David Farrell

• Bachelor of Arts
• Trinity College Dublin

We designed and synthesised a series of novel chalcones, incorporating the heterocyclic framework of 2,2-dimethyl-2,3-dihydro-4(1H)-quinolinone, which was prepared via Sonogashira coupling of a substituted orthoaniline under aqueous conditions using Pd catalysis followed by acid-mediated cyclisation. The compounds were screened against the NCI-N87...

A series of 10-((4-halo-2,6-diisopropylphenyl)imino)phenanthren-9-ones and derivatives of the phenanthrene-9,10-dione ligand have been synthesised and structurally characterised to explore two types of non-covalent interactions, namely the influence of the steric bulk upon the resulting C—H...pi and pi-stacking interactions and halogen bonding. Sel...