically approved antibiotic, which can be potentially employed as a hypoxia‐sensing molecular probe using ¹⁵ N hyperpolarized (HP) nucleus. The DNP process is very efficient for [ ¹⁵ N 3 ]MNZ with an expone...

Hyperpolarization chemistry based on reversible exchange of parahydrogen, also known as Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to attain high levels of nuclear spin hyperpolarization, which can enhance NMR and MRI signals by many orders of magnitude. SABRE has received significant attention in the sci...

Dissolution dynamic nuclear polarization (DDNP) is a versatile tool to boost signal amplitudes in solution-state nuclear magnetic resonance (NMR) spectroscopy. For DDNP, nuclei are spin-hyperpolarized "ex situ" in a dedicated DNP device and then transferred to an NMR spectrometer for detection. Dramatic signal enhancements can be achieved, enabling...

Dissolution dynamic nuclear polarization (D-DNP) experiments rely on the transfer of a sample between two high-field magnets. During this transfer, samples might experience passage through regions where the stray fields of the magnets are very weak, can approach zero, and even change their sign. This can lead to unexpected spectral features in spin...

Long-lived imbalances of spin state populations can circumvent fast quadrupolar relaxation by reducing effective longitudinal relaxation rates by about an order of magnitude. This opens new avenues for the study of dynamic processes in deuterated molecules. Here we present an analysis of the relaxation properties of deuterated methyl groups CD3. Th...

Dynamic nuclear polarization (DNP) embraces a family of methods to increase signal intensities in nuclear magnetic resonance (NMR) spectroscopy. Despite extensive theoretical work that allows one to distinguish at least five distinct mechanisms, it remains challenging to determine the relative weights of the processes that are responsible for DNP i...

Blazar emission models are usually divided into two big families, leptonic and hadronic, according to the particles which are responsible for the gamma-ray component of their spectral energy distributions. Even though leptonic models have been successful in explaining the gamma-ray emission from most blazars, hadronic models still present an intrig...

Blazar emission models are usually divided into two big families, leptonic and hadronic, according to the particles which are responsible for the gamma-ray component of their spectral energy distributions. Even though leptonic models have been successful in explaining the gamma-ray emission from most blazars, hadronic models still present an intrig...