David Garcia-Azorin

David Garcia-Azorin
Hospital Clínico Universitario de Valladolid · Department of Neurology

Doctor of Medicine

About

171
Publications
32,325
Reads
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1,308
Citations
Citations since 2016
162 Research Items
1296 Citations
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Publications

Publications (171)
Article
Full-text available
Background Migraine represents a serious burden for national health systems. However, preventive treatment is not optimally applied to reduce the severity and frequency of headache attacks and the related expenses. Our aim was to assess the persistence to traditional migraine prophylaxis available in Spain and its relationship with the healthcare r...
Article
Full-text available
Headache is among the most frequent symptoms persisting or newly developing after coronavirus disease 2019 (COVID-19) as part of the so-called long COVID syndrome. The knowledge on long COVID headache is still limited, however growing evidence is defining the features of this novel condition, in particular regarding clinical characteristics, some p...
Article
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Background The diagnosis of migraine is mainly clinical and self-reported, which makes additional examinations unnecessary in most cases. Migraine can be subtyped into chronic (CM) and episodic (EM). Despite the very high prevalence of migraine, there are no evidence-based guidelines for differentiating between these subtypes other than the number...
Preprint
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Brain-age is an emerging neuroimaging biomarker that represents the aging status of the brain using machine learning techniques from MRI data. It has been successfully applied to the study of different neurological and psychiatric conditions. We hypothesize that patients with migraine may show an increased brain age gap (difference between the age...
Article
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Importance Identification of long-term post–COVID-19 symptoms among hospitalized and nonhospitalized patients is needed. Objective To compare the presence of post–COVID-19 symptoms 2 years after acute SARS-CoV-2 infection between hospitalized and nonhospitalized patients. Design, Setting, and Participants A cross-sectional cohort study was conduc...
Article
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Safety and efficacy of vaccines against the SARS-CoV-2 coronavirus has been demonstrated in clinical trials and next by their real world use through the course of the ongoing COVID-19 pandemic. However, very rare adverse events have been detected post-authorization in certain parts of the world. This meeting report summarizes an EMA workshop's disc...
Article
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Headache is among the most frequently reported symptoms after resolution of COVID-19. We assessed structural brain changes using T1- and diffusion-weighted MRI processed data from 167 subjects: 40 patients who recovered from COVID-19 but suffered from persistent headache without prior history of headache (COV), 41 healthy controls, 43 patients with...
Article
Aim To evaluate the diagnostic accuracy of the SNNOOP10 list in the detection of high-risk headaches. Methods Patients that visited the Hospital Clínico San Carlos (Madrid) emergency department due to headache that were allocated to a Manchester Triage System level between critical and urgent were prospectively included but retrospectively analyse...
Article
Encephalopathy, a common condition among patients hospitalized with COVID-19, can be a challenge to manage and negatively affect prognosis. While encephalopathy may present clinically as delirium, subsyndromal delirium, or coma and may be a result of systemic causes such as hypoxia, COVID-19 has also been associated with more prolonged encephalopat...
Article
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Background Headache is one of the most frequently reported symptoms in post-COVID patients. The clinical phenotype of COVID-19 headache combines phenotypic features of both tension-type headache (TTH) and migraine. We aimed to assess the effectiveness, side effects and predictors of amitriptyline (AMT) response in a real-world study setting. Metho...
Preprint
Background Headache is a common manifestation of post-coronavirus disease (COVID) condition. We aimed to describe the need and effectiveness of acute and preventive medications in a series of 100 consecutive patients evaluated in a headache unit. Methods Observational descriptive study with a series of cases design. Patients with confirmed COVID di...
Conference Paper
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Background and aims: Algometry is a safe and objective technique to quantify pain, up to now used in headache research, but to a lesser extent to assess pain related to surgery. We aimed to analyze the demographic characteristics of pain related to cardiac surgery, assessed using static algometry. Methods: Adult patients consecutively undergoing c...
Conference Paper
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Background and aims: The objective was to assess grey matter longitudinal changes in patients with chronic migraine (CM) who reverse to episodic migraine (EM) compared to those who do not reverse. Methods: High-resolution 3D brain T1-weighted Magnetic Resonance Imaging data were obtained twice from migraine patients. The first acquisition was perf...
