Dattatri Nagesha

• PhD
• Professor and Principal at GITAM University

The aim of the study was to fabricate a non-woven electrospun PCL nanofiber mat (PCL-ESNF mat) which was spiked with the streptomycin to treat microbes in contaminated water. The process parameters were optimized to fabricate PCL-ESNF mat. The diameter of fiber, rate of release of drug and the concentration of streptomycin spiked on nanofibers were...

The present study was undertaken to formulate and evaluate the anti-inflammatory, anti-oxidant and anti-angiogenic activities of nanoemulsion of Memecylaene. Memecylaene was isolated from the leaves of Memecylon malabaricum by using various chromatographic methods. An oil-in-water (O/W) nanoemulsion of Memecylaene was formulated by sonication metho...

Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolamine-based micelles loaded with both, poorly solubl...

Coumarin class of organic compounds consist of 1,2-benzopyrone ring system as a basic parent scaffold. These benzopyrones are subdivided in to alpha-benzopyrones and gamma-benzopyrones; with coumarin class of compounds belongs to alpha-benzopyrones. From the last few years coumarins are synthesized in many of their derivatives forms. Their pharmaco...

Polymeric micelles are used as ‘smart drug carriers’ for targeting certain areas of the body by making them stimuli-sensitive or by attachment of a specific ligand molecule onto their surface. The main aim of using polymeric micelles is to deliver the poorly water soluble drugs. Now-a-days they are used especially in the areas of cancer therapy als...

Introduction Iron-oxide nanoparticles can act as contrast agents in magnetic resonance imaging (MRI), while radiolabeling the same platform with nuclear medicine isotopes allows imaging with positron emission tomography (PET) or single-photon emission computed tomography (SPECT), modalities that offer better quantification. For successful translati...

Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC During the last 2 decades no new clinical MRI agents have been approved for clinical use. While Gadolinium based agents have been very popular, Gd cannot be used in emerging multi-functional nano platforms that have the potential to be retained in the body leading to sever...

Unlabelled: The clinical application of gene silencing mediated by small interfering RNA (siRNA) has been limited by the lack of efficient and safe carriers. Phospholipid modification of low molecular weight polyethylenimine (PEI 1.8 kDa) dramatically increased its gene down-regulation capacity while keeping cytotoxicity levels low. The silencing...

The advent of nanotechnology has bolstered a variety of nanoparticles based platforms for different biomedical applications. A better understanding for engineering novel nanoparticles for applications in cancer staging and therapy requires careful assessment of the nanoparticle's physico-chemical properties. Herein we report a facile synthesis meth...

Detection of ultrasmall masses and identification of biological molecules have been made possible as a result of advances in nanotechnology. Development of biosensing tools has significantly contributed to high-throughput diagnosis and analytical sensing exploiting high affinity of biomolecules. MicroCantilever (MC)-based detection has emerged as a...

The application of nanotechnology in various fields has resulted in a tremendous increase in the synthesis of variety of engineered nanoparticles (NPs). These applications are possible only due to the small size and large surface area of the NPs which imparts them unique properties. Inorganic oxide NPs as iron and copper oxide NPs are widely used i...

Improvements in osteoconduction of implant biomaterials require focusing on the bone-implant interface, which is a complex multifactorial system. Surface topography of implants plays a crucial role at this interface. Nanostructured surfaces have been shown to promote serum protein adsorption and osteoblast adhesion when compared to micro-structured...

Improvements in osteoconduction of implant biomaterials require focusing on the bone-implant interface, which is a complex multifactorial system. Surface topography of implants plays a crucial role at this interface. Nanostructured surfaces have been shown to promote serum protein adsorption and osteoblast adhesion when compared to micro-structured...

For the past decade engineered nanoplatforms have seen a momentous progress in developing a multimodal theranostic formulation which can be simultaneously used for imaging and therapy. In this report we describe the synthesis and application of theranostic phospholipid based polymeric micelles for optical fluorescence imaging and controlled drug de...

