David Bervini

David Bervini
Inselspital, Universitätsspital Bern · Department of Neurosurgery

PD Dr. med MAdvSurg

About

88
Publications
8,122
Reads
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814
Citations
Additional affiliations
March 2015 - March 2015
Lausanne University Hospital
Position
  • Oberarzt
March 2015 - present
Inselspital, Universitätsspital Bern
Position
  • Oberarzt
January 2014 - February 2015
University of Lausanne
Position
  • Chef de Clinique, Cerebrovascular and Skull Base surgery Fellow
Education
January 2012 - December 2013
Macquarie University
Field of study
  • Australian School of Advanced Medicine

Publications

Publications (88)
Article
Object The aim of this study was to identify patients who are likely to benefit from surgery for unruptured brain arteriovenous malformations (ubAVMs). Methods The authors' database was interrogated for the risk and outcome of hemorrhage after referral and the outcome from surgery. Furthermore, the outcome from surgery incorporated those cases exc...
Article
Full-text available
Background and purpose: Management of brain arteriovenous malformation (bAVM) is controversial. We have analyzed the largest surgical bAVM cohort for outcome. Methods: Both operated and nonoperated cases were included for analysis. A total of 779 patients with bAVMs were consecutively enrolled between 1989 and 2014. Initial management recommenda...
Article
OBJECTIVE Cerebral cavernous malformations (CCMs) are frequently diagnosed vascular abnormalities. The hemorrhagic risk associated with the use of long-term antithrombotic medication (ATM) in patients with CCMs is a matter of controversy. The aim of this study was to determine the hemorrhagic risk associated with ATM use in patients diagnosed with...
Article
Background: Augmented reality (AR) applied to surgery refers to the virtual superimposition of computer-generated anatomical information on the surgical field. AR assistance in extracranial-intracranial (EC-IC) bypass revascularization surgery has been reported to be a helpful technical adjunct. Objective: To describe our experience of using AR...
Article
Background: Antithrombotic (anticoagulant or antiplatelet) therapy is withheld from some patients with cerebral cavernous malformations, because of uncertainty around the safety of these drugs in such patients. We aimed to establish whether antithrombotic therapy is associated with an increased risk of intracranial haemorrhage in adults with cereb...
Article
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Introduction Carotid free-floating thrombus (CFFT) is a rare cause of stroke and is thought to be associated with a high risk of recurrent cerebrovascular ischaemic events. The existing data on the natural history and optimal treatment modalities of CFFT is scanty and no clear recommendations exist. Objective A retrospective analysis, single-cente...
Article
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Background and purpose: Knowledge about different etiologies of non-traumatic intracerebral hemorrhage (ICH) and their outcomes is scarce. Methods: We assessed prevalence of pre-specified ICH etiologies and their association with outcomes in consecutive ICH patients enrolled in the prospective Swiss Stroke Registry (2014 to 2019). Results: We...
Article
Objective: While prior retrospective studies have suggested that delayed cerebral ischemia (DCI) is a predictor of neuropsychological deficits after aneurysmal subarachnoid hemorrhage (aSAH), all studies to date have shown a high risk of bias. This study was designed to determine the impact of DCI on the longitudinal neuropsychological outcome aft...
Article
Objectives Cerebral vasospasm is a severe and potentially lethal complication in patients with subarachnoid hemorrhage (SAH). Its pathogenesis is still not completely understood. The efficacy of current treatments, such as triple-H therapy or calcium channel blockers, is unsatisfactory, and a new therapy model would therefore be valuable. Electrica...
Article
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Background In Switzerland, the COVID-19 incidence during the first pandemic wave was high. We aimed to assess the association of the outbreak with acute stroke care in Switzerland in spring 2020. Methods Retrospective analysis based on the Swiss Stroke Registry, which includes consecutive patients with acute cerebrovascular events admitted to Swis...
Article
Aims We assessed the association of prior antiplatelet therapy (APT) at onset of intracerebral haemorrhage (ICH) with haematoma characteristics and outcome. Methods We performed a systematic review and meta-analysis of studies comparing ICH outcomes of patients on APT (APT-ICH) with patients not taking APT (non–APT-ICH). Primary outcomes were haem...
