Darryn Willoughby

Darryn Willoughby
Baylor College of Medicine | BCM

Doctor of Philosophy

About

34
Publications
7,974
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475
Citations

Publications

Publications (34)
Article
Full-text available
Menopause causes a reduction in estradiol (E2) and may be associated with neuromuscular degeneration. Compared to pre-menopausal (PRE-M) women, this study sought to determine dietary protein intake and whether lower levels of circulating E2 in post-menopausal women (POST-M) were occurring alongside increased levels of biomarkers of axonal and neuro...
Article
Background Thermogenic supplements are widely used in the general population to support attempted fat loss; however, the efficacy and safety of these supplements are questioned. Purpose To determine whether a thermogenic supplement affects metabolic rate, hemodynamic responses, and mood states. Methods In a randomized double-blind crossover desig...
Article
We determined if skeletal muscle extracellular matrix (ECM) content and remodeling markers adapted with resistance training or were associated with hypertrophic outcomes. Thirty-eight untrained males (21±3 yrs.) participated in whole-body resistance training (10 weeks, 2x weekly). Participants completed testing (ultrasound, peripheral quantitative...
Article
Full-text available
Supplementing with creatine is very popular amongst athletes and exercising individuals for improving muscle mass, performance and recovery. Accumulating evidence also suggests that creatine supplementation produces a variety of beneficial effects in older and patient populations. Furthermore, evidence-based research shows that creatine supplementa...
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Full-text available
Context: Research has shown the modulations of Follistatin (FST) and Myostatin (MST) following weight loss Objective: We evaluated the effects of gradual weight loss (GWL) and rapid weight loss (RWL) on serum MST, FST concentrations, and body composition in overweight and obese females. Materials and methods: Thirty-six overweight and obese females...
Article
Objective: This study evaluated the effect of leucine supplementation coupled with a calorie-restricted diet over a 12-week period in mid-life overweight and obese women on body composition and resting metabolic rate (RMR). Method: This study was a randomized, single-blind, placebo-controlled trial in which 34 women were randomly assigned to eit...
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Full-text available
Background: Anterior cruciate ligament (ACL) injuries are some of the most common knee injuries that occur in the US, accounting for around 200,000 documented cases per year. Varying levels of severity can determine whether surgery is required or if physical therapy will suffice. One of the most common complications for patients is that there is si...
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Full-text available
Background of Study: More research studies are being completed advocating for the use of exercise as an intervention and form of treatment for concussions. However, exercise can include many forms of physical activity, intensities, and durations. This systemic review and meta-analysis focused on the use of aerobic exercise, such as cycling or walki...
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Elevated circulating C-terminal agrin fragment (CAF) is a marker of neuromuscular junction degradation and sarcopenia. This study sought to determine if resistance training (RT) impacted the serum levels of CAF in perimenopausal (PERI-M) and postmenopausal (POST-M) women. A total of 35 women, either PERI-M or POST-M, participated in 10 weeks of RT....
Article
Objective: This study investigated the effects of leucine supplementation with resistance training (RT) in untrained peri- and postmenopausal women on fat free mass, strength, and select anabolic-related hormones. Method: This was a randomized, double-blind, placebo-controlled trial, in which 36 untrained women were randomly assigned to either a le...
Article
Hoffman, JR, Hoffman, MW, Zelicha, H, Gepner, Y, Willoughby, DS, Feinstein, U, and Ostfeld, I. The Effect of 2-Weeks of Inactivated Probiotic Bacillus coagulans on Endocrine, Inflammatory and Performance Responses During Self-Defense Training in Soldiers. J Strength Cond Res XX(X): 000-000, 2019-The effect of 2 weeks of inactivated Bacillus coagula...
Article
Gluten is a protein found primarily in wheat that has been associated with celiac disease. Gliadin appears to be the primary cause of celiac disease. Gliadin is a peptide contained within gluten-containing foods, and upon ingestion causes inflammation due to stimulation of helper T-cells. Inflammation is characterized by nutrient malabsorption due...
Article
Oxidative stress is a process that produces cellular damage by oxidation of cellular components such as lipids, protein, and DNA. It is also a regulator of the acute phase inflammatory response, and also involves the production of reactive oxygen species (ROS) by mitochondrial respiratory activity and from the capillary endothelium in contracting s...
Article
Background Small increases in homocysteine are associated with increased risk for cardiovascular events patients with end-stage renal disease (ESRD). Endogenous creatine intake may decrease homocysteine via negative feedback inhibition, as creatine is a by-product of methionine and homocysteine metabolism. Therefore, this study was conducted to exa...
Article
The purpose of this 6-wk study was to determine the effects of dynamic contractions supplemented with electromyostimulation (EMS) employed during a weight lifting exercise on knee extensor strength and vertical jump performance. Twenty female college track & field athletes were randomly assigned to 1 of 4 groups: non-weight-training/non-EMS (Contro...
Article
The purpose of this 6-wk study was to determine the effects of dynamic contractions supplemented with electromyo-stimulation (EMS) employed during a weight lifting exercise on knee extensor strength and vertical jump performance. Twenty female college track & field athletes were randomly assigned to 1 of 4 groups: non-weight-training/non-EMS (Contr...
Article
This study attempted to determine the effects of 12-week low- and high-intensity aerobic exercise programs on functional capacity and cardiovascular efficiency of elderly post-coronary artery bypass graft (CABG) patients. Time (Timemax), estimated maximum VO2 (VO2max), heart rate (HRmax), systolic blood pressure (SBPmax), estimated mean arterial bl...
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Full-text available
The effects of exercise training and clenbuterol on the exercise performance and muscle morphology of 69 adult male Northern grass frogs were compared. Frogs were randomly assigned to 1 of 4 groups: control (C), exercise (Ex), drug (Dr), and exercise + drug (Ex + Dr). Groups were tested before and after 6 weeks of treadmill training to evaluate tre...
Article
The effects of exercise training and clenbuterol on the exercise performance and muscle morphology of 69 adult male Northern grass frogs were compared. Frogs were randomly assigned to 1 of 4 groups: control (C), exercise (Ex), drug (Dr), and exercise + drug (Ex + Dr). Groups were tested before and after 6 weeks of treadmill training to evaluate tre...
Article
This study sought to determine the effects of transcutaneous electromyostimulation (EMS) combined with dynamic contractions employed during weight lifting exercise. Male weight-trained college athletes (N = 24) were randomly assigned to 1 of 4 groups; weight training only (Wgt), EMS only (Stim), weight training + EMS (Wgt + Stim), or control. All g...
Article
The present investigation compared the effects of three selected mesocycle-length weight training programs using partially equated volumes on upper and lower body strength. Ninety-two previously weight-trained males were tested at five intervals (T1 through T5) on freeweight bench press and parallel back squat strength before, during, and after 16...
Article
Obesity has become a global epidemic within the last 25 years, with about 65% of the adult population in America being classified as either overweight or obese. In response to this epidemic, countless dietary supplements have emerged in recent years as an easy option to assist in the weight loss process. Capsaicin and evodiamine are two thermogenic...

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