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David Peter Antonius Cohen

David Peter Antonius Cohen
Institut Curie · Département de Bioinformatique et Biologie des systèmes

PhD

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16
Publications
3,224
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657
Citations

Publications

Publications (16)
Article
Full-text available
Understanding the etiology of metastasis is very important in clinical perspective, since it is estimated that metastasis accounts for 90% of cancer patient mortality. Metastasis results from a sequence of multiple steps including invasion and migration. The early stages of metastasis are tightly controlled in normal cells and can be drastically af...
Article
Full-text available
Cancerogenesis is driven by mutations leading to aberrant functioning of a complex network of molecular interactions and simultaneously affecting multiple cellular functions. Therefore, the successful application of bioinformatics and systems biology methods for analysis of high-throughput data in cancer research heavily depends on availability of...
Article
Data visualization is an essential element of biological research, required for obtaining insights and formulating new hypotheses on mechanisms of health and disease. NaviCell Web Service is a tool for network-based visualization of 'omics' data which implements several data visual representation methods and utilities for combining them together. N...
Article
Epithelial-to-mesenchymal transition-like (EMT-like) is a critical process allowing initiation of metastases during tumour progression. Here, to investigate its role in intestinal cancer, we combine computational network-based and experimental approaches to create a mouse model with high metastatic potential. Construction and analysis of this netwo...
Article
Precision medicine in oncology is becoming reality thanks to the next-generation sequencing of tumours and the development of targeted inhibitors enabling tailored therapies. Many clinical trials base their strategy on the identification of mutations to deliver the targeted inhibitor that counteract supposedly the effect of a mutated gene. Recent r...
Article
Several decades of molecular biology research have delivered a wealth of detailed descriptions of molecular interactions in normal and tumour cells. This knowledge has been functionally organised and assembled into dedicated biological pathway resources that serve as an invaluable tool, not only for structuring the information about molecular inter...
Article
Molecular biology knowledge can be formalized and systematically represented in a computer-readable form as a comprehensive map of molecular interactions. There exist an increasing number of maps of molecular interactions containing detailed and step-wise description of various cell mechanisms. It is difficult to explore these large maps, to organi...
Article
Mathematical models serve to explain complex biological phenomena and provide predictions that can be tested experimentally. They can provide plausible scenarios of a complex biological behavior when intuition is not sufficient anymore. The process from a biological hypothesis to a mathematical model might be challenging for biologists that are not...
Article
Full-text available
The Autographa californica multiple capsid nucleopolyhedrovirus (AcMNPV) was the first baculovirus for which the complete nucleotide sequence became known. Since then 15 years lapsed and much research has been performed to elucidate putative functions of the annotated open reading frames of this virus and this endeavour is still ongoing. AcMNPV is...
Article
Full-text available
Lactobacillus plantarum is part of the natural microbiota of many food fermentations as well as the human gastro-intestinal tract. The cytosolic fraction of the proteome of L. plantarum WCFS1, whose genome has been sequenced, was studied. 2-DE was used to investigate the proteins from the cytosolic fraction isolated from mid- and late-log, early- a...
Article
The gastro-intestinal (GI) tract is the primary site of food intake, perception and conversion. It represents one of the most important metabolic organs of the body and is colonised by a myriad of microbes that contribute to nutrient processing, affect immune function, and stimulate a variety of other host activities. Genomes of GI-tract resident m...
Article
The gastrointestinal (GI) tract is the primary site of food intake, perception and conversion. It represents one of the most important metabolic organs of the body and is colonised by a myriad of microbes that contribute to nutrient processing, affect immune function, and stimulate a variety of other host activities. Genomes of GI-tract resident mi...
Article
The indigenous microbiota of humans and other animals, far from being passive bystanders, participate in a wide range of complex interactions with their host. The burgeoning field of therapeutic microbiology concerns itself with the manipulation of the indigenous microbiota in order to promote the health of the host. Providing a state-of-the-art ov...

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