Dautzenberg Bertrand

Sorbonne Université | UPMC · chest medecine

Unlabelled: Prospective longitudinal studies mainly conclude on a causal role of e-cigarettes in the initiation of cigarettes in flagrant contradiction with conclusions drawn from epidemiology and other studies showing a sharp decline in cigarette use in parallel with the spread of e-cigarette use. This systematic review explores the reasons for t...

Background Electronic cigarette (e-cigarette) use has spread among adolescents in many countries, however users’ characteristics are not well known. We aimed to compare characteristics of exclusive e-cigarette users to those of exclusive tobacco users and dual users. Methods Data come from a representative sample of 11–19 years old students in Par...

Purpose: Epidemiologic studies have documented lower rates of active smokers compared to former or non-smokers in symptomatic patients affected by coronavirus disease 2019 (COVID-19). We assessed the efficacy and safety of nicotine administered by a transdermal patch in critically ill patients with COVID-19 pneumonia. Methods: In this multicentr...

La dépendance tabagique est une maladie chronique d’origine le plus souvent pédiatrique, responsable d’une mortalité de 50 %. Il est pour le moins désolant d’observer que son traitement est dans 80 % des cas délaissé par les médecins laissant le malade se débrouiller seul. Selon les données de SP France les tentatives arrêts sont dans 2/3 des cas e...

Recent data show an interaction between COVID-19 and nicotine and indicate the need for an assessment of transdermal nicotine use in non-smokers. Assessments have been conducted into the short-term cognitive effects of nicotine and into diseases such as Parkinson's, Tourette syndrome, ADHD or ulcerative colitis. Methods: Analyses of nicotine admi...

Introduction Peu de données sont actuellement disponibles pour déterminer le meilleur traitement à proposer aux patients présentant une infection pulmonaire à Mycobacterium xenopi (MX) (2 études randomisées avec respectivement 42 et 34 patients inclus). Les données disponibles sont en faveur d’un traitement contenant rifampicine (RIF) et éthambutol...

Introduction: Preliminary reports indicated that smokers could be less susceptible to the coronavirus SARS-CoV-2, which causes Covid-19. However, once infected an increased risk of severe disease is reported. We investigated the association between smoking and COVID-19 during an outbreak of the disease on a naval vessel. Methods: We conducted a...

La dépendance tabagique est une maladie chronique d’origine le plus souvent pédiatrique, responsable d’une mortalité de 50 %. Il est pour le moins désolant d’observer que son traitement est dans 80 % des cas délaissés par les médecins laissant le malade se débrouiller seul. Selon les données de SP France les tentatives d’arrêts sont dans 2/3 des ca...

La dépendance tabagique est une maladie chronique d’origine le plus souvent pédiatrique, responsable d’une mortalité de 50 %. Il est pour le moins désolant d’observer que son traitement est dans 80 % des cas délaissés par les médecins laissant le malade se débrouiller seul. Selon les données de SP France les tentatives d’arrêts sont dans 2/3 des ca...

SETTING: The World Health Organization (WHO) recommends that multidrug-resistant tuberculosis (MDR-TB) treatment should be managed in collaboration with multidisciplinary advisory committees (consilia). A formal national Consilium has been established in France since 2005 to provide a centralised advisory service for clinicians managing MDR-TB and...

Résumé Les enjeux En France 73 000 fumeurs meurent chaque année du tabac, une maladie chronique incurable : la dépendance tabagique, une maladie d’acquisition pédiatrique. La cigarette est une drogue dure, elle accroche autant que l’héroïne, plus qu’alcool ou cannabis. L’inoculation de la dépendance nicotinique est incluse dans la stratégie formal...

Introduction En Ile-de-France, l’incidence de la tuberculose-maladie (TM) est supérieure à la moyenne nationale. Le parcours de soins ambulatoires (PSA) des patients diagnostiqués TM a été analysé afin de caractériser les populations cibles ainsi que le rôle du MG dans cette prise en charge. Matériels et méthodes Etude monocentrique descriptive ré...

Introduction Electronic cigarettes (EC) mainly with nicotine content are widely used worldwide. Although the number of publications about its use is increasing exponentially, evidence-based, unbiased, conclusive, head-to-head comparisons about its efficacy and safety as an aid for smoking cessation are lacking. Methods and analysis Design: randomi...

Introduction France has an erratic anti-smoking policy. Effectives measures follow phases of stagnation or even regression. Until recently, taxation policies were decided only in the short term. These variations give the opportunity to analyze the effect of the price increase on cigarette sales. Methods From 2000 to 2018 we study change in yearly...