The overall goal of this project is to develop means to locally radio-sensitize the prostate to enable prostate cancer (PCa) cure with the use of lower radiation doses, thereby leading to less rectal toxicity. This new approach for chemoradiation therapy (CRT), termed Biological In-Situ Image Guided Radiation Therapy BIS-IGRT, involves the coating...

The utility and promise of magnetic nanoparticles (MagNPs) for biomedicine rely heavily on accurate determination of the particle diameter attributes. While the average functional size and size distribution of the magnetic nanoparticles directly impact the implementation and optimization of nanobiotechnology applications in which they are employed,...

Image-guided radiation treatments routinely utilize implantable devices, such as radio-opaque fiducials or brachytherapy spacers, for improved spatial accuracy. We study the hypothesis that the therapeutic efficiency of IGRT can be further enhanced by biological in-situ dose painting (BIS-IGRT) using local delivery of radiosensitizers embedded with...

We have developed magnetic nano-liposomes (MNL), incorporating superparamagnetic iron oxide nanoparticles (SPION), that are versatile theranostic nanoplatform for enhanced drug delivery and monitoring of cancer treatment. MNL are prepared with a formuation of DPPC:DOTAP:CHOL and DOPE-PEG5000. Incorporation of SPIONs results in MNL with mean diamete...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Image-guided radiation treatments (IGRT) routinely utilize radio-opaque implantable devices, such as fiducials or brachytherapy spacers, for improved spatial accuracy. The therapeutic efficiency of IGRT can be further enhanced by biological in situ dose painting (BIS-IGRT) of radiosensitizers through localized delivery within the tumor using gold f...

The development of noninvasive imaging techniques for the assessment of cancer treatment is rapidly becoming highly important. The aim of the present study is to show that magnetic cationic liposomes (MCLs), incorporating superparamagnetic iron oxide nanoparticles (SPIONs), are a versatile theranostic nanoplatform for enhanced drug delivery and mon...

To characterize and evaluate chitosan film containing PLGA nanoparticles (NPs) as a platform for localized dual-drug release. Fluorescent Paclitaxel (FPTX), a hydrophobic drug, was incorporated into PLGA NPs. FPTX-loaded PLGA NPs and Carboxyfluorescein (CF), a hydrophilic model drug, were embedded into chitosan films. Release of CF and NPs from chi...

Purpose: Image‐guidedradiation treatments routinely utilize radio‐opaque implantable devices, such as fiducials or brachytherapy spacers, for improved spatial accuracy. We study the hypothesis that the therapeutic efficiency of IGRT can be enhanced through simultaneous in‐situ delivery of radiosensitizers, contained within nanoparticles and nanopor...

Nanoporous oxide coatings, such as anodic aluminum oxide (AAO), are utilized as drug-release platforms for up to weeks of delivery. A burst-release phase is followed by sustained release, the kinetics of which is described by an activated surface-density-dependent desorption model.

The characteristics of nanoporous inorganic coatings on implants or on implantable devices are reviewed. The commonly used nanoporous materials, such as aluminum oxide (Al(2)O(3)), titanium oxide (TiO(2)) and porous silicon are highlighted with illustrative examples. The critical issues for sustained release systems are examined and the elution pro...

Stable 30–50nm polymeric polyethylene glycol–phosphatidylethanolamine (PEG–PE)-based micelles entrapping superparamagnetic iron oxide nanoparticles (SPION) have been prepared. At similar concentrations of SPION, the SPION-micelles had significantly better magnetic resonance imaging (MRI) T2 relaxation signal compared to ‘plain’ SPION. Freeze-fractu...

The plasmon resonance conditions in nano-sized materials leads to local field enhancement resulting in amplified response of various linear and nonlinear optical processes at the nano-scale. In this paper, metallic nanoparticles are imaged using several modalities - brightfield, confocal reflectance, two-photon, and second harmonic generation. Two...

