Darren Thomason

• Analysis Group

A majority of patients with diabetes do not have levels of glycated hemoglobin (HbA1c) and low-density lipoprotein cholesterol (LDL-C) under control, either individually or in combination. The objective was to assess the clinical benefits and patient characteristics associated with dual-goal achievement [HbA1c <7% (53 mmol/mol) and LDL-C <100 mg/dL...

Background: Guidelines recommend maximizing the duration of effective treatment that can be achieved without chemotherapy for HR+/HER2- mBC, with the goal of avoiding toxicity and preserving quality of life. A target of three lines of ET is suggested, with CT reserved for patients requiring rapid control of symptomatic disease or who no longer bene...

Introduction: Guidelines recommend reserving chemotherapy (CT) for HR+/HER2- mBC until either endocrine-based therapy (ET) is no longer effective or for patients with visceral crisis or need for rapid tumor control. The extent to which visceral metastases (VM), regardless of whether they are contributing to visceral crisis, impact real-world treatm...

Background: Nilotinib and dasatinib have shown superior rates of molecular response (MR) compared to imatinib for the treatment of newly diagnosed chronic myeloid leukemia (CML) in chronic phase (CP). This study indirectly compares MR in patients taking nilotinib 300 mg bid with that in those taking dasatinib 100 mg qd by 12 months and through 48...

Objective: Clinical guidelines recommend that patients with HR+/HER2- metastatic breast cancer (mBC), the most prevalent mBC subtype, receive three lines of endocrine therapy (ET) prior to transitioning to chemotherapy (CT) in the absence of need for rapid response, symptomatic visceral disease, or suspected endocrine resistance. Little is known a...

OBJECTIVE This study compared the clinical and economic benefits associated with dual-goal achievement, glycated hemoglobin (HbA1c) <7% (53 mmol/mol) and LDL cholesterol (LDL-C) <100 mg/dL, with achievement of only the LDL-C goal or only the HbA1c goal in veterans with type 2 diabetes mellitus (T2DM).RESEARCH DESIGN AND METHODS This retrospective c...

Background: Compared with studies on achieving a single goal of either glycated hemoglobin (HbA1c) or low-density lipoprotein cholesterol (LDL-C) in type 2 diabetes mellitus (T2DM), the clinical benefits of dual-goal achievement (LDL-C<100 mg/dl and HbA1c<7%) are not well documented. This study investigated factors and clinical benefits associated...