Introduction Article 14 of the FCTC recommends facilitating access to smoking cessation medication. Until 2018, some EU countries had specific free of charge program for NRT, but no country had proposed general reimbursement of smoking cessation drugs as reimbursement of others essential drugs. In France a retrospective reimbursement up to 150 € pe...

Résumé Introduction L’industrie du tabac (IT) annonce que le tabac chauffé réduit les risques du tabagisme et va remplacer la cigarette. Méthode Après une interrogation Medline en février 2018, une analyse systématique des articles a été conduite. Résultats Parmi les 100 publications 2008–2018, 75 ont des auteurs affiliés à l’IT. Les émissions c...

Introduction Electronic cigarettes (e-cigarettes), sold since 2010 in many countries including France, have become widely used among adults, particularly by older smokers trying to quit or decrease tobacco use. E-cigarettes are also getting popular among adolescents. Yet, factors associated with e-cigarettes use among youth are not well known. The...

Twenty years ago there were only a few dozen of services dedicated to the care of smokers in France. In 1999, the Minister of Health (Bernard Kouchner) created the smoking cessation services (consultation de tabacologie) in France with the obligation to have a tobacco cessation service in all hospitals with more than 500 beds and at least one tobac...

Smoking is the cause of addictive behavior. Tobacco addiction is a chronic disease that makes difficult to stop smoking and leads to further use. Smoking is a risk factor for COPD, asthma and lung cancer; it may be the cause of severe perioperative complications. This finding justifies that smokers benefit from advice of stopping smoking and smokin...

Method: The analysis of a 1973 RJReynols® document identified ten physical and psychological factors in order to increase the number of young users for a brand of cigarettes. These young people are classified into three groups: pre-smokers, learners and smokers. Result: The taste for pre-smokers and learners and nicotine for smokers are main phy...

Tobacco use is not just about manufactured cigarettes. Rolling tobacco, highly prized in the wake of price increases, is estimated to carry more toxic agents than its counterpart. This study shows that the use of cigar, pipe, cigarillos and narghile also leads to a cohort of pathologies similar to or more than what is known for smoking single cigar...

Introduction Public-health actors were alarmed by the progression of experimentation of e-cigarettes in different countries since 2012 because of fear that they would be a gateway to tobacco use. In Europe, there is now near a consensus that ecigarettes need supervision as required by the TPD (control of products and advertising) or not (sales to m...

A group of 11 French medical experts has developed guidelines through a Delphi progressive consensus about smoking management at the e-cigarette era. The lack of scientific data about e-cigarettes led the experts to set out recommendations, mainly based on clinical practice while waiting for scientific validations. The validated smoking cessation t...

Introduction: The objective of this work was to assess the background of the implementation of the ban of tobacco sales to minors before the change of French law in 2016. Methods: The analysis focused on two questions to teenagers on buying tobacco, added to the four cross-sectional annual surveys of the association "Paris Sans Tabac" from 2012...

The e-cigarette has been experienced by 86.2% of smokers and 25.9% of non-smokers in Parisian schoolchildren according to the 2015 PST survey on 3516 schoolchildren. We investigate on the nicotine content of the e-liquid used by theses schoolchildren. Methods: In the 2015 survey conducted by PST on a randomized sample of 2% of 12-19 y.o. Parisian s...

The age of initiation influence smoking habit in adult. Methods: On the annual PST survey from 2002 to 2015 on a randomized select sample of 2% of 12-19yo Parisian schoolchildren, We analysed the population according to age of initiation: until 14, 15-17yo, more than 17yo. Results: Among a total of 11 511 schoolchildren respondent from 18-19yo incl...

E-cigarettes remain controversial because the scientific evidence of short term and long term effects on tolerance and the health value of a switch from tobacco to e-cigarettes is contested and controversial. Nevertheless the quality of e-cigarettes and e-liquids has improved. The main ingredients, propylene glycol, vegetable glycerine and nicotine...

This study aimed to gain insight into the impact of lung conditions on smoking behaviour and smoking cessation, and identify recommendations for smoking cessation and professional-patient communications. The study was led by the European Lung Foundation in collaboration with the European Respiratory Society Task Force on “Statement on smoking cessa...

Introduction The aim of the study was to confirm or reject the hypothesis that variation in throat-hit depends on the nicotine concentration and the voltage applied to the resistance. A secondary aim was to assess the influence of throat-hit on the willingness of subjects to switch from tobacco to e-cigarette use. Methods In this experimental blin...

Smoking and tuberculosis are two major public health issues. Tobacco smoke increases the risk of Mycobacterium tuberculosis infection and the severity of pulmonary tuberculosis. Active smoking increases the risk of relapse of pulmonary and extra-pulmonary tuberculosis after treatment; smokers are less adherent to anti-tuberculosis treatment. Smokin...