Purpose:Image guided radiation therapy(IGRT), such as lungSBRT using fiducials or prostate brachytherapy, implant objects essitial to the radiation treatment, but offering no therapeutic benefit. Such devices offer a vechicle for in‐situ delivery of radiosensitizer which could increase the biologic effective dose of the radiation. This work studies...

Fe3O4 were synthesized nanoparticles by thermal decomposition method with oleic acid as the surfactant, and to make them suitable for aqueous environments, dopamine ligand exchange was carried out on the particles. The nanoparticle size and phase was quantified by transmission electron microscopy (TEM) and x-ray diffraction (XRD), respectively. Sup...

We demonstrate three-dimensional directed assembly of single-wall carbon nanotubes (SWNT) into porous alumina nanotemplates on silicon substrates by means of electrophoresis and dielectrophoresis at ambient temperatures. Assembled SWNT provided an interconnection between the surface and base of the nanotemplate. I-V measurements clearly show that t...

Potential routes of nanomaterial exposure include inhalation, dermal contact, and ingestion. Toxicology of inhalation of ultra-fine particles has been extensively studied; however, risks of nanomaterial exposure via ingestion are currently almost unknown. Using enterocyte-like Caco-2 cells as a small intestine epithelial model, the possible toxicit...

Cancer remains one of the leading causes of death in most regions of the world, including the United States (Beardsley 1994). According to the American Cancer Society (ACS 2007), 1.5 million new cases of cancer are expected to be diagnosed in the year 2007 with approximately 560,000 projected deaths. The current treatment options are not sufficient...

The authors demonstrate a nanofabrication method utilizing nanoporous alumina templates which involves directed three dimensional assembly of nanoparticles inside the pores by means of an electrophoretic technique. In their demonstration, they have assembled polystyrene nanobeads with diameter of 50 nm inside nanopore arrays of height of 250 nm and...

Nanotemplates and nanoparticles have potential for use in the area of nanomanufacturing and biomedical applications. Using controlled anodization, nanoporous surface can be achieved on metals such as aluminum and titanium. We are using highly ordered nanoporous alumina as a template for drug delivery and to assemble nanoelements such as latex beads...

Recent advances in nonlinear optical techniques and materials such as quantum wells, nanowires and noble-metal nanoparticles have led to advances in cellular imaging wherein various nanoparticles have been shown to improve both in vitro and in vivo visualization. In this paper, we demonstrate in vitro imaging using multi-photon photoluminescence of...

Nanostructures are expected to play a key role in the fundamental investigation of neuronal activity at the nanoscale level. Neurons are complex structures with feature sizes ranging from the millimeter to micron to nanoscale regimes. Single nanowires and/or nanowire arrays can therefore offer the potential to investigate the operations of living n...

We describe nanofabrication methods to produce nanopore array templates in aluminum oxide and titanium dixode films. The method is based on anodization of thin films of aluminum and titanium under dc conditions in an acid. We also describe non-lithographic means of transferring the pore pattern from such nanoporous membranes onto a generic substrat...

An important feature of nanoparticles is the increased ratio of surface area to volume resulting in large percentage of the atoms on the surface, making them very reactive and offers opportunities to manipulate the properties through these surface atoms. For the most efficient use of nanoparticles in various applications, including biology and medi...

Nanotechnology offers unique approaches to probe and control a variety of biological and medical processes that occur at nanometer length scales, and is expected to have a revolutionary impact on biology1 and medicine2. Nanomedicine is a new paradigm that seeks to exploit the use of nanotechnology in medicine. Among the various approaches within th...

Nanotechnology offers unique approaches to probe and control a variety of biological and medical processes that occur at nanometer length scales, and is expected to have a revolutionary impact on biology1 and medicine2. Nanomedicine is a new paradigm that seeks to exploit the use of nanotechnology in medicine. Among the various approaches within th...