Article
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Background: To date, several variables have been associated with anti-CGRP receptor or ligand-antibody response with disparate results. Our objective is to determine whether machine learning (ML)-based models can predict 6, 9 and 12 months response to anti-CGRP receptor or ligand therapies among migraine patients. Methods: We performed a multice...
Article
Background Delayed-onset of headache seems a specific feature of cerebrovascular events after COVID-19 vaccines. Methods All consecutive events reported to the United States Vaccine Adverse Reporting System following COVID-19 vaccines (1 January to 24 June 2021), were assessed. The timing of headache onset post-vaccination in subjects with and wit...
Article
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Acute and post-acute neurological symptoms, signs and diagnoses have been documented in an increasing number of patients infected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which causes Coronavirus Disease 2019 (COVID-19). In this review, we aimed to summarize the current literature addressing neurological events following...
Article
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We describe a series of patients with COVID-19 who presented with seizures, reported in the Spanish Society of Neurology’s COVID-19 Registry. This observational, descriptive, multicentre, registry-based study includes patients with confirmed COVID-19 who experienced seizures during active infection. We describe the clinical presentation of COVID-19...
Article
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Resumen Introducción: Se describen las características epidemiológicas y clínicas de los casos de síndrome de trombosis con trombocitopenia (STT) notificados en España. Métodos: Se incluyeron los casos de trombosis venosa o arterial con trombocitopenia tras recibir vacuna con vectores de adenovirus no replicantes frente a la COVID-19 (AstraZeneca y...
Preprint
Diffusion Tensor Imaging (DTI) is the most employed method to assess white matter properties using quantitative parameters derived from diffusion MRI, but it presents known limitations that restricts the evaluation of complex structures. The objective of this study was the assessment of complementary diffusion measures extracted with a novel approa...
Article
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Background (1): Headache is a prevalent symptom experienced during ongoing SARS-CoV-2 infection, but also weeks after recovery. Whether cardio-pulmonary dysfunction contributes causally to headache persistence is unknown. Methods (2): We conducted a case-control analysis nested in a prospective cohort study. Individuals were recruited from August 2...
Article
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Introduction: We conducted a systematic review and meta-analysis of the cognitive effects of coronavirus disease 2019 (COVID-19) in adults with no prior history of cognitive impairment. Methods: Searches in Medline/Web of Science/Embase from January 1, 2020, to December 13, 2021, were performed following Preferred Reporting Items for Systematic...
Article
Objective: To identify the rates of neurological events following administration of mRNA (Pfizer, Moderna) or adenovirus vector (Janssen) vaccines in the U.S.. Methods: We utilized publicly available data from the U.S. Vaccine Adverse Event Reporting System (VAERS) collected between January 1, 2021-June 14, 2021. All free text symptoms that were...
Article
Background Headache is a frequent symptoms of coronavirus disease 2019 (COVID-19). Its long-term evolution remains unknown. We aim to evaluate the long-term duration of headache in patients that presented headache during the acute phase of COVID-19. Methods This is a post-hoc multicenter ambisective study including patients from six different thir...
Article
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Background The COVID-19 pandemic outbreak has dramatically disrupted healthcare systems. Two rapid WHO pulse surveys studied disruptions in mental health services, but did not particularly focus on neurology. Here, a global survey was conducted and addresses the impact of the pandemic on neurology services. Methods A cross-sectional study was carr...
Article
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Background The presence of headache during the acute phase of COVID-19 could be associated with the innate response and the cytokine release. We aim to compare the cytokine and interleukin profile in hospitalized COVID-19 patients at the moment of admission with and without headache during the course of the disease. Methods An observational analyt...
Article
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Background Headache is a frequent symptom following COVID-19 immunization with a typical onset within days post-vaccination. Cases of cerebral venous thrombosis (CVT) have been reported in adenovirus vector-based COVID-19 vaccine recipients. Findings We reviewed all vaccine related CVT published cases by April 30, 2021. We assessed demographic, cl...
Article
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Background The COVID-19 pandemic leads to disruptions of health services worldwide. To evaluate the particular impact on neurological services a rapid review was conducted. Methods Studies reporting the provision of neurological services during the pandemic and/or adopted mitigation strategies were included in this review. PubMed and World Health...