Background Electronic cigarettes (e-cig.) became widely used among adults. Data are insufficient about e-cig. experimentation among youth. Methods To assess prevalence of e-cig. experimentation and associated factors among the 12 to 19 years old we analyse a cross sectional school based survey in the city of Paris, France in 2013 on a randomly sel...

e-cigarettes remain controversial mainly because the lack of scientific evidence of short term and long term effects on tolerance and efficacy of a switch from tobacco to e-cigarette. Nevertheless the quality of e-cigarette and e-liquid is now improved. The main ingredients, propylene glycol, vegetal glycerine and nicotine are pharma grade quality...

La prévention des cancers associées à l'alcool et au tabac est notre priorité. La cavité orale est notre focus car c'est un site facilement accessible et le miroir biologique de l'ensemble du champ de la cancérisation. Pour développer des interventions pertinentes dans une population souvent défavorisée, il faut à la fois comprendre la dynamique de...

For teenager's attitudes of peers is an important determinant of behavior, including tobacco consumption. Most of teenagers try to have the same behavior than peers, so an overestimation of consumption of tobacco may drive an increase of tobacco consumption Methods: From 2011 to 2014 the cross sectional survey conduct on 2% of Paris City schoolchil...

The e-cigarette is in 2014 used nearly as often as tobacco in the 12 to 15 y.o. Paris schoolchildren (12.7% of daily smokers, occasional smokers or ex-smokers vs 9.9% e-cigarettes users). A majority of e-cigarettes users (last 30 days) did not smoke (52%) according to 2013-2014 data from the PST surveys. Methods: In the 2014 survey conducted by PST...

At the time where EU take the decision to set a maximum concentration of 20mg/ml nicotine in non-pharmaceutical e-liquid, we have check the concentrations of nicotine used in the study of 1 million puffs conducted with the first connected e-cigarette marketed in France (Smokio®). Methods: We have obtained for analysis the first data base automatica...

To confirm that the throat hit varies with e-liquid nicotine concentration and voltage of e-cigarette and assess its influence on the desire to switch from smoking tobacco to e-cigarettes use, we organized a blind test in a group of smoker students. Methods: 35 student's smokers tested five e-liquid (0-18 mg/ml nicotine) on the same cigarette adjus...

To analyze experimentation with and use of e-cigarette by middle school and high school students in Paris. Since 2012, questions about e-cigarette use have been included in the cross-sectional survey on tobacco that is administered annually since 1991 by the Paris sans tabac association. Overall, 2% of the 12-19 years-old attending school in Paris...

The use of the electronic cigarette is now common, but the characteristic of its use remains largely unknown. Method: We have analysed the parameters of 1 million puffs recorded by a connected e-cigarette (Smokio®). Results: 2,001 to 23,123 puffs (median=5,405) had been produced by each of the 185 users during the 116 days of the study period. Th...

Chronic obstructive pulmonary disease (COPD), lung cancer, asthma and pulmonary tuberculosis are common pulmonary diseases that are caused or worsened by tobacco smoking. Growing observational evidence suggests that symptoms and prognosis of these conditions improve upon smoking cessation. Despite increasing numbers of (small) randomised controlled...

Objet Le « groupe therapeutique des infections a mycobacteries difficiles a traiter » (GT) du Centre national de reference des mycobacteries (CNR) propose une aide a la prise en charge des tuberculoses MDR et XDR. L’objectif de l’etude etait d’evaluer l’activite du GT. Methodes L’activite du GT de 2005 a 2013 a ete analysee retrospectivement et com...

Before 2010, the e-cigarette remains inefficient then, its dissemination explodes in 2013 where more than 10 million people have tried it in France. The best made e-cigarette will always be potentially toxic and an addictive product. The e-cigarette is not a suitable product for non-smokers and could participate to normalize tobacco in society. To...

The campaign against smoking reduces lung cancer mortality. Even after a diagnosis of bronchial cancer, smoking cessation resulted in a decrease in mortality and reduced treatment complications.

In previous studies of the smoke from regular cigarettes and water pipes, we measured aerosol particle sizes in three streams; S1, inhaled by the smoker, S2, released by the device itself and S3, exhaled by the smoker. We used an electrostatic low-pressure impactor (ELPI), giving particle size distributions in real time and calculated median diamet...

Introduction L’information des patients devant avoir une intervention chirurgicale programmée est souvent soutenue par des fiches. Cette information est obligatoire sur le plan déontologique et légal. Parmi les 11 millions d’interventions chirurgicales annuelles, 3 millions concernent des fumeurs. Les données de la littérature reprises en 2005 dans...