This work describes the formation of porous composite materials based on a combination of bioactive mesoporous silicon and bioerodible polymers such as poly-caprolactone (PCL). The fabrication of a range of composites prepared by both salt leaching and microemulsion techniques are discussed. Particular attention to the influence of Si content in th...

The ability of Si nanowires (NW) to facilitate the growth of uniform, synthetic bone coatings along their surface and to support the facile proliferation of fibroblast cells in their presence was discussed. Si NWs attached to the Si-wafer substrate were subjected to a continuous cathodic bias in SBF at room temperature. The rate of growth of fibrob...

In this work we report a theoretical study on the use of surface modifiers of CdS nanoparticles (NPs) consisting of incompletely coordinated asymmetric metal complexes with labile and strong ligands. The sulfur centers on the NP surface replace the weak labile ligands, while the strong organic ligands in the complex provide adequate molecular orbit...

Scope and method of study. The purpose of this study was to investigate new synthetic routes to make stable CdSe and In2S 3 nanoparticles. On these newly synthesized nancolloids, the surface modification was attempted via the chalcogen sites. A mixed metal-ligand complex of Ru(bipy)2Cl2 was used for this purpose. The synthesized nanoparticles and t...

All present approaches to surface modification of nanoparticles (NPs) with organic ligands exploit metal (cadmium) sites as anchor points. To obtain efficient interaction of NP surface with p-orbitals of organic chromophores, we utilize the chalcogen (sulfur) sites on the NP surface. These sites present several advantages stemming from a stronger i...

Stable aqueous colloids of 2−3 nm In2S3 nanocrystals have been prepared by using the classical method of nanoparticle stabilization by low molecular weight thiols. TEM crystal lattice spacing, X-ray diffraction, EDAX data, and electron diffraction indicate that the nanoparticles are predominantly in β-In2S3 form. They exhibit relatively strong exci...

CdTe nanocrystals capped with 1-mercapto-2,3-propandiol, CdSe nanocrystals capped with sodium citrate, and core−shell CdSe/CdS nanocrystals capped with sodium citrate were synthesized in aqueous solutions, and their surface was modified by 3-mercaptopropyltrimethoxysilane (MPS) in water−ethanol mixtures. By addition of sodium silicate, “raisin bun”...

CdS nanoparticles (NP), 22 Angstrom, have been synthesized from cadmium 2-ethylhexanoate in DMSO as a uniformly sized dispersion. After ripening, CdS exhibits a sharp excitonic emission peak at 402 nm, while in freshly prepared dispersions a broad trapped emission at 510 nm dominates. By using one- and two-dimensional NMR spectroscopy, the conforma...

Modification with thiomolybdate results in the attachment of spatially separated MoS42- groups to the surface of CdS. This produces the red shift of excitonic absorption and emission bands and splitting of the trapped emission band. Because of the spatial gap between the thiomolybdate molecules of the modifying layer, the interaction of individual...

Well-ordered arrays of Fe3O4 nanoparticleswith a new type of packing have been produced using the Langmuir–Blodgett technique. Depending on the local absorption conditions, both 2D and 1D assemblies of nanoparticles are produced, the latter in the form of single and double chains of equally spaced nanoparticles. The Figure depicts a film of Fe3O4 n...

Nanotemplates and nanoparticles have potential for use in the area of nanomanufacturing and biomedical applications. We are using highly ordered nanoporous alumina as a template for drug delivery and to assemble nanoelements such as latex beads and single wall carbon nanotubes (SWNT) by the means of electrophoresis and/or dielectrophoresis. The res...

Iron oxide nanoparticles are used for contrast enhancement in magnetic resonance imaging (MRI). We have prepared gold-coated iron oxide nanoparticles that show no change in their superparamagnetic behavior as a consequence of coating. Their potential use as MRI contrast agents was investigated by monitoring their T2 relaxation time with concentrati...