Conference Paper
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Objective: To evaluate resting-state functional alterations in patients with persistent headache after COVID-19 resolution. Methods: Exploratory case-control study. High-resolution brain resting-state functional Magnetic Resonance Imaging data were acquired in patients with persistent headache after COVID-19 infection and healthy controls (HC). CO...
Conference Paper
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Objective: To evaluate white matter alterations in patients with persistent headache after COVID-19 resolution. Methods: Exploratory case-control study. High-resolution brain diffusion Magnetic Resonance Imaging data were acquired in patients with persistent headache after COVID-19 infection and healthy controls (HC). Tract-Based Spatial Statistics...
Poster
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Objective: To evaluate white matter alterations in patients with persistent headache after COVID-19 resolution. Methods: Exploratory case-control study. High-resolution brain diffusion Magnetic Resonance Imaging data were acquired in patients with persistent headache after COVID-19 infection and healthy controls (HC). Tract-Based Spatial Statistics...
Conference Paper
Full-text available
Objective: To evaluate gray matter alterations in patients with persistent headache after COVID-19 resolution. Methods: Exploratory case-control study. High-resolution 3D brain T1-weighted Magnetic Resonance Imaging data were acquired in patients with persistent headache after COVID-19 infection and healthy controls (HC). FreeSurfer (version 6.0) w...
Poster
Full-text available
Objective: To evaluate resting-state functional alterations in patients with persistent headache after COVID-19 resolution. Methods: Exploratory case-control study. High-resolution brain resting-state functional Magnetic Resonance Imaging data were acquired in patients with persistent headache after COVID-19 infection and healthy controls (HC). CON...
Article
Introduction: The consequences of the use of of benzodiazepines in coronavirus disease 2019 have not yet been studied. We compared the hospital prognosis of patients hospitalized for coronavirus disease 2019 in benzodiazepine users and non-users. Patients and methods: Observational study with a retrospective cohort design. All consecutive patients...
Article
Objective We intend to evaluate the change of different cognitive functions after a guard shift in physicians.MethodsA descriptive observational study was performed. The study population included Spanish physicians who were asked to complete before and immediately after their guard shift the following tests: Digit Span, TMT-A, TMT-B, Symbol Digit,...
Article
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Objective To explore the experiences of patients suffering from new daily persistent headache (NDPH) regarding the diagnostic process, treatment and medical care. Design A qualitative phenomenological study was conducted. Setting A specialised headache unit at two university hospitals in Spain between February 2017 and December 2018. Participant...
Article
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To estimate the frequency of headache in patients with confirmed COVID-19 and characterize the phenotype of headache attributed to COVID-19, comparing patients depending on the need of hospitalization and sex, an observational study was done. We systematically screened all eligible patients from a reference population of 261,431 between March 8 (fi...
Technical Report
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Thrombotic Thrombocytopenia Syndrome (TTS) has emerged as a new adverse event following immunization in individuals vaccinated with COVID-19 non-replicant adenovirus vector-based vaccines (AstraZeneca COVID-19 ChAdOx-1 vaccine and Johnson & Johnson (J&J) Janssen COVID-19 Ad26.COV2-S vaccine). TTS is a serious and life-threatening adverse event. WHO...
Article
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Background We aim to describe and compare patients and general practitioners’ opinions about the different variables related to acute and preventive treatment for migraine. Patients and methods An observational descriptive study was performed. Patients with episodic migraine and general practitioners, from our healthcare area, were invited to answ...
Article
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Background Headache is identified as a common post-COVID sequelae experienced by COVID-19 survivors. The aim of this pooled analysis is to synthesize the prevalence of post-COVID headache in hospitalized and non-hospitalized patients recovered from SARS-CoV-2 infection. Methods MEDLINE, CINAHL, PubMed, EMBASE, and Web of Science databases, as well...
Article
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OnabotulinumtoxinA is one of the main preventive treatments for chronic migraine. Despite that up to one third of patients with chronic migraine suffer from daily headache, these individuals have hardly been studied. We conducted a prospective cohort study, including patients with chronic migraine and treated with OnabotulinumtoxinA according to th...
