David A Cottrell

• Boston University

This was a double-blind randomized clinical trial to assess the effect of different pharmacological regimens on the level of prostaglandin E2 (PGE2) in urine and saliva, and to correlate the findings to the clinical course after removal of impacted lower third molars. Eighty patients were randomly divided into four groups: group 1 received placebo;...

Implant therapy has become a very predictable treatment option in the general population; however, there are certain factors that increase the risk of implant failure. The 2008 National Health Interview Survey estimates that 24.8 million men and 21.1 million women are smokers. The literature regarding cigarette smoking and dental implants currently...

Sialolithiasis is one of the most common pathologies of the submandibular gland; sialoliths account for about 80 percent of all salivary duct calculi. This report presents the unusual case of a large asymptomatic sialolith of the submandibular duct, initially diagnosed as a possible tumor. The giant sialolith was removed via an intraoral approach u...

Objectives: PubMed was searched and the information regarding cigarette smoking and implants was synthesized into a concise review article suitable for a clinician to quickly assess the state of implant placement in this significant percentage of the population. Methods: PubMed was searched and information regarding how cigarettes affect the long...

Objectives: Diabetes mellitus was once considered a contraindication to the use of dental implant therapy as it has been associated with co-morbidities including increased susceptibility to infection, impaired wound healing, and periodontitis. Dental implant therapy has become increasingly common among patients with diabetes as techniques for contr...

Diabetes mellitus was once considered a contraindication to the use of dental implant therapy as it has been associated with comorbidities, including increased susceptibility to infection, impaired wound healing, and periodontitis. Since dental implants and techniques for controlling diabetes have evolved, dental implant therapy has become increasi...

To evaluate the treatment outcomes of rigid internal fixation for the management of infected mandible fractures. A retrospective chart review of infected mandible fractures managed by a single oral and maxillofacial surgeon at a level I trauma center during a 7-year period was accomplished by independent examiners. All patients were treated with in...

Objectives: The use of barrier membranes in bone grafting procedures is widespread and its success has been well documented in the literature. However, as with most surgical techniques, there are specific complications associated with barrier membrane use. Toxic degradation byproducts, exposures, and inhibition of revascularization are potential pr...

This study evaluated the long-term effects of orthognathic surgery on subsequent growth of the maxillomandibular complex in the young cleft patient. We evaluated 12 young cleft patients (9 male and 3 female patients), with a mean age of 12 years 6 months (range, 9 years 8 months to 15 years 4 months), who underwent Le Fort I osteotomies, with maxil...

The health maintenance organizations (HMOs) in the United States continue to be a powerful force in the field of medicine. Their infiltration into dentistry has placed an emphasis on having the primary care provider (general practitioner [GP]) function as the central orchestrator from which patient care cascades. The purpose of this study is to det...

Alveolar distraction osteogenesis can be a valuable tool for implant site development. Simultaneous regeneration of hard and soft tissue and an overall decrease in treatment time compared with other methods of site preparation can be an advantage. The authors advocate the concept of "prosthetically driven alveolar distraction." Surgical planning sh...

The acronym CHARGE refers to a non-random clustering of congenital malformations whose cause remains unknown. To date, the dental features of CHARGE association are not well known. A brief review of the literature and a case in a 10-year old boy with the CHARGE association are presented. The patient had multiple dental anomalies including congenita...

This study evaluated a slightly modified extraoral approach to removing the symptomatic elongated styloid process. A brief description of this surgical technique and its comparison to the intraoral approach is provided. Four patients in whom an extraoral approach was used to expose and remove the elongated calcified stylohyoid complex were evaluate...

This study analyzes the use of a standard nomogram that can help reduce the level of anticoagulation preoperatively to effectively manage perioperative heparin therapy in chronically anticoagulated oral surgery patients who are at high risk for thromboembolism. Twenty patients with significant cardiovascular disease, ranging in age from 56 to 79 ye...

Although the systemic effects and course of the disease are well described, the etiology of sarcoidosis remains unknown. Diagnosis involves histologic, radiographic, and clinical correlation, and laboratory tests can be used to monitor disease activity and response to therapy. Active treatment of the disease is often withheld until clinical signs a...

This prospective study was designed to evaluate the long-term clinical and radiographic results of porous block hydroxyapatite (PBHA) used as a synthetic bone graft in orthognathic surgery and craniofacial augmentation. A total of 245 consecutive patients were treated initially. Inclusion criteria for this study included a minimum clinical and radi...

Tomographic radiographs of 44 healthy temporomandibular joints in 22 patients undergoing large upward and forward rotations of the maxillomandibular complex were evaluated. Immediate postsurgery results showed decreases in all areas of the joint space. Long-term results showed a decrease in the superior and posterior regions, 14.8% and 19.7%, with...

Macroglossia can create dentomusculoskeletal deformities, instability of orthodontic and orthognathic surgical procedures, and masticatory, speech, and airway problems. The cause of macroglossia must be clearly defined, and true macroglossia separated from pseudomacroglossia (displacement of the tongue created by anatomic factors other than tongue...

Advances in orthognathic surgical treatment planning and in techniques for complex, simultaneous maxillary and mandibular repositioning have resulted in improved surgical accuracy. In traditional surgical sequencing, maxillary surgery is performed first; the maxilla is set, with or without an intermediate splint, using external reference points to...

This study evaluated the long-term outcomes of 52 sternoclavicular grafts for temporomandibular joint (TMJ) reconstruction in 38 patients. Patients were divided into three groups according to preoperative diagnosis and evaluated an average of 45 months (range, 10 to 84 months) postsurgery. Group 1 consisted of 14 patients (24 joints) with previous...

A study of 56 patients (55 female, one male) with 100 reconstructed temporomandibular joints (TMJ) using the Techmedica custom-made total joint system (Techmedica Inc, Camarillo, CA) is presented. The patients ranged in age from 15 to 61 years (average, 39 years) and had 16 to 46 months' follow-up (average 30 months). Outcome groups were categorize...

Until recently, little has been written concerning the area of combined orthognathic and rhinoplastic surgery. This may be due to the paucity of surgeons trained in these disciplines and the technical difficulty of the simultaneous performance of surgical procedures. A general approach to combine orthognathic and rhinoplastic treatment planning is...

Thioamides react with -chloroperoxybenzoic acid (MCPBA) to give good yields of the corresponding amides.

Bei der Behandlung mit m-Chlorperbenzoesäure kann das Thiolactam (I) zum Lactam (III) hydrolysiert werden.