In previous studies of the smoke from regular cigarettes and water pipes, we measured aerosol particle sizes in three streams; S1, inhaled by the smoker, S2, released by the device itself and S3, exhaled by the smoker. We used an electrostatic low-pressure impactor (ELPI), giving particle size distributions in real time and calculated median diamet...

Information for patients undergoing elective surgery is often supported by factsheets. This information is required for ethical and legal reasons. Among the 11 million surgical procedures performed annually in France, three million concern smokers. Data of a 2005 French Expert's conference show that smoking doubles or triples the risk of postoperat...

Marketed since 2004 as an alternative to nicotine delivery and advertised as a valid means to smoking cessation, the electronic (e)-cigarette has been the subject of much controversy but very little experimental study. This review provides a brief summary of the current knowledge of this product. Propylene glycol and glycerol, the main ingredients...

Lobbying on tobacco in France Lobbying by cigarette manufacturers in favour of tobacco products has been one of the main vectors for the development and persistence of smoking dependency. The efficiency of this vector in spreading disease is dependent on the response of politicians who oppose these lobbies. France has experienced two five-year mand...

Objectives: To explore if the dramatic decrease in price of e-cigarette has transformed this new product into a product used for tobacco initiation among a teenage population. Methods: The authors added a question in 2012 on e-cigarette in the yearly survey on tobacco consumption in Paris schoolchildren. The study is conducted on a randomly selecte...

Tobacco prevention is the most effective prevention of cancer. Daily smoking promotes tumor progression, increases the risk of second cancer and decreases survival. The diagnosis of smoking and support for cessation and preventing recurrence is an integral part of cancer treatment. Smoking increases side effects of chemotherapy and surgery and redu...

Tobacco smoking has a significant impact on the risk of tuberculosis and the mortality of the disease. There is a strong dose-response relationship both in terms of quantity and duration of smoking. Latent tuberculous infection and tuberculosis disease are different stages of the same infectious process but the relation between smoking and the risk...

Outdoor secondhand smoke (SHS) concentrations are usually lower than indoor concentrations, yet some studies have shown that outdoor SHS levels could be comparable to indoor levels under specific conditions. The main objectives of this study were to assess levels of SHS exposure in terraces and other outdoor areas of hospitality venues and to evalu...

In France, the prevalence of women of childbearing age who smoke every day, which was 37% in 2002 according to Inserm, remains unchanged in 2010 according to INPES, and remains at 22% at the time of giving birth. The government, through measure 10 of the Premier Plan Cancer (First Cancer Plan), has implemented a strategic long-term action plan desi...

Introduction: La prévalence du tabagisme parmi le personnel de santé hospitalier au Cameroun n'est pas connue alors que le tabagisme est en expansion dans ce pays avec 13,2% de fumeurs selon l'OMS. Pour combler ce manque une enquête sur les consommations, les connaissances, opinions et attitudes vis-à-vis des fumeurs a été conduite à l'Hôpital Géné...

Introduction La prévalence du tabagisme parmi le personnel de santé hospitalier au Cameroun n'est pas connue alors que le tabagisme est en expansion dans ce pays avec 13,2% de fumeurs selon l'OMS. Pour combler ce manque une enquête sur les consommations, les connaissances, opinions et attitudes vis-à-vis des fumeurs a été conduite à l'Hôpital Génér...

Passive smoking is a serious health risk in non-smokers. The strength of tobacco control policies of the EU countries vary. This study aimed to investigate the relationship between secondhand smoke exposure, as assessed by exhaled carbon monoxide (eCO), and the strength of national tobacco control policies, in non-smokers in the EU. Data were provi...

Introduction Second hand cigarette smoke consists predominantly of nanoparticles (with two dimensions less than 100 nanometres). The aim of this study was to examine the aerosol of cigarette smoke suspended in the air of a smoking room, its disappearance over the course of time, and its retention in the airways of passive smokers, as these processe...

Second hand cigarette smoke consists predominantly of nanoparticles (with two dimensions less than 100 nanometres). The aim of this study was to examine the aerosol of cigarette smoke suspended in the air of a smoking room, its disappearance over the course of time, and its retention in the airways of passive smokers, as these processes remain poor...

Normative misperceptions have been widely documented for alcohol use among U.S. college students. There is less research on other substances or European cultural contexts. This study explores which factors are associated with alcohol, tobacco and cannabis use misperceptions among French college students, focusing on substance use. 12 classes of sec...

Almost all smokers accept that smoking is harmful and they would benefit their health by stopping, but continue smoking despite this (1). Interventions by clinicians can encourage and help many of these smokers to try to stop, but only a minority will try and few will succeed (2). Some smokers suspend their smoking if there is a good reason. For ex...