Article
OBJECTIVE Postoperative internal carotid artery (ICA) intimal flap (IF) is a potential complication after carotid endarterectomy (CEA) for carotid artery stenosis. There are no clear recommendations in the current literature on the management of this condition due to sparse evidence. Some authors advocate carotid stent placement or reoperation, whi...
Conference Paper
Full-text available
Introduction The majority of unruptured intracranial aneurysms (UIA) can be adequately characterized using 1.5 and 3 T MRI. However, findings in a relevant subgroup of patients can remain unclear due to difficulties in distinguishing aneurysms from vascular anatomical variants.1–47 T MRI may provide definitive non-invasive diagnosis in this subgrou...
Article
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Background Studies have questioned the effectiveness of surgery for the management of unruptured brain arteriovenous malformation (ubAVM). Few studies have examined functional outcomes and quality of life (QOL) prior and 12 months after surgical repair of ubAVM.Objective This study examined the effectiveness of surgical management of ubAVM by measu...
Article
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Background During carotid endarterectomy (CEA), significant amplitude decrement of somatosensory evoked potentials (SEPs) is associated with post-operative neurological deficits. Objective To investigate the association between an incomplete circle of Willis and/or contralateral ICA occlusion and subsequent changes in intra-operatively monitored S...
Article
Background: We determined the frequency of different etiologies of non-traumatic intracerebral hemorrhage (ICH) and their association with clinical characteristics and outcomes. Methods: We analyzed data from consecutive ICH patients enrolled in the prospective Swiss Stroke Registry (2014-2019). Etiology of ICH was determined according to prespecif...
Article
Full-text available
In acute ischemic stroke, intravenous thrombolysis (IVT) and acute endovascular therapy (EVT) have been shown to reduce long-term disability in randomized trials. International guidelines are partially not up to date and may not address situations for which there is limited scientific evidence. The goals of the present guidelines are to summarize t...
Article
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Background and Purpose The purpose of this study was to assess nationwide incidence and outcomes of aneurysmal subarachnoid hemorrhage (aSAH). The Swiss SOS (Swiss Study on Subarachnoid Hemorrhage) was established in 2008 and offers the unique opportunity to provide this data from the point of care on a nationwide level. Methods All patients with...
Article
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Background Vertebrobasilar dolichoectasia (VBDE) is a rare type of non-saccular intracranial aneurysm, with poor natural history and limited effective treatment options. Visualizing neurovascular microanatomy in patients with VBDE has not been previously reported, but may yield insight into the pathology, and provide important information for treat...
Article
Background: Current prognostic tools in aneurysmal subarachnoid hemorrhage (aSAH) are constrained by being primarily based on patient and disease characteristics on admission. Objective: To develop and validate a complication- and treatment-aware outcome prediction tool in aSAH. Methods: This cohort study included data from an ongoing prospective...
Article
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Background Due to its complexity and to existing treatment alternatives, exposure to intracranial aneurysm microsurgery at the time of neurosurgical residency is limited. The current state of the art includes training methods like assisting in surgeries, operating under supervision, and video training. These approaches are labor-intensive and diffi...
Article
Introduction: Management of spontaneous intracerebral hemorrhage (ICH) remains controversial despite efforts to produce high level evidence in the years past. We systematically examined the pooled literature data on the natural history and surgical management of ICH. Evidence acquisition: A systematic review was performed using the PubMed and Emba...
Article
High central venous pressure (CVP) acutely decreases venous return. How this affects hepatic oxygen transport in sepsis remains unclear. The aim of this study was to evaluate the effects of repeated increases of CVP via standard nursing procedures (NPs) on hepato-splanchnic and renal oxygen transport in a prolonged porcine sepsis model. Twenty anes...
Article
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Purpose of review This review addresses the current evidence of epidemiologic and therapeutic strategies in patients with intracranial atherosclerotic stenosis (ICAS). Recent findings There is a considerable number of patients with ICAS worldwide, especially in Asia. Modern neuroimaging techniques have improved assessment lately and they are provi...
Article
Objective Clamping of the internal carotid artery (ICA) during carotid endarterectomy (CEA) is a critical step. In our neurosurgical department, CEAs are performed with transcranial Doppler (TCD) and somatosensory evoked potential (SEP) monitoring with a 50% flow velocity/amplitude decrement warning criteria for shunting. The aim of our study was t...