Article
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Objective To investigate the association of headache during the acute phase of SARS-CoV-2 infection with long-term post-COVID headache and other post-COVID symptoms in hospitalised survivors. Methods A case-control study including patients hospitalised during the first wave of the pandemic in Spain was conducted. Patients reporting headache as a s...
Article
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Background Vaccine induced immune medicated thrombocytopenia or VITT, is a recent and rare phenomenon of thrombosis with thrombocytopenia, frequently including cerebral venous thromboses (CVT), that has been described following vaccination with adenovirus vaccines ChAdOx1 nCOV-19 (AstraZeneca) and Ad26.COV2·S Johnson and Johnson (Janssen/J&J). The...
Article
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Objective/background: The great auricular nerve (GAN) is a major sensory branch of the cervical plexus. Painful great auricular neuropathy causes pain circumscribed to the inferior preauricular region, the jaw angle, the ventral pinna, and the mastoid region. Methods: We present a 46-year-old woman experiencing facial pain in the bilateral preau...
Article
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Objective To investigate the association of pre-existing migraine in patients hospitalised and who recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with the presence of post-coronavirus disease (COVID) symptoms. Background No study has investigated the role of migraine as a risk factor for development of post-C...
Article
Background: Nummular Headache (NH) is defined in the International Classification of Headache Disorders (ICHD) by the presence of localized pain circumscribed to a small round area of the scalp, not better accounted by any other diagnosis. As in many other primary headache disorders, secondary cases might occur. To date, 13 secondary cases have be...
Article
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Resumen estructurado Introducción: Se han reportado casos de trombosis venosas cerebrales en personas vacunadas frente a COVID-19 con vacunas vectoriazadas con adenovirus no replicantes. Aportamos recomendaciones sobre el diagnóstico y manejo de pacientes con esta complicación. Método: El Grupo de Trabajo multidisciplinar, liderado por la Federació...
Article
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Introduction Cases of cerebral venous sinus thrombosis have been reported in individuals vaccinated against COVID-19 with non-replicating adenoviral vector vaccines. We issue our recommendations on the diagnosis and management of patients presenting this complication. Methods The multidisciplinary working group, led by the Spanish Federation of Me...
Article
Objective We propose a new outcome measure to assess the efficacy of migraine treatments translating the approach of the Global Burden of Disease studies from a societal to an individual level: Instead of calculating “years lived with disability”, we suggest estimating “time lost due to an attack”. Methods Time lost due to an attack is calculated...
Article
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There is an accumulating volume of research into neurological manifestations of COVID‐19. However, inconsistent study designs, inadequate controls, poorly‐validated tests, and differing settings, interventions, and cultural norms weaken study quality, comparability, and thus the understanding of the spectrum, burden and pathophysiology of these com...
Article
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Background Coronavirus disease 2019 (Covid‐19) might present neurological symptoms. We aimed to evaluate the frequency of them at the moment of emergency department (ED) visit and their impact in the prognosis. Methods Retrospective cohort study including all consecutive hospitalized cases between March 8th and April 11th, 2020. Covid‐19 diagnosis...
Article
Introduction Les personnes souffrant de migraine épisodique (ME) ou chronique (MC) signalent une baisse de leur productivité au travail et de leur activité, tant pendant qu’entre les crises de migraine. Objectifs Évaluer l’évolution depuis l’inclusion de la baisse de productivité au travail/activité et de l’impact entre les crises chez des patient...
Article
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Resumen Introducción La pandemia COVID-19 ha provocado un inusitado impulso a la telemedicina (TM). Analizamos el impacto de la pandemia en la TM aplicada en las consultas de cefaleas españolas, revisamos la literatura y lanzamos unas recomendaciones para implantar la TM en las consultas. Método Tres fases: 1) Revisión de la base Medline desde el...
Article
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RESUMEN Introducción: La pandemia ocasionada por la aparición del SARS-CoV-2, ha transformado la práctica médica y ha alterado gravemente la formación de los médicos residentes a nivel mundial. Desde la Sociedad Española de Neurología (SEN) se ha querido conocer el grado de repercusión que la COVID-19 ha tenido en el ámbito formativo entre los resi...