Article
Objective: The objective of this study was to determine patterns of care and outcomes in ruptured intracranial aneurysms (IAs) of the middle cerebral artery (MCA) in a contemporary national cohort. Methods: The authors conducted a retrospective analysis of prospective data from a nationwide multicenter registry of all aneurysmal subarachnoid hem...
Article
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Background and purpose Aneurysms of the posterior inferior cerebellar artery (PICA) are relatively uncommon and evidence is sparse about patients presenting with ruptured PICA aneurysms. We performed an analysis of the Swiss SOS national registry to describe clinical presentation, treatment pattern, and neurological outcome of patients with rupture...
Article
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Background The treatment of ruptured posterior circulation aneurysms remains challenging despite progresses in the endovascular and neurosurgical techniques. Objective To provide epidemiological characterization of subjects presenting with ruptured posterior circulation aneurysms in Switzerland and thereby assessing the treatment patterns and neur...
Article
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BACKGROUND: Rapid identification of novel targets and advancement of a vascular targeting strategy requires a comprehensive assessment of AVM endothelial membrane protein changes in response to irradiation. The aim of this study is to provide additional potential target protein molecules for evaluation in animal trials to promote intravascular thro...
Article
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Background Rapid identification of novel targets and advancement of a vascular targeting strategy requires a comprehensive assessment of AVM endothelial membrane protein changes in response to irradiation. The aim of this study is to provide additional potential target protein molecules for evaluation in animal trials to promote intravascular throm...
Article
Background and Purpose Commonly used tools to determine functional outcome after aneurysmal subarachnoid hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust outcome measure after ischemic stroke. Here, we set out to validate home-time as an outcome measure after aSAH. Methods We examined pro...
Article
Background and Purpose—Commonly used tools to determine functional outcome after aneurysmal subarachnoid hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust outcome measure after ischemic stroke. Here, we set out to validate home-time as an outcome measure after aSAH. Methods—We examined pro...
Article
Background and Purpose— Sustained successful reperfusion is an important prognostic factor for good clinical outcome in acute ischemic stroke. We aimed to identify the prevalence, clinical impact, and predictors of early reocclusion after initially successful thrombectomies within a prospective cohort. Methods— A total of 711 stroke patients with...
Article
OBJECTIVE Cerebral cavernous malformations (CCMs) are frequently diagnosed vascular malformations of the brain. Although most CCMs are asymptomatic, some can be responsible for intracerebral hemorrhage or seizures. In selected cases, microsurgical resection is the preferred treatment option. Treatment with the unselective β-blocker propranolol has...
Article
Introduction: The appropriate interpretation of natural history of brain arteriovenous malformations (bAVMs) and of factors that negatively affect the risk of future hemorrhage are important when recommending management pathways. With the present systematic review, we aim to provide an overview of the available evidence on natural history of brain...
Article
Background: For sustainability of arteriovenous malformation (AVM) surgery, results from early career cerebrovascular neurosurgeons (ECCNs) must be acceptably safe. Objective: To determine whether ECCNs performance of Spetzler-Ponce Class A AVM (SPC A) resection can be acceptably safe. Methods: ECCNs completing a cerebrovascular fellowship (20...
Article
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Background To determine the neurosurgeon’s agreement in aneurysmal subarachnoid haemorrhage (aSAH) management with special emphasis on the rater’s level of experience. A secondary aim was to analyse potential aneurysm variables associated with the therapeutic recommendation. Method Basic clinical information and admission computed tomography angiog...
Article
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Background and purpose: To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage and to estimate their impact. Methods: Retrospective analysis of prospective data from a nationwide multicenter registry on all aneurysmal subarachnoid hemorrhage cases admitted to a tertiary neurosurgical department in Swi...
Article
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Focussed radiosurgery may provide a means of inducing molecular changes on the luminal surface of diseased endothelium to allow targeted delivery of novel therapeutic compounds. We investigated the potential of ionizing radiation to induce surface expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1...
Article
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Background and purpose: Combined transarterial balloon-assisted endovascular embolization with double-lumen balloon microcatheters and concomitant transvenous balloon protection was described as a promising treatment technique for dural arteriovenous fistulae of the transverse and sigmoid sinus. The purpose of this study was to evaluate the techni...
Article
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IntroductionTo analyze whether the computed tomography angiography (CTA) spot sign predicts the intraprocedural rupture rate and outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods From a prospective nationwide multicenter registry database, 1023 patients with aneurysmal subarachnoid hemorrhage (aSAH) were analyzed retrospec...
Article
OBJECTIVE The occurrence of transdural arterial recruitment (TDAR) in association with brain arteriovenous malformation (bAVM) is uncommon, and the reason for TDAR is not understood. The aim of this cohort study was to examine patient and bAVM characteristics associated with TDAR and the implications of TDAR on management. METHODS A prospective sur...
Conference Paper
Object Postoperative visual outcomes following elective repair of unruptured paraclinoid aneurysms (UPAs) are not well defined. The objective of this study was to investigate the influence of treatment modality on visual function. Methods A systematic literature analysis using the Ovid Medline and EMBASE electronic databases was performed, encompa...
Article
Objective Postoperative visual outcomes following repair of unruptured paraclinoid aneurysms (UPAs) are not well defined. We aim to investigate the influence of treatment modality on visual function. Methods A systematic literature analysis using the Ovid Medline and EMBASE databases was performed, encompassing English language studies (published...
Article
Background Delayed cerebral ischaemia (DCI) is frequent after poor grade aneurysmal subarachnoid haemorrhage (SAH). Owing to the limited accuracy of clinical examination, DCI diagnosis is often based on multimodal monitoring. We examined the value of cerebral microdialysis (CMD) in this setting. Methods 20 comatose SAH participants underwent CMD m...
Article
OBJECTIVE The occurrence of transdural arterial recruitment (TDAR) in association with brain arteriovenous malformation (bAVM) is uncommon, and the reason for TDAR is not understood. The aim of this cohort study was to examine patient and bAVM characteristics associated with TDAR and the implications of TDAR on management. METHODS A prospective su...
Article
Objective: To visualize and treat spinal dural CSF leaks in all patients with intractable spontaneous intracranial hypotension (SIH) who underwent spinal microsurgical exploration. Methods: Patients presenting between February 2013 and July 2015 were included in this consecutive case series. The workup included spinal MRI without and with intrat...
Article
Background: We aimed to identify a group of patients with a low risk of seizure after surgery for unruptured intracranial aneurysms (UIA). Objective: To determine the risk of seizure after discharge from surgery for UIA. Methods: A consecutive prospectively collected cohort database was interrogated for all surgical UIA cases. There were 726 c...
Article
Introduction: To analyze the use of computed tomography angiography (CTA) spot sign to predict outcome in intracerebral hemorrhage (ICH) patients with aneurysmal subarachnoid hemorrhage (aSAH) from a nationwide SAH registry. Methods: All patient data was obtained from the nationwide multicenter registry database (IRB No 11–233R (NAC 11–085R)), at t...
Article
Full-text available
Aims: Aneurysmal subarachnoid hemorrhage (aSAH) accounts for a large proportion of productive life years lost to stroke. Its management requires a multidisciplinary effort. Much of the presently available data on incidence, treatment, and outcomes come from studies with a strong selection bias, studies confounding all kinds of SAH, that is, aneurys...
Article
In March, 2014, a 19-year-old woman presented to the emergency department with nausea, vomiting, and prodromal nonspecifi c visual symptoms followed by transient loss of consciousness lasting a few minutes. Her parents reported spontaneously resolving generalised tonic–clonic convulsions. She had no medical history and denied substance abuse. She h...
Article
Management of ischemic stroke in the presence of aneurysmal brain disease is controversial. Recent retrospective evidence suggests that in selected patients, intravenous thrombolysis (IVT) remains a safe approach for reperfusion. We document a case of post-thrombolysis aneurysmal rupture. Supported by additional scientific literature we postulate t...
Article
Full-text available
Objective: The cause precipitating intracranial aneurysm rupture remains unknown in many cases. It has been observed that aneurysm ruptures are clustered in time but the trigger mechanism remains obscure. As solar activity has been associated with cardiovascular mortality and morbidity we decided to study its association to aneurysm rupture in the...
Article
Full-text available